m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03395
 [1], [2]
Histone modification H3K4me1 Epigenetic Regulator MIR570HG Indirect Inhibition m6A modification MET MET METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target Hepatocyte growth factor receptor (c-Met/MET)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Regulated Target Histone H3 lysine 4 monomethylation (H3K4me1) View Details
Downstream Gene MIR570HG View Details
Crosstalk Relationship Histone modification  →  m6A Inhibition
Crosstalk Mechanism Histone modification indirectly regulates m6A modification through downstream signaling pathways
Crosstalk Summary Gain of Histone H3 lysine 4 monomethylation (H3K4me1) and H3K27ac led to the activation of MIR570HG expression. LINC00969 interacts with EZH2 and METTL3, transcriptionally regulates the level of H3K27me3 in the NLRP3 promoter region, and posttranscriptionally modifies the m6A level of NLRP3 in an m6A-YTHDF2-dependent manner METTL3 combines with Hepatocyte growth factor receptor (c-Met/MET) and causes the PI3K/AKT signalling pathway to be manipulated, which affects the sensitivity of lung cancer cells to gefitinib. METTL3 knockdown promotes apoptosis and inhibits proliferation of lung cancer cells.
Responsed Disease Lung cancer ICD-11: 2C25
 Disease Info 
Responsed Drug Gefitinib
 Drug Info 
Cell Process Pyroptosis
In-vitro Model
 PC-9 Lung adenocarcinoma Homo sapiens CVCL_B260
NCI-H3255 Lung adenocarcinoma Homo sapiens CVCL_6831
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Hepatocyte growth factor receptor (c-Met/MET) 76 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Capmatinib Approved [3]
Synonyms
1029712-80-8; INCB28060; INC-280; INC280; UNII-TY34L4F9OZ; 2-fluoro-N-methyl-4-(7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl)benzamide; INC28060; INCB-28060; INCB28060(Capmatinib); NVP-INC280; TY34L4F9OZ; Capmatinib (INCB28060); INCB 28060; 2-Fluoro-N-methyl-4-[7-[(quinolin-6-yl)methyl]imidazo[1,2-b]-[1,2,4]triazin-2-yl]benzamide; BenzaMide, 2-fluoro-N-Methyl-4-[7-(6-quinolinylMethyl)iMidazo[1,2-b][1,2,4]triazin-2-yl]-; C23H17FN6O
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MOA Modulator
Activity IC50 = 0.13 nM
External Link
CID: 25145656
TTD: D07OJZ
DrugBank: DB11791
 Compound Name Tepotinib Approved [4]
Synonyms
1100598-32-0; EMD 1214063; UNII-1IJV77EI07; Tepotinib (EMD 1214063); EMD1214063; 1IJV77EI07; MSC-2156119J; Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-; C29H28N6O2; Tepotinib [INN]; Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]; Benzonitrile, 3-(1,6-dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo
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MOA Modulator
Activity IC50 < 1 nM
External Link
CID: 25171648
TTD: D0R8QG
DrugBank: DB15133
 Compound Name Cabozantinib Approved [5]
Synonyms
Cabometyx; Cometriq
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MOA Inhibitor
Activity IC50 = 1.3 nM
External Link
CID: 25102847
TTD: D0IQ6P
DrugBank: DB08875
 Compound Name Amivantamab Approved [6]
MOA Inhibitor
External Link
TTD: DQ5X1Z
 Compound Name Crizotinib Approved [7]
Synonyms
Xalkori (TN); novel ALK inhibitors
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MOA Modulator
Activity IC50 = 0.51 nM
External Link
CID: 11626560
TTD: D03ZBT
DrugBank: DB08865
 Compound Name RG3638 Phase 3 [8]
Synonyms
Onartuzumab
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MOA Modulator
External Link
TTD: D0H9PT
 Compound Name Savolitinib Phase 3 [9]
Synonyms
1313725-88-0; AZD-6094; AZD6094; UNII-2A2DA6857R; CHEMBL3334567; 2A2DA6857R; Savolitinib [INN]; Volitinib(Savolitinib); Savolitinib [USAN:INN]; GTPL9918; SCHEMBL12489208; EX-A845; BDBM50023342; ZINC149738712; AKOS030526403; DB12048; compound 28 [PMID: 25148209]; HY-15959; AS-35250; 1H-1,2,3-Triazolo(4,5-b)pyrazine, 1-((1S)-1-imidazo(1,2-a)pyridin-6-ylethyl)-6-(1-methyl-1H-pyrazol-4-yl)-; KB-333895; FT-0700162; J-690125; 4-{1-[(1S)-1-{imidazo[1,2-a]pyri
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MOA Inhibitor
Activity IC50 = 1.995 nM
External Link
CID: 68289010
TTD: D0LW0T
DrugBank: DB12048
 Compound Name Beperminogene perplasmid Phase 3 [10]
MOA Modulator
External Link
TTD: D0N1YF
 Compound Name Tivantinib Phase 3 [11]
Synonyms
