m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05726
 [1]
m6A modification TIALD TIALD METTL16 Methylation : m6A sites Direct Enhancement Non-coding RNA TIALD AURKA  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 16 (METTL16) WRITER
 Regulator Info 
m6A Target Transcript inducer of AURKA lysosomal degradation (TIALD)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Transcript inducer of AURKA lysosomal degradation (TIALD) LncRNA View Details
Regulated Target Aurora kinase A (AURKA) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary Mechanistically, Transcript inducer of Aurora kinase A (AURKA) lysosomal degradation (TIALD) directly interacts with AURKA and facilitate its degradation through the lysosomal pathway to inhibited EMT and metastasis of HCC. AURKA's specific inhibitor alisertib exerts effective therapeutic effect on liver cancer with low TIALD expression, which might provide a new insight into HCC therapy. Our study uncovers a negative functional loop of METTL16-TIALD-AURKA axis, and identifies a new mechanism for METTL16 mediated m6A-induced decay of TIALD on AURKA signaling in HCC progression, which may provide potential prognostic and therapeutic targets for HCC.
Responsed Disease Liver cancer ICD-11: 2C12
 Disease Info 
Responsed Drug alisertib
 Drug Info 
Cell Process mRNA decay
In-vitro Model
 SNU-449 Adult hepatocellular carcinoma Homo sapiens CVCL_0454
SK-HEP-1 Liver and intrahepatic bile duct epithelial neoplasm Homo sapiens CVCL_0525
Hep-G2/C3A Hepatoblastoma Homo sapiens CVCL_1098
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
In-vivo Model In the therapeutic study, TIALD stable knockdown or control cells were further infected by lentiviruses (Ubi-MCS-firefly_Luciferase-SV40-neomycin, Genechem, China) and selected by G418 (500 μg/mL). 45 B-NDG mice were divided into 3 groups, including the control group (n = 15), TIALD knockdown group (n = 15) and Alisertib treatment group (n = 15). The modified control cells described above were injected into the mice of control group via tail vein, while the modified TIALD knockdown cells were injected into the mice of TIALD knockdown group and Alisertib treatment group.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Aurora kinase A (AURKA) 27 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name MLN8237 Phase 3 [2]
Synonyms
Alisertib
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.04 nM
External Link
CID: 24771867
TTD: D0S4JK
DrugBank: DB05220
 Compound Name AT9283 Phase 3 [3]
MOA Modulator
Activity IC50 = 3 nM
External Link
CID: 135398495
TTD: D05PZB
 Compound Name Rosiglitazone + metformin Phase 3 [4]
Synonyms
Orantinib; TSU-68; 252916-29-3; SU-6668; SU6668; SU 6668; 210644-62-5; UNII-9RL37ZZ665; Orantinib (TSU-68); NSC 702827; TSU68; CHEMBL274654; 9RL37ZZ665; TSU 68; PDGFR Tyrosine Kinase Inhibitor VI, SU6668; 2,4-Dimethyl-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-pyrrole-3-propanoic acid; J-502593; Orantinibum; 3-(2,4-dimethyl-5-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid; 3-[2,4-dimethyl-5-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; Orantinib [INN]
