Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00424)

Target Name	Aurora kinase A (AURKA)
Synonyms	EC 2.7.11.1; Aurora 2; Aurora/IPL1-related kinase 1; ARK-1; Aurora-related kinase 1; Breast tumor-amplified kinase; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A Click to Show/Hide
Gene Name	AURKA
Sequence	MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS Click to Show/Hide
Family	Protein kinase superfamily, Ser/Thr protein kinase family, Aurora subfamily
Function	Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (PubMed:26246606, PubMed:12390251, PubMed:18615013, PubMed:11039908, PubMed:17125279, PubMed:17360485). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (PubMed:26246606, PubMed:14523000). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (PubMed:27335426). Required for initial activation of CDK1 at centrosomes (PubMed:13678582, PubMed:15128871). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2 (PubMed:18056443, PubMed:15128871, PubMed:14702041, PubMed:11551964, PubMed:15147269, PubMed:15987997, PubMed:17604723, PubMed:18615013). Regulates KIF2A tubulin depolymerase activity (PubMed:19351716). Important for microtubule formation and/or stabilization (PubMed:18056443). Required for normal axon formation (PubMed:19812038). Plays a role in microtubule remodeling during neurite extension (PubMed:19668197). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (PubMed:14702041). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (PubMed:11551964). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (PubMed:17604723, PubMed:20643351). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (PubMed:28218735). Click to Show/Hide
Gene ID	6790
HGNC ID	HGNC:11393
Ensembl Gene ID	ENSG00000087586
KEGG ID	hsa:6790
Chromosomal Location	20q13.2

RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00424)

Aurora kinase A (AURKA)

Adenosine-to-Inosine editing (A-to-I)

In total 5 m6A sequence/site(s) in this target gene
mod ID: A2ISITE010757		Click to Show/Hide the Full List
mod site	chr20:56388689-56388690:-		[1]
Sequence	CCTCCCGAGTAGCTGGGATTACAGGTGACTGCCACCACGCT
Transcript ID List	ENST00000395911.5; ENST00000395915.7; ENST00000312783.10; ENST00000420474.5; ENST00000441357.5; ENST00000371356.6; ENST00000451915.1; ENST00000456249.5; ENST00000347343.6; ENST00000422322.5; ENST00000395913.7; ENST00000395914.5; ENST00000395907.5
External Link	RMBase: RNA-editing_site_88474
mod ID: A2ISITE010758		Click to Show/Hide the Full List
mod site	chr20:56388699-56388700:-		[1]
Sequence	CCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGACTG
Transcript ID List	ENST00000420474.5; ENST00000395911.5; ENST00000395914.5; ENST00000395915.7; ENST00000312783.10; ENST00000371356.6; ENST00000451915.1; ENST00000395907.5; ENST00000422322.5; ENST00000456249.5; ENST00000395913.7; ENST00000347343.6; ENST00000441357.5
External Link	RMBase: RNA-editing_site_88475
mod ID: A2ISITE010759		Click to Show/Hide the Full List
mod site	chr20:56388728-56388729:-		[1]
Sequence	ACCTCTGCTTCCTGGGTTTAAGTGATTCTCCTGCCTCAGCC
Transcript ID List	ENST00000395915.7; ENST00000371356.6; ENST00000395914.5; ENST00000441357.5; ENST00000422322.5; ENST00000312783.10; ENST00000420474.5; ENST00000395913.7; ENST00000395907.5; ENST00000456249.5; ENST00000451915.1; ENST00000347343.6; ENST00000395911.5
External Link	RMBase: RNA-editing_site_88476
mod ID: A2ISITE010760		Click to Show/Hide the Full List
mod site	chr20:56388729-56388730:-		[1]
Sequence	AACCTCTGCTTCCTGGGTTTAAGTGATTCTCCTGCCTCAGC
Transcript ID List	ENST00000456249.5; ENST00000312783.10; ENST00000420474.5; ENST00000395907.5; ENST00000441357.5; ENST00000395915.7; ENST00000395914.5; ENST00000371356.6; ENST00000395913.7; ENST00000422322.5; ENST00000395911.5; ENST00000451915.1; ENST00000347343.6
External Link	RMBase: RNA-editing_site_88477
mod ID: A2ISITE010761		Click to Show/Hide the Full List
mod site	chr20:56388759-56388760:-		[1]
Sequence	GAGTGCAATGGTGTGATCTCAGCTCACTGCAACCTCTGCTT
Transcript ID List	ENST00000395914.5; ENST00000395913.7; ENST00000347343.6; ENST00000395911.5; ENST00000312783.10; ENST00000422322.5; ENST00000371356.6; ENST00000451915.1; ENST00000395915.7; ENST00000395907.5; ENST00000456249.5; ENST00000420474.5; ENST00000441357.5
External Link	RMBase: RNA-editing_site_88478