905854-02-6; ARQ-197; ARQ197; ARQ 197; Tivantinib (ARQ 197); (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; UNII-PJ4H73IL17; PJ4H73IL17; 1000873-98-2; (3R,4R)-3-(5,6-Dihydro-4H-pyrrolo(3,2,1-ij)quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione; Tivantinib [USAN:INN]; 1228508-24-4; ARQ 197, Tivantinib; Tivantinib (ARQ-197); ARQ 197 (Tivantinib); cc-86; SCHEMBL44944; Tivantinib (JAN/USAN/INN); GTPL7948; CHEMBL2103882; CHEBI:91398; QCR-102
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MOA Inhibitor
Activity Ki = 355 nM
External Link
CID: 11494412
TTD: D0ZI1F
DrugBank: DB12200
 Compound Name MGCD516 Phase 2/3 [8]
Synonyms
Sitravatinib
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MOA Inhibitor
External Link
CID: 25212148
TTD: D05BLN
DrugBank: DB15036
 Compound Name LY-2875358 Phase 2 [12]
Synonyms
C-Met mAb (cancer), Eli Lilly; Anti-c-Met antibody (cancer), Lilly
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External Link
TTD: D03SXS
 Compound Name SAR-125844 Phase 2 [13]
Synonyms
Met inhibitor (iv, cancer), sanofi-aventis
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MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 25182860
TTD: D07ARN
DrugBank: DB15382
 Compound Name Emibetuzumab Phase 2 [14]
MOA Inhibitor
External Link
TTD: D0FE7D
 Compound Name AMG 337 Phase 2 [15]
MOA Modulator
Activity IC50 = 1 nM
External Link
CID: 44181686
TTD: D0G0BL
 Compound Name AMG 208 Phase 2 [16]
Synonyms
AMG-208; 1002304-34-8; AMG208; UNII-Y2SR66P7VM; 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline; Y2SR66P7VM; CHEBI:90626; 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline; 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline; C22H17N5O2; 7-methoxy-4-[(6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline; 7-methoxy-4-({6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl}methoxy)quinoline; Triazolopyridazine, 4; 3cd8
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MOA Modulator
Activity IC50 = 9 nM
External Link
CID: 24864821
TTD: D0OK2N
DrugBank: DB08079
 Compound Name HM-5016504 Phase 2 [8]
Synonyms
C-Met inhibitor (cancer), Hutchison
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MOA Inhibitor
External Link
TTD: D0R0YW
 Compound Name Telisotuzumab vedotin Phase 2 [17]
Synonyms
ABBV-399
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External Link
TTD: D42TUS
 Compound Name APL-101 Phase 2 [18]
Synonyms
Bozitinib; PLB-1001; 1440964-89-5; Vebreltinib; Vebreltinib [USAN]; UNII-2WZP8A9VFN; 2WZP8A9VFN; Bozitinib (PLB-1001); SCHEMBL15594471; BDBM107096; CBI-3103; s6762; WHO 11677; HY-125017; CS-0088607; US9695175, 44; 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6- fluoro-2-methyl-2H-indazol-5-yl)methyl)-; 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5- yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine
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MOA Inhibitor
External Link
CID: 72202701
TTD: DV3Y7F
 Compound Name CMX-2043 Phase 2 [19]
MOA Modulator
External Link
CID: 49802864
TTD: D01TBJ
DrugBank: DB12795
 Compound Name LY2801653 Phase 2 [20]
Synonyms
Merestinib; 1206799-15-6; LY-2801653; UNII-5OGS5K699E; N-(3-fluoro-4-((1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl)oxy)phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide; 5OGS5K699E; N-(3-Fluoro-4-{[1-Methyl-6-(1h-Pyrazol-4-Yl)-1h-Indazol-5-Yl]oxy}phenyl)-1-(4-Fluorophenyl)-6-Methyl-2-Oxo-1,2-Dihydropyridine-3-Carboxamide; C30H22F2N6O3; Merestinib [USAN]; SCHEMBL679002; LY2801653 (Merestinib); GTPL9841; CHEMBL3545307; QCR-139; DTXSID20659635; SYN1222; QHADVLVFMKEIIP-UHFFFAOYSA-N
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MOA Modulator
Activity IC50 = 4.7 nM
External Link
CID: 44603533
TTD: D06EGV
DrugBank: DB12381
 Compound Name XL880 Phase 2 [21]
Synonyms
GSK 089; GSK 1363089; GSK1363089; XL 880; GSK1363089, GSK089, foretinib, EXEL-2880, XL880; 88Z; MET inhibitors
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MOA Modulator
Activity IC50 = 0.4 nM
External Link
CID: 42642645
TTD: D0D1GF
DrugBank: DB12307
 Compound Name ChronSeal Phase 1/2 [22]
Synonyms
Antibiotic-free recombinant HGF, Linkoping; Recombinant HGF, Kringle/ChronTech; Recombinant HGF, Kringle/Tripep
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MOA Inhibitor
