Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00522)

Target Name	Matrix metalloproteinase-14 (MMP14)
Synonyms	MMP-14; EC 3.4.24.80; MMP-X1; Membrane-type matrix metalloproteinase 1; MT-MMP 1; MTMMP1; Membrane-type-1 matrix metalloproteinase; MT1-MMP; MT1MMP Click to Show/Hide
Gene Name	MMP14
Sequence	MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAAAVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV Click to Show/Hide
Family	Peptidase M10A family
Function	Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Click to Show/Hide
Gene ID	4323
HGNC ID	HGNC:7160
Ensembl Gene ID	ENSG00000157227
KEGG ID	hsa:4323
Chromosomal Location	14q11.2

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00522)

Matrix metalloproteinase-14 (MMP14)

N6-methyladenosine (m6A)

In total 52 m6A sequence/site(s) in this target gene
mod ID: M6ASITE018802		Click to Show/Hide the Full List
mod site	chr14:22836581-22836582:+		[1]
Sequence	AGGAGAGAGCGAGAGAGGGAACCAGACCCCAGTTCGCCGAC
Motif Score	2.930744048
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000547074.1
External Link	RMBase: m6A_site_239782
mod ID: M6ASITE018803		Click to Show/Hide the Full List
mod site	chr14:22836586-22836587:+		[1]
Sequence	AGAGCGAGAGAGGGAACCAGACCCCAGTTCGCCGACTAAGC
Motif Score	2.876744048
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547074.1; ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239783
mod ID: M6ASITE018804		Click to Show/Hide the Full List
mod site	chr14:22836623-22836624:+		[1]
Sequence	AAGCAGAAGAAAGATCAAAAACCGGAAAAGAGGAGAAGAGC
Motif Score	2.185083333
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547279.1; ENST00000547074.1; ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239784
mod ID: M6ASITE018805		Click to Show/Hide the Full List
mod site	chr14:22836646-22836647:+		[1]
Sequence	GGAAAAGAGGAGAAGAGCAAACAGGCACTTTGAGGAACAAT
Motif Score	2.20572619
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11; ENST00000547279.1; ENST00000547074.1
External Link	RMBase: m6A_site_239785
mod ID: M6ASITE018806		Click to Show/Hide the Full List
mod site	chr14:22836662-22836663:+		[1]
Sequence	GCAAACAGGCACTTTGAGGAACAATCCCCTTTAACTCCAAG
Motif Score	2.951386905
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000547279.1; ENST00000547074.1; ENST00000311852.11
External Link	RMBase: m6A_site_239786
mod ID: M6ASITE018807		Click to Show/Hide the Full List
mod site	chr14:22836724-22836725:+		[1]
Sequence	AAGTTCAGTGCCTACCGAAGACAAAGGCGCCCCGAGGGAGT
Motif Score	2.897386905
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547074.1; ENST00000311852.11; ENST00000548162.1; ENST00000547279.1
External Link	RMBase: m6A_site_239787
mod ID: M6ASITE018808		Click to Show/Hide the Full List
mod site	chr14:22836814-22836815:+		[1]
Sequence	GGCTGACCCGGTGGTCTCGGACCATGTCTCCCGCCCCAAGA
Motif Score	3.622404762
Cell/Tissue List	HepG2; U2OS; H1A; H1B; MM6; Huh7; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547279.1; ENST00000547074.1; ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239788
mod ID: M6ASITE018809		Click to Show/Hide the Full List
mod site	chr14:22836834-22836835:+		[1]
Sequence	ACCATGTCTCCCGCCCCAAGACCCCCCCGTTGTCTCCTGCT
Motif Score	2.876744048
Cell/Tissue List	HepG2; H1A; H1B; MM6; CD4T; peripheral-blood; GSC-11; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547279.1; ENST00000311852.11; ENST00000547074.1; ENST00000548162.1
External Link	RMBase: m6A_site_239789
mod ID: M6ASITE018810		Click to Show/Hide the Full List
mod site	chr14:22837191-22837192:+		[1]