N6-methyladenosine (m6A)

In total 36 m6A sequence/site(s) in this target gene
mod ID: M6ASITE053726		Click to Show/Hide the Full List
mod site	chr20:56369448-56369449:-		[2]
Sequence	TAAGGGCTTATTTTTTTAAAACATTGGAGTCATAGCATGTG
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395913.7; ENST00000395914.5; ENST00000371356.6; ENST00000312783.10; ENST00000395915.7; ENST00000347343.6; ENST00000395911.5
External Link	RMBase: m6A_site_537629
mod ID: M6ASITE053727		Click to Show/Hide the Full List
mod site	chr20:56369535-56369536:-		[2]
Sequence	TGAGAGTGTGAAAAATAGGAACACGTGCTCTACCTCCATTT
Motif Score	2.951386905
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395914.5; ENST00000395915.7; ENST00000395911.5; ENST00000312783.10; ENST00000347343.6; ENST00000371356.6; ENST00000395913.7
External Link	RMBase: m6A_site_537630
mod ID: M6ASITE053728		Click to Show/Hide the Full List
mod site	chr20:56369976-56369977:-		[3]
Sequence	AGAAAGCTCCACATCAATAAACATGACACTCTGAAGTGAAA
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; Huh7; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000312783.10; ENST00000395911.5; ENST00000347343.6; ENST00000395907.5; ENST00000371356.6; ENST00000395915.7; ENST00000395913.7; ENST00000395914.5
External Link	RMBase: m6A_site_537631
mod ID: M6ASITE053729		Click to Show/Hide the Full List
mod site	chr20:56369986-56369987:-		[2]
Sequence	CTCCCTATTCAGAAAGCTCCACATCAATAAACATGACACTC
Motif Score	2.053113095
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000371356.6; ENST00000312783.10; ENST00000395911.5; ENST00000395913.7; ENST00000395907.5; ENST00000395914.5; ENST00000395915.7; ENST00000347343.6
External Link	RMBase: m6A_site_537632
mod ID: M6ASITE053730		Click to Show/Hide the Full List
mod site	chr20:56370047-56370048:-		[2]
Sequence	TGCCCTCAATCTAGAACGCTACACAAGAAATATTTGTTTTA
Motif Score	2.078666667
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395911.5; ENST00000395913.7; ENST00000395907.5; ENST00000371356.6; ENST00000347343.6; ENST00000395914.5; ENST00000395915.7; ENST00000312783.10
External Link	RMBase: m6A_site_537633
mod ID: M6ASITE053731		Click to Show/Hide the Full List
mod site	chr20:56370072-56370073:-		[4]
Sequence	TGAAGTTTATTTTACCATTGACTGCTGCCCTCAATCTAGAA
Motif Score	3.28175
Cell/Tissue List	A549
Seq Type List	m6A-CLIP/IP
Transcript ID List	ENST00000395907.5; ENST00000312783.10; ENST00000395913.7; ENST00000395914.5; ENST00000371356.6; ENST00000347343.6; ENST00000395911.5; ENST00000395915.7
External Link	RMBase: m6A_site_537634
mod ID: M6ASITE053732		Click to Show/Hide the Full List
mod site	chr20:56370101-56370102:-		[3]
Sequence	TGCCATATAACCTGACAGGAACATGCTACTGAAGTTTATTT
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000347343.6; ENST00000312783.10; ENST00000395911.5; ENST00000395907.5; ENST00000395914.5; ENST00000395915.7; ENST00000395913.7; ENST00000371356.6
External Link	RMBase: m6A_site_537635
mod ID: M6ASITE053733		Click to Show/Hide the Full List
mod site	chr20:56370107-56370108:-		[2]
Sequence	CAGGGCTGCCATATAACCTGACAGGAACATGCTACTGAAGT
Motif Score	2.859755952
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000371356.6; ENST00000395914.5; ENST00000347343.6; ENST00000395915.7; ENST00000395911.5; ENST00000395907.5; ENST00000312783.10; ENST00000395913.7
External Link	RMBase: m6A_site_537636