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5329099
TTD: D0A1AQ
DrugBank: DB12072
 Compound Name ENMD-2076 Phase 2 [5]
Synonyms
934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; UNII-J6U9WP10T7; ENMD2076; J6U9WP10T7; CHEMBL482968; 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine; 6-(4-METHYL-1-PIPERAZINYL)-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-[(1E)-2-PHENYLETHENYL]-4-PYRIMIDINAMINE; ENMD-981693; MLS006011042; SCHEMBL596481; GTPL7885; SCHEMBL15668060; SCHEMBL10122872; ENND-2076; EX-A235; DTXSID60239430; MolPort-009-679-391; AOB87159
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 14 nM
External Link
CID: 16041424
TTD: D0S7HM
 Compound Name VX-680 Phase 2 [4]
Synonyms
Tozasertib; MK 0457; VX 680; VX6; L-001281814; MK-045; MK-0457; Tozasertib (USAN); VX-68; MK-0457, Tozasertib, VX680, VX-680; N-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide; N-(4-(4-(3-methyl-1H-pyrazol-5-ylamino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid N-(4-((4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl)sulfanyl)phenyl)amide; Cyclopropane carboxylic acid{4-[4-(4-methyl-piperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)-pyrimidin-2-ylsulphanyl]-phenyl}-amide; Cyclopropanecarboxylic Acid {4-[4-(4-Methyl-Piperazin-1-Yl)-6-(5-Methyl-2h-Pyrazol-3-Ylamino)-Pyrimidin-2-Ylsulfanyl]-Phenyl}-Amide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.24 nM
External Link
CID: 5494449
TTD: D02XNW
 Compound Name ABT-348 Phase 2 [6]
Synonyms
ILORASERTIB; 1227939-82-3; UNII-6L5D03D975; ABT 348; ABT348; 6L5D03D975; A-968660; Abbott-969660; Ilorasertib [USAN:INN]; Ilorasertib (USAN); Kinome_405; GTPL9914; A-968660.0; SCHEMBL3381224; CHEMBL1980297; DTXSID10153718; WPHKIQPVPYJNAX-UHFFFAOYSA-N; BCP07256; ZINC63298074; BDBM50381716; SB16853; CS-6804; DB11694; KB-74395; HY-16018; US8722890, 1; Z-3287; US8722890, 2; D10423; N-(4-{4-amino-7-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin-3-yl}phenyl)-N'-(3-fluorophenyl)urea
    Click to Show/Hide
MOA Modulator
Activity IC50 = 12 nM
External Link
CID: 46207586
TTD: D08HOM
DrugBank: DB11694
 Compound Name PHA-739358 Phase 2 [5]
Synonyms
Danusertib; PHA 739358; Danusertib, PHA-739358; (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; 5-Amido-pyrrolopyrazole 9d
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2.5 nM
External Link
CID: 11442891
TTD: D02RJY
DrugBank: DB11778
 Compound Name LY3295668 Phase 1/2 [7]
Synonyms
1919888-06-4; (2R,4R)-1-(3-Chloro-2-fluorobenzyl)-4-((3-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyridin-2-yl)methyl)-2-methylpiperidine-4-carboxylic acid; AK-01; LY-3295668; (2R,4R)-1-[(3-chloro-2-fluorophenyl)methyl]-4-({3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridin-2-yl}methyl)-2-methylpiperidine-4-carboxylic acid; UNII-1WX8O5XV4R; 1WX8O5XV4R; SCHEMBL17747406; NSC816863; NSC-816863; Aurora A kinase inhibitor LY3295668; HY-114258; CS-0080775; LY3295668 (AK-01); A16869; (2R,4R)-1-[(3-Chloro-2-fluoro-phenyl)methyl]-4-[[3-fluoro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyridyl]methyl]-2-methyl-piperidine-4-carboxylic acid; 1-((3-Chloro-2-fluorophenyl)methyl)-4-((3-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyridinyl)methyl)-2-methyl-, (2R,4R)-,4-piperidinecarboxylic acid; 4-Piperidinecarboxylic acid, 1-((3-chloro-2-fluorophenyl)methyl)-4-((3-fluoro-6-((5-methyl-1H-pyrazol-3-yl)amino)-2-pyridinyl)methyl)-2-methyl-, (2R,4R)-; EG7
