m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT05019
|
[1], [2] | |||
Non-coding RNA
DARS-AS1
IGF2BP3
lncRNA miRNA circRNA
Direct
Enhancement
m6A modification
SCD
SCD
IGF2BP3
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | READER | |||
| m6A Target | Stearoyl-CoA desaturase (SCD) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Non-coding RNA (ncRNA) | ||||
| Epigenetic Regulator | DARS1 antisense RNA 1 (DARS1-AS1) | LncRNA | View Details | ||
| Regulated Target | Insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) | View Details | |||
| Crosstalk Relationship | ncRNA → m6A | Enhancement | |||
| Crosstalk Mechanism | ncRNAs directly impacts m6A modification through modulating the expression level of m6A regulator | ||||
| Crosstalk Summary | Downregulation of LncRNA DARS1-AS1 Inhibits the Tumorigenesis of Cervical Cancer via Inhibition of IGF2BP3, Mechanistically, IGF2BP3 regulated Stearoyl-CoA desaturase (SCD) mRNA m6A modifications via IGF2BP3-METTL14 complex, thereby enhanced CC proliferation, metastasis, and lipid metabolism. | ||||
| Responsed Disease | Cervical cancer | ICD-11: 2C77 | |||
In-vitro Model |
SiHa | Cervical squamous cell carcinoma | Homo sapiens | CVCL_0032 | |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | ||
References