m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05029
|
[1] | |||
Non-coding RNA
miR-1226-3p
METTL3
lncRNA miRNA circRNA
Direct
Inhibition
m6A modification
TUBB4B
TUBB4B
METTL3
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Tubulin beta-4B chain (TUBB4B) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | hsa-miR-1226-3p | microRNA | View Details | ||
| Regulated Target | Methyltransferase-like protein 3 (METTL3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Inhibition | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through recruiting m6A regulator | ||||
| Crosstalk Summary | Overexpressing miRNAs significantly increased the amount of mRNAs associated with METTL3, whereas downregulating miRNA abundance by antagomirs significantly reduced METTL3 binding on mRNAs (i.e., DGCR2 and Tubulin beta-4B chain (TUBB4B), targeted by miR-423-3p and hsa-miR-1226-3p, respectively) in HeLa cells | ||||
In-vitro Model |
HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | |