m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05515
 [1]
m6A modification MALAT1 MALAT1 METTL3 Methylation : m6A sites Direct Enhancement Non-coding RNA MALAT1 MYC  lncRNA       miRNA   circRNA
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) LncRNA View Details
Regulated Target Myc proto-oncogene protein (MYC) View Details
Crosstalk Relationship m6A  →  ncRNA Enhancement
Crosstalk Mechanism m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA
Crosstalk Summary This study highlighted METTL3 as a tumor promoter in Thymic tumors and Myc proto-oncogene protein (MYC) as a promising target to be exploited for the treatment of TET. High expression of c-MYC protein is enabled by lncRNA Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), which is methylated and delocalized by METTL3. Silencing of METTL3 combined with cisplatin or c-MYC inhibitor induces cell death in TET cells. Blocking of c-MYC by using JQ1 inhibitor cooperates with METTL3 depletion in the inhibition of proliferation and induction of cell death.
Responsed Disease Thymic epithelial tumors ICD-11: 2C27.Y
 Disease Info 
Responsed Drug JQ1
 Drug Info 
Cell Process Cell proliferation
In-vitro Model
 T1889 Thymic undifferentiated carcinoma Homo sapiens CVCL_D024
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Myc proto-oncogene protein (MYC) 3 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name AVI-5126 Phase 2 [2]
Synonyms
Resten-CP; NeuGene (CABG), AVI
    Click to Show/Hide
External Link
TTD: D01VDI
 Compound Name Resten-NG Phase 2 [3]
Synonyms
Resten-NG (TN)
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External Link
TTD: D0M4MG
 Compound Name TWS-119 Investigative [4]
Synonyms
TWS119; 601514-19-6; 3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol; TWS 119; GSK inhibitor XII; GSK-3beta Inhibitor XII, TWS119; Neurogenesis Inducer, TWS119; CHEMBL405759; 3-(6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenol; 3-((6-(3-AMINOPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)OXY)PHENOL; 3-{[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy}phenol; Phenol, 3-[[6-(3-aminophenyl)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-; K00245; MLS006011018; GTPL5980; SCHEMBL5559045; GSK-3BETA INHIB
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External Link
CID: 9549289
TTD: D0T8KR
2C27: Thymoma 70 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name PHA848125 Phase 2 [5]
Synonyms
Milciclib; PHA-848125; 802539-81-7; PHA 848125; Milciclib (PHA-848125); UNII-688000M8S8; MMV676602; 4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide; 688000M8S8; N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide; Milciclib [INN]; N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-4,5-Dihydro-1h-Pyrazolo[4,3-H]quinazoline-3-Carboxamide
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External Link
CID: 16718576
TTD: D0Q9UX
 Compound Name Six-membered heterocyclic benzamide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2015143654Example29
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External Link
TTD: D0ZE6H
 Compound Name PMID28270021-Compound-WO2014078408Example26 Patented [6]
External Link
TTD: D0YN0I
 Compound Name Azaindazole amide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2014016434Example30
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External Link
TTD: D0Y1NH
 Compound Name PMID28270021-Compound-WO2013009582Example76 Patented [6]
External Link
TTD: D0Y0XJ
 Compound Name N-acylpyrrolidine ether derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2016020784Example11
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External Link
TTD: D0X4LA
 Compound Name N-acylpiperidine ether derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example164
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External Link
TTD: D0X1LP
 Compound Name Imidazo pyridine derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2015200341Example96
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External Link
TTD: D0WI7N
 Compound Name PMID28270021-Compound-WO2015042088Example12 Patented [6]
External Link
TTD: D0VD5J
 Compound Name Pyrazolo[1,5-a]pyridine derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2013088257Example240
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External Link
TTD: D0V9ZJ
 Compound Name Tri-substituted urea derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2013176970Example1
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External Link
TTD: D0UQ2G
 Compound Name Six-membered heterocyclic benzamide derivative 5 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148344Example152
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External Link
TTD: D0UN4M
 Compound Name PMID28270021-Compound-WO2015042088Example11 Patented [6]
External Link
TTD: D0U5XI
 Compound Name Pyrido[3,2-d]pyrimidine derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2012125668Example27
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External Link
TTD: D0U3RD
 Compound Name Five membered heterocyclic benzamide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148350Example36
