m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05356
|
[1] | |||
Non-coding RNA
DARS-AS1
METTL3
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
DARS
DARS
METTL3
Methylation
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Aspartate--tRNA ligase, cytoplasmic (DARS) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | DARS1 antisense RNA 1 (DARS1-AS1) | LncRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | DARS1-AS1 recruits METTL3/METTL14 to bind and enhance Aspartate--tRNA ligase, cytoplasmic (DARS) mRNA m6A modification and translation for cytoprotective autophagy in cervical cancer | ||||
| Responsed Disease | Cervical cancer | ICD-11: 2C77 | |||
| Pathway Response | Autophagy | hsa04140 | |||
| Cell Process | Cell autophagy | ||||