m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05036
|
[1] | |||
Non-coding RNA
let-7g
METTL3
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
LAMTOR5
LAMTOR5
METTL3
Methylation
 : m6A sites
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Ragulator complex protein LAMTOR5 (LAMTOR5/HBXIP) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | MicroRNA let-7g (MIRLET7G) | microRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator | ||||
| Crosstalk Summary | Ragulator complex protein LAMTOR5 (LAMTOR5/HBXIP) up-regulates METTL3 by suppressing MIRLET7G, in which METTL3 increased HBXIP expression forming a positive feedback loop of HBXIP/let-7g/METTL3/HBXIP, leading to accelerated cell proliferation in breast cancer. | ||||
| Responsed Disease | Breast cancer | ICD-11: 2C60 | |||
| Pathway Response | Apoptosis | hsa04210 | |||
| Cell Process | Cell differentiation and apoptosis | ||||
| Glutamine metabolism | |||||
| Apoptosis (hsa04210) | |||||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| 2C60: Breast cancer | 2 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
 Compound Name |
Entrectinib | Approved | [2] | |
|---|---|---|---|---|
| Synonyms |
1108743-60-7; RXDX-101; UNII-L5ORF0AN1I; Entrectinib (RXDX-101); L5ORF0AN1I; Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-; Benzamide, N-(5-((3,5-difluorophenyl)methyl)-1H-indazol-3-yl)-4-(4-methyl-1-piperazinyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-; Entrectinib [USAN:INN]; YMX; Kinome_2659; Entrectinib(rxdx-101); Entrectinib (USAN/INN); SCHEMBL3512601; GTPL8290; CHEMBL1983268; KS-00000TSK
Click to Show/Hide
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| External Link | ||||
| Compound Name |
Everolimus | Approved | [3] | |
| External Link | ||||
References