m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03400
 [1], [2]
Histone modification H3K4me1 Epigenetic Regulator MIR570HG Indirect Inhibition m6A modification MTOR MTOR METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Serine/threonine-protein kinase mTOR (MTOR)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Regulated Target Histone H3 lysine 4 monomethylation (H3K4me1) View Details
Downstream Gene MIR570HG View Details
Crosstalk Relationship Histone modification  →  m6A Inhibition
Crosstalk Mechanism Histone modification indirectly regulates m6A modification through downstream signaling pathways
Crosstalk Summary Gain of Histone H3 lysine 4 monomethylation (H3K4me1) and H3K27ac led to the activation of MIR570HG expression. LINC00969 interacts with EZH2 and METTL3, transcriptionally regulates the level of H3K27me3 in the NLRP3 promoter region, and posttranscriptionally modifies the m6A level of NLRP3 in an m6A-YTHDF2-dependent manner METTL3-mediated m6A methylation promotes lung cancer progression via activating PI3K/AKT/Serine/threonine-protein kinase mTOR (MTOR) pathway.
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Responsed Drug Gefitinib
 Drug Info 
Cell Process Pyroptosis
In-vitro Model
 A-549 Lung adenocarcinoma Homo sapiens CVCL_0023
In-vivo Model 5 × 106 A549 cells overexpressing METTL3 (Lv-METTL3) or control (Lv-Ctrl) were suspended in 100 uL phosphate-buffered saline (PBS), and were subcutaneously injected into mouse lower right flank. Drug treatment started in the Lv-METTL3 group when the tumour volume reached around 100 mm3. Mice were randomly divided into three groups to receive vehicle, GSK2536771 (30 mg/kg) or rapamycin (1 mg/kg). Drugs were administrated daily through intraperitoneal injection for 18 days. Treatment conditions were chosen as previously reported.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Serine/threonine-protein kinase mTOR (MTOR) 72 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Novolimus Approved [3]
MOA Inhibitor
External Link
CID: 9854320
TTD: D03FCF
 Compound Name Temsirolimus Approved [4]
Synonyms
Torisel
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MOA Inhibitor
Activity IC50 = 1760 nM
External Link
CID: 6918289
TTD: D0ES1Q
 Compound Name Everolimus Approved [5]
Synonyms
Afinitor; Afinitor (TN); CERTICAN(R); Certican; Certican (TN); Everolimus (JAN/USAN/INN); Everolimus [USAN]; MTOR kinase inhibitors; NVP-RAD-001; RAD 001; RAD-001; RAD-001C; RAD001; RAD001, SDZ-RAD, Certican, Zortress, Afinitor, Everolimus; SDZ-RAD; Zortress
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MOA Inhibitor
External Link
CID: 6442177
TTD: D0K3QS
DrugBank: DB01590
 Compound Name Zotarolimus Approved [6]
Synonyms
Abt-578; Zotarolimus (TN)
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MOA Modulator
Activity IC50 = 3.3 nM
External Link
CID: 9876378
TTD: D0V7WS
 Compound Name Sirolimus Approved [7]
Synonyms
53123-88-9; Rapamune; Rapamycin (Sirolimus); AY-22989; Rapammune; sirolimusum; WY-090217; RAPA; Antibiotic AY 22989; AY 22989; UNII-W36ZG6FT64; CCRIS 9024; CHEBI:9168; SILA 9268A; W36ZG6FT64; HSDB 7284; C51H79NO13; NSC 226080; DE-109; NCGC00021305-05; DSSTox_CID_3582; DSSTox_RID_77091; DSSTox_GSID_23582; Cypher; Supralimus; Wy 090217; Perceiva; RAP; RPM; Rapamycin from Streptomyces hygroscopicus; SIIA 9268A; LCP-Siro; MS-R001; Rapamune (TN); Rapamycin (TN); Sirolimus (RAPAMUNE); Rapamycin C-7, analog 4; Sirolimus (USAN/INN); Sirolimus [USAN:BAN:INN]; Sirolimus, Rapamune,Rapamycin; Heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy; 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine; 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; 23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29; 3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; Sirolimus (MTOR inhibitor)
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MOA Inhibitor
External Link
CID: 5284616
TTD: D03LJR
DrugBank: DB00877
 Compound Name PF-04449913 Approved [8]
Synonyms
Glasdegib; 1095173-27-5; PF 04449913; UNII-K673DMO5H9; K673DMO5H9; CHEMBL2043437; Glasdegib (PF-04449913); Glasdegib [USAN:INN]; Glasdegib (USAN/INN); PF-04449913;Glasdegib; GTPL8201; Glasdegib(PF-04449913); EX-A858; MolPort-035-789-706; SFNSLLSYNZWZQG-VQIMIIECSA-N; ZINC68251434; PF-913; BDBM50385635; 2640AH; AKOS027324121; CS-2
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MOA Inhibitor
External Link
CID: 25166913
TTD: D0S5LO
DrugBank: DB11978
 Compound Name Ridaforolimus Phase 3 [9]
Synonyms
Deforolimus; AP 23573; MK 8669; AP-23573; MK-8669; AP23573, MK-8669, Ridaforolimus, Deforolimus
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MOA Inhibitor
External Link
CID: 11520894
TTD: D0O3CV
DrugBank: DB06233
 Compound Name INK128 Phase 2 [10]