Sequence	TTTTCCCAGTCCTTGGAAGAACTTTACAACTGGGGCGAACT
Motif Score	3.373380952
Cell/Tissue List	HepG2; H1A; H1B; MM6; CD4T; peripheral-blood; GSC-11; MSC; iSLK; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000547074.1; ENST00000547279.1; ENST00000548162.1
External Link	RMBase: m6A_site_239790
mod ID: M6ASITE018811		Click to Show/Hide the Full List
mod site	chr14:22837209-22837210:+		[2]
Sequence	GAACTTTACAACTGGGGCGAACTCCCCCTTCCCCGATTCCC
Motif Score	3.373380952
Cell/Tissue List	H1A; H1B; MM6; CD4T; peripheral-blood; GSC-11; MSC; iSLK; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000547279.1; ENST00000311852.11; ENST00000547074.1; ENST00000548162.1
External Link	RMBase: m6A_site_239791
mod ID: M6ASITE018812		Click to Show/Hide the Full List
mod site	chr14:22837254-22837255:+		[3]
Sequence	GCTCTGCTCTCAGCTCTGGAACCGCCTGATAAACATTTGGA
Motif Score	2.930744048
Cell/Tissue List	MM6; peripheral-blood; MSC; iSLK; TIME; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1; ENST00000547074.1; ENST00000547279.1
External Link	RMBase: m6A_site_239792
mod ID: M6ASITE018813		Click to Show/Hide the Full List
mod site	chr14:22837266-22837267:+		[4]
Sequence	GCTCTGGAACCGCCTGATAAACATTTGGACTCCGCTCAAAC
Motif Score	2.20572619
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000547074.1; ENST00000547279.1; ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239793
mod ID: M6ASITE018814		Click to Show/Hide the Full List
mod site	chr14:22837274-22837275:+		[4]
Sequence	ACCGCCTGATAAACATTTGGACTCCGCTCAAACCCCGCGCT
Motif Score	4.065041667
Cell/Tissue List	MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1; ENST00000547279.1; ENST00000547074.1
External Link	RMBase: m6A_site_239794
mod ID: M6ASITE018815		Click to Show/Hide the Full List
mod site	chr14:22842257-22842258:+		[5]
Sequence	GAGGATCCCTTGTTCTTGAGACAGAGGCGTTGCGCATGAGG
Motif Score	2.897386905
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000547596.1; ENST00000311852.11; ENST00000548162.1; ENST00000548761.1
External Link	RMBase: m6A_site_239795
mod ID: M6ASITE018816		Click to Show/Hide the Full List
mod site	chr14:22842663-22842664:+		[6]
Sequence	AGGCCCCAACATTGGAGGAGACACCCACTTTGACTCTGCCG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; peripheral-blood; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239796
mod ID: M6ASITE018817		Click to Show/Hide the Full List
mod site	chr14:22842692-22842693:+		[7]
Sequence	TTGACTCTGCCGAGCCTTGGACTGTCAGGAATGAGGATCTG
Motif Score	4.065041667
Cell/Tissue List	peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239797
mod ID: M6ASITE018818		Click to Show/Hide the Full List
mod site	chr14:22843262-22843263:+		[8]
Sequence	CCCCATCCTTCCAGGAAATGACATCTTCCTGGTGGCTGTGC
Motif Score	2.859755952
Cell/Tissue List	kidney; hESC-HEK293T
Seq Type List	m6A-REF-seq; MAZTER-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239798
mod ID: M6ASITE018819		Click to Show/Hide the Full List
mod site	chr14:22843361-22843362:+		[7]
Sequence	ACCCTTTTACCAGTGGATGGACACGGAGAATTTTGTGCTGC
Motif Score	3.643047619
Cell/Tissue List	peripheral-blood; endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239799
mod ID: M6ASITE018820		Click to Show/Hide the Full List
mod site	chr14:22843753-22843754:+		[7]
Sequence	AGATGCCCCCTCAACCCAGGACTACCTCCCGGCCTTCTGTT
Motif Score	4.065041667
Cell/Tissue List	peripheral-blood
Seq Type List	m6A-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239800
mod ID: M6ASITE018821		Click to Show/Hide the Full List
mod site	chr14:22844632-22844633:+		[6]
Sequence	CCTCCTGTCCTCCCCAGGAGACAAGCATTGGGTGTTTGATG