External Link
TTD: D09ZNL
 Compound Name Anti-C-met CAR-T cells Phase 1/2 [23]
MOA CAR-T-Cell-Therapy
External Link
TTD: D0A3OE
 Compound Name BMS-777607 Phase 1/2 [24]
Synonyms
1025720-94-8; BMS 777607; 1196681-44-3; BMS777607; ASLAN-002; UNII-A3MMS6HDO1; N-(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; A3MMS6HDO1; N-[4-[(2-Amino-3-chloropyridin-4-yl)oxy]-3-fluorophenyl]-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide; N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
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MOA Inhibitor
Activity IC50 < 2.512 nM
External Link
CID: 24794418
TTD: D0O6WV
DrugBank: DB12064
 Compound Name Sym015 Phase 1/2 [9]
MOA Inhibitor
External Link
TTD: D0B4OK
 Compound Name MK-2461 Phase 1/2 [25]
Synonyms
MK 2461
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MOA Inhibitor
Activity IC50 = 0.4 nM
External Link
CID: 44137946
TTD: D00DRL
 Compound Name REGN5093 Phase 1 [26]
MOA Inhibitor
External Link
TTD: D01FSX
 Compound Name PF-4217903 Phase 1 [27]
Synonyms
2-(4-(1-(Quinolin-6-ylmethyl)-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol; PF-04217903; 956905-27-4; PF04217903; PF 04217903; UNII-CYJ9ATV1IJ; CYJ9ATV1IJ; CHEMBL2001019; 1159490-85-3; aka PF-04217903; C19H16N8O; 2-[4-(3-Quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-pyrazol-1-yl]-ethanol; 2-(4-(1-(Quinolin-6-ylmethyl)-1H-(1,2,3)triazolo(4,5-b)pyrazin-6-yl)-1H-pyrazol-1-yl)ethanol; 3zxz; PDMUGYOXRHVNMO-UHFFFAOYSA-N
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MOA Inhibitor
Activity EC50 = 0.3 nM
External Link
CID: 17754438
TTD: D01LCC
DrugBank: DB12848
 Compound Name ABBV-399 Phase 1 [14]
MOA Inhibitor
External Link
TTD: D02EOR
 Compound Name CBT-101 Phase 1 [9]
Synonyms
L-Asparaginyl-L-leucyl-glycyl-L-valyl-L-[S-(acetamidomethyl)]cysteinamide hydrochloride
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MOA Inhibitor
External Link
TTD: D04XUJ
 Compound Name MK-8033 Phase 1 [28]
Synonyms
1001917-37-8; UNII-350H6PBQ5Q; 3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-N-(2-pyridinylmethyl)-5H-benzo[4,5]cyclohepta[1,2-b]pyridine-7-methanesulfonamide; 350H6PBQ5Q; CHEMBL2323775; MK8033; 1-(3-(1-Methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo(4,5)cyclohepta(1,2-b)pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide; 1-[2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridin-9-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide
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MOA Inhibitor
Activity IC50 = 0.6 nM
External Link
CID: 45142457
TTD: D05OMT
 Compound Name Autologous T Cells Expressing MET scFv CAR Phase 1 [29]
MOA CAR-T-Cell-Therapy
External Link
TTD: D0D1HI
 Compound Name ABT-700 Phase 1 [30]
MOA Modulator
External Link
TTD: D0I2IY
 Compound Name Hepapoietin Phase 1 [31]
Synonyms
APS-1010; Hepapoietin, SnowBrand; Hepapoietin (liver/kidney disease); Hepapoietin (liver/kidney disease), Atlas Pharmaceuticals
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MOA Inhibitor
External Link
TTD: D0N6VK
 Compound Name EMD-1204831 Phase 1 [32]
MOA Inhibitor
External Link
CID: 25134692
TTD: D0Y8UV
 Compound Name JNJ-38877605 Phase 1 [33]
Synonyms
C-met inhibitor, Ortho Biotech Oncology Research & Development; C-met inhibitor (solid tumors), ORD/J&J PRD
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MOA Inhibitor
Activity IC50 = 0.95 nM
External Link
CID: 46911863
TTD: D0YT8P
DrugBank: DB13113
 Compound Name SGX523 Phase 1 [34]
Synonyms
SGX-523; SGX523, SGX-523
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MOA Inhibitor
Activity IC50 = 3.1 nM
External Link
CID: 24779724
TTD: D0ZU5F
DrugBank: DB08584
 Compound Name TR1801-ADC Phase 1 [35]
External Link
TTD: DU6H8Z
 Compound Name LY3164530 Phase 1 [36]
MOA Modulator
External Link
TTD: D01IJM
 Compound Name C-Met/PD-L1 CAR-T Cell Phase 1 [37]
MOA CAR-T-Cell-Therapy(Dual specific)
External Link
TTD: D03GTO
 Compound Name E-7050 Phase 1 [38]
Synonyms
C-Met and VEGF-2 tyrosine kinase inhibitor (oral, cancer), Eisai
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MOA Modulator
Activity IC50 = 14 nM
External Link
CID: 16118392
TTD: D09ETH
DrugBank: DB11977
 Compound Name XL092 Phase 1 [39]
Synonyms
SCHEMBL21200856; NSC828252; XL-092; NSC-828252; 2367004-54-2