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External Link
TTD: D0T4CF
 Compound Name PMID28270021-Compound-WO2010077680 109 Patented [6]
External Link
TTD: D0T0HM
 Compound Name Pyrrolo[2,3-d]pyrimidine derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2012137089cE-245677
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External Link
TTD: D0S0II
 Compound Name Pyrido[3,2-d]pyrimidine derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2012125668Example12
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External Link
TTD: D0RR8O
 Compound Name Pyrazolo[4,3-c]pyridine derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2014053965Example3
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External Link
TTD: D0RK6W
 Compound Name PMID28270021-Compound-WO2014129431Example8-1 Patented [6]
External Link
TTD: D0QT8L
 Compound Name PMID28270021-Compound-WO2010077680 201 Patented [6]
External Link
TTD: D0PY0G
 Compound Name Pyrrolo[2,3-b]pyridine derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2008063888P-0171
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External Link
TTD: D0P8SR
 Compound Name Pyrazolo[4,3-h]quinazoline-3-carboxamide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2010106028Milciclib (PHA-848125)
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External Link
TTD: D0O8SX
 Compound Name Bicyclic heteroaryl benzamide derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148354Example41
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External Link
TTD: D0O0GZ
 Compound Name Bicyclic heteroaryl benzamide derivative 7 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148373Example36
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External Link
TTD: D0N6NG
 Compound Name Triazolo[4,3-b]pyridazine derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2012125667Example24
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External Link
TTD: D0MZ7K
 Compound Name PMID28270021-Compound-WO2015042088Example4 Patented [6]
External Link
TTD: D0M8VS
 Compound Name PMID28270021-Compound-WO2016054807Example112 Patented [6]
External Link
TTD: D0LK8E
 Compound Name Bicyclic heteroaryl benzamide derivative 5 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148373Example104
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External Link
TTD: D0KC8X
 Compound Name PMID28270021-Compound-WO2010077680 495 Patented [6]
External Link
TTD: D0K6IM
 Compound Name PMID28270021-Compound-WO2010077680 103 Patented [6]
External Link
TTD: D0J4CA
 Compound Name Bicyclic heteroaryl benzamide derivative 4 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148354Example99
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External Link
TTD: D0I9FU
 Compound Name PMID28270021-Compound-WO2013161919Example85-117 Patented [6]
External Link
TTD: D0I2OO
 Compound Name Bicyclic heteroaryl benzamide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148354Example21(R or S)
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External Link
TTD: D0HF1A
 Compound Name Six-membered heterocyclic benzamide derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2015143654Example41
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External Link
TTD: D0H3ZG
 Compound Name PMID28270021-Compound-WO2010077680 481 Patented [6]
External Link
TTD: D0FL8A
 Compound Name Bicyclic heteroaryl benzamide derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148354Example33(R or S)
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External Link
TTD: D0F8BF
 Compound Name PMID28270021-Compound-WO2010077680 803 Patented [6]
External Link
TTD: D0F2BF
 Compound Name Six-membered heterocyclic benzamide derivative 4 Patented [6]
Synonyms
PMID28270021-Compound-WO2015143654Example62
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External Link
TTD: D0EC4Z
 Compound Name Bicyclic heteroaryl benzamide derivative 8 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148373Example41(S)
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External Link
TTD: D0DY5R
 Compound Name Pyrrolo[3,2-c]pyridine derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2014053968Example5
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External Link
TTD: D0DQ5G
 Compound Name Pyrazolo[1,5-a]pyridine derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2013088256Example59
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External Link
TTD: D0DN3Q
 Compound Name Five membered heterocyclic benzamide derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148350Example81
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External Link
TTD: D0CY3U
 Compound Name Tri-substituted urea derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2013176970Example2
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External Link
TTD: D0CG8N
 Compound Name N-(phenylpyrazolyl)benzamide derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2013132376Example157
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External Link
TTD: D0C3RK
