m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05752
|
[1] | |||
m6A modification
miR-181a
miR-181a
WTAP
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
miR-181a
SFRP1
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Wilms tumor 1-associating protein (WTAP) | WRITER | |||
| m6A Target | miR-181a | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | miR-181a | microRNA | View Details | ||
| Regulated Target | Secreted frizzled related protein 1 (SFRP1) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | The WTAP/YTHDC1/miR-181a and miR-181c/Secreted frizzled related protein 1 (SFRP1) axis regulated the differentiation fate of BMSCs, suggesting that it might be a potential therapeutic target for osteoporosis. | ||||
| Responsed Disease | Osteoporosis | ICD-11: FB83.1 | |||
| Pathway Response | Wnt signaling pathway | hsa04310 | |||
| Cell Process | Cell differentiation | ||||
In-vitro Model |
BMSCs (BMSCs were obtained from the femurs and tibias of 2-3-week-old Sprague-Dawley male rats (Animal Center of Sun Yat-sen University)) | ||||