m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03231
 [1]
m6A modification G9a G9a FTO Demethylation : m6A sites Indirect Enhancement Histone modification H3K9me2 G9a OPRM1
m6A Modification:
m6A Regulator Fat mass and obesity-associated protein (FTO) ERASER
 Regulator Info 
m6A Target Histone-lysine N-methyltransferase EHMT2 (G9a)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone-lysine N-methyltransferase EHMT2 (EHMT2) WRITER View Details
Regulated Target Histone H3 lysine 9 dimethylation (H3K9me2) View Details
Downstream Gene OPRM1 View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification indirectly regulates histone modification through downstream signaling pathways
Crosstalk Summary Peripheral nerve injury increases the expression of the m6A demethylase fat-mass and obesity-associated proteins (FTO) in the injured DRG via the activation of Runx1, a transcription factor that binds to the Fto gene promoter. Mimicking this increase erases m6A in euchromatic Histone-lysine N-methyltransferase EHMT2 (EHMT2) mRNA (encoding the histone methyltransferase G9a) and elevates the level of G9a (regulating Histone H3 lysine 9 dimethylation (H3K9me2) level) in DRG and leads to the upregulation of OPRM1. Conversely, blocking this increase reverses a loss of m6A sites in Ehmt2 mRNA and destabilizes the nerve injury-induced G9a upregulation in the injured DRG and alleviates nerve injury-associated pain hypersensitivities. FTO contributes to neuropathic pain likely through stabilizing nerve injury-induced upregulation of G9a in a YTHDF2 dependent manner, a neuropathic pain initiator, in primary sensory neurons.
Responsed Disease Neuropathic pain ICD-11: 8E43.0
 Disease Info 
In-vivo Model For the SNL model, after the animals were anesthetized with isoflurane, an incision on the lower back was made and the lumbar transverse process was removed. The underlying spinal nerve (L4 in mice and L5 in rats) was isolated and ligated with a 3-0 silk thread in rats or 7-0 silk thread in mice. The ligated nerve was then transected distal to the ligature. The skin and muscles were finally closed in layers. For the CCI model, unilateral exposed sciatic nerve was loosely ligated with 3-0 silk thread at four sites with an interval of about 1 mm proximal to trifurcation of the sciatic nerve.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Histone-lysine N-methyltransferase EHMT2 (EHMT2) 7 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name MS012 Preclinical [2]
Synonyms
CHEMBL4086403; 2089617-83-2 (free base); N2-hexyl-6,7-dimethoxy-N4-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine; BDBM50501525; N~2~-hexyl-6,7-dimethoxy-N~4~-(1-methylpiperidin-4-yl)quinazoline-2,4-diamine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 137348638
TTD: DJ1Q9B
 Compound Name BIX-01294 Preclinical [3]
Synonyms
BIX01294; BIX 01294
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 67 nM
External Link
CID: 25150857
TTD: D06PPL
 Compound Name A-366 Preclinical [4]
Synonyms
A 366; A366
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 76285486
TTD: D0C5EG
 Compound Name UNC0321 Investigative [5]
Synonyms
UNC-0321; UNC 0321
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 9000 nM
External Link
CID: 46901937
TTD: D0CX4W
 Compound Name BRD9539 Investigative [6]
Synonyms
BRD-9539; BRD 9539
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1500 nM
External Link
CID: 73755260
TTD: D0RO9T
 Compound Name UNC0642 Investigative [7]
Synonyms
1481677-78-4; UNC 0642; UNC-0642; CHEMBL2441082; 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; Barrett; GTPL7017; SCHEMBL17372593; AOB2595; MolPort-035-765-953; EX-A2241; BCP08266; ZINC96285772; BDBM50442103; AKOS024458509; SB19046; CS-5269; NCGC00189140-01; NCGC00189140-02; AS-16721; HY-13980; BC600721; AK547424; UNC0642, > KB-146019; J-008448
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 2.5 nM
External Link
CID: 53315878
TTD: D0BI4T
 Compound Name UNC0638 Investigative [8]
Synonyms
1255580-76-7; UNC-0638; UNC 0638; UNII-26A103L2FO; 2-Cyclohexyl-N-(1-isopropylpiperidin-4-yl)-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazolin-4-amine; CHEMBL1231795; 26A103L2FO; 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; 1255517-77-1; 2-cyclohexyl-6-methoxy-N-[1-(propan-2-yl)piperidin-4-yl]-7-[3-(pyrrolidin-1-yl)propoxy]quinazolin-4-amine; 2-Cyclohexyl-N-(1-isopropyl-4-piperidinyl)-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.7 nM
External Link
CID: 46224516
TTD: D0GK7A
Mu-type opioid receptor (OPRM1) 511 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Propoxyphene Hydrochloride Approved [9]
Synonyms
Darvon; Dolene; Kesso-gesic; Prophene 65; Propoxyphene Hydrochloride 65; Darvon-n; Propoxyphene Napsylate
    Click to Show/Hide
MOA Modulator
External Link
CID: 15424
TTD: D03HCZ
 Compound Name Levomethadyl Acetate Approved [10]
Synonyms
LAAM; Levacetilmetadol; Levacetylmethadol; Levacetylmethadolum; Levomethadyl; Orlaam; Levacetylmethadol [INN]; Levacetilmetadol [INN-Spanish]; Levacetylmethadol (INN); Levacetylmethadolum [INN-Latin]; Levo-Alphacetylmethadol; Levo-Methadyl acetate; Levomethadyl acetate (USAN); Orlaam (TN); A-l-acetylmethadol; Alpha-l-Acetylmethadol; L-alpha-Acetylmethadol; Levo-alpha-Acetylmethadol; N-alpha-Acetylmethadol; Alpha-(-)-Acetylmethadol; [(3S,6S)-6-(dimethylamino)-4,4-diphenylheptan-3-yl] acetate; [S-(R*,R*)]-beta-[2-Dimethylamino)propyl]-alpha-ethyl-beta-phenylbenzeneethanol acetate (ester); Benzeneethanol, beta-[(2S)-2-(dimethylamino)propyl]-alpha-ethyl-beta-phenyl-, acetate (ester), (alphaS)-(9CI); (-)-alpha-Acetylmethadol; (1S,4S)-4-(dimethylamino)-1-ethyl-2,2-diphenylpentyl acetate; (3S,6S)-6-(dimethylamino)-4,4-diphenylheptan-2-yl acetate; 1-alpha-Acetylmethadol; 3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, acetate (ester), (3S,6S)-(-)-(8CI)