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MOA Inhibitor
External Link
CID: 139350422
TTD: D1TNJ2
 Compound Name BPI-9016 M Phase 1 [40]
MOA Inhibitor
External Link
TTD: D95YSW
 Compound Name AZD9592 Phase 1 [41]
External Link
TTD: DN47VK
 Compound Name TPX-0022 Phase 1 [42]
Synonyms
CSF1R-IN-2; SCHEMBL20694441; TPX0022; NSC820832; NSC-820832; HY-111787; CS-0091874; 2271119-26-5
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MOA Inhibitor
External Link
CID: 137455315
TTD: D7M8LI
 Compound Name RXDX-106 Phase 1 [43]
Synonyms
CEP-40783; 1437321-24-8; CEP40783; UNII-1969ZJE05Q; 1969ZJE05Q; N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; RXDX-106 (CEP-40783); SCHEMBL16089863; BCP25839; EX-A2540; MFCD28502441; NSC797770; s8570; AKOS032960472; ZINC205893112; CCG-270157; CS-6371; NSC-797770; SB18930; AC-31425; AS-35141; HY-100946; N-(4-((6,7-Dimethoxy-4-quinolinyl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide
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MOA Inhibitor
External Link
CID: 71576419
TTD: D7HZ3T
 Compound Name Altiratinib Phase 1 [44]
MOA Inhibitor
Activity IC50 = 2.7 nM
External Link
CID: 54576299
TTD: D0FA6S
 Compound Name Mteron-F1 Preclinical [45]
MOA Stimulator
External Link
TTD: D0NO6E
 Compound Name NPS-1034 Preclinical [46]
Synonyms
1221713-92-3; CHEMBL3810063; 1-(4-fluorophenyl)-N-[3-fluoro-4-[(3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,3-dimethyl-5-oxopyrazole-4-carboxamide; N-(3-fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide.; SCHEMBL1963111; BCP15998; NPS1034;NPS 1034; BDBM50172077; s7669; ZINC68204845; CCG-270007; NCGC00481564-01; AC-31427; AK685795; BS-14709; HY-100509; CS-0019643; N-(3-fluoro-4-((3-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)-2-(4-fluorophenyl)-1,5-dimethyl-3-oxo-2,3-dihydro-1H-pyrazole-4-carboxamide; S4K
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MOA Inhibitor
External Link
CID: 46194178
TTD: D1AD6L
 Compound Name ALD-805 Investigative [8]
External Link
TTD: D00FZA
 Compound Name PHA-665752 Investigative [8]
Synonyms
477575-56-7; PHA 665752; PHA665752; TCMDC-125885; UNII-0VXU5T5R3J; (2R)-1-[[5-[(Z)-[5-[[(2,6-DICHLOROPHENYL)METHYL]SULFONYL]-1,2-DIHYDRO-2-OXO-3H-INDOL-3-YLIDENE]METHYL]-2,4-DIMETHYL-1H-PYRROL-3-YL]CARBONYL]-2-(1-PYRROLIDINYLMETHYL)PYRROLIDINE; 0VXU5T5R3J; CHEMBL450786; CHEBI:90197; (R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimethyl-4-(2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl)-1H-pyrrol-2-yl)methylene)indolin-2-one; PHA-665752 hydrate
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MOA Inhibitor
Activity IC50 = 9 nM
External Link
CID: 10461815
TTD: D00TBD
 Compound Name APS-3010 Investigative [8]
Synonyms
Hepatic growth factor inhibitor (cancer), Atlas Pharmaceuticals
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MOA Inhibitor
External Link
TTD: D03LZK
 Compound Name LA-480 Investigative [8]
Synonyms
Bispecific c-Met monoclonal antibody (cancer), Lilly
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External Link
TTD: D05GSI
 Compound Name Anti-cMET mab Investigative [8]
Synonyms
Anti-cMET mAb (undisclosed indication); Anti-cMET mAb (undisclosed indication), PharmAbcine; CMET inhibitor (mAb, undisclosed indication), PharmAbcine
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MOA Inhibitor
External Link
TTD: D07CFW
 Compound Name AM7 Investigative [47]
Synonyms
pyrimidone, 22; AM 7; AM-7
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MOA Inhibitor
Activity IC50 = 8.9 nM
External Link
CID: 11650194
TTD: D07OXC
 Compound Name mab 224G11 Investigative [8]
Synonyms
C-Met antagonist monoclonal antibody (cancer); C-Met antagonist monoclonal antibody (cancer), Pierre Fabre/Abbott
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External Link
TTD: D0AD6Z
 Compound Name TP-801 Investigative [8]
Synonyms
C-Met tyrosine kinase inhibitor (oral, cancer), Tiger Pharmatech
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MOA Inhibitor
External Link
TTD: D0BS6B
 Compound Name SU11274 Investigative [48]
Synonyms
Met kinase Inhibitor; SU-11274
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MOA Inhibitor
Activity IC50 = 10 nM
External Link
CID: 9549297
TTD: D0E1QI
 Compound Name PF-00614435 Investigative [8]
Synonyms