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 121333423
TTD: D3QEZ2
 Compound Name MLN8054 Phase 1 [4]
Synonyms
ZZL; MLN-8054
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1 nM
External Link
CID: 11712649
TTD: D0A5MC
DrugBank: DB13061
 Compound Name TAS-119 Phase 1 [8]
MOA Inhibitor
External Link
TTD: D0L3RO
 Compound Name VIC-1911 Phase 1 [9]
Synonyms
TAS 119
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D6FX2G
 Compound Name R763 Phase 1 [10]
MOA Inhibitor
External Link
CID: 11569967
TTD: D0E5XA
DrugBank: DB06347
 Compound Name MK-5108 Phase 1 [11]
Synonyms
1010085-13-8; VX-689; MK 5108; MK5108; MK-5108 (VX-689); UNII-H8J407531S; VX689; VX 689; CHEMBL3600873; H8J407531S; 4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid; 4-(3-Chloranyl-2-Fluoranyl-Phenoxy)-1-[[6-(1,3-Thiazol-2-Ylamino)pyridin-2-Yl]methyl]cyclohexane-1-Carboxylic Acid; (1r,4r)-4-(3-chloro-2-fluorophenoxy)-1-((6-(thiazol-2-ylamino)pyridin-2-yl)methyl)cyclohexane-1-carboxylic acid; Cyclohexanecarboxylic acid,; MK-5108/VX-689
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.046 nM
External Link
CID: 24748204
TTD: D0J6AB
DrugBank: DB12556
 Compound Name HPP-607 Phase 1 [12]
MOA Inhibitor
External Link
TTD: D05LKZ
 Compound Name CYC116 Phase 1 [13]
Synonyms
693228-63-6; CYC-116; CHEMBL482967; Kinome_636; 4-methyl-5-(2-(4-morpholinophenylamino)pyrimidin-4-yl)thiazol-2-amine; 4-Methyl-5-(2-((4-morpholinophenyl)amino)-pyrimidin-4-yl)thiazol-2-amine; 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine; 4-methyl-5-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)thiazol-2-amine; 2uue; CYC 116; GPSZYOIFQZPWEJ-UHFFFAOYSA-N; 2c5t; AC1O4WKE; MLS006011244; SCHEMBL2074998; SYN1034; EX-A753; CYC-116/CYC116; MolPort-009-679-476; HMS3244O12; HMS3244P11; BCPP000273
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 8 nM
External Link
CID: 6420138
TTD: D0CY1B
 Compound Name AMG 900 Phase 1 [14]
Synonyms
AMG-900; 945595-80-2; AMG900; UNII-9R2G075611; N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine; 9R2G075611; N-(4-((3-(2-aminopyrimidin-4-yl)pyridin-2-yl)oxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine; N-[4-[3-(2-aminopyrimidin-4-yl)pyridin-2-yl]oxyphenyl]-4-(4-methylthiophen-2-yl)phthalazin-1-amine; N-(4-(3-(2-aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen- 2-yl)phthalazin-1-amine; IVUGFMLRJOCGAS-UHFFFAOYSA-N
    Click to Show/Hide
MOA Modulator
Activity IC50 = 5 nM
External Link
CID: 24856041
TTD: D0EJ3B
 Compound Name SNS-314 Phase 1 [15]
Synonyms
SN-314
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24995524
TTD: D0OA5G
DrugBank: DB07361
 Compound Name PF-03814735 Discontinued in Phase 1 [5]
Synonyms
