m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05072
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[1] | |||
Non-coding RNA
UCA1
FTO
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
NFE2L2
NFE2L2
FTO
Demethylation
: m6A sites
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| m6A Modification: | |||||
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| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | Nuclear factor erythroid 2-related factor 2 (NFE2L2) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | Urothelial cancer associated 1 (UCA1) | LncRNA | View Details | ||
| Regulated Target | FTO alpha-ketoglutarate dependent dioxygenase (FTO) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator | ||||
| Crosstalk Summary | lncRNA UCA1 inhibits oxidative stress and ferroptosis, thereby preventing cardiomyocyte aging. This protective effect is likely mediated by increasing the expression of demethylase FTO and reducing m6A modification, which promotes the expression of Nuclear factor erythroid 2-related factor 2 (NFE2L2). | ||||
| Responsed Disease | DOX-induced cardiotoxicity | ICD-11: BA00.Z | |||
In-vitro Model |
H9c2(2-1) | Normal | Rattus norvegicus | CVCL_0286 | |
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Nuclear factor erythroid 2-related factor 2 (NFE2L2) | 72 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
| Omaveloxolone | Approved | [2] | ||
| Synonyms |
RJCWBNBKOKFWNY-HGNIWHNWSA-N; N-((4aR,6aR,6bS,12aS,14aR,14bR)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide; 1474034-05-3; AKOS030526563
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| MOA | Activator | |||
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| SFX-01 | Phase 2 | [3] | ||
| MOA | Activator | |||
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| ABT-RTA-408 | Phase 2 | [4] | ||
| MOA | Modulator | |||
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| OT-551 | Phase 2 | [5] | ||
| Synonyms |
Tempol-H prodrug, Othera
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| MOA | Inhibitor | |||
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| OT551 | Phase 2 | [6] | ||
| MOA | Activator | |||
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| CXA10 | Phase 2 | [7] | ||
| MOA | Activator | |||
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| HPP971 | Phase 1 | [8] | ||
| Synonyms |
ANT 401
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| MOA | Activator | |||
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| Benzamide derivative 6 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-86
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| MOA | Inhibitor | |||
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| Benzo[d]oxazole derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-79
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| MOA | Inhibitor | |||
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| PMID28454500-Compound-93 | Patented | [9] | ||
| MOA | Inhibitor | |||
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| PMID28454500-Compound-92 | Patented | [9] | ||
| MOA | Inhibitor | |||
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| 4-(2-cyclohexylethoxy) aniline derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-89
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| MOA | Inhibitor | |||
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| Benzo[d]oxazole derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-80
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| MOA | Inhibitor | |||
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| Thiazole derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-84
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| MOA | Inhibitor | |||
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| Benzamide derivative 5 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-85
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| MOA | Inhibitor | |||
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| Benzo[d]oxazole derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-81
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| MOA | Inhibitor | |||
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| Benzo[d]oxazole derivative 4 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-82
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| MOA | Inhibitor | |||
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| 4-(2-cyclohexylethoxy) aniline derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-88
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| MOA | Inhibitor | |||
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| PMID28454500-Compound-96 | Patented | [9] | ||
| MOA | Inhibitor | |||