Synonyms
1224844-38-5; Sapanisertib; INK-128; INK 128; INK 128 (MLN0128); TAK-228; UNII-JGH0DF1U03; JGH0DF1U03; 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine; INK-0128; 3-(2-Amino-5-benzoxazolyl)-1-(1-methylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; C15H15N7O; 5-(4-amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine; 5-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]-pyrimidin-3-yl)benzo[d]oxazol-2-amine; Sapanisertib (USAN/INN)
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MOA Inhibitor
Activity Ki = 1 nM
External Link
CID: 45375953
TTD: D03DPZ
DrugBank: DB11836
 Compound Name OSI-027 Phase 2 [11]
MOA Inhibitor
External Link
CID: 135398516
TTD: D0H7XL
DrugBank: DB12387
 Compound Name ABI-009 Phase 2 [12]
MOA Inhibitor
External Link
TTD: D0W3UV
 Compound Name Salirasib Discontinued in Phase 1/2 [3]
Synonyms
162520-00-5; Farnesylthiosalicylic acid; S-Farnesylthiosalicylic acid; UNII-MZH0OM550M; MZH0OM550M; CHEMBL23293; AK186909; Farnesyl Thiosalicylic Acid; 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic Acid; 2-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]sulfanylbenzoic acid; 2-((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienylthio)benzoic acid; 2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic acid; Benzoic acid, 2-(((2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrienyl)thio)-; FTS; Farnesylthiosalicyclic acid; FTS, Thyreos; Ras antagonists, Thyreos; S-trans; Th-101; Trans-farnesylthiosalicylicacid; FTS (oral, cancer), Concordia; Farnesylthiosalicyclic acid (oral, cancer), Concordia; Ras-inhibitors (cancer), Concordia; FTS (oral, cancer), Concordia/Ono; KD032
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MOA Modulator
External Link
CID: 5469318
TTD: D00KTV
DrugBank: DB12681
 Compound Name SAR245409 Phase 2 [3]
MOA Inhibitor
Activity IC50 = 157 nM
External Link
CID: 16123056
TTD: D01PGR
DrugBank: DB12400
 Compound Name SF1126 Phase 2 [12]
Synonyms
CC-1126; SF-1126; L-Serine, N2-(1,4-dioxo-4-((4-(4-oxo-8-phenyl-4H-1-benzopyran-2-yl)morpholinium-4-yl)methoxy)butyl)-L-arginylglycyl-L-alpha-aspartyl-, inner salt
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MOA Inhibitor
External Link
CID: 66577114
TTD: D03NJY
 Compound Name PF-05212384 Phase 2 [13]
Synonyms
PKI-587; 1197160-78-3; Gedatolisib; PKI587; PKI 587; 1-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-(4,6-dimorpholino-1,3,5-triazin-2-yl)phenyl)urea; PF 05212384; UNII-96265TNH2R; PF-05212384 (PKI-587); CHEMBL592445; 96265TNH2R; N-[4-[[4-(Dimethylamino)-1-piperidinyl]carbonyl]phenyl]-N'-[4-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]phenyl]urea; Gedatolisib (PF-05212384, PKI-587); Urea, N-(4-((4-(dimethylamino)-1-piperidinyl)carbonyl)phenyl)-N'-(4-(4,6-di-4-morpholinyl-1,3,5-triazin-2-yl)phenyl)-
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MOA Modulator
Activity IC50 = 0.4 nM
External Link
CID: 44516953
TTD: D0D8JB
DrugBank: DB11896
 Compound Name LY3023414 Phase 2 [14]
MOA Modulator
External Link
CID: 57519748
TTD: D0H1WC
DrugBank: DB12167
 Compound Name PF-04691502 Phase 2 [15]
Synonyms
1013101-36-4; PF 04691502; UNII-4W39NS61KI; 4W39NS61KI; 2-amino-8-((1r,4r)-4-(2-hydroxyethoxy)cyclohexyl)-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7(8H)-one; CHEMBL1234354; PF04691502; 2-Amino-8-[trans-4-(2-Hydroxyethoxy)cyclohexyl]-6-(6-Methoxypyridin-3-Yl)-4-Methylpyrido[2,3-D]pyrimidin-7(8h)-One; 2-Amino-8-[4-(2-hydroxyethoxy)cyclohexyl]-6-(6-methoxypyridin-3-yl)-4-methylpyrido[2,3-d]pyrimidin-7-one
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MOA Modulator
Activity IC50 = 7.9 nM
External Link
CID: 25033539
TTD: D0N5JZ
DrugBank: DB11974
 Compound Name GDC-0980/RG7422 Phase 2 [3]
Synonyms
Apitolisib; 1032754-93-0; GDC-0980; GDC0980; RG7422; (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one; UNII-1C854K1MIJ; GDC-0980 (RG7422); Apitolisib (GDC-0980, RG7422); 1C854K1MIJ; CHEMBL1922094; RG-7422; (2s)-1-(4-{[2-(2-Aminopyrimidin-5-Yl)-7-Methyl-4-(Morpholin-4-Yl)thieno[3,2-D]pyrimidin-6-Yl]methyl}piperazin-1-Yl)-2-Hydroxypropan-1-One; J-502360; C23H30N8O3S
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MOA Modulator
Activity Ki = 17 nM
External Link
CID: 25254071
TTD: D0O6VZ
DrugBank: DB12180
 Compound Name BEZ235 Phase 2 [16]
Synonyms
BEZ-235; S14-0511; NVP-BEZ-235; NVP-BEZ235, BEZ235; 2-(4-(2,3-dihydro-3-methyl-2-oxo-8-(quinolin-3-yl)imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
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MOA Modulator
Activity IC50 = 5 nM
External Link
CID: 11977753
TTD: D0VG0D
DrugBank: DB11651
 Compound Name MM-141 Phase 2 [12]
MOA Inhibitor
External Link
TTD: D00BUO
 Compound Name PQR309 Phase 2 [3]
Synonyms