942490-07-5; PF 03814735; PF-3814735; PF03814735; Kinome_1769; MLS006010949; CHEMBL1983111; SB19308; NCGC00389594-01; KB-74441; SMR004703046; BCP0726000114; J3.628.238J; N-(2-(6-((4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1,2,3,4-tetrahydro-1,4-epiminonaphthalen-9-yl)-2-oxoethyl)acetamide; N-[2-(4-{[4-(cyclobutylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-11-azatricyclo[6.2.1.0^{2,7}]undeca-2(7),3,5-trien-11-yl)-2-oxoethyl]acetamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.8 nM
External Link
CID: 51346455
TTD: D0H7AC
DrugBank: DB13059
 Compound Name 2-(1H-pyrazol-3-yl)-1H-benzimidazole Investigative [16]
MOA Inhibitor
Activity IC50 = 910 nM
External Link
CID: 763936
TTD: D04YQF
DrugBank: DB08065
 Compound Name ZM-447439 Investigative [17]
Synonyms
331771-20-1; ZM447439; ZM 447439; N-[4-[[6-METHOXY-7-[3-(4-MORPHOLINYL)PROPOXY]-4-QUINAZOLINYL]AMINO]PHENYL]BENZAMIDE; TCMDC-125873; UNII-RSN3P9776R; CHEMBL202721; RSN3P9776R; N-(4-((6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)benzamide; C29H31N5O4; N-[4-({6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-yl}amino)phenyl]benzamide; N-(4-{[6-Methoxy-7-(3-Morpholin-4-Ylpropoxy)quinazolin-4-Yl]amino}phenyl)benzamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 110 nM
External Link
CID: 9914412
TTD: D0QC0W
 Compound Name 4-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine Investigative [18]
Synonyms
CHEMBL1089985; SCHEMBL2239177; 1H-Pyrrolo[2,3-b]pyridine, 4-(1H-pyrazol-4-yl)-; BDBM50315770
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46885627
TTD: D04MYT
 Compound Name 7-fluoroindirubin-3-oxime Investigative [19]
MOA Inhibitor
External Link
CID: 11845975
TTD: D00TKJ
 Compound Name Indirubin-3-acetoxime Investigative [19]
MOA Inhibitor
Activity IC50 = 2300 nM
External Link
CID: 136043837
TTD: D06AGN
 Compound Name Indirubin-3-methoxime Investigative [19]
MOA Inhibitor
Activity IC50 = 4300 nM
External Link
CID: 136043836
TTD: D0V6LP
 Compound Name 6-bromoindirubin-3-oxime Investigative [19]
Synonyms
6-bromoindirubin-3'-oxime (BIO)
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MOA Inhibitor
External Link
CID: 448949
TTD: D06OAH
DrugBank: DB03444
 Compound Name Phosphonothreonine Investigative [20]
Synonyms
phosphothreonine; O-phospho-L-threonine; 1114-81-4; L-Threonine O-phosphate; (2S,3R)-2-amino-3-(phosphonooxy)butanoic acid; O-Phosphothreonine; L-Threonine phosphate; Threoninium dihydrogen phosphate; O-phosphono-L-threonine; L-Threonine O-3-phosphate; O3-phosphothreonine; 27530-80-9; threonine phosphate ester; (2S,3R)-2-amino-3-hydroxybutanoic acid 3-phosphate; Threonine, O-phosphono-; H-Thr(PO3H2)-OH; C4H10NO6P; phospho-l-threonine; EINECS 214-217-5; Synonyms Sources; (S)-2-Amino-3-hydroxybutanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10976469
TTD: D05BHG
DrugBank: DB02482
 Compound Name Indirubin-3'-monoxime Investigative [19]
Synonyms
indirubin-3'-oxime; 160807-49-8; indirubin-3-oxime; Indirubin-3monoxime; Indirubin-3-monoxime; 3-[3-(Hydroxyamino)-1H-indol-2-yl]indol-2-one; CHEBI:43645; Indirubin 3'-monoxime; indirubin-3'-monooxime; Indirubin-3& CHEMBL216543; CHEMBL126077; (Z)-1H,1'H-[2,3']BIINDOLYLIDENE-3,2'-DIONE-3-OXIME; UNM-0000305771; 3-[1,3-dihydro-3-(hydroxyimino)-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one; 667463-82-3; IXM; SR-01000075929; Indirubin-3; Indirubin 3-oxime; Tocris-1813; BiomolKI_000070