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| PMID28454500-Compound-94 | Patented | [9] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| PMID28454500-Compound-91 | Patented | [9] | ||
| MOA | Inhibitor | |||
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| 4-(2-cyclohexylethoxy) aniline derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-87
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| MOA | Inhibitor | |||
| Activity | IC50 = 2900 nM | |||
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| PMID28454500-Compound-95 | Patented | [9] | ||
| MOA | Inhibitor | |||
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| Thiazole derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-83
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| MOA | Inhibitor | |||
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| 4-(2-cyclohexylethoxy) aniline derivative 4 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-90
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| MOA | Inhibitor | |||
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| PMID28454500-Compound-57 | Patented | [9] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 81 nM | |||
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| PMID28454500-Compound-8 | Patented | [9] | ||
| MOA | Activator | |||
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| Pyrazino[2,1-a]isoquinolin derivative 4 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-31
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| MOA | Activator | |||
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| PMID28454500-Compound-36 | Patented | [9] | ||
| MOA | Activator | |||
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| Naphthalene derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-62
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| MOA | Inhibitor | |||
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| PMID28454500-Compound-58 | Patented | [9] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 84 nM | |||
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| Chalcone derivative 4 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-19
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| MOA | Activator | |||
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| 2-hydroxybenzamide derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-38
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| MOA | Activator | |||
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| Vinyl sulfone derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-20
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| MOA | Activator | |||
| Activity | EC50 = 530 nM | |||
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| Pyrazino[2,1-a]isoquinolin derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-29
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| MOA | Activator | |||
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| Diterpenoid derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-47
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| MOA | Activator | |||
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| 1-phenyl-1,3,4-triazole derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-76
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| MOA | Inhibitor | |||
| Activity | Kd = 23000 nM | |||
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| PMID28454500-Compound-13 | Patented | [9] | ||
| MOA | Activator | |||
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| 1-phenyl-1,3,4-triazole derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-77
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| MOA | Inhibitor | |||
| Activity | Kd = 17000 nM | |||
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| PMID28454500-Compound-12 | Patented | [9] | ||
| MOA | Activator | |||
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| Pyrazino[2,1-a]isoquinolin derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-28
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| MOA | Activator | |||
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| PMID28454500-Compound-41 | Patented | [9] | ||
| MOA | Activator | |||
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| Chalcone derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-17
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| MOA | Activator | |||
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| PMID28454500-Compound-34 | Patented | [9] | ||
| MOA | Activator | |||
| External Link | ||||
| PMID28454500-Compound-33 | Patented | [9] | ||
| MOA | Activator | |||
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| Chalcone derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-18