    Click to Show/Hide
MOA Agonist
External Link
CID: 15130
TTD: D05PIZ
DrugBank: DB01227
 Compound Name Anileridine Hydrochloride Approved [11]
Synonyms
Anileridine Phosphate; Leritine
    Click to Show/Hide
MOA Modulator
External Link
CID: 31338
TTD: D05ZTJ
 Compound Name Buprenorphine Approved [12]
Synonyms
Buprel; Buprenex; Buprenophine; Buprenorfina; Buprenorphinum; Probuphine; Temgesic; Buprenorphine Hcl; RX 6029M; Buprenex (TN); Buprenorfina [INN-Spanish]; Buprenorphine [INN:BAN]; Buprenorphinum [INN-Latin]; Subutex (TN); Temgesic (TN); Buprenorphine (JAN/INN); RX-6029-M; Suboxone (TN); [5alpha,7alpha(S)]-17-(Cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol; (-)-buprenorphine; (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-(methyloxy)-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol; (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol; 17-Cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol; 2-(N-Cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-7alpha-yl)-3,3-dimethyl-2-butanol; 2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol; 21-(Cyclopropyl-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-cyclopropyl-7alpha-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine; 6,14-Ethenomorphinan-7-methanol; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)-(9CI); 6029-M
    Click to Show/Hide
MOA Agonist
External Link
CID: 644073
TTD: D06AWE
DrugBank: DB00921
 Compound Name Naloxegol Approved [13]
Synonyms
NKTR-118
    Click to Show/Hide
MOA Modulator
External Link
CID: 56959087
TTD: D07LCF
DrugBank: DB09049
 Compound Name Alvimopan Approved [14]
Synonyms
Alvimopan anhydrous; LY 246736; LY246736; Adl 8-2698; Entereg (TN); Trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine; Glycine, N-[2-[[4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-1-oxo-3-phenylpropyl; 2-[[(2S)-2-benzyl-3-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]propanoyl]amino]acetic acid
    Click to Show/Hide
MOA Antagonist
Activity Ki = 0.3162 nM
External Link
CID: 5488548
TTD: D0D7KC
DrugBank: DB06274
 Compound Name Fentanyl Approved [15]
Synonyms
Fentanil; Phentanyl; Fentora; Sublimaze; Fentanila; Fentanest; Duragesic; Fentanylum; Durogesic; Sentonil; 437-38-7; Duragesic-100; IONSYS; Duragesic-25; Duragesic-75; Duragesic-50; Duragesic-12; Fentanyl-25; Fentanyl-75; Fentanyl-12; Fentanyl-50; Fentanylum [INN-Latin]; Fentanila [INN-Spanish]; Fentanyl-100; 1-Phenethyl-4-N-propionylanilinopiperidine; Matrifen; Sublimase; N-(1-Phenethylpiperidin-4-yl)-N-phenylpropionamide; N-(1-Phenethyl-4-piperidyl)propionanilide; N-Phenethyl-4-(N-propionylanilino)piperidine; Fentanil [DCIT]; Subsys; Fentanyl-37; Fentanyl-62; Fentanyl-87; Abstral; Actiq; Lazanda; Onsolis; Fentanyl Citrate; Fentanyl Citrate Preservative Free; Sublimaze Preservative Free; fentanyl (transmucosal film, pain), Auxilium Pharmaceuticals
    Click to Show/Hide
MOA Modulator
Activity EC50 = 0.51 nM
External Link
CID: 3345
TTD: D0E1WI
DrugBank: DB00813
 Compound Name Alfentanil Approved [16]
Synonyms
Alfenta; Alfentanilum; Alfentanyl; Alfenta (TN); Alfentanil (INN); Alfentanil [INN:BAN]; Alfentanilum [INN-Latin]; Rapifen (TN); N-[1-[2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl]-4-(methoxymethyl)-4-piperidyl]propionanilide; N-[1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl]-N-phenylpropanamide; N-(1-(2-(4-Ethyl-4,5-dihydro-5-oxotetrazolyl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilid; N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide; N-(1-(2-(4-Ethyl-4,5-dihydro-5-oxotetrazolyl)ethyl)-4-(methoxymethyl)-4-piperidyl)-N-phenylpropionamid; N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide; N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-[(methyloxy)methyl]piperidin-4-yl}-N-phenylpropanamide
    Click to Show/Hide
MOA Agonist
External Link
CID: 51263
TTD: D0G5QB
DrugBank: DB00802
 Compound Name Methadyl Acetate Approved [17]
Synonyms
ALPHACETYLMETHADOL; Acemethadone; Acetilmetadol; Acetylmethadol; Acetylmethadolum; Amidolacetate; Levamethadyl; Acetilmetadol [INN-Spanish]; Acetylmethadol (INN); Acetylmethadolum [INN-Latin]; Methadyl acetate (USAN); Methadyl acetate [USAN:BAN]; N-LAMM; Race-Acetylmethadol; [6-(dimethylamino)-4,4-diphenylheptan-3-yl] acetate; Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, acetate (ester); Benzeneethanol, .beta.-[2-(dimethylamino)propyl]-.alpha.-ethyl-.beta.-phenyl-, acetate; (R,S)-4-Dimethylamino-1-ethyl-2,2-diphenylpentyl acetat; 1-Ethyl-4-dimethylamino-2,2-diphenylpentylacetat; 3-Acetoxy-6-dimethylamino-4,4-diphenylheptane; 4-(Dimethylamino)-1-ethyl-2,2-diphenylpentyl acetate; 6-(Dimethylamino)-4,4-Diphenyl-3-Heptanol Acetate
    Click to Show/Hide
MOA Agonist
External Link
CID: 10517
TTD: D0GR0T
DrugBank: DB01433
 Compound Name Buprenorphine + naloxone Approved [18]
Synonyms
Buprenorphine/naloxone; [5 ,7 (S)]-17-(Cyclopropylmethyl)- -(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy- -methyl-6,14-ethenomorphinan-7-methanol; SCHEMBL18085614; Buprenorphine 10 mg/ml in Methanol; Buprenorphine 01 mg/ml in Methanol; ALKS5461
    Click to Show/Hide
MOA Agonist
External Link
CID: 6321408
TTD: D0H2JP
 Compound Name Diphenoxylate Approved [19]
Synonyms