Motif Score	2.897386905
Cell/Tissue List	hESC-HEK293T; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239801
mod ID: M6ASITE018822		Click to Show/Hide the Full List
mod site	chr14:22844666-22844667:+		[5]
Sequence	TTTGATGAGGCGTCCCTGGAACCTGGCTACCCCAAGCACAT
Motif Score	2.930744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239802
mod ID: M6ASITE018823		Click to Show/Hide the Full List
mod site	chr14:22844683-22844684:+		[6]
Sequence	GGAACCTGGCTACCCCAAGCACATTAAGGAGCTGGGCCGAG
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239803
mod ID: M6ASITE018824		Click to Show/Hide the Full List
mod site	chr14:22844716-22844717:+		[6]
Sequence	GGGCCGAGGGCTGCCTACCGACAAGATTGATGCTGCTCTCT
Motif Score	2.865571429
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239804
mod ID: M6ASITE018825		Click to Show/Hide the Full List
mod site	chr14:22844757-22844758:+		[5]
Sequence	TCTGGATGCCCAATGGAAAGACCTACTTCTTCCGTGGAAAC
Motif Score	2.876744048
Cell/Tissue List	endometrial
Seq Type List	m6A-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239805
mod ID: M6ASITE018826		Click to Show/Hide the Full List
mod site	chr14:22844776-22844777:+		[6]
Sequence	GACCTACTTCTTCCGTGGAAACAAGTAAGACCTCAACCCCT
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T; endometrial
Seq Type List	MAZTER-seq; m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239806
mod ID: M6ASITE018827		Click to Show/Hide the Full List
mod site	chr14:22845303-22845304:+		[9]
Sequence	GGATAGCGAGTACCCCAAGAACATCAAAGTCTGGGAAGGGA
Motif Score	2.951386905
Cell/Tissue List	Huh7; endometrial
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239807
mod ID: M6ASITE018828		Click to Show/Hide the Full List
mod site	chr14:22845731-22845732:+		[1]
Sequence	CACTTACTTCTACAAGGGGAACAAATACTGGAAATTCAACA
Motif Score	2.951386905
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MT4; MM6; Huh7; peripheral-blood; GSC-11; HEK293A-TOA; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239808
mod ID: M6ASITE018829		Click to Show/Hide the Full List
mod site	chr14:22845771-22845772:+		[1]
Sequence	AACCAGAAGCTGAAGGTAGAACCGGGCTACCCCAAGTCAGC
Motif Score	2.930744048
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239809
mod ID: M6ASITE018830		Click to Show/Hide the Full List
mod site	chr14:22845800-22845801:+		[1]
Sequence	CCCCAAGTCAGCCCTGAGGGACTGGATGGGCTGCCCATCGG
Motif Score	4.065041667
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239810
mod ID: M6ASITE018831		Click to Show/Hide the Full List
mod site	chr14:22845841-22845842:+		[1]
Sequence	GAGGCCGGCCGGATGAGGGGACTGAGGAGGAGACGGAGGTG
Motif Score	4.065041667
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; H1299; MM6; Huh7; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239811
mod ID: M6ASITE018832		Click to Show/Hide the Full List
mod site	chr14:22845988-22845989:+		[1]
Sequence	TCTTCTTCAGACGCCATGGGACCCCCAGGCGACTGCTCTAC
Motif Score	3.622404762
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239812
mod ID: M6ASITE018833		Click to Show/Hide the Full List
mod site	chr14:22846028-22846029:+		[1]
Sequence	CTGCCAGCGTTCCCTGCTGGACAAGGTCTGACGCCCACCGC
Motif Score	3.643047619
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239813
mod ID: M6ASITE018834		Click to Show/Hide the Full List
mod site	chr14:22846074-22846075:+		[1]
Sequence	CGCCCACTCCTACCACAAGGACTTTGCCTCTGAAGGCCAGT
Motif Score	4.065041667
Cell/Tissue List	HepG2; U2OS; H1A; H1B; hNPCs; hESCs; fibroblasts; MM6; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; iSLK; MSC; TIME; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239814