Bimiralisib; 1225037-39-7; PI3K-IN-2; PQR-309; UNII-6Z3QHB00LB; 6Z3QHB00LB; 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine; 5-[bis(morpholin-4-yl)-1,3,5-triazin-2-yl]-4-(trifluoromethyl)pyridin-2-amine; 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine; Bimiralisib [INN]; Bimiralisib [USAN]; Bimiralisib [WHO-DD]; NCB5; SCHEMBL1309049; GTPL8383; Bimiralisib free base; ADGGYDAFIHSYFI-UHFFFAOYSA-N; EX-A2018; BCP15887; PQR-309(PI3K-IN-2)
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MOA Inhibitor
Activity Ki = 62 nM
External Link
CID: 58507717
TTD: D0TU7B
DrugBank: DB14846
 Compound Name AZD2014 Phase 2 [17]
Synonyms
1009298-59-2; Vistusertib; AZD-2014; AZD 2014; UNII-0BSC3P4H5X; 0BSC3P4H5X; cc-551; 3-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[5,6-e]pyrimidin-7-yl]-N-methylbenzamide; CHEMBL2336325; 3-[2,4-Bis((3S)-3-methyLmorpholin-4-yl)pyrido-[5,6-e]pyrimidin-7-yl]-N-methylbenzamide; C25H30N6O3; 3-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-N-methylbenzamide; 3-[2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl]-N-methylbenzamide; Vistusertib [INN]; Vistusertib [USAN]; Vistusertib (JAN/INN)
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MOA Inhibitor
Activity IC50 = 2.8 nM
External Link
CID: 25262792
TTD: D0Z2UQ
DrugBank: DB11925
 Compound Name CC-223 Phase 1/2 [18]
Synonyms
GW 791343 HYDROCHLORIDE; GW791343 trihydrochloride; 309712-55-8; 1019779-04-4; GW791343 HCl; GW791343 (trihydrochloride); GW791343; GW-791343; 2-[(3,4-Difluorophenyl)amino]-N-[2-methyl-5-(1-piperazinylmethyl)phenyl]-acetamide trihydrochloride; GW791343 (HCL); GW-791343 hydrochloride; C20H27Cl3F2N4O; GW 791343 Trihydrochloride; C20H24F2N4O.3ClH; CTK8F0044; EX-A438; GW 791343 HCl; WSBRAHWNJBXXJM-UHFFFAOYSA-N; MolPort-023-219-209; BCP23425; AKOS024457596; CS-1030; BCP9000749; API0008007; HY-15470; BCP0726000290; RT-017402; KB-272661
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MOA Modulator
Activity IC50 = 10 nM
External Link
CID: 58298316
TTD: D05EXN
DrugBank: DB12570
 Compound Name BGT226 Phase 1/2 [19]
Synonyms
BGT-226 free base; 915020-55-2; UNII-ZXE7F2GMJJ; BGT226 free base; ZXE7F2GMJJ; BGT-226; 8-(6-Methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-trifluoromethylphenyl]-1,3-dihydroimidazo[4,5-c]quinolin-2-one; CHEBI:71967; BGT 226; NVPBGT226; 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 8-(6-Methoxy-pyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl-3-trifluoromethyl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one; NPV-BGT226; SCHEMBL146939
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MOA Modulator
External Link
CID: 11978790
TTD: D0X7IN
 Compound Name ME-344 Phase 1/2 [20]
Synonyms
NV-128; NV-344; MTOR inhibitor (cancer), Novogen; MTOR inhibitors (cancer), Marshall Edwards
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MOA Inhibitor
External Link
CID: 68026984
TTD: D03IXK
DrugBank: DB13062
 Compound Name BI 860585 Phase 1 [21]
MOA Inhibitor
External Link
TTD: D08PSC
 Compound Name LAM-001 Phase 1 [22]
MOA Inhibitor
External Link
TTD: D0QN5M
 Compound Name DS-3078 Phase 1 [23]
MOA Modulator
External Link
TTD: D0R9VX
 Compound Name GDC-0349 Phase 1 [24]
Synonyms
MTORC1/2 inhibitors
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MOA Inhibitor
Activity Ki = 3.8 nM
External Link
CID: 59239165
TTD: D0U8QH
DrugBank: DB13072
 Compound Name CERC 006 Phase 1 [25]
Synonyms
(+/-)-Cyclohexanecarboxylic acid, 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo(5,1-f)(1,2,4)triazin-7-yl)-, trans-; (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexane-1-carboxylic acid; (1r,4r)-4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; (1r,4r)-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo-[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; 1187559-66-5; 25MKH1SZ0M; 4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f] [1,2,4]Triazin-7-yl)cyclohexanecarboxylic Acid; 4-[(5Z)-4-amino-5-(7-methoxyindol-2-ylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid; 4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]cyclohexane-1-carboxylic acid; 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid; 936890-98-1; 936890-98-1 (free acid); A-1065; AC-31517; AEVI-006; AKOS030238938; AKOS037643584; AM81260; AS-17003; ASP 7486; ASP4786; ASP7486; ASP-7486; BCP02613; BCP9001034; BDBM185151; BRD-K94294671-003-01-3; CCG-268721; CERC 006; CERC006; CERC-006; CHEBI:91363; CHEMBL2132692; CHEMBL3120215; CS-0257; Cyclohexanecarboxylic acid, 4-(4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo(5,1-f)(1,2,4)triazin-7-yl)-, trans-; Cyclohexanecarboxylic acid, 4-[4-amino-5-(7-methoxy-1h-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-, trans-; DB12387; DTXSID901025951; EX-A143; F17371; HMS3656H05; HMS3748I11; HY-10423; J-523839; JROFGZPOBKIAEW-HAQNSBGRSA-N; LS-14875; MLS006011006; NCGC00250395-01; NCGC00386179-01; NCGC00386179-04; NCGC00387858-03; NSC800810; NSC-800810; OSI 027; OSI027; OSI-027; Q27163231; Q27253978; s2624; SB19259; SCHEMBL20482333; SCHEMBL22594988; SCHEMBL22787096; SCHEMBL976795; SCHEMBL976796; SMR004702804; SW220246-1; trans-4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl)cyclohexanecarboxylic acid; TRANS-4-[4-AMINO-5-(7-METHOXY-1H-INDOL-2-YL)IMIDAZO[5,1-F][1,2,4]TRIAZIN-7-YL]CYCLOHEXANECARBOXYLIC ACID; trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid; trans-4-[4-amino-5-(7-methoxy-1H-indol-2-yl)-imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid; UNII-25MKH1SZ0M