Difenossilato; Difenoxilato; Diphenoxalate; Diphenoxylatum; Difenossilato [DCIT]; Difenoxilato [Spanish]; Diphenoxylate HCl; Diphenoxylate Monohydrochloride; Diphenoxylate hydrochloride; Diphenoxylatum [Latin]; NIH 7562; R 1132; Difenoxilato [INN-Spanish]; Diphenoxylate (INN); Diphenoxylate [INN:BAN]; Diphenoxylate hydrochloride (USP); Diphenoxylate hydrochloride(usp); Diphenoxylatum [INN-Latin]; R 1132 (antiperistaltic); R-1132; Co-phenotrope (TN); Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotate monohydrochloride; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylate; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidine-4-carboxylate hydrochloride; Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester; Ethyl 1-(3-cyano-3,3-diphenylpropyl)-4-phenylpiperidin-1-ium-4-carboxylate chloride; Isonipecotic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, hydrochloride; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotic acid ethyl ester; 1-(3-Cyano-3,3-diphenylpropyl)-4-phenylisonipecotic acid ethyl ester hydrochloride; 1-(3-cyano-3,3-diphenylpropyl)-4-(ethoxycarbonyl)-4-phenylpiperidinium chloride; 2,2-Diphenyl-4-(4-carbethoxy-4-phenylpiperidino)butyronitrile; 4-Ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile, hydrochloride; 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester; 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester (9CI); 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride; 4-ethoxycarbonyl-alpha,alpha,4-triphenyl-1-piperidinebutyronitrile hydrochloride
    Click to Show/Hide
MOA Agonist
External Link
CID: 13505
TTD: D0J2TN
DrugBank: DB01081
 Compound Name Naldemedine Tosylate Approved [20]
MOA Antagonist
External Link
CID: 56837137
TTD: D0Q2HO
 Compound Name Remifentanil Approved [21]
Synonyms
Remifentanyl; Ultiva; GI 87084B; GI 87084X; GI87084B; Remifentanil (INN); Remifentanil [INN:BAN]; Ultiva (TN); Methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate; 1-Piperidinepropanoic acid, 4-(methoxy-carbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester; 3-(4-methoxycarbonyl-4-((1-oxopropyl)phenylamino)-1-piperidine)propanoic acid methyl ester; 4-carboxy-4-(n-phenylpropionamido)-1-piperidinepropionic acid dimethyl ester
    Click to Show/Hide
MOA Agonist
External Link
CID: 60815
TTD: D0T5OX
DrugBank: DB00899
 Compound Name Morphine Approved [22]
Synonyms
Avinza; Kadian; Morphine Sulfate; Depodur; Astramorph Pf; Duramorph Pf; Infumorph; Ms Contin; Oramorph Sr
    Click to Show/Hide
MOA Modulator
Activity Ki = 0.14 nM
External Link
CID: 5288826
TTD: D0WE3O
DrugBank: DB00295
 Compound Name Naloxone Approved [23]
Synonyms
Nalone; Nalossone; Naloxona; Naloxonum; Narcan; Narcanti; Narcon; DBL Naloxone; Nalossone [DCIT]; Naloxone HCl; EN 1530base; DBL Naloxone (TN); L-Naloxone; N-Allylnoroxymorphone; Nalone (TN); Naloxona [INN-Spanish]; Naloxone (INN); Naloxone [INN:BAN]; Naloxonum [INN-Latin]; Narcan (TN); Narcanti (TN); N-Allyl-noroxymorphone; L-N-Allyl-14-hydroxynordihydromorphinone; L-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; N-Allyl-4,5alpha-epoxy-3,14-dihydroxy-6-morphinanon; Morphinan-6-one, 17-allyl-4,5alpha-epoxy-3,14-dihydroxy-(8CI); Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)-(9CI); (-)-N-allyl-14-hydroxynordihydroxymorphinan-6-one; (-)-Naloxone; (5alpha)-3,14-dihydroxy-17-prop-2-en-1-yl-4,5-epoxymorphinan-6-one; (5alpha)-4,5-Epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-one; 1-N-Allyl-14-hydroxynordihydromorphinone; 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro(4,5-bcd)furanone; 12-Allyl-7,7a,8,9-tetrahydro-3,7a-dihydroxy-4aH-8,9c-iminoethanophenanthro[4,5-bcd]furan-5(6H)-one; 17-Allyl-4,5-alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-Allyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one; 17-allyl-3,14-dihydroxy-4,5alpha-epoxymorphinan-6-one; 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one
    Click to Show/Hide
MOA Antagonist
Activity Ki = 0.23 nM
External Link
CID: 5284596
TTD: D0X3FX
DrugBank: DB01183
 Compound Name Hydrocodone Approved [24]
Synonyms
Dihydrocodeinone; Hydrocodon; Hydrocone; Hydroconum; Codinovo; Dicodid; Multacodin; Bekadid; hidrocodona; Idrocodone; Hydrocodonum; Idrocodone [DCIT]; DICO; (-)-Dihydrocodeinone; Hydrocodonum [INN-Latin]; 125-29-1; Hidrocodona [INN-Spanish]; Codeinone, dihydro-; Hydrocodone polistirex; Hydrocodone [INN:BAN]; UNII-6YKS4Y3WQ7; 4,5-alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one; 6-Oxo-3-methoxy-N-methyl-4,5-epoxymorphinan; 4,5alpha-Epoxy-3-methoxy-17-methylmorphinan-6-one; HSDB 3097; EINECS 204-733-9; BRN 0094193; Hydrocodeinonebitartrate; Hydrocon; Anexsia (TN); Dicodid (TN); Duodin (TN); Hycet (TN); Hycodan (TN); Hycomine (TN); Hydrocodone (INN); Hydrokon (TN); Hydrovo (TN); Kolikodol (TN); Lorcet (TN); Lortab (TN); Mercodinone (TN); Norco (TN); Norgan (TN); Novahistex (TN); Orthoxycol (TN); Symtan (TN); Synkonin (TN); Vicodin (TN); Morphinan-6-one, 4,5alpha-epoxy-3-methoxy-17-methyl-(8CI); Morphinan-6-one, 4,5-epoxy-3-methoxy-17-methyl-, (5alpha)-(9CI); (5alpha)-17-methyl-3-(methyloxy)-4,5-epoxymorphinan-6-one; 3-methoxy-17-methyl-4,5alpha-epoxymorphinan-6-one; KP-201 hydrocodone prodrug
    Click to Show/Hide
MOA Modulator
Activity Ki = 9.5 nM
External Link
CID: 5284569
TTD: D0X5KF
DrugBank: DB00956
 Compound Name Anileridine Approved [25]
Synonyms
Adopol; Alidine; Anileridina; Anileridinum; Apidol; Apodol; Leritin; Nipecotan; Anileridina [INN-Spanish]; Anileridine [INN:BAN]; Anileridinum [INN-Latin]; Leritine (TN); Anileridine (USP/INN); N-beta-(p-Aminophenyl)ethylnormeperidine; Ethyl 1-(4-aminophenethyl)-4-phenylisonipecotate; Ethyl 1-(p-aminophenethyl)-4-phenylisonipecotate; Ethyl 1-[2-(4-aminophenyl)ethyl]-4-phenylpiperidine-4-carboxylate; Isonipecotic acid, 1-(p-aminophenethyl)-4-phenyl-, ethyl ester; Ethyl 1-(2-(4-aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylate; N-(beta-(p-Aminophenyl)ethyl)-4-phenyl-4-carbethoxypiperidine; 1-(2-(4-Aminophenyl)ethyl)-4-phenyl-4-piperidinecarboxylic acid ethyl ester; 1-(p-Aminophenethyl)-4-phenylisonipecotic acid ethyl ester; 1-(p-Aminophenethyl)-4-phenylpiperidine-4-carboxylic acid ethyl ester; 1-[2-(4-Aminophenyl)ethyl]-4-phenyl-4-piperidinecarboxlic acid ethyl ester; 4-Piperidinecarboxylic acid, 1-(2-(4-aminophenyl)ethyl)-4-phenyl-, ethyl ester; 4-Piperidinecarboxylic acid, 1-[2-(4-aminophenyl)ethyl]-4-phenyl-, ethyl ester