PF-00658968; PF-00851623; PF-02311803; PF-4254644; PF-851623; PF-899555; C-Met (HGFR) inhibitors (cancer), Pfizer
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MOA Inhibitor
External Link
TTD: D0G3ZN
 Compound Name CMET Avimer polypeptides Investigative [8]
Synonyms
CMET Avimer polypeptides (cancer); MEDI-555; CMET Avimer polypeptides (cancer), MedImmmue; CMET-targeting anticancer avimers, MedImmune; CMET-targeting avimers (cancer), Avidia/MedImmune
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MOA Inhibitor
External Link
TTD: D0I2PS
 Compound Name PRS-110 Investigative [8]
Synonyms
C-Met inhibitor (cancer), Pieris; C-mesenchymal-epithelial transition factor (lipoprotein/protein recombinant, cancer), Pieris AG
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MOA Inhibitor
External Link
TTD: D0M0SV
 Compound Name 1-benzyl-1H-pyrrolo[3,2-b]pyridine Investigative [49]
Synonyms
CHEMBL561256; 1-benzyl-4-azaindole; 1h-pyrrolo[3,2-b]pyridine,1-(phenylmethyl)-; SCHEMBL4716978; LOGFFHFLSCMKJF-UHFFFAOYSA-N; BDBM50295764; ZINC43079815; 50426-35-2
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MOA Inhibitor
Activity IC50 = 19 nM
External Link
CID: 45267314
TTD: D0N5XG
 Compound Name RP-1040 Investigative [8]
Synonyms
RP-1086; RP-1087; RP-1088; RP-1101; RP-1103; RP-1105; RP-1109; RP-1110; RP-1111; RP-1112; C-Met kinase inhibitors (oral,cancer); C-Met kinase inhibitors (oral, cancer), Incozen Therapeutics/Rhizen Pharmaceuticals
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0N6QO
 Compound Name BAY-85-3474 Investigative [8]
Synonyms
Met inhibitor (cancer), Bayer Schering
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0NX6F
 Compound Name GE-137 Investigative [50]
MOA Modulator
External Link
CID: 91827375
TTD: D0PS7U
 Compound Name 3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine Investigative [49]
Synonyms
CHEMBL538932; 633303-90-9; SCHEMBL3889418; CTK2A9458; DTXSID00621754; XIVJYIWQYBHEBJ-UHFFFAOYSA-N; BDBM50295740; 3-(Benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 3-(phenylsulfonyl)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1175 nM
External Link
CID: 22028181
TTD: D0S0GT
 Compound Name 1-(2-nitrophenethyl)-1H-pyrrolo[3,2-b]pyridine Investigative [49]
Synonyms
CHEMBL540744
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 45272467
TTD: D0S1II
 Compound Name ALD-806 Investigative [8]
Synonyms
Anti-HGF mAb (cancer), Alder Biopharmaceuticals
    Click to Show/Hide
External Link
TTD: D0T1YH
 Compound Name 1-(phenylsulfonyl)-1H-pyrrolo[3,2-b]pyridine Investigative [49]
Synonyms
1-(Phenylsulfonyl)-4-azaindole; 677302-44-2; CHEMBL556118; SCHEMBL3705420; HGOGRVVSSAWHTO-UHFFFAOYSA-N; BDBM50295729; ZINC42923799; AKOS032961360; KB-3354225
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3500 nM
External Link
CID: 45270766
TTD: D0U4JW
 Compound Name DP-3590 Investigative [8]
Synonyms
DP-4157; DP-4693; DP-4756; C-Met kinase inhibitors (solid tumor/metastatic cancer); C-Met kinase inhibitors (solid tumor/metastatic cancer), Deciphera
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: D0W8GP
 Compound Name HuMax-cMet Investigative [8]
Synonyms
CMet-targeting human IgG1 antibody (cancer), Genmab
    Click to Show/Hide
External Link
TTD: D0Z4RX
 Compound Name YH013 Investigative [51]
External Link
TTD: D0AM9O
 Compound Name PMID24210504C1o Investigative [52]
Synonyms
GTPL8143; BDBM50444090
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8 nM
External Link
CID: 44256277
TTD: D04CUA
 Compound Name PMID21123062C27 Investigative [53]
Synonyms
GTPL8210; BDBM50334085
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 44 nM
External Link
CID: 50942314
TTD: D0RO9R
 Compound Name PMID21967808CR-16 Investigative [54]
Synonyms
GTPL8213; BDBM50361564
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 26 nM
External Link
CID: 56597775
TTD: D00EMH
 Compound Name BMS-536924 Investigative [55]
MOA Inhibitor
Activity IC50 = 4870 nM
External Link
CID: 135440466
TTD: D0M4SY
2C25: Lung cancer 52 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Adagrasib Approved [56]
Synonyms