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MOA Inhibitor
External Link
CID: 135398516
TTD: D1RLY2
DrugBank: DB12387
 Compound Name DS-7423 Phase 1 [26]
MOA Modulator
External Link
TTD: D0X4RT
 Compound Name PWT-33597 Phase 1 [27]
Synonyms
PI3 kinase alpha/mTOR dual inhibitor (cancer), Pathway Therapeutics
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MOA Modulator
External Link
CID: 46917355
TTD: D0Y0FE
 Compound Name VS-5584 Phase 1 [3]
Synonyms
5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine; 1246560-33-7; VS-5584 (SB2343); UNII-W71J4X250V; SB-2343; SB2343; CHEMBL3393066; W71J4X250V; 5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine; C17H22N8O; QYBGBLQCOOISAR-UHFFFAOYSA-N; SCHEMBL539098; GTPL8382; EX-A288; DTXSID10677328; MolPort-035-757-944; HMS3652B16; BCP08247; 2797AH; ZINC95644685; s7016; VS5584; BDBM50059635; AKOS024465057; 5-(9-isopropyl-8-methyl-2-morpholin-4-yl-9H-purin-6-yl)-pyrimidin-2-ylamine; SB16877
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MOA Modulator
External Link
CID: 46912230
TTD: D0U3DP
DrugBank: DB12986
 Compound Name PMID25726713-Compound-49 Patented [28]
MOA Inhibitor
Activity IC50 < 1 nM
External Link
TTD: D07TVO
 Compound Name PMID25726713-Compound-51 Patented [28]
MOA Inhibitor
Activity IC50 < 1 nM
External Link
TTD: D0KH7Q
 Compound Name PMID25726713-Compound-48 Patented [28]
MOA Inhibitor
Activity IC50 < 1 nM
External Link
TTD: D0WJ3W
 Compound Name PMID25726713-Compound-47 Patented [28]
MOA Inhibitor
Activity IC50 < 1 nM
External Link
TTD: D0X5VI
 Compound Name PMID25726713-Compound-50 Patented [28]
MOA Inhibitor
Activity IC50 < 1 nM
External Link
TTD: D0Y8JF
 Compound Name AZD8055 Discontinued in Phase 1/2 [29]
Synonyms
1009298-09-2; AZD-8055; AZD 8055; [5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol; (5-(2,4-bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; UNII-970JJ37FPW; 970JJ37FPW; CHEMBL1801204; AK109550; (5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol
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MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 25262965
TTD: D0K1VK
DrugBank: DB12774
 Compound Name TAFA-93 Discontinued in Phase 1 [30]
Synonyms
MTOR inhibitor, Isotechnika; Rapamycin prodrug, Isotechnika; Transplant rejection therapy, Isotechnika
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 54601137
TTD: D0H5MX
 Compound Name SCR-44001 Terminated [31]
Synonyms
MTOR pathway inhibitors (cancer); PI3K modulators, BioImage; SCR-0044001; SCR-0334654; SCR-0335319; TOP-216; MTOR pathway inhibitors (cancer), TopoTarget; MTOR pathway inhibitors (cancer), BioImage/TopoTarget
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D05SXC
 Compound Name (4-(6-morpholino-9H-purin-2-yl)phenyl)methanol Investigative [32]
Synonyms
CHEMBL594669; SCHEMBL4442909
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
CID: 25069592
TTD: D00GQM
 Compound Name Rapamycin complexed with immunophilin FKBP12 Investigative [33]
MOA Inhibitor
External Link
TTD: D01AQN
 Compound Name C-16-(S)-3-methylindolerapamycin Investigative [34]
Synonyms
CHEMBL503885
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5 nM
External Link
CID: 44576240
TTD: D02TCF
 Compound Name PF-05094037 Investigative [3]
Synonyms
PF-05171310; PF-05181059; MTOR inhibitors (cancer), Pfizer
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D03XRZ
 Compound Name SX-MTR1 Investigative [3]
Synonyms
MTOR modulators (small peptide mimetics, bladder cancer), Serometrix
    Click to Show/Hide
MOA Modulator
External Link
TTD: D05SOW
 Compound Name 2-(6-morpholino-9H-purin-2-yl)phenol Investigative [32]
MOA Inhibitor
Activity IC50 = 2500 nM
External Link
CID: 135955185
TTD: D07JKB
 Compound Name P-2281 Investigative [3]
Synonyms
MTOR inhibitor (ulcerative colitis), Piramal
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D07NFT
 Compound Name X-387 Investigative [3]
Synonyms
MTOR inhibitors (cancer), Shanghai Institute of Materia Medica
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D08BTX
