m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05739
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[1] | |||
m6A modification
Circ_MIRLET7BHG
Circ_MIRLET7BHG
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
circMIRLET7BHG
IGF2BP1
lncRNA miRNA circRNA
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Circ_MIRLET7BHG | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_MIRLET7BHG | circRNA | View Details | ||
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | Mechanistically, methyltransferase-like 3 (METTL3) enhanced Circ_MIRLET7BHG expression via m6A methylation, which enhanced ADAM10 mRNA stability via interaction with Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1),thereby promoting AR by inducing epithelial barrier dysfunction. | ||||
| Responsed Disease | Allergic rhinitis | ICD-11: CA08 | |||
| Cell Process | RNA stability | ||||
| Cell infiltration, Cell apoptosis, inflammatory | |||||
In-vitro Model |
HNEpC (Human Nasal Epithelial Cells) | ||||
| In-vivo Model | Briefly, the mice were intraperitoneally injected with 25 μg OVA mixed with 1 mg aluminum hydroxide gel was intraperitoneally injected into mice once a week for three weeks. Subsequently, nostril challenge with 500 μg OVA was performed once a day for one week. The control mice were exposed to PBS (vehicle). LV-sh-NC or LV-sh-circMIRLET7BHG (1 × 107 TU/mL, GenePharma) were injected into mice via the tail vein two days before the nostril challenge. | ||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| CA08: BackgroundAllergic rhinitis | 2 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
Conjugated Estrogens | Approved | [2] | |
|---|---|---|---|---|
| Synonyms |
Par Estro; evex; Premarin; Conestoral; NSC18313; Sodium estrone 3-monosulfate; Estrone, hydrogen sulfate sodium salt; AC1NS0NL; NSC-18313; sodium [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate; Estra-1,5(10)-trien-17-one, 3-(sulfooxy)-, sodium; Carentil; Congest; Estroplus; Menotabs; Oestrogen; Prelestrin; Presomil; Progens; Conjugated Equine Estrogens; Conjugated Estrogenic Substances; Conjugated estrogenic hormones; Conjugated oestrogens; Conjugated oestrogens [Steroidal oestrogens]; Steroidal estrogens; ASTA Medica Brand of Estrogens, Conjugated; Almirall Brand of Estrogens, Conjugated; Equine Estrogens, Conjugated; Estro-Feminal; Estrogenic Hormones, Conjugated; Estrogenic substances, conjugated; Estrogens, conjugated USP; Estrogens, conjugated [USP]; Estrogens, conjugated synthetic A; Estrogens, steroidal; Solvay Brand of Estrogens, Conjugated; Trianon Brand of Estrogens, Conjugated; Wyeth Brand of Estrogens, Conjugated; Estrogens, conjugated (USP); Estrogens, conjugated-equine; Mack Brand of Estrogens, Conjugated (USP); Major Brand of Estrogens, Conjugated (USP); Pasadena Brand of Estrogens, Conjugated (USP); Pharmacia Brand of Estrogens, Conjugated (USP); CES; Estra-1,3,5(10)-trien-17-one, 3-(sulfooxy)-, sodium salt
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| Compound Name |
Carbinoxamine | Approved | [3] | |
| Synonyms |
Allergefon; Carbinoxamina; Carbinoxaminum; Clistin; Clistine; Paracarbinoxamine; Paracarinoxamine; Rotoxamine; Carbinoxamine base; Carbinoxamina [INN-Spanish]; Carbinoxamine (INN); Carbinoxamine [INN:BAN]; Carbinoxaminum [INN-Latin]; Clistin (TN); McN-R 73Z; Palgic (TN); {2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine; N,N-Dimethyl-2-(p-chloro-alpha-(2-pyridyl)benzyloxy)ethylamine; Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-(9CI); (+-)-Carbinoxamine; 2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine; 2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine; 2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine; 2-{[(4-chlorophenyl)(pyridin-2-yl)methyl]oxy}-N,N-dimethylethanamine
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References