mod ID: M6ASITE018835		Click to Show/Hide the Full List
mod site	chr14:22846297-22846298:+		[10]
Sequence	AGCCTCTGCCCCTCAGGGGAACCCTGTAGCTTTGTGTCTGT
Motif Score	2.930744048
Cell/Tissue List	U2OS; MM6; peripheral-blood; iSLK; MSC; TIME
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239815
mod ID: M6ASITE018836		Click to Show/Hide the Full List
mod site	chr14:22846363-22846364:+		[10]
Sequence	GCTCTGCACTTGAAGGCAGGACCCTCAGACCTCGCTGGTAA
Motif Score	3.622404762
Cell/Tissue List	U2OS; Huh7; iSLK; MSC; TIME
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239816
mod ID: M6ASITE018837		Click to Show/Hide the Full List
mod site	chr14:22846371-22846372:+		[9]
Sequence	CTTGAAGGCAGGACCCTCAGACCTCGCTGGTAAAGGTCAAA
Motif Score	2.876744048
Cell/Tissue List	Huh7; iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239817
mod ID: M6ASITE018838		Click to Show/Hide the Full List
mod site	chr14:22846440-22846441:+		[4]
Sequence	TGACATACCTTAACCTCTGAACTCTGACCTCAGGAGGCTCT
Motif Score	3.373380952
Cell/Tissue List	iSLK; MSC
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239818
mod ID: M6ASITE018839		Click to Show/Hide the Full List
mod site	chr14:22846556-22846557:+		[1]
Sequence	TAATCTTGTTGAGGGTAGAGACCCTGAGACAGTGTGAGGGG
Motif Score	2.876744048
Cell/Tissue List	HepG2; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239819
mod ID: M6ASITE018840		Click to Show/Hide the Full List
mod site	chr14:22846564-22846565:+		[1]
Sequence	TTGAGGGTAGAGACCCTGAGACAGTGTGAGGGGGTGGGGAC
Motif Score	2.897386905
Cell/Tissue List	HepG2; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239820
mod ID: M6ASITE018841		Click to Show/Hide the Full List
mod site	chr14:22846583-22846584:+		[1]
Sequence	GACAGTGTGAGGGGGTGGGGACTGCCAAGCCACCCTAAGAC
Motif Score	4.065041667
Cell/Tissue List	HepG2; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239821
mod ID: M6ASITE018842		Click to Show/Hide the Full List
mod site	chr14:22846602-22846603:+		[1]
Sequence	GACTGCCAAGCCACCCTAAGACCTTGGGAGGAAAACTCAGA
Motif Score	2.876744048
Cell/Tissue List	HepG2; peripheral-blood; MSC; endometrial
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239822
mod ID: M6ASITE018843		Click to Show/Hide the Full List
mod site	chr14:22846616-22846617:+		[1]
Sequence	CCTAAGACCTTGGGAGGAAAACTCAGAGAGGGTCTTCGTTG
Motif Score	2.627720238
Cell/Tissue List	HepG2; H1B; peripheral-blood; GSC-11; MSC; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239823
mod ID: M6ASITE018844		Click to Show/Hide the Full List
mod site	chr14:22846690-22846691:+		[1]
Sequence	TGCCTCACCTACCCCAGGGAACTTCCAAGGAAGGAGCCTGA
Motif Score	3.373380952
Cell/Tissue List	HepG2; U2OS; H1B; CD4T; peripheral-blood; GSC-11; MSC; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239824
mod ID: M6ASITE018845		Click to Show/Hide the Full List
mod site	chr14:22846721-22846722:+		[1]
Sequence	AGGAGCCTGAGCCACTGGGGACTAAGTGGGCAGAAGAAACC
Motif Score	4.065041667
Cell/Tissue List	HepG2; U2OS; H1B; CD4T; peripheral-blood; GSC-11; MSC; endometrial; NB4; MM6
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239825
mod ID: M6ASITE018846		Click to Show/Hide the Full List
mod site	chr14:22846739-22846740:+		[1]
Sequence	GGACTAAGTGGGCAGAAGAAACCCTTGGCAGCCCTGTGCCT
Motif Score	2.185083333
Cell/Tissue List	HepG2; U2OS; H1B; MM6; CD4T; peripheral-blood; GSC-11; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239826
mod ID: M6ASITE018847		Click to Show/Hide the Full List
mod site	chr14:22846807-22846808:+		[1]
Sequence	TCACAGTTAGAAGAGCTGAAACCAGGGGTGCAGCTGTCAGG