mod ID: M6ASITE053734		Click to Show/Hide the Full List
mod site	chr20:56370166-56370167:-		[3]
Sequence	AACAAAGAATCAGCTAGCAAACAGTCTTAGGAATCGTGCAG
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq; m6A-REF-seq
Transcript ID List	ENST00000371356.6; ENST00000395915.7; ENST00000395911.5; ENST00000347343.6; ENST00000395913.7; ENST00000395907.5; ENST00000395914.5; ENST00000312783.10
External Link	RMBase: m6A_site_537637
mod ID: M6ASITE053735		Click to Show/Hide the Full List
mod site	chr20:56370185-56370186:-		[3]
Sequence	AAAACCATCAAATTGCCAAAACAAAGAATCAGCTAGCAAAC
Motif Score	2.20572619
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; GM12878; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000395915.7; ENST00000312783.10; ENST00000371356.6; ENST00000347343.6; ENST00000395913.7; ENST00000395907.5; ENST00000395914.5; ENST00000395911.5
External Link	RMBase: m6A_site_537638
mod ID: M6ASITE053736		Click to Show/Hide the Full List
mod site	chr20:56370202-56370203:-		[3]
Sequence	ATCACAGCAAATTCATCAAAACCATCAAATTGCCAAAACAA
Motif Score	2.185083333
Cell/Tissue List	HeLa; HepG2; HEK293T; A549; U2OS; hNPCs; hESCs; fibroblasts; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TIME; TREX
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000395907.5; ENST00000395914.5; ENST00000347343.6; ENST00000395913.7; ENST00000312783.10; ENST00000395915.7; ENST00000395911.5; ENST00000371356.6
External Link	RMBase: m6A_site_537639
mod ID: M6ASITE053737		Click to Show/Hide the Full List
mod site	chr20:56370232-56370233:-		[3]
Sequence	ATGCTCAGAGAAGTACTTGAACACCCCTGGATCACAGCAAA
Motif Score	2.951386905
Cell/Tissue List	HeLa; HepG2; HEK293T; hESC-HEK293T; U2OS; hNPCs; hESCs; fibroblasts; A549; LCLs; H1299; MM6; Huh7; Jurkat; peripheral-blood; HEK293A-TOA; iSLK; MSC; TREX
Seq Type List	m6A-seq; MeRIP-seq; MAZTER-seq
Transcript ID List	ENST00000395913.7; ENST00000347343.6; ENST00000395911.5; ENST00000395915.7; ENST00000371356.6; ENST00000395914.5; ENST00000395907.5; ENST00000312783.10
External Link	RMBase: m6A_site_537640
mod ID: M6ASITE053738		Click to Show/Hide the Full List
mod site	chr20:56370283-56370284:-		[3]
Sequence	GCCAGGGACCTCATTTCAAGACTGTTGAAGCATAATCCCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; H1299; Huh7; Jurkat; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000371356.6; ENST00000395913.7; ENST00000395911.5; ENST00000312783.10; ENST00000395915.7; ENST00000395907.5; ENST00000347343.6; ENST00000395914.5
External Link	RMBase: m6A_site_537641
mod ID: M6ASITE053739		Click to Show/Hide the Full List
mod site	chr20:56370296-56370297:-		[3]
Sequence	TGTAACAGAGGGAGCCAGGGACCTCATTTCAAGACTGTTGA
Motif Score	3.622404762
Cell/Tissue List	HeLa; HEK293T; hNPCs; hESCs; fibroblasts; A549; H1299; Huh7; Jurkat; HEK293A-TOA; iSLK
Seq Type List	m6A-seq; MeRIP-seq
Transcript ID List	ENST00000312783.10; ENST00000395913.7; ENST00000395914.5; ENST00000395911.5; ENST00000395915.7; ENST00000347343.6; ENST00000395907.5; ENST00000371356.6
External Link	RMBase: m6A_site_537642
mod ID: M6ASITE053740		Click to Show/Hide the Full List
mod site	chr20:56370404-56370405:-		[5]
Sequence	AACTGCAGGCCAAGATCCGAACATCTATACTATTTGATCTC
Motif Score	2.951386905
