Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT05072
[1]
Non-coding RNA UCA1 FTO  lncRNA       miRNA   circRNA Direct Enhancement m6A modification NFE2L2 NFE2L2 FTO Demethylation : m6A sites
m6A Modification:
m6A Regulator Fat mass and obesity-associated protein (FTO) ERASER
m6A Target Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Non-coding RNA (ncRNA)
Epigenetic Regulator Urothelial cancer associated 1 (UCA1) LncRNA View Details
Regulated Target FTO alpha-ketoglutarate dependent dioxygenase (FTO) View Details
Crosstalk Relationship ncRNA  →  m6A Enhancement
Crosstalk Mechanism ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator
Crosstalk Summary lncRNA UCA1 inhibits oxidative stress and ferroptosis, thereby preventing cardiomyocyte aging. This protective effect is likely mediated by increasing the expression of demethylase FTO and reducing m6A modification, which promotes the expression of Nuclear factor erythroid 2-related factor 2 (NFE2L2).
Responsed Disease DOX-induced cardiotoxicity ICD-11: BA00.Z
In-vitro Model
H9c2(2-1) Normal Rattus norvegicus CVCL_0286
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Nuclear factor erythroid 2-related factor 2 (NFE2L2) 72 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Omaveloxolone Approved [2]
Synonyms
RJCWBNBKOKFWNY-HGNIWHNWSA-N; N-((4aR,6aR,6bS,12aS,14aR,14bR)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide; 1474034-05-3; AKOS030526563
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MOA Activator
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 Compound Name SFX-01 Phase 2 [3]
MOA Activator
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 Compound Name ABT-RTA-408 Phase 2 [4]
MOA Modulator
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 Compound Name OT-551 Phase 2 [5]
Synonyms
Tempol-H prodrug, Othera
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MOA Inhibitor
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 Compound Name OT551 Phase 2 [6]
MOA Activator
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 Compound Name CXA10 Phase 2 [7]
MOA Activator
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 Compound Name HPP971 Phase 1 [8]
Synonyms
ANT 401
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MOA Activator
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 Compound Name Benzamide derivative 6 Patented [9]
Synonyms
PMID28454500-Compound-86
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MOA Inhibitor
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 Compound Name Benzo[d]oxazole derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-79
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MOA Inhibitor
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 Compound Name PMID28454500-Compound-93 Patented [9]
MOA Inhibitor
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 Compound Name PMID28454500-Compound-92 Patented [9]
MOA Inhibitor
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 Compound Name 4-(2-cyclohexylethoxy) aniline derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-89
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MOA Inhibitor
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 Compound Name Benzo[d]oxazole derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-80
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MOA Inhibitor
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 Compound Name Thiazole derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-84
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MOA Inhibitor
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 Compound Name Benzamide derivative 5 Patented [9]
Synonyms
PMID28454500-Compound-85
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MOA Inhibitor
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 Compound Name Benzo[d]oxazole derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-81
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MOA Inhibitor
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 Compound Name Benzo[d]oxazole derivative 4 Patented [9]
Synonyms
PMID28454500-Compound-82
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MOA Inhibitor
External Link
 Compound Name 4-(2-cyclohexylethoxy) aniline derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-88
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MOA Inhibitor
External Link
 Compound Name PMID28454500-Compound-96 Patented [9]
MOA Inhibitor
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 Compound Name PMID28454500-Compound-94 Patented [9]
MOA Inhibitor
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 Compound Name PMID28454500-Compound-91 Patented [9]
MOA Inhibitor
External Link
 Compound Name 4-(2-cyclohexylethoxy) aniline derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-87
