m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05206
|
[1] | |||
Non-coding RNA
CircHIPK3
IGF2BP2
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
Krm1
Krm1
IGF2BP2
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | |||
| m6A Target | Kremen protein 1 (KRM1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_HIPK3 | circRNA | View Details | ||
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | m6A-modified circRNA was found to increase mRNA stability by functioning as a scaffold for the binding of IGF2BP2 and mRNA. This phenomenon was also observed in the present study, and we identified Kremen protein 1 (KRM1) as a target gene of the Circ_HIPK3/IGF2BP2 complex. | ||||
| Responsed Disease | Calcific aortic valve disease | ICD-11: BB71 | |||