Cell/Tissue List	HEK293T; HeLa; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000395914.5; ENST00000371356.6; ENST00000395913.7; ENST00000395907.5; ENST00000395911.5; ENST00000347343.6; ENST00000395915.7; ENST00000312783.10
External Link	RMBase: m6A_site_537643
mod ID: M6ASITE053741		Click to Show/Hide the Full List
mod site	chr20:56370423-56370424:-		[5]
Sequence	TTCTTTCCTTATCAGCCTGAACTGCAGGCCAAGATCCGAAC
Motif Score	3.373380952
Cell/Tissue List	HEK293T; HeLa; HEK293A-TOA
Seq Type List	MeRIP-seq; m6A-seq
Transcript ID List	ENST00000395915.7; ENST00000312783.10; ENST00000395914.5; ENST00000395913.7; ENST00000395911.5; ENST00000371356.6; ENST00000347343.6; ENST00000395907.5
External Link	RMBase: m6A_site_537644
mod ID: M6ASITE053742		Click to Show/Hide the Full List
mod site	chr20:56370518-56370519:-		[2]
Sequence	GAAGCCTCCTTTTGAGGCAAACACATACCAAGAGACCTACA
Motif Score	2.20572619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395907.5; ENST00000312783.10; ENST00000395915.7; ENST00000371356.6; ENST00000395914.5; ENST00000395911.5; ENST00000395913.7; ENST00000347343.6
External Link	RMBase: m6A_site_537645
mod ID: M6ASITE053743		Click to Show/Hide the Full List
mod site	chr20:56373424-56373425:-		[2]
Sequence	GCAGATTTTGGGTGGTCAGTACATGCTCCATCTTCCAGGTA
Motif Score	2.856142857
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395907.5; ENST00000395911.5; ENST00000347343.6; ENST00000395914.5; ENST00000312783.10; ENST00000395913.7; ENST00000395915.7; ENST00000371356.6
External Link	RMBase: m6A_site_537646
mod ID: M6ASITE053744		Click to Show/Hide the Full List
mod site	chr20:56373479-56373480:-		[3]
Sequence	TAGAGACATTAAGCCAGAGAACTTACTTCTTGGATCAGCTG
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000347343.6; ENST00000395907.5; ENST00000395911.5; ENST00000395913.7; ENST00000395915.7; ENST00000312783.10; ENST00000371356.6; ENST00000441357.5; ENST00000395914.5
External Link	RMBase: m6A_site_537647
mod ID: M6ASITE053745		Click to Show/Hide the Full List
mod site	chr20:56373494-56373495:-		[3]
Sequence	GAAGAGAGTTATTCATAGAGACATTAAGCCAGAGAACTTAC
Motif Score	2.897386905
Cell/Tissue List	HeLa; hESC-HEK293T
Seq Type List	m6A-seq; MAZTER-seq
Transcript ID List	ENST00000371356.6; ENST00000395911.5; ENST00000395915.7; ENST00000312783.10; ENST00000395907.5; ENST00000347343.6; ENST00000395913.7; ENST00000395914.5; ENST00000441357.5
External Link	RMBase: m6A_site_537648
mod ID: M6ASITE053746		Click to Show/Hide the Full List
mod site	chr20:56381440-56381441:-		[3]
Sequence	CAAAGTTTGATGAGCAGAGAACTGCTACTGTAAGTGTTCAT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395911.5; ENST00000441357.5; ENST00000312783.10; ENST00000347343.6; ENST00000371356.6; ENST00000395913.7; ENST00000395907.5; ENST00000395915.7; ENST00000395914.5
External Link	RMBase: m6A_site_537649
mod ID: M6ASITE053747		Click to Show/Hide the Full List
mod site	chr20:56381465-56381466:-		[3]
Sequence	GTTTATAGAGAACTTCAGAAACTTTCAAAGTTTGATGAGCA
Motif Score	2.627720238
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395907.5; ENST00000441357.5; ENST00000312783.10; ENST00000395913.7; ENST00000371356.6; ENST00000347343.6; ENST00000395911.5; ENST00000395914.5; ENST00000395915.7
External Link	RMBase: m6A_site_537650
mod ID: M6ASITE053748		Click to Show/Hide the Full List
mod site	chr20:56381474-56381475:-		[3]
Sequence	CTTGGAACAGTTTATAGAGAACTTCAGAAACTTTCAAAGTT
