m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05851
|
[1] | |||
m6A modification
ASH1L
ASH1L
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Histone modification
H3K4me3
ASH1L
IL23R
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Histone-lysine N-methyltransferase ASH1L (ASH1L) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Histone-lysine N-methyltransferase ASH1L (ASH1L) | WRITER | View Details | ||
| Regulated Target | Histone H3 lysine 4 trimethylation (H3K4me3) | View Details | |||
| Downstream Gene | IL23R | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Enhancement | |||
| Crosstalk Mechanism | m6A modification impacts directly histone modification through modulating the expression level of histone-associated enzymes | ||||
| Crosstalk Summary | METTL3 promoted the expression of Histone-lysine N-methyltransferase ASH1L (ASH1L) via enhancing its stability in a YT521-B homology domain containing 2 (YTHDC2)-dependent manner, which further decreased the expression of IL-17 and IL-23 receptor (IL23R) by modulating Histone H3 lysine 4 trimethylation (H3K4me3) levels, resulting in reduced pathogenic Th17 responses. | ||||
| Responsed Disease | Uveitis | ICD-11: 9A96 | |||
| Pathway Response | TLR3-IRF7 signaling pathway | hsa00148 | |||
| Cell Process | mRNA stability | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| 9A96: Uveitis | 1 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
Sivelestat | Application submitted | [2] | |
|---|---|---|---|---|
| Synonyms |
127373-66-4; UNII-DWI62G0P59; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; Elastase Inhibitor IV; C20H22N2O7S; N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid; Sivelestat (ONO-5046); LY544349; CHEMBL76688; LY 544349; DWI62G0P59; Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-; N-(o-(p-Pivaloyloxybenzene)sulfonylaminobenzoyl)glycine
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| External Link | ||||
References