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MOA Inhibitor
Activity IC50 = 2900 nM
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 Compound Name PMID28454500-Compound-95 Patented [9]
MOA Inhibitor
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 Compound Name Thiazole derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-83
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MOA Inhibitor
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 Compound Name 4-(2-cyclohexylethoxy) aniline derivative 4 Patented [9]
Synonyms
PMID28454500-Compound-90
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MOA Inhibitor
External Link
 Compound Name PMID28454500-Compound-57 Patented [9]
MOA Inhibitor
Activity IC50 = 81 nM
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 Compound Name PMID28454500-Compound-8 Patented [9]
MOA Activator
External Link
 Compound Name Pyrazino[2,1-a]isoquinolin derivative 4 Patented [9]
Synonyms
PMID28454500-Compound-31
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MOA Activator
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 Compound Name PMID28454500-Compound-36 Patented [9]
MOA Activator
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 Compound Name Naphthalene derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-62
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MOA Inhibitor
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 Compound Name PMID28454500-Compound-58 Patented [9]
MOA Inhibitor
Activity IC50 = 84 nM
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 Compound Name Chalcone derivative 4 Patented [9]
Synonyms
PMID28454500-Compound-19
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MOA Activator
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 Compound Name 2-hydroxybenzamide derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-38
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MOA Activator
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 Compound Name Vinyl sulfone derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-20
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MOA Activator
Activity EC50 = 530 nM
External Link
 Compound Name Pyrazino[2,1-a]isoquinolin derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-29
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MOA Activator
External Link
 Compound Name Diterpenoid derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-47
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MOA Activator
External Link
 Compound Name 1-phenyl-1,3,4-triazole derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-76
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MOA Inhibitor
Activity Kd = 23000 nM
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 Compound Name PMID28454500-Compound-13 Patented [9]
MOA Activator
External Link
 Compound Name 1-phenyl-1,3,4-triazole derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-77
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MOA Inhibitor
Activity Kd = 17000 nM
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 Compound Name PMID28454500-Compound-12 Patented [9]
MOA Activator
External Link
 Compound Name Pyrazino[2,1-a]isoquinolin derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-28
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MOA Activator
External Link
 Compound Name PMID28454500-Compound-41 Patented [9]
MOA Activator
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 Compound Name Chalcone derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-17
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MOA Activator
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 Compound Name PMID28454500-Compound-34 Patented [9]
MOA Activator
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 Compound Name PMID28454500-Compound-33 Patented [9]
MOA Activator
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 Compound Name Chalcone derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-18
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MOA Activator
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 Compound Name PMID28454500-Compound-50 Patented [9]
MOA Activator
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 Compound Name 1-phenyl-1,3,4-triazole derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-78
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MOA Inhibitor
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 Compound Name PMID28454500-Compound-3 Patented [9]
MOA Activator
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 Compound Name Pyridyl compound 1 Patented [9]
Synonyms
PMID28454500-Compound-15
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MOA Activator
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 Compound Name PMID28454500-Compound-32 Patented [9]
MOA Activator
