m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05176
|
[1] | |||
Non-coding RNA
CircCDK1
IGF2BP2
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
CPPED1
CPPED1
IGF2BP2
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) | READER | |||
| m6A Target | Serine/threonine-protein phosphatase CPPED1 (CPPED1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Circ_CDK1 | circRNA | View Details | ||
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | By competitively binding to IGF2BP2, Circ_CDK1 blocked the m6A modification of Serine/threonine-protein phosphatase CPPED1 (CPPED1) in IGF2BP2-dependent manner. Moreover, the circCDK1-mediated decrease of CPPED1 activated the PI3K/AKT signal pathway to facilitate progression of LSCC. | ||||
| Responsed Disease | Laryngeal squamous cell carcinoma | ICD-11: 2C23.Z | |||
In-vitro Model |
Tu 177 | Laryngeal squamous cell carcinoma | Homo sapiens | CVCL_4913 | |
| AMC-HN-8 | Laryngeal squamous cell carcinoma | Homo sapiens | CVCL_5966 | ||
|
NP69SV40T
|
N.A. | Homo sapiens | CVCL_F755 | ||
| HEK293T | Normal | Homo sapiens | CVCL_0063 | ||
| In-vivo Model | The mice were subcutaneously inoculated with TU177 cells stably transfected with lentiviruses carrying sh-circCDK1/sh-NC, respectively (2.5 × 106, 200ul). | ||||