 Compound Name 4-(6-morpholino-9H-purin-2-yl)phenol Investigative [32]
MOA Inhibitor
Activity IC50 = 450 nM
External Link
CID: 135955186
TTD: D09FBN
 Compound Name EM-101 Investigative [3]
Synonyms
EM-100 series; LY-3; LY-303511; MTOR pathway inhibitors (cancer), Emiliem; MTOR pathway inhibitors (cancer), NIH
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 3971
TTD: D09VHS
 Compound Name EC-0845 Investigative [3]
Synonyms
MTOR modulator (inflammatory disease), Endocyte
    Click to Show/Hide
MOA Modulator
External Link
TTD: D0A8ES
 Compound Name 4-(2-(thiophen-2-yl)-9H-purin-6-yl)morpholine Investigative [32]
Synonyms
CHEMBL604876; SCHEMBL4439490
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2800 nM
External Link
CID: 25074311
TTD: D0AH8Q
 Compound Name SB-2280 Investigative [3]
Synonyms
SB-2602; Selective mTOR inhibitors (cancer); Selective mTOR inhibitors (cancer), S*BIO
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0E1YN
 Compound Name 4-(2-(thiophen-3-yl)-9H-purin-6-yl)morpholine Investigative [32]
Synonyms
CHEMBL608095; SCHEMBL4438208
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3900 nM
External Link
CID: 25074312
TTD: D0F1SI
 Compound Name torin 1 Investigative [35]
Synonyms
Torin-1
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4.32 nM
External Link
CID: 49836027
TTD: D0H0HR
 Compound Name EC-0565 Investigative [3]
Synonyms
Folate-everolimus conjugate (inflammation), Endocyte
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0H4KF
 Compound Name OXA-01 Investigative [3]
Synonyms
MTORC1/mTORC2 inhibitor (cancer) OSI Pharmaceuticals
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 45276387
TTD: D0J9PK
 Compound Name AR-mTOR-26 Investigative [3]
Synonyms
AR-mTOR-1; MTORC1/2 inhibitors (cancer); MTORC1/2 inhibitors (cancer), Array BioPharma
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0N9TK
 Compound Name 2-chloro-N-(6-cyanopyridin-3-yl)propanamide Investigative [36]
Synonyms
1112994-35-0; SCHEMBL1483919; CHEMBL446834; VFOLQYOVUCHHET-UHFFFAOYSA-N
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25141337
TTD: D0P0UV
 Compound Name 3-(6-morpholino-9H-purin-2-yl)phenol Investigative [32]
Synonyms
CHEMBL593515; SCHEMBL4443377; FUDQNOGEMXSUSQ-UHFFFAOYSA-N
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1650 nM
External Link
CID: 16049458
TTD: D0TC5H
 Compound Name AP-21967 Investigative [34]
Synonyms
CHEMBL525042; SCHEMBL18176922; C-16-(S)-7-methylindolerapamycin
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 44576241
TTD: D0U8GR
 Compound Name 4-(2-(1H-indol-6-yl)-9H-purin-6-yl)morpholine Investigative [32]
Synonyms
CHEMBL611630
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 150 nM
External Link
CID: 46225260
TTD: D0Y1DR
 Compound Name Torin2 Investigative [37]
Synonyms
Torin 2; 1223001-51-1; Torin-2; 9-(6-aminopyridin-3-yl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one; 9-(6-AMINO-3-PYRIDINYL)-1-[3-(TRIFLUOROMETHYL)PHENYL]-BENZO[H]-1,6-NAPHTHYRIDIN-2(1H)-ONE; CHEMBL1765602; C24H15F3N4O; CHEBI:90682; 9-(6-Aminopyridin-3-Yl)-1-[3-(Trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2(1h)-One; 9-(6-AMINOPYRIDIN-3-YL)-1-(3-(TRIFLUOROMETHYL)PHENYL)BENZO[H][1,6]NAPHTHYRIDIN-2(1H)-ONE; 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)-phenyl)benzo[h][1,6]naphthyridin-2(1H)-one; BENZO[H]-1,6-NAPHTHYRIDIN-2(1H)-ONE, 9-(6-AMINO-3-PYRIDINYL)-1-[3-(TRIFLUOROMETHYL)PHENYL]-; 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]benzo[h]-1,6-naphthyridin-2(1H)-one; cc-275; MLS006011167; GTPL8839; SCHEMBL6876328; AOB3537; DTXSID00679917; EX-A431; HMS3265O05; HMS3265O06; HMS3265P05; HMS3265P06; HMS3651N13; BCP02612; ABP000908; BDBM50341209; MFCD18782652; NSC775727; s2817; ZINC71318831; AKOS024458055; CCG-265003; CS-0236; NSC-775727; PB34957; NCGC00263216-01; NCGC00263216-02; NCGC00263216-09; NCGC00263216-13; 9-(6-AMINO-PYRIDIN-3-YL)-1-(3-TRIFLUOROMETHYL-PHENYL)-1H-BENZO[H][1,6]NAPHTHYRIDIN-2-ONE; AC-31520; AK171126; AS-74405; HY-13002; SMR004702936; AB0035864; DB-084736; FT-0700124; SW218309-2; Y0293; Q-4148; J-519481; BRD-K68174511-001-01-7; Q27089008; 9-(6-amino-3-pyridyl)-1-[3-(trifluoromethyl)phenyl]benzo[h][1,6]naphthyridin-2-one; 17G; 9-(6-Amino-3-pyridinyl)-1-[3-(trifl uoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H) -one; 9-(6-AMINOPYRIDIN-3-YL)-1-[3-(TRIFLUOROMETHYL)PHENYL]-1H,2H-BENZO[H]1,6-NAPHTHYRIDIN-2-ONE
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 51358113
TTD: D2B7WM
 Compound Name HM-5016699 Investigative [3]
Synonyms
Dual PI3K/mTOR inhibitor (cancer); Dual PI3K/mTOR inhibitor (cancer), Hutchison
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D02ELN
 Compound Name PF-03772304 Investigative [38]
Synonyms