2326521-71-3; MRTX-849; UNII-8EOO6HQF8Y; 8EOO6HQF8Y; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile; CHEMBL4594350; SCHEMBL20974691; GTPL10888; Kras G12C inhibitor MRTX849; BCP31538; EX-A3258; MRTX 849; MFCD32263433; s8884; compound 20 [PMID: 32250617]; BS-16211; HY-130149; CS-0105265; 2-Piperazineacetonitrile, 4-(7-(8-chloro-1-naphthalenyl)-5,6,7,8-tetrahydro-2-(((2S)-1-methyl-2-pyrrolidinyl)methoxy)pyrido(3,4-d)pyrimidin-4-yl)-1-(2-fluoro-1-oxo-2-propen-1-yl)-, (2S)-
    Click to Show/Hide
External Link
CID: 138611145
TTD: DUQV41
 Compound Name Amivantamab Approved [57]
External Link
TTD: DQ5X1Z
 Compound Name Mobocertinib Approved [58]
Synonyms
1847461-43-1; TAK-788; TAK788; AP32788; UNII-39HBQ4A67L; 39HBQ4A67L; propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Mobocertinib [INN]; Mobocertinib [USAN]; AP-32788; Mobocertinib (TAK788); Mobocertinib(TAK-788); SCHEMBL17373133; GTPL10468; BDBM368374; BCP31045; EX-A3392; US10227342, Example 10; MFCD32669806; NSC825519; s6813; TAK-788;AP32788; WHO 11183; NSC-825519; example 94 [WO2015195228A1]; HY-135815; CS-0114256; TAK-788;TAK 788; AP 32788; 5-Pyrimidinecarboxylic acid, 2-((4-((2-(dimethylamino)ethyl)methylamino)-2-methoxy-5-((1-oxo-2-propen-1-yl)amino)phenyl)amino)-4-(1-methyl-1H-indol-3-yl)-, 1-methylethyl ester; C(C=C)(=O)NC=1C(=CC(=C(C=1)NC1=NC=C(C(=N1)C1=CN(C2=CC=CC=C12)C)C(=O)OC(C)C)OC)N(C)CCN(C)C; Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
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External Link
CID: 118607832
TTD: DI4HA7
 Compound Name Sugemalimab Approved in China [59]
External Link
TTD: DDZ48Y
 Compound Name Sacituzumab govitecan Approved [60]
Synonyms
1491917-83-9; 1535963-91-7; 1796566-95-4; CYSTEINYL CL2A-SN-38; DA64T2C2IO; DTXSID401335985; EX-A4354; F82944; GOVITECAN CYSTEINYL CONJUGATE; hRS 7SN38; hRS7-SN38; IMMU 132; IMMU-132; M9BYU8XDQ6; Sacituzumab govitecan; Sacituzumab govitecan [USAN]; sacituzumab-govitecan; Satralizumab linker; SN-38 CYSTEINYL CONJUGATE; UNII-M9BYU8XDQ6
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External Link
CID: 91668186
TTD: D8LAE2
 Compound Name Atezolizumab Approved [61]
External Link
TTD: D0YM2K
 Compound Name Tepotinib Approved [4]
Synonyms
1100598-32-0; EMD 1214063; UNII-1IJV77EI07; Tepotinib (EMD 1214063); EMD1214063; 1IJV77EI07; MSC-2156119J; Benzonitrile, 3-[1,6-dihydro-1-[[3-[5-[(1-methyl-4-piperidinyl)methoxy]-2-pyrimidinyl]phenyl]methyl]-6-oxo-3-pyridazinyl]-; C29H28N6O2; Tepotinib [INN]; Benzonitrile, 3-[1,6-Dihydro-1-[[3-[5-[(1-Methyl-4-Piperidinyl)Methoxy]-2-PyriMidinyl]Phenyl]Methyl]-6-Oxo-3-Pyridazinyl]; Benzonitrile, 3-(1,6-dihydro-1-((3-(5-((1-methyl-4-piperidinyl)methoxy)-2-pyrimidinyl)phenyl)methyl)-6-oxo
    Click to Show/Hide
External Link
CID: 25171648
TTD: D0R8QG
DrugBank: DB15133
 Compound Name Sotorasib Approved [62]
Synonyms
AMG-510; AMG510; AMG-510 racemate; 2252403-56-6; AMG 510; Kras G12C inhibitor 9; 2296729-00-3; UNII-2B2VM6UC8G; 2B2VM6UC8G; CHEMBL4535757; 2296729-00-3 (racemate); 4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-[(2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl]pyrido[2,3-d]pyrimidin-2-one; Sotorasib [INN]; 6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)-4-((2S)-2-methyl-4-prop-2-enoylpiperazin-1-yl)pyrido(2,3-d)pyrimidin-2-one; AMG510 racemate; Sotorasib [USAN]; AMG-510(racemate); Kras mutant-targeting AMG 510; SCHEMBL20560375; GTPL10678; AMG 510 pound>>AMG-510; AMY16918; BCP30452; BCP33368; EX-A3538; BDBM50514402; NSC818433; s8830; WHO 11370; DB15569; NSC-818433; BS-16684; HY-114277; CS-0081316; compound (R)-38 [PMID: 31820981]; (1m)-6-Fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)-4-((2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl)pyrido(2,3-d)pyrimidin-2(1H)-one; (1S)-4-((S)-4-Acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 2296729-66-1; Pyrido(2,3-d)pyrimidin-2(1H)-one, 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(1-methylethyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl)-
    Click to Show/Hide
External Link
CID: 137278711
TTD: D0R7LD
DrugBank: DB15569
 Compound Name Entrectinib Approved [63]
Synonyms
1108743-60-7; RXDX-101; UNII-L5ORF0AN1I; Entrectinib (RXDX-101); L5ORF0AN1I; Benzamide, N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-; Benzamide, N-(5-((3,5-difluorophenyl)methyl)-1H-indazol-3-yl)-4-(4-methyl-1-piperazinyl)-2-((tetrahydro-2H-pyran-4-yl)amino)-; Entrectinib [USAN:INN]; YMX; Kinome_2659; Entrectinib(rxdx-101); Entrectinib (USAN/INN); SCHEMBL3512601; GTPL8290; CHEMBL1983268; KS-00000TSK
