Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00552)
Target Name Interleukin-23 receptor (IL23R)
Synonyms
IL-23 receptor; IL-23R
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Gene Name IL23R
Sequence
MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK
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Family Type I cytokine receptor family, Type 2 subfamily
Function
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. {ECO:0000269|PubMed:12023369}.
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Gene ID 149233
HGNC ID HGNC:19100
Ensembl Gene ID ENSG00000162594
KEGG ID hsa:149233
Chromosomal Location 1p31.3
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00552)
Interleukin-23 receptor (IL23R)
N6-methyladenosine (m6A)
In total 8 m6A sequence/site(s) in this target gene
mod ID: M6ASITE030583 Click to Show/Hide the Full List
mod site chr1:67169517-67169518:+ [1]
Sequence AAATCACAAGGATTAATAAAACAACAGCTCGGCTTTGGTAT
Motif Score 2.20572619
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35032
mod ID: M6ASITE030584 Click to Show/Hide the Full List
mod site chr1:67169542-67169543:+ [1]
Sequence AGCTCGGCTTTGGTATAAAAACTTTCTGGAACCACATGCTT
Motif Score 2.627720238
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000347310.9; ENST00000637002.1
External Link RMBase: m6A_site_35033
mod ID: M6ASITE030585 Click to Show/Hide the Full List
mod site chr1:67169552-67169553:+ [1]
Sequence TGGTATAAAAACTTTCTGGAACCACATGCTTCTATGTACTG
Motif Score 2.930744048
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35034
mod ID: M6ASITE030586 Click to Show/Hide the Full List
mod site chr1:67169591-67169592:+ [1]
Sequence TGCACTGCTGAATGTCCCAAACATTTTCAAGAGACACTGAT
Motif Score 2.20572619
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35035
mod ID: M6ASITE030587 Click to Show/Hide the Full List
mod site chr1:67169604-67169605:+ [1]
Sequence GTCCCAAACATTTTCAAGAGACACTGATATGTGGAAAAGAC
Motif Score 2.897386905
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35036
mod ID: M6ASITE030588 Click to Show/Hide the Full List
mod site chr1:67169623-67169624:+ [1]
Sequence GACACTGATATGTGGAAAAGACATTTCTTCTGGATGTAAGT
Motif Score 2.897386905
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35037
mod ID: M6ASITE030589 Click to Show/Hide the Full List
mod site chr1:67258767-67258768:+ [1]
Sequence ATTACTTCCTTAACACTTAAACCACCAGTTGATTCCTTAGA
Motif Score 2.185083333
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000395227.2; ENST00000425614.3; ENST00000473881.2; ENST00000637002.1; ENST00000347310.9
External Link RMBase: m6A_site_35038
mod ID: M6ASITE030590 Click to Show/Hide the Full List
mod site chr1:67258995-67258996:+ [1]
Sequence CCCAGTGAAACTATTCCAGAACAGACCCTGCTTCCTGATGA
Motif Score 2.951386905
Cell/Tissue List GM12878
Seq Type List m6A-seq
Transcript ID List ENST00000473881.2; ENST00000425614.3; ENST00000347310.9; ENST00000637002.1; ENST00000395227.2
External Link RMBase: m6A_site_35039