m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT05061				[1]
Non-coding RNA miR-615-3p YTHDF2 lncRNA miRNA circRNA Direct Enhancement m⁶A modification FBLN1 FBLN1 YTHDF2 : m⁶A sites
m6A Regulator	YTH domain-containing family protein 2 (YTHDF2)			READER	Regulator Info
m6A Target	Fibulin-1 (FBLN1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	Non-coding RNA (ncRNA)
Epigenetic Regulator	hsa-miR-615-3p			microRNA	View Details
Regulated Target	YTH domain-containing family protein 2 (YTHDF2)				View Details
Crosstalk Relationship	ncRNA → m6A			Enhancement
Crosstalk Mechanism	ncRNAs directly impacts m6A modification through recruiting m6A regulator
Crosstalk Summary	hsa-miR-615-3p inhibited Fibulin-1 (FBLN1) and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m6A-miRNA interaction manner
Responsed Disease	Maxillofacial bone defect is a critical obstacle for maxillofacial tumors and periodontal diseases.		ICD-11: NA02		Disease Info
In-vitro Model	HEK293T	Normal	Homo sapiens		CVCL_0063

References

Ref 1	miR615-3p inhibited FBLN1 and osteogenic differentiation of umbilical cord mesenchymal stem cells by associated with YTHDF2 in a m(6)A-miRNA interaction manner. Cell Prolif. 2024 Jun;57(6):e13607. doi: 10.1111/cpr.13607. Epub 2024 Feb 14.