    Click to Show/Hide
MOA Agonist
External Link
CID: 8944
TTD: D0X6HD
DrugBank: DB00913
 Compound Name Nalfurafine hcl Approved [26]
Synonyms
Nalfurafine hydrochloride; TRK-820; Remitch; Nalfurafine (hydrochloride); 152658-17-8; UNII-25CC4N0P8J; 25CC4N0P8J; CHEMBL490665; AC 820; Nalfurafine hydrochloride [USAN:JAN]; (-)-17-(Cyclopropylmethyl)-3,14; A-dihydroxy-4,5; A-epoxy-6; A-[N-methyl-trans-3-(3-furyl)acrylamido]morphinan Hydrochloride; (2E)-N-[(5; A)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-2-propenamide Hydrochloride; SCHEMBL19856501; DTXSID70426071; DJSFYNINGIMKAG-FQJQBBMWSA-N; BCP15625; Remitch (TN)
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 1.7 nM
External Link
CID: 6918287
TTD: D02RXG
 Compound Name Oxycodone Approved [27]
MOA Modulator
Activity Ki = 12 nM
External Link
CID: 5284603
TTD: D03SKD
DrugBank: DB00497
 Compound Name Methylnaltrexone bromide Approved [28]
Synonyms
Relistor; Methylnaltrexone (Bromide); Naltrexone methobromide; 73232-52-7; N-Methylnaltrexone Bromide; MRZ-2663BR; N-Cyclopropylmethyl-noroxymorphone Methobromide; Methylnaltrexone; MNTX; C21H26NO4Br; MOA-728; Relistor (TN); MRZ 2663BR; Naltrexone Methyl Bromide; N-Methyl Naltrexone Bromide; MNTX-302; SCHEMBL2798188; CHEMBL1201770; IFGIYSGOEZJNBE-KNLJMPJLSA-N; ONO-3849; Methylnaltrexone bromide (JAN/USAN); 3844AH; AKOS015896214; CS-0762; AN-37324; HY-75766; Methylnaltrexone bromide, &gt; W-5330; CHIR-01020
    Click to Show/Hide
MOA Modulator
Activity Ki = 5.48 nM
External Link
CID: 5361917
TTD: D03YVO
 Compound Name Hydromorphone Approved [29]
Synonyms
Dihydromorphinone; Dimorphone; Idromorfone; Hydromorphon; Dihydromorfinon; Hydromorfona; Laudacon; DiMo; Hydromorphonum; 7,8-Dihydromorphinone; Novolaudon; Hidromorfona; Dilaudid; Dilaudid Oros; Hydromorfona [Spanish]; Dihydromorfinon [Czech]; 466-99-9; Hydromorphonum [INN-Latin]; Hidromorfona [INN-Spanish]; Palladone; 6-Deoxy-7,8-dihydro-6-oxomorphine; Morphinone, dihydro-; Idromorfone [DCIT]; Laudicon; Hydromorphone [INN:BAN]; Dilaudid-hp; 4,5-Epoxy-3-hydroxy-17-methylmorphinan-6-one; Hydromorphone HCL; Dilaudid (TN); Hydromorphone (INN); Palladone (TN); Palladone SR (TN); Morphinan-6-one, 4,5alpha-epoxy-3-hydroxy-17-methyl-(8CI); (-)-(5R)-4,5-Epoxy-3-hydroxy-9alpha-methylmorphinan-6-one; (-)-Hydromorphone; (5alpha)-3-hydroxy-17-methyl-4,5-epoxymorphinan-6-one; 3-hydroxy-17-methyl-4,5alpha-epoxymorphinan-6-one; 4,5alpha-Epoxy-3-hydroxy-17-methyl-6-morphinanone; Hydromorphone prodrug
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.28 nM
External Link
CID: 5284570
TTD: D04JHN
DrugBank: DB00327
 Compound Name Eluxadoline Approved [30]
Synonyms
MuDelta
    Click to Show/Hide
MOA Modulator
Activity EC50 = 1 nM
External Link
CID: 11250029
TTD: D09ZXR
DrugBank: DB09272
 Compound Name Levopropoxyphene Napsylate Anhydrous Approved [11]
Synonyms
Novrad
    Click to Show/Hide
MOA Modulator
External Link
CID: 6604497
TTD: D0HF0W
 Compound Name Tapentadol hydrochloride Approved [28]
Synonyms
Tapentadol; 175591-23-8; Nucynta; Palexia; UNII-H8A007M585; 3-((1R,2R)-3-(Dimethylamino)-1-ethyl-2-methylpropyl)phenol; 3-((2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl)phenol; phenol, 3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]-; BN-200; H8A007M585; CG-5503; (R,R)-Tapentadol; Tapentadol [USAN:INN]; 3-[(2R,3R)-1-(dimethylamino)-2-methylpentan-3-yl]phenol; Phenol, 3-((1R,2R)-3-(dimethylamino)-1-ethyl-2-methylpropyl)-; CG5503; BN 200; CG 5503; Tapentadol (USAN/INN); 3-(1-DIMETHYLAMINO-2-METHYL-PENTAN-3-YL)PHENOL
    Click to Show/Hide
MOA Modulator
External Link
CID: 9838021
TTD: D0K4MH
 Compound Name Morphine-6-glucuronide Phase 3 [31]
Synonyms
Morphine 6-glucuronide; 20290-10-2; UNII-64Y9KYM60R; Morphine 6-beta-D-glucopyranosiduronide; 64Y9KYM60R; CHEBI:80581; MORPHINE GLUCURONIDE; MORPHINE 6-GLUCURONIDE(MINOR); beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-yl; Morphine 6-beta-D-Glucuronide; Glucopyranosiduronic acid, 7,8-didehydro-4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-alpha-yl-, beta-D-; Morphine glucuronide [INN]; morphine-glucuronide
    Click to Show/Hide
MOA Agonist
Activity Ki = 12.9 nM
External Link
CID: 5360621
TTD: D01UXW
DrugBank: DB06409
 Compound Name GRT-6005 Phase 3 [32]
Synonyms
Cebranopadol; 863513-91-1; GRT6005; UNII-7GDW9S3GN3; GRT 6005; 7GDW9S3GN3; Cebranopadol [USAN:INN]; Cebranopadol (USAN/INN); Cebranopadol(GRT-6005); SCHEMBL566256; SCHEMBL154336; GTPL8866; CHEMBL3545616; CHEMBL2364605; SCHEMBL10035739; CHEMBL3962932; SCHEMBL19336241; SCHEMBL14183935; MolPort-039-063-422; BDBM177926; ZINC3950145; EX-A1095; BCP09612; BDBM50101095; BDBM50101112; AKOS032953927; AKOS025402576; AKOS025290738; DB12830; CS-1323; SB16531; NCGC00378895-01; AK170452; HY-15536; AS-35183; Centrally-acting nociceptin agonist analgesic (oral liquid, pain/diabetic neuropathy), Grunenthal; GRT 6005/06
    Click to Show/Hide
MOA Modulator
Activity Ki = 0.7 nM
External Link
CID: 11848225
TTD: D03TBJ
DrugBank: DB12830
 Compound Name NKTR-181 Phase 3 [33]
MOA Agonist
External Link
CID: 73673720
TTD: D0K2ID
DrugBank: DB14146
 Compound Name TD-1211 Phase 2 [34]
Synonyms
Axelopran; UNII-85U7ROB149; 85U7ROB149; 949904-48-7; Axelopran [USAN:INN]; TD 1211; SCHEMBL1773803; SCHEMBL1773801; CHEMBL3137313; AKOS027337117; SB16947; DB12013; Benzamide, 3-((3-endo)-8-(2-((cyclohexylmethyl)((2S)-2,3-dihydroxy-1-oxopropyl)amino)ethyl)-8-azabicyclo(3.2.1)oct-3-yl)-
    Click to Show/Hide
MOA Modulator
External Link
CID: 67156338
TTD: D02INX
DrugBank: DB12013