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4000 nM
External Link
CID: 3707
TTD: D0Y0ES
DrugBank: DB02052
2C12: Liver cancer 49 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name 90Y-loaded resin microspheres Approved [21]
External Link
TTD: DGWE36
 Compound Name Thymalfasin Phase 2 [22]
Synonyms
Zadaxin; 62304-98-7; Thymosin alpha1; Thymosin alpha 1; Thymosin alpha1 (ox); Thymosin alpha1 (human); Thymalfasin [USAN:INN]; UNII-W0B22ISQ1C; Thymosin-alpha-1; 69440-99-9; Thymosin alpha1 (cattle); C129H215N33O55; W0B22ISQ1C; Zadaxin (TN); Thymalfasin alfa 1
    Click to Show/Hide
External Link
CID: 16130571
TTD: D0I5KX
 Compound Name Ferumoxides Approved [23]
Synonyms
AMI-25; 119683-68-0; Feridex; Feridex IV; Superparamagnetic iron oxide; UNII-G6N3J05W84; Ferumoxides [USAN:USP:BAN]; CCRIS 6722; HSDB 8072; AC1O5DID; G6N3J05W84; iron(2+); iron(3+); Iron oxide crystal is inverse spinel (X-ray data); Fe(II) and Fe(III) are present (Mossbauer Spectroscopy; Physical form is a colloidal particle of nonstoichiometric
    Click to Show/Hide
External Link
CID: 6432052
TTD: D08QAC
DrugBank: DB06215
 Compound Name DTI-015 Approved [24]
Synonyms
Carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin; Nitrumon; Carmubris; Gliadel; BiCNU; Bi CNU; Carmustinum; Bischlorethylnitrosurea; Bischlorethylnitrosourea; Carmustina; Becenun; Becenum; Bischloroethyl nitrosourea; N,N'-BIS(2-CHLOROETHYL)-N-NITROSOUREA; Bis(2-chloroethyl)nitrosourea; Urea, N,N'-bis(2-chloroethyl)-N-nitroso-; Gliadel Wafer; FDA 0345; Bischloroethylnitrosourea; SRI 1720; 1,3-Bis(2-chloroethyl)nitrosourea; BiCNU (TN); Carmustinum [INN-Latin]; Carmustina [INN-Spanish]; DTI 015; NCI-C04773; SK; Injectable carmustine, Direct Therapeutics
    Click to Show/Hide
External Link
CID: 2578
TTD: D01OXI
DrugBank: DB00262
 Compound Name Nofazinlimab Phase 3 [25]
Synonyms
CS1003; EQ176
    Click to Show/Hide
External Link
TTD: DX9GT7
 Compound Name PV-10 Phase 3 [26]
Synonyms
632-69-9; Rose bengal sodium; Rose bengal disodium salt; R105 sodium; Rose-bengal (131 I) natrium; Food Red No 105, sodium salt; EINECS 211-183-3; Food Red Color No 105, sodium salt; Sel disodique de rose bengale iodee (131 I); Rose bengale (131 I) sodique [INN-French]; Rosa bengala sodica (131 I) [INN-Spanish]; Roseum bengalense (131 I) natricum [INN-Latin]; 2,4,5,7-Tetraido(m,p,o',m')tetrachlorofluorescein, disodium salt; Fluorescein, 4,5,6,7-tetrachloro-2',4',5',7'-tetraiodo-, disodium salt; Disodium
    Click to Show/Hide
External Link
CID: 69438
TTD: D0L2VT
 Compound Name Brivanib Phase 3 [27]
Synonyms
649735-46-6; BMS-540215; Brivanib (BMS-540215); BMS 540215; UNII-DDU33B674I; Brivanib [USAN]; BMS540215; DDU33B674I; CHEMBL377300; (2R)-1-[4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]propanol; Brivanib (USAN); (2R)-1-[4-[(4-FLUORO-2-METHYL-1H-INDOL-5-YL)OXY]-5-METHYL-PYRROLO[2,1-F][1,2,4]TRIAZIN-6-YL]OXYPROPAN-2-OL; (2R)-1-({4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl}oxy)propan-2-ol
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External Link
CID: 11234052
TTD: D0HS5V
DrugBank: DB11958
 Compound Name JX-594 Phase 3 [28]
Synonyms