External Link
 Compound Name PMID28454500-Compound-60 Patented [9]
MOA Inhibitor
Activity IC50 = 140 nM
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 Compound Name PMID28454500-Compound-40 Patented [9]
MOA Activator
External Link
 Compound Name 3-phenyl propanoic derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-68
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MOA Inhibitor
Activity IC50 = 61 nM; Kd = 59000 nM
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 Compound Name PMID28454500-Compound-35 Patented [9]
MOA Activator
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 Compound Name PMID28454500-Compound-49 Patented [9]
MOA Activator
External Link
 Compound Name PMID28454500-Compound-9 Patented [9]
MOA Activator
External Link
 Compound Name PMID28454500-Compound-59 Patented [9]
MOA Inhibitor
Activity IC50 = 90 nM
External Link
 Compound Name 3-phenyl propanoic derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-67
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MOA Inhibitor
Activity IC50 > 1000000 nM
External Link
 Compound Name 3-phenyl propanoic derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-69
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MOA Inhibitor
Activity Kd = 1.3 nM
External Link
 Compound Name Diterpenoid derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-48
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MOA Activator
External Link
 Compound Name PMID28454500-Compound-11 Patented [9]
MOA Activator
External Link
 Compound Name PMID28454500-Compound-37 Patented [9]
MOA Activator
External Link
 Compound Name Chalcone derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-16
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MOA Activator
External Link
 Compound Name Pyrazino[2,1-a]isoquinolin derivative 3 Patented [9]
Synonyms
PMID28454500-Compound-30
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MOA Activator
External Link
 Compound Name 2-hydroxybenzamide derivative 2 Patented [9]
Synonyms
PMID28454500-Compound-39
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MOA Activator
External Link
 Compound Name PMID28454500-Compound-10 Patented [9]
MOA Activator
External Link
 Compound Name 1,2,3,4-tetrahydroisoquinoline derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-61
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MOA Inhibitor
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 Compound Name Trepenoid derivative 1 Patented [9]
Synonyms
PMID28454500-Compound-14
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MOA Activator
External Link
 Compound Name CAT4001 Preclinical [3]
MOA Activator
External Link
 Compound Name M102 Preclinical [10]
MOA Activator
External Link
 Compound Name TFM735 Preclinical [11]
MOA Activator
External Link
BA00: DOX-induced cardiotoxicity 23 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Alkavervir Approved [12]
External Link
 Compound Name Phenoxybenzamine Approved [12]
Synonyms
Bensylyt; Bensylyte; Benzylyt; Dibenylene; Dibenylin; Dibenyline; Dibenziran; Dibenzylene; Dibenzylin; Dibenzyran; Fenossibenzamina; Fenoxibenzamina; Phenoxybenzaminum; Bensylyt NEN; Fenossibenzamina [DCIT]; POB HCl; Phenoxybenzamine Hcl; A 688; Dibenzyline (TN); Fenoxibenzamina [INN-Spanish]; Phenoxybenzamine (INN);Phenoxybenzamine [INN:BAN]; Phenoxybenzaminum [INN-Latin]; N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine; Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine; N-(2-chloroethyl)-N-(phenylmethyl)-1-(phenyloxy)propan-2-amine; 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane; 688A
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External Link
 Compound Name Ethacrynate Sodium Approved [12]
External Link
 Compound Name Mecamylamine Approved [12]
Synonyms
Mecamilamina; Mecamine; Mecamylaminum; Mekamine; Mevasine; Revertina; Versamine; Inversine hydrochloride; Mecamilamina [DCIT]; Mecamilamina [Italian]; Mevasin hydrochloride; Inversine (TN); Mecamylamine [INN:BAN]; Mecamylaminum [INN-Latin]; N-Methyl-2-isocamphanamine; N,2,3,3-Tetramethyl-2-norbornamine; N,2,3,3-Tetramethyl-2-norcamphanamine; N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisokamfan; 3-Methylaminoisokamfan [Czech]; 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
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External Link
 Compound Name Nicardipine Approved [13]
Synonyms
Nicardipino; Nicardipinum; Cardene IV; Nicardipine LA; Cardene (TN); Nicardipine (INN); Nicardipine [INN:BAN]; Nicardipino [INN-Spanish]; Nicardipinum [INN-Latin]; Y-93; Methyl 2-[methyl(phenylmethyl)amino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 2-(Benzylmethylamino)ethylmethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-(benzylmethylamino)ethyl methyl ester; 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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External Link