 Compound Name OPNT001 Phase 2 [35]
MOA Antagonist
External Link
TTD: D04PUO
 Compound Name ALKS33 Phase 2 [36]
Synonyms
Samidorphan
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.052 nM
External Link
CID: 11667832
TTD: D0T0ZW
DrugBank: DB12543
 Compound Name Met-enkephalin Phase 2 [37]
Synonyms
H-Tyr-Gly-Gly-Phe-Met-OH; 58569-55-4; Tyr-Gly-Gly-Phe-Met-OH; METENKEFALIN; [Met]enkephalin; [5-Methionine]Enkephalin; TYR-GLY-GLY-PHE-MET; Enkephalin M; UNII-9JEZ9OD3AS; (Met5)-enkephalin; Lupex; 9JEZ9OD3AS; CHEMBL13786; CHEBI:6618; ENKEPHALIN, METHIONINE; Opioid growth factor; [Met5]-ENKEPHALIN; [Met5]Enkephalin acetate salt hydrate; Porcine beta-endorphin 1-5; (2S,5S,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-(2-(methylthio)ethyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 13 nM
External Link
CID: 443363
TTD: D0V5WL
DrugBank: DB12668
 Compound Name ORP-101 Phase 2 [38]
Synonyms
1820753-68-1; 6,14-ETHENOMORPHINAN-7-METHANOL, 3,3'-(1,2-ETHANEDIYLBIS(OXY))BIS(17-(CYCLOPROPYLMETHYL)-.ALPHA.-(1,1-DIMETHYLETHYL)-4,5-EPOXY-18,19-DIHYDRO-6-METHOXY-.ALPHA.-METHYL-, (.ALPHA.S,5.ALPHA.,7.ALPHA.)-(.ALPHA.'S,5'.ALPHA.,7'.ALPHA.)-; 6,14-Ethenomorphinan-7-methanol, 3,3'-(1,2-ethanediylbis(oxy))bis(17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-6-methoxy-alpha-methyl-, (alphaS,5alpha,7alpha)-(alpha'S,5'alpha,7'alpha)-; Buprenorphine dimer; CHEMBL4594402; EX-A6870; ORP-101; SCHEMBL19231198; SE6KE496VO; UNII-SE6KE496VO
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 92042890
TTD: DW7OF1
 Compound Name Carfentanil Phase 2 [39]
Synonyms
Carfentanyl; Carfentanila; Carfentanilum; Wildnil; 59708-52-0; Carfentanil [INN]; Carfentanila [Spanish]; UNII-LA9DTA2L8F; Carfentanilum [INN-Latin]; Carfentanila [INN-Spanish]; Methyl 1-phenylethyl-4-(N-phenylpropionamido)isonipecotate; CHEBI:61084; Methyl 4-(N-propionyl-N-phenylamino)-1-(2-phenylethyl)-4-piperidine-carboxylate; Methyl 4-(N-(1-oxopropyl)-N-phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylate; 4-((1-Oxopropyl)phenylamino)-1-(2-phenylethyl)-4-piperidinecarboxylic acid methyl ester
    Click to Show/Hide
MOA Agonist
Activity EC50 = 0.0049 nM
External Link
CID: 62156
TTD: D03PJU
DrugBank: DB01535
 Compound Name TPM-1/Morphine Phase 2 [40]
MOA Inhibitor
External Link
TTD: D0LU5Q
 Compound Name Cyt-1010 Phase 1 [41]
MOA Agonist
External Link
CID: 44129692
TTD: D05ONA
 Compound Name GSK1521498 Phase 1 [42]
Synonyms
GSK-1521498; GSK-1521498B
    Click to Show/Hide
MOA Agonist
External Link
CID: 24737629
TTD: D0G1YO
DrugBank: DB12886
 Compound Name TRV734 Phase 1 [43]
MOA Agonist
External Link
TTD: D0OK6F
 Compound Name NOCICEPTIN Phase 1 [44]
Synonyms
Orphanin FQ; Nociceptin/orphanin FQ; 170713-75-4; Orphanin FQ (rat); Orphanin FQ (swine); Orphanin FQ (human); Nociceptin (1-17); UNII-7AYI9N34FF; Orphanin FQ (pig); 7AYI9N34FF; CHEBI:80266; Human nociceptin; L-Glutamine, L-phenylalanylglycylglycyl-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-alanyl-L-asparaginyl-; Nociceptin (human); Nociceptin(1-17)-OH; FGGFTGARKSARKLANQ; Orphaninfq(swine)(9ci); GTPL1681; CHEMBL396460; BDBM50004178; AKOS024458690
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 270 nM
External Link
CID: 16131448
TTD: D0W4YO
 Compound Name AIKO-150 Phase 1 [29]
Synonyms
6beta-Naltrexol; beta-Naltrexol; 6beta-Hydroxynaltrexone; 6alpha-Hydroxynaltrexone; 49625-89-0; 6alpha-Naltrexol; UNII-J0W963M37T; CHEMBL140278; J0W963M37T; naltrexol; Naltrexone-6-beta-ol; alpha-Naltrexol; 6beta-Naltrexone; 6alpha-Naltrexone; 6-alpha-naltrexol; N-Cyclopropylmethyl-7,8-dihydro-14-hydroxynorisomorphine; SCHEMBL679700; DTXSID80197942; JLVNEHKORQFVQJ-PYIJOLGTSA-N; ZINC6092289; BDBM50001709; NCGC00165851-01; FT-0672600; Opioid neutral antagonists (iv, pain), Aiko Biotechnology; 6-beta-naltrexol
    Click to Show/Hide
MOA Antagonist
Activity Ki = 0.19 nM
External Link
CID: 5486554
TTD: D00HBR
 Compound Name MCP-201 Phase 1 [45]
MOA Agonist
External Link
TTD: D01AKU
 Compound Name SALVINORIN A Phase 1 [46]
Synonyms
Salvinorin; Divinorin A; 83729-01-5; UNII-T56W91NG6J; CHEMBL445332; T56W91NG6J; CHEBI:67900; 2H-Naphtho(2,1-c)pyran-7-carboxylic acid, 9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-, methyl ester, (2S-(2alpha,4aalpha,6abeta,7beta,9beta,10aalpha,10bbeta))-; (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester; (-)-Salvinorin A; herbal ecstasy; Mexican mint; salvinorin-A; Salvonorin A; Diviner's S
    Click to Show/Hide
MOA Inhibitor
Activity Ki > 1000 nM
External Link
CID: 128563
TTD: D06EXA
DrugBank: DB12327
 Compound Name BCH-2687 Discontinued in Phase 2 [47]
MOA Agonist
External Link
TTD: D01PCE
 Compound Name Transdur-sufentanil Discontinued in Phase 2 [48]
Synonyms
Sufentanil transdermal patch
    Click to Show/Hide
MOA Agonist
External Link
CID: 65494
TTD: D01SJC
 Compound Name ADL-5945 Discontinued in Phase 2 [49]
Synonyms
OpRA III
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D09MTC
 Compound Name TREFENTANIL HYDROCHLORIDE Discontinued in Phase 2 [50]
Synonyms
A-3665; ANQ-3665; Trefentanil hydrochloride < Rec INNM; N-[1-[2-(4-Ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-phenylpiperidin-4-yl]-N-(2-fluorophenyl)propionamide hydrochloride; 1-[2-(4-Ethyl-5-oxo-4,5-dihydro-1H-tetrazol-1-yl)ethyl]-4-[N-(2-fluorophenyl)propionamido]-4-phenylpiperidine hydrochloride
    Click to Show/Hide
MOA Agonist
External Link
CID: 60727
TTD: D0IW4R
 Compound Name Frakefamide Discontinued in Phase 2 [51]
Synonyms
BCH-3963; LEF-553; LEF-576; SPD-759; LEF, AstraZeneca/BioChem Pharma
    Click to Show/Hide
MOA Agonist
External Link
CID: 9829352
TTD: D0N1HL
 Compound Name MIRFENTANIL HYDROCHLORIDE Discontinued in Phase 2 [52]
Synonyms
