m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05452
|
[1] | |||
m6A modification
ZFAS1
ZFAS1
METTL3
Methylation
 : m6A sites
Direct
Enhancement
Non-coding RNA
ZFAS1
MIR647
lncRNA miRNA circRNA
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | ZNFX1 antisense RNA 1 (ZFAS1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | ZNFX1 antisense RNA 1 (ZFAS1) | LncRNA | View Details | ||
| Regulated Target | MicroRNA 647 (MIR647) | View Details | |||
| Crosstalk Relationship | m6A → ncRNA | Enhancement | |||
| Crosstalk Mechanism | m6A regulators directly modulate the functionality of ncRNAs through specific targeting ncRNA | ||||
| Crosstalk Summary | ZNFX1 antisense RNA 1 (ZFAS1) sequestered MicroRNA 647 (MIR647), and this RNA-RNA interaction is regulated by METLL3-mediated m6A modification in cervical cancer. | ||||
| Responsed Disease | Cervical cancer | ICD-11: 2C77 | |||
| Cell Process | Cell proliferation | ||||
| Cell migration | |||||
| Cell invasion | |||||
In-vitro Model |
HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |
| SiHa | Cervical squamous cell carcinoma | Homo sapiens | CVCL_0032 | ||
| C-33 A | Cervical squamous cell carcinoma | Homo sapiens | CVCL_1094 | ||
| Ca Ski | Cervical squamous cell carcinoma | Homo sapiens | CVCL_1100 | ||
| HEK293T | Normal | Homo sapiens | CVCL_0063 | ||
| In-vivo Model | Nude mice were subjected to a subcutaneous injection of 5× 106 control and ZFAS1 silencing CaSki cells suspended in 0.2 mL DMEM medium. | ||||