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External Link
CID: 25141092
TTD: D0O0LS
DrugBank: DB11986
 Compound Name Repotrectinib Approved [64]
Synonyms
FIKPXCOQUIZNHB-RRKGBCIJSA-N; SCHEMBL20438940; TPX 0005; BCP19778
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External Link
CID: 135565923
TTD: D05NFR
 Compound Name MYL-1402O Phase 3 [65]
Synonyms
bevacizumab biosimilar
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External Link
TTD: DYH3Q6
 Compound Name AB154 Phase 3 [66]
Synonyms
Domvanalimab
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External Link
TTD: DT1FS0
 Compound Name Datopotamab deruxtecan Phase 3 [67]
External Link
TTD: DP41HV
 Compound Name CS1001 Phase 3 [68]
External Link
TTD: D3MP1S
 Compound Name JDQ443 Phase 3 [69]
Synonyms
(S)-JDQ-443; 1-(6-((4S)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl)-2-azaspiro[3.3]heptan-2-yl)prop-2-en-1-one; 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-inda zol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]- 2-Propen-1-one; 1-[6-[(4R)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-2-propen-1-one; 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one; 1-{6-[(4M)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5- methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2- azaspiro[3.3]heptan-2-yl}prop-2-en-1-one; 1-{6-[(4M)-4-(5-Chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl}prop-2-en-1-one; 2653994-08-0; 2653994-10-4; 2-Propen-1-one, 1-[6-[(4R)-4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methyl-1H-indazol-5-yl)-1H-pyrazol-1-yl]-2-azaspiro[3.3]hept-2-yl]-; AKOS040757949; AT36708; BDBM50579985; CHEMBL5077861; compound 5 [PMID: 35404998]; CS-0226220; CS-0311034; EX-A5693; example 1a [WO2021120890A1]; GLXC-25533; GTPL11715; HY-139612A; JDQ 443; JDQ 443 [WHO-DD]; JDQ443; JDQ-443; MS-29737; NSC846146; NSC-846146; NVP-JDQ443; NVP-JDQ-443; Opnurasib; opnurasib [INN]; -PROPEN-1-ONE, 1-(6-((4R)-4-(5-CHLORO-6-METHYL-1H-INDAZOL-4-YL)-5-METHYL-3-(1-METHYL-1H-INDAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-AZASPIRO(3.3)HEPT-2-YL)-; Q3W0H3V1LQ; SCHEMBL23533580
    Click to Show/Hide
External Link
CID: 156501355
TTD: D37IQM
 Compound Name TRS003 Phase 3 [70]
External Link
TTD: D2KVG4
 Compound Name Tusamitamab ravtansine Phase 3 [71]
Synonyms
SAR408701
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External Link
TTD: D2D6NJ
 Compound Name RG6058 Phase 3 [72]
Synonyms
Tiragolumab
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External Link
TTD: D0L4VD
 Compound Name GSK4069889 Phase 2 [73]
Synonyms
TSR-022
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External Link
TTD: DZW53X
 Compound Name APL-101 Phase 2 [74]
Synonyms
Bozitinib; PLB-1001; 1440964-89-5; Vebreltinib; Vebreltinib [USAN]; UNII-2WZP8A9VFN; 2WZP8A9VFN; Bozitinib (PLB-1001); SCHEMBL15594471; BDBM107096; CBI-3103; s6762; WHO 11677; HY-125017; CS-0088607; US9695175, 44; 1,2,4-Triazolo(4,3-b)pyridazine, 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6- fluoro-2-methyl-2H-indazol-5-yl)methyl)-; 6-(1-Cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5- yl)methyl)-1,2,4-triazolo(4,3-b)pyridazine
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External Link
CID: 72202701
TTD: DV3Y7F
 Compound Name SGN-LIV1A Phase 2 [75]
Synonyms
Ladiratuzumab Vedotin
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External Link
TTD: DS6B1L
 Compound Name BNT116 Phase 2 [76]
External Link
TTD: DR39GZ
 Compound Name AZD7789 Phase 2 [77]
External Link
TTD: DNI7E3
 Compound Name L-DOS47 Phase 1/2 [78]
External Link
TTD: DN3Z5D
 Compound Name NC318 Phase 2 [79]
External Link
TTD: D9UZ5Q
 Compound Name Vorolanib Phase 2 [80]
Synonyms
UNII-YP8G3I74EL; YP8G3I74EL; 1013920-15-4; (S,Z)-N-(1-(Dimethylcarbamoyl)pyrrolidin-3-yl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide; Vorolanib [INN]; SCHEMBL2439528; CHEMBL4297587; N-((3S)-1-(dimethylcarbamoyl)pyrrolidin-3-yl)-5-((Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide; s6843; DB15247; HY-109019; CS-0030517; Q27294638; 1H-Pyrrole-3-carboxamide, N-((3S)-1-((dimethylamino)carbonyl)-3-pyrrolidinyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