MTOR inhibitors, Biotica; MTOR inhibitors, Wyeth; PF-04979064; PF-05017255; PF-05168899; WYE-125132; WYE-132; WYE-178; WYE-354; WYE-600; WYE-687; Imidazolo and pyrazolopyrimidine derivatives (cancer), Pfizer; Imidazolopyrimidine derivatives (cancer), Pfizer; Imidazolopyrimidine derivatives (cancer), Wyeth; Non-rapamycin mTOR/PI3K inhibitors (cancer); PI3K/mTOR signalling inhibitors (cancer), Wyeth; Non-rapamycin mTOR/PI3K inhibitors (cancer), Pfizer; 5H-pyrrolo[3,2-d]pyridimine analogs (cancer), Wyeth
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MOA Inhibitor
External Link
TTD: D05RSS
 Compound Name PP-242 Investigative [39]
Synonyms
PP242; TORKinib
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8 nM
External Link
CID: 135565635
TTD: D0H2CM
 Compound Name CU-906 Investigative [3]
MOA Inhibitor
External Link
TTD: D0JD4S
 Compound Name P-6915 Investigative [3]
Synonyms
PI3K/mTOR inhibitors (cancer), Piramal
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0QE9F
 Compound Name 2-Morpholin-4-yl-pyrimido[2,1-a]isoquinolin-4-one Investigative [40]
Synonyms
Compound 401; 168425-64-7; 2-morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one; 2-(morpholin-4-yl)pyrimido[2,1-a]isoquinolin-4-one; CHEMBL179242; 2-(4-MORPHOLINYL)-4H-PYRIMIDO[2,1-A]ISOQUINOLIN-4-ONE; Compound401; SCHEMBL10092321; KS-00001DEG; CTK4D2994; DTXSID20434626; MolPort-023-276-726; HMS3229D15; EX-A1016; BCP04303; BDBM50159620; ZINC13608047; AKOS016369524; CS-5624; NCGC00378805-02; HY-19341; KB-224235; M2537; B7337; S-7713; J-010456
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5300 nM
External Link
CID: 10039361
TTD: D0T0BY
 Compound Name 2-(2-Methyl-morpholin-4-yl)-benzo[h]chromen-4-one Investigative [40]
Synonyms
CHEMBL435507; SCHEMBL3545107
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4800 nM
External Link
CID: 10017389
TTD: D0X7TB
 Compound Name Ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate Investigative [40]
Synonyms
2-(Morpholin-4-yl)-benzo[h]chromen-4-one; 154447-35-5; NU7026; NU 7026; DNA-PK Inhibitor II; NU-7026; 2-morpholino-4H-benzo[h]chromen-4-one; LY293646; LY-293646; 2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one; 2-(4-morpholinyl)-4H-naphtho[1,2-b]pyran-4-one; CHEMBL104468; AK186905; DNA-Dependent Protein Kinase Inhibitor II; 2-morpholin-4-ylbenzo[h]chromen-4-one; SCHEMBL610237; ZINC9230; GTPL5959; KS-00000XHI; CTK0E7833; CHEBI:92165; DTXSID10432010; AOB2835; MolPort-009-019-548; HMS3229C11; EX-A1100; BCP04736; IN1364; s2893
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6400 nM
External Link
CID: 9860529
TTD: D0W1ST
 Compound Name PP121 Investigative [39]
Synonyms
PP-121; PP 121
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 24905142
TTD: D03EHM
DrugBank: DB08052
2C25: Lung cancer 52 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Adagrasib Approved [41]
Synonyms
2326521-71-3; MRTX-849; UNII-8EOO6HQF8Y; 8EOO6HQF8Y; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile; CHEMBL4594350; SCHEMBL20974691; GTPL10888; Kras G12C inhibitor MRTX849; BCP31538; EX-A3258; MRTX 849; MFCD32263433; s8884; compound 20 [PMID: 32250617]; BS-16211; HY-130149; CS-0105265; 2-Piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
    Click to Show/Hide
External Link
CID: 138611145
TTD: DUQV41
 Compound Name Amivantamab Approved [42]
External Link
TTD: DQ5X1Z
 Compound Name Mobocertinib Approved [43]
Synonyms
1847461-43-1; TAK-788; TAK788; AP32788; UNII-39HBQ4A67L; 39HBQ4A67L; propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Mobocertinib [INN]; Mobocertinib [USAN]; AP-32788; Mobocertinib (TAK788); Mobocertinib(TAK-788); SCHEMBL17373133; GTPL10468; BDBM368374; BCP31045; EX-A3392; US10227342, Example 10; MFCD32669806; NSC825519; s6813; TAK-788;AP32788; WHO 11183; NSC-825519; example 94 [WO2015195228A1]; HY-135815; CS-0114256; TAK-788;TAK 788; AP 32788; 5-Pyrimidinecarboxylic acid, 2-((4-((2-(dimethylamino)ethyl)methylamino)-2-methoxy-5-((1-oxo-2-propen-1-yl)amino)phenyl)amino)-4-(1-methyl-1H-indol-3-yl)-, 1-methylethyl ester; C(C=C)(=O)NC=1C(=CC(=C(C=1)NC1=NC=C(C(=N1)C1=CN(C2=CC=CC=C12)C)C(=O)OC(C)C)OC)N(C)CCN(C)C; Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
    Click to Show/Hide
External Link
CID: 118607832
TTD: DI4HA7
 Compound Name Sugemalimab Approved in China [44]
External Link
TTD: DDZ48Y
 Compound Name Sacituzumab govitecan Approved [45]
Synonyms
1491917-83-9; 1535963-91-7; 1796566-95-4; CYSTEINYL CL2A-SN-38; DA64T2C2IO; DTXSID401335985; EX-A4354; F82944; GOVITECAN CYSTEINYL CONJUGATE; hRS 7SN38; hRS7-SN38; IMMU 132; IMMU-132; M9BYU8XDQ6; Sacituzumab govitecan; Sacituzumab govitecan [USAN]; sacituzumab-govitecan; Satralizumab linker; SN-38 CYSTEINYL CONJUGATE; UNII-M9BYU8XDQ6
    Click to Show/Hide
External Link
CID: 91668186
TTD: D8LAE2
 Compound Name Atezolizumab Approved [46]
External Link
