m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05082
 [1]
Non-coding RNA MEG3 HNRNPA1  lncRNA       miRNA   circRNA Direct Enhancement m6A modification Sirt2 Sirt2 hnRNPA1 : m6A sites
m6A Modification:
m6A Regulator Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) READER
 Regulator Info 
m6A Target NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Maternally expressed 3 (MEG3) LncRNA View Details
Regulated Target Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary m6A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/NAD-dependent protein deacetylase sirtuin-2 (SIRT2) Axis
Responsed Disease Traumatic brain injury induced by controlled cortical impact injury ICD-11: NA07
 Disease Info 
In-vitro Model
 HT22 Normal Mus musculus CVCL_0321
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) 15 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ISIS 112000 Investigative [2]
External Link
TTD: D00LSM
 Compound Name ISIS 112022 Investigative [2]
External Link
TTD: D00SQD
 Compound Name ISIS 112019 Investigative [2]
External Link
TTD: D04XOE
 Compound Name ISIS 112005 Investigative [2]
External Link
TTD: D06QZK
 Compound Name ISIS 112002 Investigative [2]
External Link
TTD: D07FSX
 Compound Name ISIS 112023 Investigative [2]
External Link
TTD: D07RUF
 Compound Name ISIS 111992 Investigative [2]
External Link
TTD: D0D9OL
 Compound Name ISIS 112003 Investigative [2]
External Link
TTD: D0GD1R
 Compound Name ISIS 111997 Investigative [2]
External Link
TTD: D0H0YU
 Compound Name ISIS 112004 Investigative [2]
External Link
TTD: D0H6OL
 Compound Name ISIS 112001 Investigative [2]
External Link
TTD: D0N7OK
 Compound Name ISIS 112024 Investigative [2]
External Link
TTD: D0QU6S
 Compound Name ISIS 112020 Investigative [2]
External Link
TTD: D0T0XZ
 Compound Name ISIS 111993 Investigative [2]
External Link
TTD: D0Y4TS
 Compound Name ISIS 112021 Investigative [2]
External Link
TTD: D0Z4RI
NAD-dependent protein deacetylase sirtuin-2 (SIRT2) 11 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name BDBM50363780 Patented [3]
Synonyms
CHEMBL1945260; CHEMBL1962973
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 39500 nM
External Link
CID: 49847188
TTD: D00RNS
 Compound Name BDBM50363782 Patented [3]
Synonyms
CHEMBL1945264; CHEMBL1962780
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 21200 nM
External Link
CID: 49847118
TTD: D07NKC
 Compound Name AC1LFGWU Patented [4]
Synonyms
Oprea1_144688; SCHEMBL16409995; ZINC310666; STK508156; AKOS003273711; MCULE-1481833521; ST45014551; SR-01000248344; SR-01000248344-1; 8-(4-methyl(1,2,4-triazol-3-ylthio))-5-nitroquinoline; 8-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-5-nitroquinoline; 8-[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]-5-nitroquinoline
    Click to Show/Hide
MOA Inhibitor
Activity IC50 > 50000000nM
External Link
CID: 802800
TTD: D07YHN
 Compound Name ZINC915379 Patented [4]
Synonyms
CHEMBL2315467; BAS 02073268; SCHEMBL16409978; BDBM50424850; AKOS000586084; MCULE-1228568202; 3-Benzylsulfanyl-5-phenoxymethyl-4-phenyl-4H-[1,2,4]triazole
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7000 nM
External Link
CID: 1162727
TTD: D0F6NT
 Compound Name US9359293, TM Patented [5]
Synonyms
SCHEMBL18103197; CHEMBL3940508; BDBM234208
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 50 nM
External Link
CID: 71533676
TTD: D0MW0K
 Compound Name US9359293, TA Patented [5]
Synonyms
SCHEMBL18103200; CHEMBL3892393; BDBM234205
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 105000 nM
External Link
CID: 122580129
TTD: D0PL1I
 Compound Name BDBM50363773 Patented [3]
Synonyms
CHEMBL1945137; CHEMBL1962885
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 32500 nM
External Link
CID: 49847196
TTD: D0V2UZ
 Compound Name US9359293, TB Patented [5]
Synonyms
SCHEMBL18103198; CHEMBL3968962; BDBM234206
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3000 nM
External Link
CID: 122580127
TTD: D0X9SE
 Compound Name AC1LOJYQ Patented [4]
Synonyms
SCHEMBL16409996; ZINC1076986; 3-[(4-nitrophenyl)methylsulfanyl]-5-(phenoxymethyl)-4-phenyl-1,2,4-triazole; MCULE-8783896159
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10000 nM
External Link
CID: 1264500
TTD: D0Y1WA
 Compound Name AGK2 Investigative [6]
Synonyms
AGK-2; AGK 2
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2800 nM
External Link
CID: 2130404
TTD: D0E3NT
 Compound Name INDUS-815C Investigative [7]
Synonyms
VEGF modulator (age related macular degeneration/retinopathy), Indus Biotech; INDUS-815C (Huntington's disease), Indus Biotech; INDUS-815C (age related macular degeneration/retinopathy), Indus Biotech; SIRT2 inhibtior (Parkinson's disease/dementia/Huntington's disease), Indus Biotech; NAD-dependent deacetylase sirtuin-2inhibitor (Parkinson's disease/dementia/Huntington's disease), Indus Biotech
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0IR8J
References
Ref 1 m(6)A-Induced lncRNA MEG3 Promotes Cerebral Ischemia-Reperfusion Injury Via Modulating Oxidative Stress and Mitochondrial Dysfunction by hnRNPA1/Sirt2 Axis. Mol Neurobiol. 2024 Sep;61(9):6893-6908. doi: 10.1007/s12035-024-04005-x. Epub 2024 Feb 15.
Ref 2 US patent application no. 6,165,789, Antisense modulation of hnRNP A1 expression.
Ref 3 Aroyl thiourea derivatives. US9365508.
Ref 4 Small molecule activators of NRF2 pathway. US9737525.
Ref 5 Methods of treatment using modulators of SIRT2. US9359293.
Ref 6 Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9.
Ref 7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2708).