 Compound Name Guanabenz Approved [14]
Synonyms
GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
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External Link
 Compound Name Benzthiazide Approved [15]
Synonyms
Aquapres; Aquasec; Aquatag; Benzothiazide; Benzotiazida; Benzthazide; Benzthiazidum; Benztiazide; Dihydrex; Diucen;Diucene; Edemex; Exna; Exosalt; Fouane; Fovane; Freeuril; HyDrine; Lemazide; Proaqua; Regulon; Urazide; Urese; Benztiazide [DCIT]; P 1393; Pfizer 1393; Aqua-Scrip; Aquatag (TN); Benzotiazida [INN-Spanish]; Benzthiazidum [INN-Latin]; Dihydrex (TN); Diucen (TN); Edemax (TN); Exna (TN); Foven (TN); Hy-drine; Pro-aqua; Rid-ema; S-Aqua; Benzthiazide (JAN/INN); Benzthiazide [USAN:INN:BAN]; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)menthyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide; 3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(((phenylmethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide; 6-chloro-3-{[(phenylmethyl)thio]methyl}-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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External Link
 Compound Name Mephentermine Approved [12]
Synonyms
Mefenterdrin; Mefentermin; Mefentermina; Mephenterdrine; Mephenterdrinum; Mephenterminum; Mephetedrine; Mephine; Vialin; Wyamine; Wyfentermina; Mefentermina [INN-Spanish]; Mephentermine (INN); Mephentermine [INN:BAN]; Mephenterminum [INN-Latin]; N-Methylphentermine; WY-585; Mephentermine Sulfate (2:1); N,alpha,alpha-Trimethylbenzeneethanamine; N,alpha,alpha-Trimethylphenethylamine; Omega-Phenyl-tert-butyl-methylamine; N-Methyl-omega-phenyl-t-butylamine; N-Methyl-omega-phenyl-tert-butylamine; N,2-dimethyl-1-phenylpropan-2-amine; 2-Methyl-2-methylamino-1-phenylpropane; 2-Methylamino-2-methyl-1-phenylpropane
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External Link
 Compound Name Olmesartan medoxomil Approved [16]
Synonyms
Benevas; Benicar; Olmetec; Olvance; Forest Brand of Olmesartan Medoxomil; Olmesartan medoximil; Sankyo Brand of Olmesartan Medoxomil; Cs 866; Benicar (TN); Berlin-Chemie Brand of Olmesartan Medoxomil; CS-866; CS-866DM; CS-866RN; DE-092; KS-1182; Olmetec (TN); Benicar, Olmetec,Olmesartan; Olmesartan medoxomil (JAN/USAN); (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate; (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(tetrazol-5-yl)phenyl)phenyl)methylimidazol-5-carboxylate; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl ester; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; 1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
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External Link
 Compound Name Ethacrynic acid Approved [17]
Synonyms
Crinuryl; Edecril; Edecrina; Endecril; Ethacrynate; Hidromedin; Hydromedin; Mingit; Otacril; Reomax; Taladren; Uregit; Acide etacrynique; Acido etacrinico; Acidum etacrynicum; Etacrinic acid; Etacrynic Acid; Etakrinic acid; Ethacrinic acid; Ethacryinic Acid; Kyselina ethakrynova; Kyselina ethakrynova [Czech]; Methylenebutyryl phenoxyacetic acid; Methylenebutyrylphenoxyacetic acid; E0526; MK 595; Acide etacrynique [INN-French]; Acido etacrinico [INN-Spanish]; Acidum etacrynicum [INN-Latin]; Edecrin (TN); Ethacrinique (acide); Ethacrynic Acid, Sodium Salt; Ethacrynic acid (USP); Ethacrynic acid [USAN:BAN]; MK-595; Etacrynic acid (JP15/INN); [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid; [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova [Czech]; [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid; (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic acid; (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid; (4-(2-Methylenebutyryl)-2,3-dichlorophenoxy)acetic acid; 2,3-Dichloro-4(2-methylene-butyryl)phenoxy] acetic acid; 2,3-Dichloro-4-(2-methylenebutyl)phenoxyacetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxy acetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid; 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
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 Compound Name Timolol Approved [18]
Synonyms
Aquanil; Betim; Betimol; Blocadren; Istalol; Optimol; Proflax; TIM; Temserin; Tenopt; Timacar; Timololum; Timopic; Timoptol; Timolol GFS; Timolol [USAN]; Timoptic OcuDose; Apo-Timol; Apo-Timop; Betimol (TN); Blocadren (TN); Istalol (TN); MK-950; Novo-Timol; Nu-Timolol; Phoxal-timolol; Tim-AK; Timolol (INN); Timolol (TN); Timololum [INN-Latin]; Timoptic (TN); Timoptic-XE; Apo-Timol (TN); Apo-Timop (TN); Gen-Timolol (TN); L-714,465; Nu-Timolol (TN); PMS-Timolol (TN); Phoxal-timolol (TN); Tim-AK (TN); Timoptic OcuDose. (TN); Timoptic-XE (TN); S(-)-Timolol maleate; Timolol Maleate, (1:1) Salt; S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole; (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole; (2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; (S)-timolol