Motif Score	3.373380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395907.5; ENST00000441357.5; ENST00000395915.7; ENST00000395913.7; ENST00000312783.10; ENST00000395911.5; ENST00000395914.5; ENST00000371356.6; ENST00000347343.6
External Link	RMBase: m6A_site_537651
mod ID: M6ASITE053749		Click to Show/Hide the Full List
mod site	chr20:56381488-56381489:-		[3]
Sequence	TGGAATATGCACCACTTGGAACAGTTTATAGAGAACTTCAG
Motif Score	2.951386905
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395907.5; ENST00000441357.5; ENST00000395911.5; ENST00000312783.10; ENST00000347343.6; ENST00000395915.7; ENST00000395913.7; ENST00000395914.5; ENST00000371356.6
External Link	RMBase: m6A_site_537652
mod ID: M6ASITE053750		Click to Show/Hide the Full List
mod site	chr20:56381552-56381553:-		[3]
Sequence	AGGCATCCTAATATTCTTAGACTGTATGGTTATTTCCATGA
Motif Score	3.319380952
Cell/Tissue List	HeLa
Seq Type List	m6A-seq
Transcript ID List	ENST00000395913.7; ENST00000395914.5; ENST00000395907.5; ENST00000347343.6; ENST00000395915.7; ENST00000441357.5; ENST00000312783.10; ENST00000371356.6; ENST00000395911.5
External Link	RMBase: m6A_site_537653
mod ID: M6ASITE053751		Click to Show/Hide the Full List
mod site	chr20:56383155-56383156:-		[6]
Sequence	GAGGCAGTGGGCTTTGGAAGACTTTGAAATTGGTCGCCCTC
Motif Score	3.319380952
Cell/Tissue List	hNPCs; LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000347343.6; ENST00000420474.5; ENST00000395907.5; ENST00000371356.6; ENST00000422322.5; ENST00000395914.5; ENST00000395913.7; ENST00000441357.5; ENST00000395911.5; ENST00000312783.10; ENST00000395915.7
External Link	RMBase: m6A_site_537654
mod ID: M6ASITE053752		Click to Show/Hide the Full List
mod site	chr20:56384292-56384293:-		[6]
Sequence	GAGGAGGAACTGGCATCAAAACAGAAAAATGAAGAATCAAA
Motif Score	2.20572619
Cell/Tissue List	hNPCs; LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000420474.5; ENST00000395913.7; ENST00000312783.10; ENST00000395915.7; ENST00000422322.5; ENST00000395914.5; ENST00000441357.5; ENST00000395907.5; ENST00000347343.6; ENST00000371356.6; ENST00000395911.5
External Link	RMBase: m6A_site_537655
mod ID: M6ASITE053753		Click to Show/Hide the Full List
mod site	chr20:56384304-56384305:-		[6]
Sequence	GAAAATAATCCTGAGGAGGAACTGGCATCAAAACAGAAAAA
Motif Score	3.373380952
Cell/Tissue List	hNPCs; LCLs
Seq Type List	m6A-seq
Transcript ID List	ENST00000395907.5; ENST00000395915.7; ENST00000395913.7; ENST00000371356.6; ENST00000441357.5; ENST00000395914.5; ENST00000422322.5; ENST00000347343.6; ENST00000395911.5; ENST00000312783.10; ENST00000420474.5
External Link	RMBase: m6A_site_537656
mod ID: M6ASITE053754		Click to Show/Hide the Full List
mod site	chr20:56386294-56386295:-		[2]
Sequence	TGTCTCCAGGCCACTGAATAACACCCAAAAGAGCAAGCAGC
Motif Score	2.168095238
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000347343.6; ENST00000420474.5; ENST00000395913.7; ENST00000312783.10; ENST00000395911.5; ENST00000395914.5; ENST00000422322.5; ENST00000441357.5; ENST00000395907.5; ENST00000456249.5; ENST00000371356.6; ENST00000395915.7
External Link	RMBase: m6A_site_537657
mod ID: M6ASITE053755		Click to Show/Hide the Full List
mod site	chr20:56386372-56386373:-		[2]
Sequence	ACAAAAGCTTGTCTCCAGTCACAAGCCGGTTCAGAATCAGA
Motif Score	2.047297619