A-3508 hydrochloride; ANQ-3508 HCl; Mirfentanil hydrochloride < Rec INNM; OHM-10579 (free base); N-(1-Phenethyl-4-piperidinyl)-N-(2-pyrazinyl)furan-2-carboxamide hydrochloride
    Click to Show/Hide
MOA Agonist
External Link
CID: 60697
TTD: D0O0AH
 Compound Name DPI-3290 Discontinued in Phase 2 [53]
Synonyms
DPI-3290W93; (+)-3-[1(R)-[4-Allyl-2(S),5(R)-dimethylpiperazin-1-yl]-1-(3-hydroxyphenyl)methyl]-N-(3-fluorophenyl)-N-methylbenzamide; 3290W93
    Click to Show/Hide
MOA Agonist
External Link
CID: 9826770
TTD: D0G1YN
 Compound Name Dynorphin a Discontinued in Phase 2 [54]
Synonyms
80448-90-4; Dynorphin A porcine; Dynorphin-(1-17); UNII-9M18T0TD14; 9M18T0TD14; MFCD00076351; Dynorphin A1-17; Dynorphin A (swine); Dynorphin acetate; Dynorphin A (1-17), porcine; JMNJYGMAUMANNW-FIXZTSJVSA-N; BDBM50096785; AKOS024457469; Dynorphin A porcine, &gt; NCGC00167144-01
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16133805
TTD: D0Y8SK
 Compound Name ADL-7445 Discontinued in Phase 1 [49]
Synonyms
Mu-opioid antagonists (opioid-induced bowel disorder), Adolor; 14-beta-aminonaltrexone
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D03MNS
 Compound Name KN-203 Discontinued in Phase 1 [55]
Synonyms
Mu-opioid recceptor agonist (urinary incontinence), Grunenthal/KeyNeurotek
    Click to Show/Hide
MOA Agonist
External Link
TTD: D0T9MQ
 Compound Name VP004 Discontinued in Phase 1 [56]
External Link
TTD: D0J5XZ
 Compound Name GNTI Preclinical [57]
Synonyms
G 3416; GNTI di-trifluoroacetate; Guanidinyl-naltrindole di-trifluoroacetate; 5'-Guanidinonaltrindole di(trifluoroacetate) salt hydrate; 5'-Guanidinylnaltrindole dihydrochloride
    Click to Show/Hide
MOA Antagonist
External Link
CID: 9826034
TTD: D0X6SZ
 Compound Name LY-25582 Preclinical [58]
Synonyms
3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol; LY-255582; LY255582; CHEMBL300662; 119193-09-8; LY 255582; SCHEMBL2740453; AOB5354; (3R,4R)3-[1-(3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol; ZINC3783617; BDBM50045775; NCGC00408804-01; AS-16869; LY255582, &gt; 3-[(3R,4R)-1-((S)-3-Cyclohexyl-3-hydroxy-propyl)-3,4-dimethyl-piperidin-4-yl]-phenol; 3-((3R,4R)-1-((S)-3-cyclohexyl-3-hydroxypropyl)-3,4-dimethylpiperidin-4-yl)phenol; 1-Piperidinepropanol,
    Click to Show/Hide
MOA Antagonist
Activity Ki = 0.043 nM
External Link
CID: 9906198
TTD: D0C2QF
 Compound Name 443C81 Terminated [59]
Synonyms
BW 443C; BW-443C81
    Click to Show/Hide
MOA Modulator
External Link
CID: 101630908
TTD: D0E8SE
 Compound Name BCH-150 Terminated [60]
MOA Modulator
External Link
TTD: D0J8XO
 Compound Name Sameridine Terminated [61]
Synonyms
143257-97-0; UNII-NQP2Y50Y6B; NQP2Y50Y6B; Sameridine [INN]; sameridine[inn]; AC1Q5ICP; SCHEMBL419071; AC1L24E2; CHEMBL2104504; DTXSID30162367; 4-Piperidinecarboxamide,N-ethyl-1-hexyl-N-methyl-4-phenyl-; ZINC3797855; AKOS015909863; N-Ethyl-1-hexyl-N-methyl-4-phenylisonipecotamide; I14-31849
    Click to Show/Hide
MOA Modulator
External Link
CID: 65996
TTD: D0K9TC
 Compound Name DBO-11 Terminated [31]
Synonyms
166374-49-8; Naxifylline (USAN/INN)
    Click to Show/Hide
MOA Agonist
External Link
CID: 23724971
TTD: D0PE1A
 Compound Name DBO-17 Terminated [31]
MOA Agonist
External Link
CID: 10042211
TTD: D0XH1H
 Compound Name BIPHALIN Terminated [62]
Synonyms
(Tyr-ala-gly-phe-NH2)2; D-Enk-O; Dala(2); D-ENK; Bis(tyr-ala-gly-phenh2)hydrazide; CHEMBL200199; 83916-01-2; (Tyrosyl-alanyl-glycyl-phenylalaninamide)dimer; Bis(tyrosyl-alanyl-glycyl-phenylalaninamide)hydrazide; L-Phenylalanine, N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-, 2-(N-(N-(N-L-tyrosyl-D-alanyl)glycyl)-L-phenylalanyl)hydrazide; enkephalin dimer; AC1NUPQ3; BDBM21014; DTXSID80232802; ZINC150345473; LS-187519; LS-186863
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 1 nM
External Link
CID: 5487663
TTD: D0LX5D
 Compound Name SB-213698 Terminated [63]
Synonyms
TAN-67
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9950038
TTD: D08YUP
 Compound Name SNF-9007 Terminated [64]
Synonyms
CHEMBL407057; BDBM21146; Asp-Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-[(3S)-3-amino-3-formamidopropanoic acid]-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9898185
TTD: D0W8TS
 Compound Name Dmt-Sar-Phe-D-2-Nal-NH Investigative [65]
Synonyms
CHEMBL254927; BDBM50232770
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44447368
TTD: D00NZP
 Compound Name NE-2 Investigative [27]
MOA Agonist
External Link
TTD: D00PQS
 Compound Name CODEINONE Investigative [66]
Synonyms
6-Codeinone; 467-13-0; UNII-22B5AW0ANN; (5alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-one; EINECS 207-386-1; BRN 0094188; 22B5AW0ANN; CHEBI:18399; 3-methoxy-17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-6-one; Morphinan-6-one, 7,8-didehydro-4,5-alpha-epoxy-3-methoxy-17-methyl-; 6-Oxocodeine; (-)-Codeinone; SCHEMBL100655; CHEMBL257627; DTXSID70196909; XYYVYLMBEZUESM-CMKMFDCUSA-N; ZINC4097036; API0000487; LS-92114; C06171; 7,8-Didehydro-4,5; A-epoxy-3-methoxy-17-methyl-morphinan-6-one
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 294 nM
External Link
CID: 5459910
TTD: D00PYB
 Compound Name AIKO-152 Investigative [27]
Synonyms
AIKO-150 + opioid analgesic (pain/opiate dependence), Aiko Biotechnology
    Click to Show/Hide
MOA Modulator
External Link
TTD: D00YMN
 Compound Name [Tyr-Pro-Phe-Phe-NH-]2 Investigative [67]
Synonyms
CHEMBL386887
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44390628
TTD: D01ESN
 Compound Name DC6S Investigative [68]
MOA Inhibitor
External Link
CID: 44414725
TTD: D01MHO
 Compound Name Tyr-Pro-Hfe-Phe-NH2 Investigative [69]
Synonyms
CHEMBL378466
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 14991618
TTD: D01MKM
 Compound Name AIKO-151 Investigative [27]
Synonyms
Mu-opioid antagonist (oral, opiate dependence), Aiko Biotechnology