TTD: D0YM2K
 Compound Name Tepotinib Approved [47]
Synonyms
1100598-32-0; EMD 1214063; UNII-1IJV77EI07; Tepotinib (EMD 1214063); EMD1214063; 1IJV77EI07; MSC-2156119J; Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-; C29H28N6O2; Tepotinib [INN]; Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]; Benzonitrile, 3-(1,6-dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo
    Click to Show/Hide
External Link
CID: 25171648
TTD: D0R8QG
DrugBank: DB15133
 Compound Name Sotorasib Approved [48]
Synonyms
AMG-510; AMG510; AMG-510 racemate; 2252403-56-6; AMG 510; Kras G12C inhibitor 9; 2296729-00-3; UNII-2B2VM6UC8G; 2B2VM6UC8G; CHEMBL4535757; 2296729-00-3 (racemate); 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one; Sotorasib [INN]; 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one; AMG510 racemate; Sotorasib [USAN]; AMG-510(racemate); Kras mutant-targeting AMG 510; SCHEMBL20560375; GTPL10678; AMG 510 pound>>AMG-510; AMY16918; BCP30452; BCP33368; EX-A3538; BDBM50514402; NSC818433; s8830; WHO 11370; DB15569; NSC-818433; BS-16684; HY-114277; CS-0081316; compound (R)-38 [PMID: 31820981]; (1m)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-4-((2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl)pyrido(2,3-d)pyrimidin-2(1H)-one; (1S)-4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 2296729-66-1; Pyrido(2,3-d)pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(1-methylethyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl)-
    Click to Show/Hide
External Link
CID: 137278711
TTD: D0R7LD
DrugBank: DB15569
 Compound Name Entrectinib Approved [49]
Synonyms
1108743-60-7; RXDX-101; UNII-L5ORF0AN1I; Entrectinib (RXDX-101); L5ORF0AN1I; Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-; Benzamide, N-(5-((3,5-difluorophenyl)methyl)-1H-indazol-3-yl)-4-(4-methyl-1-piperazinyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-; Entrectinib [USAN:INN]; YMX; Kinome_2659; Entrectinib(rxdx-101); Entrectinib (USAN/INN); SCHEMBL3512601; GTPL8290; CHEMBL1983268; KS-00000TSK
    Click to Show/Hide
External Link
CID: 25141092
TTD: D0O0LS
DrugBank: DB11986
 Compound Name Repotrectinib Approved [50]
Synonyms
FIKPXCOQUIZNHB-RRKGBCIJSA-N; SCHEMBL20438940; TPX 0005; BCP19778
    Click to Show/Hide
External Link
CID: 135565923
TTD: D05NFR
 Compound Name MYL-1402O Phase 3 [51]
Synonyms
bevacizumab biosimilar
    Click to Show/Hide
External Link
TTD: DYH3Q6
 Compound Name AB154 Phase 3 [52]
Synonyms
Domvanalimab
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External Link
TTD: DT1FS0
 Compound Name Datopotamab deruxtecan Phase 3 [53]
External Link
TTD: DP41HV
 Compound Name CS1001 Phase 3 [54]
External Link
TTD: D3MP1S
 Compound Name JDQ443 Phase 3 [55]
Synonyms
(S)-JDQ-443; 1-(6-((4S)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptan-2-yl)prop-2-en-1-one; 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-inda zol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]- 2-Propen-1-one; 1-[6-[(4R)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-2-propen-1-one; 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one; 1-{6-[(4M)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5- methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2- azaspiro[3.3]heptan-2-yl}prop-2-en-1-one; 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl}prop-2-en-1-one; 2653994-08-0; 2653994-10-4; 2-Propen-1-one, 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-; AKOS040757949; AT36708; BDBM50579985; CHEMBL5077861; compound 5 [PMID: 35404998]; CS-0226220; CS-0311034; EX-A5693; example 1a [WO2021120890A1]; GLXC-25533; GTPL11715; HY-139612A; JDQ 443; JDQ 443 [WHO-DD]; JDQ443; JDQ-443; MS-29737; NSC846146; NSC-846146; NVP-JDQ443; NVP-JDQ-443; Opnurasib; opnurasib [INN]; -PROPEN-1-ONE, 1-(6-((4R)-4-(5-CHLORO-6-METHYL-1H-INDAZOL-4-YL)-5-METHYL-3-(1-METHYL-1H-INDAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-AZASPIRO(3.3)HEPT-2-YL)-; Q3W0H3V1LQ; SCHEMBL23533580
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CID: 156501355
TTD: D37IQM
 Compound Name TRS003 Phase 3 [56]
External Link
TTD: D2KVG4
 Compound Name Tusamitamab ravtansine Phase 3 [57]
Synonyms
SAR408701
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External Link
TTD: D2D6NJ
 Compound Name RG6058 Phase 3 [58]
Synonyms
Tiragolumab
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External Link
TTD: D0L4VD
 Compound Name GSK4069889 Phase 2 [59]
Synonyms
TSR-022
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External Link
TTD: DZW53X
 Compound Name APL-101 Phase 2 [60]
Synonyms