 Compound Name PMID28270021-Compound-WO2016054807Example80 Patented [6]
External Link
TTD: D0BO1H
 Compound Name 3-amino-5-benzyl-substituted indazole derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2010106028Entrectinib (RXDX-101)
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External Link
TTD: D0AU4G
 Compound Name Pyrrolo[2,3-d]pyrimidine derivative 4 Patented [6]
Synonyms
PMID28270021-Compound-WO2012137089PF-06278121 (Example 9)
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External Link
TTD: D0AG2A
 Compound Name PMID28270021-Compound-WO2016054807Example71 Patented [6]
External Link
TTD: D08CZY
 Compound Name N-acylpyrrolidine ether derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2016020784Example12
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External Link
TTD: D08BIH
 Compound Name Six-membered heterocyclic benzamide derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2015143654Example60
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External Link
TTD: D07VFQ
 Compound Name PMID28270021-Compound-WO2010077680 811 Patented [6]
External Link
TTD: D07KVL
 Compound Name Bicyclic heteroaryl benzamide derivative 6 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148373Example111
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External Link
TTD: D07CPL
 Compound Name Bicyclic heteroaryl benzamide derivative 9 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148373Example42(R)
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External Link
TTD: D07AJO
 Compound Name Pyrrolo[2,3-b]pyridine derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2008063888P-0180
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External Link
TTD: D06GOT
 Compound Name Six-membered heterocyclic benzamide derivative 7 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148344Example96
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External Link
TTD: D05MRY
 Compound Name PMID28270021-Compound-WO2014078408Example1 Patented [6]
External Link
TTD: D05AQT
 Compound Name N-acylpiperidine ether derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example114
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External Link
TTD: D04RXX
 Compound Name Six-membered heterocyclic benzamide derivative 6 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148344Example59
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External Link
TTD: D04JCD
 Compound Name N-acylpiperidine ether derivative 6 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example9
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External Link
TTD: D04GCC
 Compound Name Five membered heterocyclic benzamide derivative 2 Patented [6]
Synonyms
PMID28270021-Compound-WO2015148350Example76
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External Link
TTD: D04BRW
 Compound Name N-acylpiperidine ether derivative 5 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example3
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External Link
TTD: D03BAY
 Compound Name PMID28270021-Compound-WO2013009582Example16 Patented [6]
External Link
TTD: D02ZQN
 Compound Name N-acylpiperidine ether derivative 7 Patented [6]
Synonyms
PMID28270021-Compound-WO2016009296Example15
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External Link
TTD: D02OLJ
 Compound Name Pyrrolo[2,3-b]pyridine derivative 3 Patented [6]
Synonyms
PMID28270021-Compound-WO2010129570P-2061
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External Link
TTD: D02IBX
 Compound Name PMID28270021-Compound-WO2014152663 701 Patented [6]
External Link
TTD: D02ETU
 Compound Name N-acylpiperidine ether derivative 1 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example113
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External Link
TTD: D00XXZ
 Compound Name PMID28270021-Compound-WO2016054807Example1 Patented [6]
External Link
TTD: D00MGO
 Compound Name N-acylpiperidine ether derivative 4 Patented [6]
Synonyms
PMID28270021-Compound-WO2015092610Example2
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External Link
TTD: D00FJH
 Compound Name PMID28270021-Compound-WO2016054807Example82 Patented [6]
External Link
TTD: D00EUL
References
Ref 1 METTL3-dependent MALAT1 delocalization drives c-Myc induction in thymic epithelial tumors. Clin Epigenetics. 2021 Sep 16;13(1):173. doi: 10.1186/s13148-021-01159-6.
Ref 2 Efficacy of a phosphorodiamidate morpholino oligomer antisense compound in the inhibition of corneal transplant rejection in a rat cornea transplant model. J Ocul Pharmacol Ther. 2012 Apr;28(2):194-201. doi: 10.1089/jop.2011.0135. Epub 2011 Dec 7.
Ref 3 Local delivery of c-myc neutrally charged antisense oligonucleotides with transport catheter inhibits myointimal hyperplasia and positively affects vascular remodeling in the rabbit balloon injury model. Catheter Cardiovasc Interv. 2001 Oct;54(2):247-56. doi: 10.1002/ccd.1277.
Ref 4 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.
Ref 5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7938).
Ref 6 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part II.Expert Opin Ther Pat. 2017 Jul;27(7):831-849.