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D02VUL
 Compound Name MM3A6S Investigative [68]
Synonyms
CHEMBL379928
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10454860
TTD: D02YXR
 Compound Name BREMAZOCINE Investigative [70]
Synonyms
(-)-Bremazocine; Bremazocine, (-)-; 75684-07-0; 2-(1-Hydroxy-cyclopropylmethyl)-5-ethyl-9,9-dimethyl-2'-hydroxy-6,7-benzomorphan; 2,6-Methano-3-benzazocin-8-ol, 6-ethyl-1,2,3,4,5,6-hexahydro-3-((1-hydroxycyclopropyl)methyl)-11,11-dimethyl-, (2R)-; SureCN157210; AC1Q2C6X; SCHEMBL157210; CHEBI:3171; GTPL1603; ZINC3870315; PDSP2_001570; PDSP1_001586; C11791; UNII-ISF76M2DBE component ZDXGFIXMPOUDFF-XLIONFOSSA-N
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 443406
TTD: D03BUD
 Compound Name Tyr-Pro-Hfe-Pro-NH2 Investigative [69]
Synonyms
CHEMBL380286
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413086
TTD: D03NCF
 Compound Name NCT-400 Investigative [27]
MOA Modulator
External Link
TTD: D03PCP
 Compound Name Tyr-Pro-D-(NMe)Phe-D-Pro-NH2 Investigative [71]
Synonyms
CHEMBL163808
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44375783
TTD: D04IHL
 Compound Name 6-(4-(2-(benzylamino)ethyl)phenoxy)picolinamide Investigative [72]
Synonyms
CHEMBL235560; SCHEMBL3702023; JKDWSAGAQLISRL-UHFFFAOYSA-N; BDBM50219927
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 643.47 nM
External Link
CID: 44434931
TTD: D04JCJ
 Compound Name Tyr-Pro-Phe-Phg-NH2 Investigative [69]
Synonyms
CHEMBL378111
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413074
TTD: D04MYP
 Compound Name SL-3111 Investigative [73]
Synonyms
CHEMBL143592; SCHEMBL9881223; BDBM50068132
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9909743
TTD: D05CRC
 Compound Name Tyr-Pro-Phe-D-Phg-NH2 Investigative [69]
Synonyms
CHEMBL208990
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413117
TTD: D05ETG
 Compound Name Tyr-Sar-Phe-D-2-Nal-NH2 Investigative [65]
Synonyms
CHEMBL254926
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44447367
TTD: D05HOH
 Compound Name Ac-D-pro-L-Phe-D-trp-L-Phe-NH2 Investigative [74]
Synonyms
CHEMBL450818
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 340 nM
External Link
CID: 44583427
TTD: D05XCV
 Compound Name [D-Ala2]Met-enkephalinamide Investigative [75]
Synonyms
CHEMBL287480
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44280469
TTD: D05XPU
 Compound Name ORIPAVINE Investigative [66]
Synonyms
UNII-575AOU51CR; 467-04-9; EINECS 207-385-6; BRN 0046094; CHEBI:7782; 575AOU51CR; 6,7,8,14-Tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-morphinan-3-ol; (5alpha)-6,7,8,14-Tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol; Morphinan-3-ol, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-6-methoxy-17-methyl-; 3-O-demethyl-thebaine; SCHEMBL37889; 4-27-00-02270 (Beilstein Handbook Reference); CHEMBL437602; DEA No. 9330; SCHEMBL19880919; DTXSID10196908; ZKLXUUYLEHCAMF-UUWFMWQGSA-N; Oripavine 0.1 mg/ml in Methanol
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 277 nM
External Link
CID: 5462306
TTD: D05YXS
 Compound Name YGGWL-NH2 Investigative [76]
Synonyms
CHEMBL504973
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 12.1 nM
External Link
CID: 44577308
TTD: D06ESC
 Compound Name KIN-4044 Investigative [27]
Synonyms
Mu opioid antagonist (NSCLC), Kinentia
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D06LCW
 Compound Name Tyr-D-Ala-Gly-NMePhe Investigative [77]
Synonyms
CHEMBL583426
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 45483974
TTD: D06QLG
 Compound Name M3B6S Investigative [68]
Synonyms
CHEMBL209751
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414877
TTD: D06YVE
 Compound Name Endomorphins Investigative [27]
Synonyms
EM-1; EM-2; Endomorphins (chronic inflammation); Endomorphin EM-1, University of Bristol; Endomorphin EM-2, University of Bristol; Endomorphins (chronic inflammation), University of Bristol
    Click to Show/Hide
MOA Modulator
External Link
TTD: D07GZG
 Compound Name DM3A6S Investigative [68]
Synonyms
CHEMBL437682
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414785
TTD: D07UJV
 Compound Name Tyr-Pro-Phe-Hfe-NH2 Investigative [69]
Synonyms
CHEMBL211147
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 14991612
TTD: D07XXX
 Compound Name (+/-)-TRANS-U-50488 METHANESULFONATE Investigative [78]
Synonyms
NCG-C00093883-01
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9912313
TTD: D08QSN
 Compound Name 3-(2-Methyl-2-aza-bicyclo[3.3.1]non-5-yl)-phenol Investigative [79]
Synonyms
CHEMBL285250; 27107-68-2; CTK0I5787; DTXSID80494706; BDBM50000570; AKOS022657931; 3-(2-Methyl-2-azabicyclo[3.3.1]nonan-5-yl)phenol; Phenol, 3-(2-methyl-2-azabicyclo[3.3.1]non-5-yl)-; 2-Methyl-5-(3-hydroxyphenyl)-2-azabicyclo[3.3.1]nonane
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 12368881
TTD: D08UZJ
 Compound Name AKUAMMINE Investigative [78]
MOA Inhibitor
External Link
CID: 13491909
TTD: D09FVG
 Compound Name Semorphone Investigative [80]
Synonyms
(-)-4,5alpha-Epoxy-3,14-dihydroxy-17-(2-methoxyethyl)morphinan-6-one hydrochloride; (-)-4,5alpha-Epoxy-3,14-dihydroxy-N-(2-methoxyethyl)morphinan-6-one hydrochloride; MR-2264 (free base); MRZ-2264 (free base); N-(2-Methoxyethyl)noroxymorphone hydrochloride; Semorphone hydrochloride
    Click to Show/Hide
MOA Modulator
External Link
CID: 5491906
TTD: D09MXM
 Compound Name YGWFL-NH2 Investigative [76]
Synonyms
CHEMBL455502
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 112.5 nM
External Link
CID: 44577349
TTD: D09TCT
 Compound Name YRFB Investigative [81]
Synonyms
CHEMBL215513
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416268
TTD: D0A1XG
 Compound Name NRT-300 Investigative [27]
Synonyms
NCT-300
    Click to Show/Hide
MOA Modulator
External Link