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| MOA | Activator | |||
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| PMID28454500-Compound-50 | Patented | [9] | ||
| MOA | Activator | |||
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| 1-phenyl-1,3,4-triazole derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-78
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| MOA | Inhibitor | |||
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| PMID28454500-Compound-3 | Patented | [9] | ||
| MOA | Activator | |||
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| Pyridyl compound 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-15
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| MOA | Activator | |||
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| PMID28454500-Compound-32 | Patented | [9] | ||
| MOA | Activator | |||
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| PMID28454500-Compound-60 | Patented | [9] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 140 nM | |||
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| PMID28454500-Compound-40 | Patented | [9] | ||
| MOA | Activator | |||
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| 3-phenyl propanoic derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-68
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| MOA | Inhibitor | |||
| Activity | IC50 = 61 nM; Kd = 59000 nM | |||
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| PMID28454500-Compound-35 | Patented | [9] | ||
| MOA | Activator | |||
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| PMID28454500-Compound-49 | Patented | [9] | ||
| MOA | Activator | |||
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| PMID28454500-Compound-9 | Patented | [9] | ||
| MOA | Activator | |||
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| PMID28454500-Compound-59 | Patented | [9] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 90 nM | |||
| External Link | ||||
| 3-phenyl propanoic derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-67
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| MOA | Inhibitor | |||
| Activity | IC50 > 1000000 nM | |||
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| 3-phenyl propanoic derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-69
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| MOA | Inhibitor | |||
| Activity | Kd = 1.3 nM | |||
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| Diterpenoid derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-48
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| MOA | Activator | |||
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| PMID28454500-Compound-11 | Patented | [9] | ||
| MOA | Activator | |||
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| PMID28454500-Compound-37 | Patented | [9] | ||
| MOA | Activator | |||
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| Chalcone derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-16
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| MOA | Activator | |||
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| Pyrazino[2,1-a]isoquinolin derivative 3 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-30
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| MOA | Activator | |||
| External Link | ||||
| 2-hydroxybenzamide derivative 2 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-39
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| MOA | Activator | |||
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| PMID28454500-Compound-10 | Patented | [9] | ||
| MOA | Activator | |||
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| 1,2,3,4-tetrahydroisoquinoline derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-61
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| MOA | Inhibitor | |||
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| Trepenoid derivative 1 | Patented | [9] | ||
| Synonyms |
PMID28454500-Compound-14
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| MOA | Activator | |||
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| CAT4001 | Preclinical | [3] | ||
| MOA | Activator | |||
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| M102 | Preclinical | [10] | ||
| MOA | Activator | |||
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| TFM735 | Preclinical | [11] | ||
| MOA | Activator | |||
| External Link | ||||
| BA00: DOX-induced cardiotoxicity | 23 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
| Alkavervir | Approved | [12] | ||
| External Link | ||||
| Phenoxybenzamine | Approved | [12] | ||
| Synonyms |