Bozitinib; PLB-1001; 1440964-89-5; Vebreltinib; Vebreltinib [USAN]; UNII-2WZP8A9VFN; 2WZP8A9VFN; Bozitinib (PLB-1001); SCHEMBL15594471; BDBM107096; CBI-3103; s6762; WHO 11677; HY-125017; CS-0088607; US9695175, 44; 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6- fluoro-2-methyl-2H-indazol-5-yl)methyl)-; 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5- yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine
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External Link
CID: 72202701
TTD: DV3Y7F
 Compound Name SGN-LIV1A Phase 2 [61]
Synonyms
Ladiratuzumab Vedotin
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TTD: DS6B1L
 Compound Name BNT116 Phase 2 [62]
External Link
TTD: DR39GZ
 Compound Name AZD7789 Phase 2 [63]
External Link
TTD: DNI7E3
 Compound Name L-DOS47 Phase 1/2 [64]
External Link
TTD: DN3Z5D
 Compound Name NC318 Phase 2 [65]
External Link
TTD: D9UZ5Q
 Compound Name Vorolanib Phase 2 [66]
Synonyms
UNII-YP8G3I74EL; YP8G3I74EL; 1013920-15-4; (S,Z)-N-(1-(Dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide; Vorolanib [INN]; SCHEMBL2439528; CHEMBL4297587; N-((3S)-1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide; s6843; DB15247; HY-109019; CS-0030517; Q27294638; 1H-Pyrrole-3-carboxamide, N-((3S)-1-((dimethylamino)carbonyl)-3-pyrrolidinyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
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CID: 59215954
TTD: D8AG3S
DrugBank: DB15247
 Compound Name Xofigo Phase 2 [67]
External Link
TTD: D6B7FP
 Compound Name Bintrafusp alfa Phase 2 [68]
External Link
TTD: D5J3BL
 Compound Name Voyager-V1 Phase 2 [69]
Synonyms
VSV-IFNBeta-NIS
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External Link
TTD: D4AGB6
 Compound Name AB-106 Phase 2 [70]
Synonyms
DS6051b; GTPL11198; AB106
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External Link
CID: 154699459
TTD: D2KV8B
 Compound Name RO-5126766 Phase 2 [71]
Synonyms
VS-6766; CH-5126766; Dual Raf/MEK protein kinase inhibitor (cancer), Roche
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External Link
CID: 16719221
TTD: D0M6BD
DrugBank: DB15254
 Compound Name TC-210 Phase 1/2 [72]
External Link
TTD: DX6O9V
 Compound Name EMB-01 Phase 1/2 [73]
External Link
TTD: DWQ6J1
 Compound Name NM21-1480 Phase 1/2 [74]
External Link
TTD: DUVH60
 Compound Name MRx0518 Phase 1/2 [75]
External Link
TTD: DP4J2K
 Compound Name DZD9008 Phase 1/2 [76]
External Link
TTD: DM8Y2N
 Compound Name BGB-A425 Phase 1/2 [77]
External Link
TTD: D7UIZ1
 Compound Name Rilvegostomig Phase 1/2 [78]
Synonyms
AZD2936
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External Link
TTD: D4RMC9
 Compound Name IK-007 Phase 1/2 [79]
Synonyms
grapiprant
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External Link
TTD: D1KES8
 Compound Name IBI318 Phase 1 [80]
External Link
TTD: DX30BA
 Compound Name GEN-011 Phase 1 [81]
External Link
TTD: DR1YQ7
 Compound Name ENV-105 Phase 1 [82]
Synonyms
Carotuximab
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External Link
TTD: DQ8K3R
 Compound Name AMG 160 Phase 1 [83]
External Link
TTD: DOY4E6
 Compound Name ADP-A2M10 Phase 1 [84]
External Link
TTD: DM38KC
 Compound Name MEDI5752 Phase 1 [85]
External Link
TTD: D7L1MP
 Compound Name PF-07104091 Phase 1 [86]
External Link
TTD: D5TH2B
 Compound Name PF-06936308 Phase 1 [87]
External Link
TTD: D2LUK7
 Compound Name GEM3PSCA Phase 1 [88]
External Link
TTD: D1L7DE
 Compound Name PF-07257876 Phase 1 [89]
External Link
TTD: D1A7OP
 Compound Name Cosibelimab Phase 1 [90]
Synonyms
CK-301/TG-1501
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External Link
TTD: D17URP
 Compound Name Gemcitabine Approved [91]
External Link
CID: 60750
TTD: D0AJ3K
DrugBank: DB00441
 Compound Name SMI-4a Investigative [92]
Synonyms
438190-29-5; SMI 4a; TCS PIM-1 4a; (Z)-SMI-4a; (Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione; (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione; CHEMBL183906; (5Z)-5-[[3-(TRIFLUOROMETHYL)PHENYL]METHYLENE]-2,4-THIAZOLIDINEDIONE; (5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione; 327033-36-3; C11H6F3NO2S; (Z)-5-(3-(Trifluoromethyl)benzylidene)-thiazolidine-2,4-dione; (5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione; Pim inhibitor 4a; 3vc4; SMI-4q; TCS PIM-1-4a; 5-(3-(Trifluoromethyl)benzylidene)thiazolidine-2,4-dione; 5-[3-(Trifluoromethyl)benzylidene]thiazolidine-2,4-dione; cc-717; thiazolidine-2,4-dione, 4a; SCHEMBL2541382; SCHEMBL2541388; BDBM26626; AOB6260; EX-A111; SYN1113; BDBM138364; HMS3229J21; 2720AH; HY-16576A; MFCD01152003; s8005; ZINC12576047; AKOS001314163; SMI-4a, >=98% (HPLC); CCG-265027; NCGC00345836-02; NCGC00345836-14; AC-32861; HY-15474; AB0165836; EC-000.2291; J3.561.866J; A11945; W-5256; US8877795, 12; Q27451064; 5-[[3-(trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
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CID: 1361334
TTD: DAJ3D2
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