m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05303
 [1]
Non-coding RNA CRNDE HNRNPA1  lncRNA       miRNA   circRNA Direct Enhancement m6A modification UCHL5 UCHL5 hnRNPA1 : m6A sites
m6A Modification:
m6A Regulator Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) READER
 Regulator Info 
m6A Target Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Colorectal neoplasia differentially expressed (CRNDE) LncRNA View Details
Regulated Target Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary hnRNPA1 bound to CRNDE and remained in the nucleus, which inhibited Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) expression through the formation of CRNDE-hnRNPA1-mRNA complex.
Responsed Disease Delayed encephalopathy ICD-11: 8D43.0Y
 Disease Info 
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) 15 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ISIS 112000 Investigative [2]
External Link
TTD: D00LSM
 Compound Name ISIS 112022 Investigative [2]
External Link
TTD: D00SQD
 Compound Name ISIS 112019 Investigative [2]
External Link
TTD: D04XOE
 Compound Name ISIS 112005 Investigative [2]
External Link
TTD: D06QZK
 Compound Name ISIS 112002 Investigative [2]
External Link
TTD: D07FSX
 Compound Name ISIS 112023 Investigative [2]
External Link
TTD: D07RUF
 Compound Name ISIS 111992 Investigative [2]
External Link
TTD: D0D9OL
 Compound Name ISIS 112003 Investigative [2]
External Link
TTD: D0GD1R
 Compound Name ISIS 111997 Investigative [2]
External Link
TTD: D0H0YU
 Compound Name ISIS 112004 Investigative [2]
External Link
TTD: D0H6OL
 Compound Name ISIS 112001 Investigative [2]
External Link
TTD: D0N7OK
 Compound Name ISIS 112024 Investigative [2]
External Link
TTD: D0QU6S
 Compound Name ISIS 112020 Investigative [2]
External Link
TTD: D0T0XZ
 Compound Name ISIS 111993 Investigative [2]
External Link
TTD: D0Y4TS
 Compound Name ISIS 112021 Investigative [2]
External Link
TTD: D0Z4RI
Ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name PMID26077642-Compound-Figure3A Patented [3]
MOA Inhibitor
External Link
TTD: D0A8EN
8D43: Neurological disorders due to toxicity 1 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Charybdotoxin Approved [4]
Synonyms
ChTX; CTX Toxin; Quinquestriatus Toxin; Charybdotoxin (reduced); Toxin, CTX; Toxin, Quinquestriatus
    Click to Show/Hide
External Link
CID: 56842037
TTD: D0U5OB
References
Ref 1 LncRNA CRNDE binds hnRNPA1 to facilitate carbon monoxide poisoning-induced delayed encephalopathy via inhibiting UCHL5-mediated SMO deubiquitination. Metab Brain Dis. 2023 Mar;38(3):1097-1113. doi: 10.1007/s11011-022-01157-4. Epub 2023 Jan 17.
Ref 2 US patent application no. 6,165,789, Antisense modulation of hnRNP A1 expression.
Ref 3 Deubiquitinases (DUBs) and DUB inhibitors: a patent review. Expert Opin Ther Pat. 2015;25(10):1191-1208. doi: 10.1517/13543776.2015.1056737. Epub 2015 Jun 16.
Ref 4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2328).