Pexastimogene devacirepvec
    Click to Show/Hide
External Link
TTD: D0HB0V
 Compound Name ABH001 Phase 3 [29]
External Link
TTD: D05LPP
 Compound Name MTC-DOX Phase 2/3 [30]
Synonyms
MTC-doxorubicin
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External Link
TTD: D0W9AI
 Compound Name KD018 Phase 2 [31]
External Link
TTD: D0NB9T
 Compound Name Doxorubicin-eluting beads Phase 2 [32]
Synonyms
DC Bead (TN)
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External Link
TTD: D0M5CD
 Compound Name 32-P BioSilicon Phase 2 [33]
Synonyms
BrachySil
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External Link
TTD: D0M1YS
 Compound Name Cixutumumab Phase 2 [34]
Synonyms
LY3012217
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External Link
TTD: D0E5DP
 Compound Name [131I]-Metuximab Phase 2 [35]
External Link
TTD: D0E5BW
 Compound Name Darinaparsin Phase 2 [36]
Synonyms
ZIO-101
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External Link
CID: 11683005
TTD: D03ZME
DrugBank: DB06179
 Compound Name Tigatuzumab Phase 2 [37]
External Link
TTD: D03LTO
 Compound Name CMC-001 Phase 2 [38]
Synonyms
Manganese-based MRI contrast agent (liver tumor imaging), CMC Contrast
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External Link
TTD: D00WMJ
 Compound Name OBP-301 Phase 1/2 [39]
External Link
TTD: D0D8ZK
 Compound Name MBO7133 Phase 1/2 [40]
External Link
TTD: D0C3MW
 Compound Name INCB62079 Phase 1/2 [26]
External Link
TTD: D0BE8H
 Compound Name NV-1020 Phase 1/2 [41]
External Link
TTD: D0B6EA
 Compound Name DCVax-Liver Phase 1/2 [42]
Synonyms
Dendritic cell-based immunotherapy (liver cancer), Northwest Biotherapeutics
    Click to Show/Hide
External Link
TTD: D00ESH
 Compound Name SRF388 Phase 1 [43]
External Link
TTD: DLY89F
 Compound Name ET140202 Phase 1 [44]
External Link
TTD: D4K2OF
 Compound Name ADP-A2AFP Phase 1 [45]
External Link
TTD: D31ORV
 Compound Name SM04755 Phase 1 [46]
External Link
TTD: D0P5XM
 Compound Name Anti-CEA CAR-T therapy Phase 1 [26]
External Link
TTD: D0OP1L
 Compound Name PI-166 Phase 1 [47]
External Link
TTD: D0J2YR
 Compound Name CRS-100 Phase 1 [48]
External Link
TTD: D0B4DL
 Compound Name Autologous ET1402L1-CART cells Phase 1 [49]
External Link
TTD: D09TGO
 Compound Name Anti-CD133-CAR vector-transduced T cells Phase 1 [50]
External Link
TTD: D09HRH
 Compound Name MRX34 Phase 1 [51]
External Link
TTD: D08SJY
 Compound Name ALN-VSP Phase 1 [52]
External Link
TTD: D08JMI
 Compound Name EPCAM-targeted CAR-T cells Clinical trial [53]
External Link
TTD: D0T8DD
 Compound Name ADI Discontinued in Phase 3 [54]
Synonyms
Arginine deiminase
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External Link
CID: 46906074
TTD: D0O4EV
 Compound Name GN-1140 Discontinued in Phase 2 [55]
External Link
TTD: D0V4CL
 Compound Name OGT-719 Discontinued in Phase 2 [56]
Synonyms
OGS-719
    Click to Show/Hide
External Link
CID: 9838997
TTD: D0C2CH
 Compound Name AFP-Scan Discontinued in Phase 2 [57]
External Link
TTD: D08CCC
 Compound Name SR1078 Preclinical [58]
Synonyms