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 Compound Name Nadolol Approved [19]
Synonyms
Anabet; Corgard; Corgaretic; Nadic; Nadololum; Solgol; SQ 11725; SQ11725; Anabet (TN); Corgard (TN); Corzide (TN); Nadololum [INN-Latin]; SQ-11725; Solgol (TN); Alti-Nadolol (TN); Apo-Nadol (TN); Novo-Nadolol (TN); Nadolol (JP15/USP/INN); Nadolol [USAN:BAN:INN:JAN]; (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol; 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol; 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol
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 Compound Name Seractide Acetate Approved [12]
Synonyms
Acthar Gel-synthetic
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 Compound Name Bendroflumethiazide Approved [20]
Synonyms
Aprinox; BHFT; Bendrofluazide; Bendroflumethazide; Bendroflumethiazidum; Bendroflumetiazida; Bendroflumetiazide; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bristuric; Bristuron; Centyl; Corzide; Flumersil; Flumesil; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturine; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rauzide; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea; Bendroflumethiazide [USP]; Bendroflumetiazide [DCIT]; Rautrax N; Relan beta; BL H368; FT 8; FT 81; Be 724-A; Bendroflumethiazidum [INN-Latin]; Bendroflumetiazida [INN-Spanish]; Benzy-rodiuran; NATURETIN-10; NATURETIN-5; Naturetin (TN); Neo-naclex; Neo-rontyl; Naturetin-2.5; Bendroflumethiazide (JAN/USP/INN); (+-)-3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
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 Compound Name Pinacidil Approved [21]
Synonyms
Pinacidilum; P 1134; S 1230; P-154; Pinacidil (anhydrous); Pinacidilum [INN-Latin]; S-1230; N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine; Guanidine, 2-cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)-, monohydrate; Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate; (+-)-Pinacidil; (+/-)-N-Cyano-N'-4-pyridinyl-N"-(1,2,2-trimethylpropyl)guanidine; (R,S)-Pinacidil; (inverted question mark)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine; 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine; 2-Cyano-3-(4-pyridinyl)-1-(1,2,2-trimethylpropyl)guanidine; 2-Cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)guanidine monohydrate
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 Compound Name Veratrum Viride Root Approved [12]
Synonyms
Vertavis
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 Compound Name Cilnidipine Phase 3 [22]
Synonyms
Atelec; Cinaldipine; Cinalong; Siscard; Cilnidipine [INN]; FRC 8653; Atelec (TN); FRC-8653; Cilnidipine (JAN/INN); (+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester; 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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 Compound Name Alilusem Phase 3 [23]
Synonyms
M-12285; M-17000; M-17055; MD-31
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 Compound Name ACT-280778 Phase 2 [24]
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 Compound Name RMJH-111b Phase 1/2 [25]
Synonyms
Trimagnesium dicitrate; MAGNESIUM CITRATE; 3344-18-1; Trimagnesium citrate; UNII-RHO26O1T9V; magnesium dicitrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3); 7779-25-1; RHO26O1T9V; Magnesium citrate, Mg3(C6H5O7)2; trimagnesium;2-hydroxypropane-1,2,3-tricarboxylate; Trimagnesiumdicitrat; MAGNESIUMCITRATE; NSC-83517; Magnesium citrate (VAN); Magnesium citrate [USP]; Magnesium citrate (3:2); Trimagnesiumdicitrate; EINECS 222-093-9; Tectlol (TN); NSC 83517; Tri Magnesium Citrate; EC 222-093-9; Magnesium citrate (JAN/USP); C12H10Mg3O14; CHEMBL3989480; CHEBI:131391; DTXSID601015151; AKOS028109620; DB11110; H259; DB-048405; Citric acid, magnesium salt (2:3) (8CI); FT-0628080; FT-0628081; D03265; Q4177438; magnesium 2-hydroxypropane-1,2,3-tricarboxylate (3/2); 1,2,3-Propanetricarboxylic acid, hydroxy-, magnesium salt (2:3); 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3) (9CI); Citric acid, magnesium salt (2:3), Citric acid, magnesium salt (2:3) (8CI), EINECS 222-093-9, LS-121081, MAGNESIUM CITRATE, Magnesium citrate (3:2), Magnesium citrate, Mg3(C6H5O7)2, Magnesium; MAGNESIUM CITRATE, Magnesium citrate (3:2), Magnesium citrate, Mg3(C6H5O7)2, Magnesium citrate [USAN], Magnesium citrate (VAN), NSC 83517, Trimagnesiumdicitrat, Trimagnesium dicitrate
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 Compound Name RMJH-111b Phase 1/2 [26]
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 Compound Name SKF-105494 Phase 1 [27]
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 Compound Name MK-8266 Phase 1 [28]
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References
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