Bensylyt; Bensylyte; Benzylyt; Dibenylene; Dibenylin; Dibenyline; Dibenziran; Dibenzylene; Dibenzylin; Dibenzyran; Fenossibenzamina; Fenoxibenzamina; Phenoxybenzaminum; Bensylyt NEN; Fenossibenzamina [DCIT]; POB HCl; Phenoxybenzamine Hcl; A 688; Dibenzyline (TN); Fenoxibenzamina [INN-Spanish]; Phenoxybenzamine (INN);Phenoxybenzamine [INN:BAN]; Phenoxybenzaminum [INN-Latin]; N-Phenoxyisopropyl-N-benzyl-beta-chloroethylamine; Benzyl(2-chloroethyl)-(1-methyl-2-phenoxyethyl)amine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzenemethanamine; N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine; N-benzyl-N-(2-chloroethyl)-1-phenoxypropan-2-amine; N-(2-chloroethyl)-N-(phenylmethyl)-1-(phenyloxy)propan-2-amine; 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane; 688A
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| Ethacrynate Sodium | Approved | [12] | ||
| External Link | ||||
| Mecamylamine | Approved | [12] | ||
| Synonyms |
Mecamilamina; Mecamine; Mecamylaminum; Mekamine; Mevasine; Revertina; Versamine; Inversine hydrochloride; Mecamilamina [DCIT]; Mecamilamina [Italian]; Mevasin hydrochloride; Inversine (TN); Mecamylamine [INN:BAN]; Mecamylaminum [INN-Latin]; N-Methyl-2-isocamphanamine; N,2,3,3-Tetramethyl-2-norbornamine; N,2,3,3-Tetramethyl-2-norcamphanamine; N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine; N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine; 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisokamfan; 3-Methylaminoisokamfan [Czech]; 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
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| Nicardipine | Approved | [13] | ||
| Synonyms |
Nicardipino; Nicardipinum; Cardene IV; Nicardipine LA; Cardene (TN); Nicardipine (INN); Nicardipine [INN:BAN]; Nicardipino [INN-Spanish]; Nicardipinum [INN-Latin]; Y-93; Methyl 2-[methyl(phenylmethyl)amino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 2-(Benzylmethylamino)ethylmethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)pyridine-3,5-dicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(benzylmethylamino)ethyl methyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-[methyl(phenylmethyl)amino]ethyl ester; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-(benzylmethylamino)ethyl methyl ester; 5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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| Guanabenz | Approved | [14] | ||
| Synonyms |
GBZ; Guanabenzo; Guanabenzum; Wytensin; Guanabenz acetate; Guanabenz monoacetate; Wy 8678; Wy 8678 base; BR-750; Guanabenz [USAN:INN]; Guanabenz(USAN); Guanabenzo [INN-Spanish]; Guanabenzum [INN-Latin]; Wy-8678; Wytensin (TN); Guanabenz (USAN/INN); [(2,6-Dichlorobenzylidene)amino]guanidine; N-((2,6-Dichlorobenzylidene)amino)guanidine; Guanidine, ((2,6-dichlorobenzylidene)amino)-(8CI); N-(2,6-Dichlorobenzylidene)-N'-amidinohydrazine; ((2,6-Dichlorobenzylidene)amino)guanidine; 2,6-Dichlorobenzylideneaminoguanidine;2-((2,6-Dichlorophenyl)methylene)-hydrazinecarboximidamide; 2-[(E)-(2,6-dichlorophenyl)methylideneamino]guanidine
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| Benzthiazide | Approved | [15] | ||
| Synonyms |
Aquapres; Aquasec; Aquatag; Benzothiazide; Benzotiazida; Benzthazide; Benzthiazidum; Benztiazide; Dihydrex; Diucen;Diucene; Edemex; Exna; Exosalt; Fouane; Fovane; Freeuril; HyDrine; Lemazide; Proaqua; Regulon; Urazide; Urese; Benztiazide [DCIT]; P 1393; Pfizer 1393; Aqua-Scrip; Aquatag (TN); Benzotiazida [INN-Spanish]; Benzthiazidum [INN-Latin]; Dihydrex (TN); Diucen (TN); Edemax (TN); Exna (TN); Foven (TN); Hy-drine; Pro-aqua; Rid-ema; S-Aqua; Benzthiazide (JAN/INN); Benzthiazide [USAN:INN:BAN]; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)menthyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide; 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine-1,1-dioxide; 3-(benzylsulfanylmethyl)-6-chloro-1,1-dioxo-4H-1; 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide; 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-3-(((phenylmethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-Chloro-7-sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide; 6-chloro-3-{[(phenylmethyl)thio]methyl}-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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| Mephentermine | Approved | [12] | ||
| Synonyms |
Mefenterdrin; Mefentermin; Mefentermina; Mephenterdrine; Mephenterdrinum; Mephenterminum; Mephetedrine; Mephine; Vialin; Wyamine; Wyfentermina; Mefentermina [INN-Spanish]; Mephentermine (INN); Mephentermine [INN:BAN]; Mephenterminum [INN-Latin]; N-Methylphentermine; WY-585; Mephentermine Sulfate (2:1); N,alpha,alpha-Trimethylbenzeneethanamine; N,alpha,alpha-Trimethylphenethylamine; Omega-Phenyl-tert-butyl-methylamine; N-Methyl-omega-phenyl-t-butylamine; N-Methyl-omega-phenyl-tert-butylamine; N,2-dimethyl-1-phenylpropan-2-amine; 2-Methyl-2-methylamino-1-phenylpropane; 2-Methylamino-2-methyl-1-phenylpropane