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External Link
CID: 59215954
TTD: D8AG3S
DrugBank: DB15247
 Compound Name Xofigo Phase 2 [81]
External Link
TTD: D6B7FP
 Compound Name Bintrafusp alfa Phase 2 [82]
External Link
TTD: D5J3BL
 Compound Name Voyager-V1 Phase 2 [83]
Synonyms
VSV-IFNBeta-NIS
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External Link
TTD: D4AGB6
 Compound Name AB-106 Phase 2 [84]
Synonyms
DS6051b; GTPL11198; AB106
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External Link
CID: 154699459
TTD: D2KV8B
 Compound Name RO-5126766 Phase 2 [85]
Synonyms
VS-6766; CH-5126766; Dual Raf/MEK protein kinase inhibitor (cancer), Roche
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External Link
CID: 16719221
TTD: D0M6BD
DrugBank: DB15254
 Compound Name TC-210 Phase 1/2 [86]
External Link
TTD: DX6O9V
 Compound Name EMB-01 Phase 1/2 [87]
External Link
TTD: DWQ6J1
 Compound Name NM21-1480 Phase 1/2 [88]
External Link
TTD: DUVH60
 Compound Name MRx0518 Phase 1/2 [89]
External Link
TTD: DP4J2K
 Compound Name DZD9008 Phase 1/2 [90]
External Link
TTD: DM8Y2N
 Compound Name BGB-A425 Phase 1/2 [91]
External Link
TTD: D7UIZ1
 Compound Name Rilvegostomig Phase 1/2 [92]
Synonyms
AZD2936
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External Link
TTD: D4RMC9
 Compound Name IK-007 Phase 1/2 [93]
Synonyms
grapiprant
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External Link
TTD: D1KES8
 Compound Name IBI318 Phase 1 [94]
External Link
TTD: DX30BA
 Compound Name GEN-011 Phase 1 [95]
External Link
TTD: DR1YQ7
 Compound Name ENV-105 Phase 1 [96]
Synonyms
Carotuximab
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External Link
TTD: DQ8K3R
 Compound Name AMG 160 Phase 1 [97]
External Link
TTD: DOY4E6
 Compound Name ADP-A2M10 Phase 1 [98]
External Link
TTD: DM38KC
 Compound Name MEDI5752 Phase 1 [99]
External Link
TTD: D7L1MP
 Compound Name PF-07104091 Phase 1 [100]
External Link
TTD: D5TH2B
 Compound Name PF-06936308 Phase 1 [101]
External Link
TTD: D2LUK7
 Compound Name GEM3PSCA Phase 1 [102]
External Link
TTD: D1L7DE
 Compound Name PF-07257876 Phase 1 [103]
External Link
TTD: D1A7OP
 Compound Name Cosibelimab Phase 1 [104]
Synonyms
CK-301/TG-1501
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External Link
TTD: D17URP
 Compound Name Gemcitabine Approved [7]
External Link
CID: 60750
TTD: D0AJ3K
DrugBank: DB00441
 Compound Name SMI-4a Investigative [105]
Synonyms
438190-29-5; SMI 4a; TCS PIM-1 4a; (Z)-SMI-4a; (Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione; (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione; CHEMBL183906; (5Z)-5-[[3-(TRIFLUOROMETHYL)PHENYL]METHYLENE]-2,4-THIAZOLIDINEDIONE; (5Z)-5-[[3-(trifluoromethyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione; 327033-36-3; C11H6F3NO2S; (Z)-5-(3-(Trifluoromethyl)benzylidene)-thiazolidine-2,4-dione; (5Z)-5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione; Pim inhibitor 4a; 3vc4; SMI-4q; TCS PIM-1-4a; 5-(3-(Trifluoromethyl)benzylidene)thiazolidine-2,4-dione; 5-[3-(Trifluoromethyl)benzylidene]thiazolidine-2,4-dione; cc-717; thiazolidine-2,4-dione, 4a; SCHEMBL2541382; SCHEMBL2541388; BDBM26626; AOB6260; EX-A111; SYN1113; BDBM138364; HMS3229J21; 2720AH; HY-16576A; MFCD01152003; s8005; ZINC12576047; AKOS001314163; SMI-4a, >=98% (HPLC); CCG-265027; NCGC00345836-02; NCGC00345836-14; AC-32861; HY-15474; AB0165836; EC-000.2291; J3.561.866J; A11945; W-5256; US8877795, 12; Q27451064; 5-[[3-(trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
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External Link
CID: 1361334
TTD: DAJ3D2
References
Ref 1 LncRNA LINC00969 promotes acquired gefitinib resistance by epigenetically suppressing of NLRP3 at transcriptional and posttranscriptional levels to inhibit pyroptosis in lung cancer. Cell Death Dis. 2023 May 8;14(5):312. doi: 10.1038/s41419-023-05840-x.
Ref 2 RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma. J Cell Mol Med. 2021 Mar;25(5):2418-2425. doi: 10.1111/jcmm.16114. Epub 2021 Jan 24.
Ref 3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
Ref 4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2021
Ref 5 Clinical pipeline report, company report or official report of Exelixis (2011).
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