Motif Score	2.185083333
Cell/Tissue List	HepG2; U2OS; H1A; H1B; fibroblasts; MM6; CD4T; peripheral-blood; GSC-11; MSC; endometrial; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239827
mod ID: M6ASITE018848		Click to Show/Hide the Full List
mod site	chr14:22846897-22846898:+		[1]
Sequence	CTGAAGGCCACAGAGAAAGAACCTTGCCCAAACTCAGGCAG
Motif Score	2.930744048
Cell/Tissue List	HepG2; U2OS; H1A; H1B; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239828
mod ID: M6ASITE018849		Click to Show/Hide the Full List
mod site	chr14:22846908-22846909:+		[1]
Sequence	AGAGAAAGAACCTTGCCCAAACTCAGGCAGCTGGGGCTGAG
Motif Score	2.627720238
Cell/Tissue List	HepG2; U2OS; H1A; H1B; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239829
mod ID: M6ASITE018850		Click to Show/Hide the Full List
mod site	chr14:22846942-22846943:+		[1]
Sequence	GGCTGAGGCCCAAAGGCAGAACAGCCAGAGGGGGCAGGAGG
Motif Score	2.951386905
Cell/Tissue List	HepG2; U2OS; H1A; H1B; fibroblasts; MM6; Huh7; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239830
mod ID: M6ASITE018851		Click to Show/Hide the Full List
mod site	chr14:22846965-22846966:+		[1]
Sequence	GCCAGAGGGGGCAGGAGGGGACCAAAAAGGAAAATGAGGAC
Motif Score	3.622404762
Cell/Tissue List	HepG2; U2OS; H1A; H1B; fibroblasts; LCLs; MM6; Huh7; CD4T; peripheral-blood; GSC-11; endometrial; GSCs; NB4
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239831
mod ID: M6ASITE018852		Click to Show/Hide the Full List
mod site	chr14:22847417-22847418:+		[10]
Sequence	TGGTGGCCATGGTACCGGGGACTTGGGAGAGTGAGACCCAG
Motif Score	4.065041667
Cell/Tissue List	U2OS; endometrial; NB4
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000548162.1; ENST00000311852.11
External Link	RMBase: m6A_site_239832
mod ID: M6ASITE018853		Click to Show/Hide the Full List
mod site	chr14:22847432-22847433:+		[10]
Sequence	CGGGGACTTGGGAGAGTGAGACCCAGTGGAGGGAGCAAGAG
Motif Score	2.876744048
Cell/Tissue List	U2OS
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000311852.11; ENST00000548162.1
External Link	RMBase: m6A_site_239833

Ref 1	Efficacy of MEK inhibition in patients with histiocytic neoplasms. Nature. 2019 Mar;567(7749):521-524. doi: 10.1038/s41586-019-1012-y. Epub 2019 Mar 13.
Ref 2	m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 2014 Dec 4;15(6):707-19. doi: 10.1016/j.stem.2014.09.019. Epub 2014 Oct 16.
Ref 3	FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNA Demethylase. Cancer Cell. 2017 Jan 9;31(1):127-141. doi: 10.1016/j.ccell.2016.11.017. Epub 2016 Dec 22.
Ref 4	Viral and cellular N(6)-methyladenosine and N(6),2'-O-dimethyladenosine epitranscriptomes in the KSHV life cycle. Nat Microbiol. 2018 Jan;3(1):108-120. doi: 10.1038/s41564-017-0056-8. Epub 2017 Nov 6.
Ref 5	m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat Cell Biol. 2018 Sep;20(9):1074-1083. doi: 10.1038/s41556-018-0174-4. Epub 2018 Aug 27.
Ref 6	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 7	R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m(6)A/MYC/CEBPA Signaling. Cell. 2018 Jan 11;172(1-2):90-105.e23. doi: 10.1016/j.cell.2017.11.031. Epub 2017 Dec 14.
Ref 8	Single-base mapping of m(6)A by an antibody-independent method. Sci Adv. 2019 Jul 3;5(7):eaax0250. doi: 10.1126/sciadv.aax0250. eCollection 2019 Jul.
Ref 9	N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host Microbe. 2016 Nov 9;20(5):654-665. doi: 10.1016/j.chom.2016.09.015. Epub 2016 Oct 20.
Ref 10	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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