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| Olmesartan medoxomil | Approved | [16] | ||
| Synonyms |
Benevas; Benicar; Olmetec; Olvance; Forest Brand of Olmesartan Medoxomil; Olmesartan medoximil; Sankyo Brand of Olmesartan Medoxomil; Cs 866; Benicar (TN); Berlin-Chemie Brand of Olmesartan Medoxomil; CS-866; CS-866DM; CS-866RN; DE-092; KS-1182; Olmetec (TN); Benicar, Olmetec,Olmesartan; Olmesartan medoxomil (JAN/USAN); (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylate; (5-methyl-2-oxo-1,3-dioxolen-4-yl)methoxy-4-(1-hydroxy-1-methylethyl)-2-propyl-1-(4-(2-(tetrazol-5-yl)phenyl)phenyl)methylimidazol-5-carboxylate; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl) (1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl) methyl ester; 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester; 1H-imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
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| Ethacrynic acid | Approved | [17] | ||
| Synonyms |
Crinuryl; Edecril; Edecrina; Endecril; Ethacrynate; Hidromedin; Hydromedin; Mingit; Otacril; Reomax; Taladren; Uregit; Acide etacrynique; Acido etacrinico; Acidum etacrynicum; Etacrinic acid; Etacrynic Acid; Etakrinic acid; Ethacrinic acid; Ethacryinic Acid; Kyselina ethakrynova; Kyselina ethakrynova [Czech]; Methylenebutyryl phenoxyacetic acid; Methylenebutyrylphenoxyacetic acid; E0526; MK 595; Acide etacrynique [INN-French]; Acido etacrinico [INN-Spanish]; Acidum etacrynicum [INN-Latin]; Edecrin (TN); Ethacrinique (acide); Ethacrynic Acid, Sodium Salt; Ethacrynic acid (USP); Ethacrynic acid [USAN:BAN]; MK-595; Etacrynic acid (JP15/INN); [2,3-Dichloro-4-(2-methylenebutyryl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid; [2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid; [4-(2-Methylenebutyryl)-2,3-dichlorophenoxy]acetic acid; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova; Kyselina 4-(2-(1-butenyl)karbonyl)-2,3-dichlorfenoxyoctova [Czech]; [2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic acid; (2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid; (2,3-Dichloro-4-(2-methylenebutyryl)phenoxy)acetic acid; (2,3-Dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid; (4-(2-Methylenebutyryl)-2,3-dichlorophenoxy)acetic acid; 2,3-Dichloro-4(2-methylene-butyryl)phenoxy] acetic acid; 2,3-Dichloro-4-(2-methylenebutyl)phenoxyacetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxy acetic acid; 2,3-Dichloro-4-(2-methylenebutyryl)phenoxyacetic acid; 2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid
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| Timolol | Approved | [18] | ||
| Synonyms |
Aquanil; Betim; Betimol; Blocadren; Istalol; Optimol; Proflax; TIM; Temserin; Tenopt; Timacar; Timololum; Timopic; Timoptol; Timolol GFS; Timolol [USAN]; Timoptic OcuDose; Apo-Timol; Apo-Timop; Betimol (TN); Blocadren (TN); Istalol (TN); MK-950; Novo-Timol; Nu-Timolol; Phoxal-timolol; Tim-AK; Timolol (INN); Timolol (TN); Timololum [INN-Latin]; Timoptic (TN); Timoptic-XE; Apo-Timol (TN); Apo-Timop (TN); Gen-Timolol (TN); L-714,465; Nu-Timolol (TN); PMS-Timolol (TN); Phoxal-timolol (TN); Tim-AK (TN); Timoptic OcuDose. (TN); Timoptic-XE (TN); S(-)-Timolol maleate; Timolol Maleate, (1:1) Salt; S-(-)-3-(3-tert-Butylamino-2-hydroxypropoxy)-4-morpholino-1,2,5-thiadiazole; (-)-3-Morpholino-4-(3-tert-butylamino-2-hydroxypropoxy)-1,2,5-thiadiazole; (2S)-1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (2S)-1-[(1,1-dimethylethyl)amino]-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol; (S)-1-(1,1-(Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-2-propanol; (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol; (S)-timolol
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| Nadolol | Approved | [19] | ||
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Anabet; Corgard; Corgaretic; Nadic; Nadololum; Solgol; SQ 11725; SQ11725; Anabet (TN); Corgard (TN); Corzide (TN); Nadololum [INN-Latin]; SQ-11725; Solgol (TN); Alti-Nadolol (TN); Apo-Nadol (TN); Novo-Nadolol (TN); Nadolol (JP15/USP/INN); Nadolol [USAN:BAN:INN:JAN]; (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol; 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol; 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol
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| Seractide Acetate | Approved | [12] | ||
| Synonyms |
Acthar Gel-synthetic
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| Bendroflumethiazide | Approved | [20] | ||
| Synonyms |
