m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05520				[1]
m⁶A modification HOXC13-AS HOXC13-AS FTO Demethylation : m⁶A sites Direct Enhancement Non-coding RNA HOXC13-AS Regulated Target lncRNA miRNA circRNA
m6A Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	Regulator Info
m6A Target	HOXC13 antisense RNA (HOXC13-AS)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	HOXC13 antisense RNA (HOXC13-AS)			LncRNA	View Details
Crosstalk Relationship	m6A → ncRNA			Enhancement
Crosstalk Mechanism	m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary	FTO-stabilized HOXC13 antisense RNA (HOXC13-AS) epigenetically up-regulated FZD6 and activated Wnt/beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT, suggesting HOXC13-AS as a potential target for cervical cancer treatment.
Responsed Disease	Cervical cancer		ICD-11: 2C77		Disease Info
Pathway Response	Wnt signaling pathway				hsa04310
Cell Process	Cell proliferation
	Cell invasion
	Epithelial-mesenchymal transition
In-vitro Model	C-33 A	Cervical squamous cell carcinoma	Homo sapiens		CVCL_1094
	C-4-I	Cervical squamous cell carcinoma	Homo sapiens		CVCL_2253
	HeLa	Endocervical adenocarcinoma	Homo sapiens		CVCL_0030
	SiHa	Cervical squamous cell carcinoma	Homo sapiens		CVCL_0032

References

Ref 1	FTO-stabilized lncRNA HOXC13-AS epigenetically upregulated FZD6 and activated Wnt/Beta-catenin signaling to drive cervical cancer proliferation, invasion, and EMT. J BUON. 2021 Jul-Aug;26(4):1279-1291.