1246525-60-9; SR 1078; SR-1078; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(trifluoromethyl)benzamide; CHEMBL3094387; N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide; N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide; SCHEMBL4880524; C17H10F9NO2; DTXSID30591895; BCP09203; EX-A2215; 4063AH; BDBM50444350; s5775; ZINC98052696; AKOS024458390; CS-1045; NCGC00379222-02; AK547149; AS-55921; HY-14422; W-5797; SR-03000001078; SR-03000001078-1; SR-03000001078-2
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External Link
CID: 17980288
TTD: D9D6QN
 Compound Name Occlusin Preclinical [59]
Synonyms
Occlusin 50 Injection; Occlusin 500 injection
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External Link
TTD: D00INM
 Compound Name HRC-201 Terminated [60]
Synonyms
Hemoglobin-imaging conjugate (HepSelect), Hemosol
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External Link
TTD: D09ZCH
 Compound Name 1,2,3,4,5,6-hexabromocyclohexane Investigative [61]
Synonyms
1837-91-8; Benzene hexabromide; Cyclohexane, 1,2,3,4,5,6-hexabromo-; Hexabromocyclohexane; JAK2 Inhibitor II; ACMC-1BQJT; SCHEMBL459442; trans-alpha-Benzene hexabromide; CHEMBL444236; DTXSID4052687; CHEBI:93940; NSC7908; HMS3268H22; HMS3413C10; HMS3677C10; NSC-7908; ZINC1586309; ANW-23174; MFCD00059127; s5902; Cyclohexane,2,3,4,5,6-hexabromo-; AKOS015836040; 1,2,3,4,5,6-Hexabromo-cyclohexane; 1,2,3,4,5,6-Hexabromocyclohexane #; NCGC00092358-01; NCGC00092358-02; 1,2,3,4,5,6-hexakis(bromanyl)cyclohexane; A4510; FT-0633875; JAK2 Inhibitor II - CAS 1837-91-8; 1,2,3,4,5,6-Hexabromocyclohexane;NSC7908; A812818; 1,2,3,4,5,6-Hexabrom-cyclohexan (I(2)-Form); J-011778; 1,2,3,4,5,6-Hexabromocyclohexane, >=98% (HPLC); BRD-K06817181-001-01-5; Q27165694
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External Link
CID: 74603
TTD: DLW69V
 Compound Name STP-322 Investigative [62]
Synonyms
Multi-targeted siRNA therapeutic cocktail (nanoparticle, liver tumor), Sirnaomics
    Click to Show/Hide
External Link
TTD: D0R8KF
 Compound Name AMB-8LK Investigative [62]
Synonyms
Cancer therapy (monoclonal antibody), MAT Biopharma; Y90 anti-ferritin monoclonal antibody (cancer), MAT Biopharma; Yttrium-90 anti-ferritin mAb (cancer), MAT Biopharma; Yttrium-90 anti-ferritin mAb (Hodgkin's disease/pancreatic/liver cancer), MAT Biopharma; 90Y-AMB8LK mAb (cancer), MAT Biopharma; 90Y-AMB8LK monoclonal antibody (cancer), MAT Biopharma; 90Y-labelled anti-ferritin monoclonal antibody (cancer), MAT Biopharma
    Click to Show/Hide
External Link
TTD: D0P2MD
 Compound Name MiR-34a mimics Investigative [62]
Synonyms
MiR-34a mimics (liver cancer)
    Click to Show/Hide
External Link
TTD: D0M9TD
 Compound Name P53 fusion protein Investigative [62]
Synonyms
P53 fusion protein (pancreatic/liver cancer)
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External Link
TTD: D06WLG
 Compound Name OP-05 Investigative [62]
Synonyms
OP-05 program (prodrug, liver tumor); OP-05 program (prodrug, liver tumor), Onco-Pharmakon
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External Link
TTD: D02OIP
 Compound Name GR-DD1 Investigative [62]
Synonyms
Cytotoxin (hepatic metastasis), ERYtech
    Click to Show/Hide
External Link
TTD: D00QFV
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