Aprinox; BHFT; Bendrofluazide; Bendroflumethazide; Bendroflumethiazidum; Bendroflumetiazida; Bendroflumetiazide; Bendrofumethiazide; Bentride; Benuron; Benzhydroflumethiazide; Benzydroflumethiazide; Benzylhydroflumethiazide; Benzylrodiuran; Berkozide; Bristuric; Bristuron; Centyl; Corzide; Flumersil; Flumesil; Intolex; Livesan; Naigaril; Nateretin; Naturetin; Naturine; Niagaril; Nikion; Orsile; Pluryl; Pluryle; Plusuril; Poliuron; Rauzide; Repicin; Salural; Salures; Sinesalin; Sodiuretic; Thiazidico; Urlea; Bendroflumethiazide [USP]; Bendroflumetiazide [DCIT]; Rautrax N; Relan beta; BL H368; FT 8; FT 81; Be 724-A; Bendroflumethiazidum [INN-Latin]; Bendroflumetiazida [INN-Spanish]; Benzy-rodiuran; NATURETIN-10; NATURETIN-5; Naturetin (TN); Neo-naclex; Neo-rontyl; Naturetin-2.5; Bendroflumethiazide (JAN/USP/INN); (+-)-3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-, 1,1-dioxide; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-benzyl-3,4-dihydro-6-(trifluoromethyl)-,1,1-dioxide; 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide; 3-(phenylmethyl)-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-3,4-dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 3-Benzyl-6-trifluoromethyl-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine, 1,1-dioxide; 6-trifluoromethyl-3-benzyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide
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| Pinacidil | Approved | [21] | ||
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Pinacidilum; P 1134; S 1230; P-154; Pinacidil (anhydrous); Pinacidilum [INN-Latin]; S-1230; N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine; Guanidine, 2-cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)-, monohydrate; Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate; (+-)-Pinacidil; (+/-)-N-Cyano-N'-4-pyridinyl-N"-(1,2,2-trimethylpropyl)guanidine; (R,S)-Pinacidil; (inverted question mark)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine; 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine; 2-Cyano-3-(4-pyridinyl)-1-(1,2,2-trimethylpropyl)guanidine; 2-Cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)guanidine monohydrate
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| Veratrum Viride Root | Approved | [12] | ||
| Synonyms |
Vertavis
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| Cilnidipine | Phase 3 | [22] | ||
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Atelec; Cinaldipine; Cinalong; Siscard; Cilnidipine [INN]; FRC 8653; Atelec (TN); FRC-8653; Cilnidipine (JAN/INN); (+-)-(E)-Cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate; 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester; 2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; 3-O-(2-methoxyethyl) 5-O-[(E)-3-phenylprop-2-enyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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| Alilusem | Phase 3 | [23] | ||
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M-12285; M-17000; M-17055; MD-31
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| ACT-280778 | Phase 2 | [24] | ||
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| RMJH-111b | Phase 1/2 | [25] | ||
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Trimagnesium dicitrate; MAGNESIUM CITRATE; 3344-18-1; Trimagnesium citrate; UNII-RHO26O1T9V; magnesium dicitrate; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3); 7779-25-1; RHO26O1T9V; Magnesium citrate, Mg3(C6H5O7)2; trimagnesium;2-hydroxypropane-1,2,3-tricarboxylate; Trimagnesiumdicitrat; MAGNESIUMCITRATE; NSC-83517; Magnesium citrate (VAN); Magnesium citrate [USP]; Magnesium citrate (3:2); Trimagnesiumdicitrate; EINECS 222-093-9; Tectlol (TN); NSC 83517; Tri Magnesium Citrate; EC 222-093-9; Magnesium citrate (JAN/USP); C12H10Mg3O14; CHEMBL3989480; CHEBI:131391; DTXSID601015151; AKOS028109620; DB11110; H259; DB-048405; Citric acid, magnesium salt (2:3) (8CI); FT-0628080; FT-0628081; D03265; Q4177438; magnesium 2-hydroxypropane-1,2,3-tricarboxylate (3/2); 1,2,3-Propanetricarboxylic acid, hydroxy-, magnesium salt (2:3); 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3) (9CI); Citric acid, magnesium salt (2:3), Citric acid, magnesium salt (2:3) (8CI), EINECS 222-093-9, LS-121081, MAGNESIUM CITRATE, Magnesium citrate (3:2), Magnesium citrate, Mg3(C6H5O7)2, Magnesium; MAGNESIUM CITRATE, Magnesium citrate (3:2), Magnesium citrate, Mg3(C6H5O7)2, Magnesium citrate [USAN], Magnesium citrate (VAN), NSC 83517, Trimagnesiumdicitrat, Trimagnesium dicitrate
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| RMJH-111b | Phase 1/2 | [26] | ||
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| SKF-105494 | Phase 1 | [27] | ||
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| MK-8266 | Phase 1 | [28] | ||
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References
: m6A sites