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000441357.5; ENST00000312783.10; ENST00000395914.5; ENST00000420474.5; ENST00000456249.5; ENST00000395915.7; ENST00000395913.7; ENST00000422322.5; ENST00000371356.6; ENST00000395907.5; ENST00000395911.5; ENST00000347343.6; ENST00000451915.1
External Link	RMBase: m6A_site_537658
mod ID: M6ASITE053756		Click to Show/Hide the Full List
mod site	chr20:56386392-56386393:-		[2]
Sequence	CAGCGCATTCCTTTGCAAGCACAAAAGCTTGTCTCCAGTCA
Motif Score	2.830589286
Cell/Tissue List	hESC-HEK293T
Seq Type List	MAZTER-seq
Transcript ID List	ENST00000395913.7; ENST00000451915.1; ENST00000347343.6; ENST00000395907.5; ENST00000395914.5; ENST00000456249.5; ENST00000395915.7; ENST00000312783.10; ENST00000420474.5; ENST00000395911.5; ENST00000441357.5; ENST00000422322.5; ENST00000371356.6
External Link	RMBase: m6A_site_537659
mod ID: M6ASITE053757		Click to Show/Hide the Full List
mod site	chr20:56390616-56390617:-		[7]
Sequence	GCGGGGATATTTGATAAGAAACTTCAGTGAAGGCCGGGCGC
Motif Score	2.627720238
Cell/Tissue List	U2OS
Seq Type List	MeRIP-seq
Transcript ID List	ENST00000420474.5; ENST00000395911.5; ENST00000395915.7; ENST00000422322.5; ENST00000441357.5; ENST00000395907.5; ENST00000456249.5; ENST00000395914.5; ENST00000347343.6; ENST00000312783.10; ENST00000451915.1; ENST00000395913.7; ENST00000371356.6
External Link	RMBase: m6A_site_537660
mod ID: M6ASITE053758		Click to Show/Hide the Full List
mod site	chr20:56392104-56392105:-		[3]
Sequence	GGCGGACGAGGACGGCGGGGACAAGGGGCGGCTGGTCGGAG
Motif Score	3.643047619
Cell/Tissue List	HeLa; HepG2; HEK293T; HEK293A-TOA; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000420474.5; ENST00000456249.5; ENST00000395911.5; ENST00000395907.5; ENST00000441357.5; ENST00000312783.10; ENST00000395914.5; ENST00000451915.1; ENST00000422322.5; ENST00000395913.7; ENST00000347343.6; ENST00000395915.7; ENST00000371356.6
External Link	RMBase: m6A_site_537661
mod ID: M6ASITE053759		Click to Show/Hide the Full List
mod site	chr20:56392144-56392145:-		[3]
Sequence	GGGAGCCGACGGGTGGGTAGACCGTGGGGGATATCTCAGTG
Motif Score	2.876744048
Cell/Tissue List	HeLa; HepG2; HEK293A-TOA; HEC-1-A
Seq Type List	m6A-seq
Transcript ID List	ENST00000441357.5; ENST00000395907.5; ENST00000395913.7; ENST00000451915.1; ENST00000347343.6; ENST00000395915.7; ENST00000456249.5; ENST00000312783.10; ENST00000395914.5; ENST00000371356.6; ENST00000395911.5; ENST00000420474.5
External Link	RMBase: m6A_site_537662
mod ID: M6ASITE053760		Click to Show/Hide the Full List
mod site	chr20:56392187-56392188:-		[3]
Sequence	AACGGCTGAGCTCTTGGAAGACTTGGGTCCTTGGGTCGCAG
Motif Score	3.319380952
Cell/Tissue List	HeLa; HepG2; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000395915.7; ENST00000456249.5; ENST00000371356.6; ENST00000441357.5; ENST00000312783.10; ENST00000420474.5; ENST00000395913.7; ENST00000395911.5; ENST00000347343.6; ENST00000395907.5; ENST00000395914.5; ENST00000451915.1
External Link	RMBase: m6A_site_537663
mod ID: M6ASITE053761		Click to Show/Hide the Full List
mod site	chr20:56392220-56392221:-		[3]
Sequence	ACTCCTATTTAAAAAGAAGAACCTTTGAATTCTAACGGCTG
Motif Score	2.930744048
Cell/Tissue List	HeLa; HEK293A-TOA
Seq Type List	m6A-seq
Transcript ID List	ENST00000420474.5; ENST00000395914.5; ENST00000312783.10; ENST00000395913.7; ENST00000395915.7
External Link	RMBase: m6A_site_537664

N7-methylguanosine (m7G)

In total 1 m6A sequence/site(s) in this target gene
mod ID: m7GSITE000084		Click to Show/Hide the Full List
mod site	chr20:56370655-56370656:-		[8]
Sequence	CCTCCCTCCGTTTTCAGGAGGACCACTCTCTGTGGCACCCT
Cell/Tissue List	A549; HeLa; HepG2
Seq Type List	BoRed-seq&m7G-RIP-seq; m7G-seq
Transcript ID List	ENST00000395913.7; ENST00000395915.7; ENST00000312783.10; ENST00000395907.5; ENST00000395914.5; ENST00000347343.6; ENST00000395911.5; ENST00000371356.6
External Link	RMBase: m7G_site_574

2'-O-Methylation (2'-O-Me)

In total 1 m6A sequence/site(s) in this target gene
mod ID: 2OMSITE000262		Click to Show/Hide the Full List
mod site	chr20:56392185-56392186:-		[9]
Sequence	CGGCTGAGCTCTTGGAAGACTTGGGTCCTTGGGTCGCAGGT
Cell/Tissue List	HeLa
Seq Type List	Nm-seq
Transcript ID List	ENST00000456249.5; ENST00000395915.7; ENST00000420474.5; ENST00000395911.5; ENST00000371356.6; ENST00000312783.10; ENST00000395914.5; ENST00000347343.6; ENST00000395913.7; ENST00000441357.5; ENST00000395907.5; ENST00000451915.1
External Link	RMBase: Nm_site_3542

Ref 1	Systematic identification of abundant A-to-I editing sites in the human transcriptome. Nat Biotechnol. 2004 Aug;22(8):1001-5. doi: 10.1038/nbt996. Epub 2004 Jul 18.
Ref 2	Deciphering the "m(6)A Code" via Antibody-Independent Quantitative Profiling. Cell. 2019 Jul 25;178(3):731-747.e16. doi: 10.1016/j.cell.2019.06.013. Epub 2019 Jun 27.
Ref 3	VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 2018 Feb 27;4:10. doi: 10.1038/s41421-018-0019-0. eCollection 2018.
Ref 4	A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24.
Ref 5	N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014 Jan 2;505(7481):117-20. doi: 10.1038/nature12730. Epub 2013 Nov 27.
Ref 6	Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sites. Cell Rep. 2014 Jul 10;8(1):284-96. doi: 10.1016/j.celrep.2014.05.048. Epub 2014 Jun 26.
Ref 7	RNA-methylation-dependent RNA processing controls the speed of the circadian clock. Cell. 2013 Nov 7;155(4):793-806. doi: 10.1016/j.cell.2013.10.026.
Ref 8	METTL1 Promotes let-7 MicroRNA Processing via m7G Methylation. Mol Cell. 2019 Jun 20;74(6):1278-1290.e9. doi: 10.1016/j.molcel.2019.03.040. Epub 2019 Apr 25.
Ref 9	Nm-seq maps 2'-O-methylation sites in human mRNA with base precision. Nat Methods. 2017 Jul;14(7):695-698. doi: 10.1038/nmeth.4294. Epub 2017 May 15.

Epigenetic Target Information

Cite M6AREG

Correspondence

Prof. Feng ZHU

Prof. Shuiping Liu

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