TTD: D0C0FG
 Compound Name H-Tyr-D-Ala-(R or S)Atc-Asp-Val-Val-Gly-NH2 Investigative [82]
Synonyms
CHEMBL124941; BDBM50001459; 3-[(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-1,2,3,4-tetrahydro-naphthalene-2-carbonyl)-amino]-N-{1-[1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44348645
TTD: D0C1AN
 Compound Name Tyr-Pro-Phg-Pro-NH2 Investigative [69]
Synonyms
CHEMBL425421
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413146
TTD: D0C2ZW
 Compound Name C6S Investigative [68]
Synonyms
CHEMBL1417
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414814
TTD: D0D0XP
 Compound Name Tyr-Pro-Phe-D-2-Nal-NH2 Investigative [65]
Synonyms
CHEMBL375070
    Click to Show/Hide
MOA Inhibitor
Activity Ki > 1000 nM
External Link
CID: 11498201
TTD: D0D1VB
 Compound Name Tyr-D-Ala-Phe-Thr[-D-Glc(OAc)4]-Tyr-Pro-Ser-NH2 Investigative [83]
MOA Inhibitor
External Link
CID: 73345457
TTD: D0E7CA
 Compound Name Tyr-Pro-Phe-D-Ala-Bn Investigative [84]
Synonyms
CHEMBL577748
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 8.67 nM
External Link
CID: 45487600
TTD: D0F8CD
 Compound Name naloxonazine Investigative [85]
Synonyms
NSC 612113
    Click to Show/Hide
MOA Antagonist
Activity Ki = 1.445 nM
External Link
CID: 9576413
TTD: D0G1IF
 Compound Name Tyr-Pro-Phg-Phe-NH2 Investigative [69]
Synonyms
CHEMBL211119
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413203
TTD: D0G2BN
 Compound Name KNT-5 Investigative [86]
MOA Inhibitor
External Link
CID: 46232162
TTD: D0G2YV
 Compound Name N-alpha-amidino-Tyr(Me)-D-Pro-Gly-Trp-Phe-NH2 Investigative [87]
Synonyms
CHEMBL243724; BDBM50201411; N alpha-amidino-Tyr(Me)-D-Pro-Gly-Trp-Phe-NH2
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44428306
TTD: D0HL7Q
 Compound Name Ac-L-Phe-D-trp-L-Phe-D-pro-NH2 Investigative [74]
Synonyms
CHEMBL442612
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 360 nM
External Link
CID: 44583428
TTD: D0I1ZN
 Compound Name DM3B6S Investigative [68]
Synonyms
CHEMBL213737
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414801
TTD: D0IC5F
 Compound Name Tyr-Pro-Phe-Ala-Bn Investigative [84]
Synonyms
CHEMBL577749
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 122 nM
External Link
CID: 45487602
TTD: D0IQ0S
 Compound Name YPAA-NH2 Investigative [76]
Synonyms
CHEMBL466147
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 705 nM
External Link
CID: 44577307
TTD: D0IU2K
 Compound Name KIN-3031 Investigative [27]
Synonyms
Mu opioid angonist (CNS formulation, pain), Kinentia
    Click to Show/Hide
MOA Modulator
External Link
TTD: D0J0ZU
 Compound Name Tyr-Pro-Phe-D-Val-Bn Investigative [84]
Synonyms
CHEMBL577746
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4.97 nM
External Link
CID: 44555371
TTD: D0J5IR
 Compound Name [Tyr-Pro-Phe-NH-CH2-]2 Investigative [67]
Synonyms
CHEMBL180286
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44390664
TTD: D0J9DO
 Compound Name YAWF-NH2 Investigative [76]
Synonyms
CHEMBL445690
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3190 nM
External Link
CID: 44577306
TTD: D0JX3P
 Compound Name Tyr-Pro-Trp-D-Val-Bn Investigative [84]
Synonyms
CHEMBL577745
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2.32 nM
External Link
CID: 44555370
TTD: D0KQ8A
 Compound Name H-Tyr-D-Ala-Tic-Asp-Val-Val-Gly-NH2 Investigative [82]
Synonyms
CHEMBL330991; BDBM50001460; 3-[(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionyl}-1,2,3,4-tetrahydro-isoquinoline-3-carbonyl)-amino]-N-{1-[1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10485385
TTD: D0KW4Y
 Compound Name YPWA-NH2 Investigative [76]
Synonyms
CHEMBL512955
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 72.7 nM
External Link
CID: 44577305
TTD: D0N3GU
 Compound Name Ethylmorphine Investigative [88]
Synonyms
Codethyline; DIONINE; 76-58-4; Morphine, ethyl-; Ethyl morphine; UNII-RWO67D87EU; Ethylmorphine [BAN]; 3-O-Ethylmorphine; EINECS 200-970-7; RWO67D87EU; CHEBI:4902; DEA No. 9190; Dionin; Ethylmorphine (BAN); NCGC00168251-01; Ethomorphine; Morphinan-6-alpha-ol, 7,8-didehydro-4,5-alpha-epoxy-3-ethoxy-17-methyl-; (4R,4aR,7S,7aR,12bS)-9-ethoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol; Morphine 3-ethyl ether; AC1Q37UW; Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-ethoxy-17-methyl-
    Click to Show/Hide
MOA Agonist
External Link
CID: 5359271
TTD: D0N5QC
DrugBank: DB01466
 Compound Name THEBAINE Investigative [66]
Synonyms
Paramorphine; 3-O-Methyl-oripavin; 115-37-7; UNII-2P9MKG8GX7; Thebain; 4,5alpha-Epoxy-3,6-dimethoxy-17-methyl-6,8-morphinadien; EINECS 204-084-1; 2P9MKG8GX7; (5R,9R,13S)-4,5-Epoxy-3,6-dimethoxy-9alpha-methyl-6,8-morphinadien; CHEBI:9519; DEA No. 9333; NCGC00160239-01; DSSTox_RID_81337; DSSTox_CID_26099; DSSTox_GSID_46099; Morphinan, 6,7,8,14-tetradehydro-4,5-alpha-epoxy-3,6-dimethoxy-17-methyl-; 3,6-dimethoxy-17-methyl-6,7,8,14-tetradehydro-4,5alpha-epoxymorphinan
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 5600 nM
External Link
CID: 5324289
TTD: D0O2LD
 Compound Name [Tyr-Pro-Phe-Phe-NH-CH2-]2 Investigative [67]
Synonyms
CHEMBL409336
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44390629
TTD: D0O7XU
 Compound Name Ac-YGGFL-NH2 Investigative [76]
Synonyms
CHEMBL500212
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 37.3 nM
External Link
CID: 15747210
TTD: D0P2DF
 Compound Name Tyr-(R)-spiro-Aba-Gly-Phe-NH2 Investigative [89]
Synonyms
CHEMBL401142
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24755139
TTD: D0P2QV
 Compound Name D-Phe-Cys-Tyr--Trp-Lys-Thr-Pen-Thr-NH2 Investigative [90]
Synonyms
CHEMBL274400
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44316657
TTD: D0P7YV
 Compound Name MORPHICEPTIN Investigative [91]
Synonyms
Deproceptin; Tyr-pro-phe-pro amide; Tyr-pro-phe-D-pro-NH2; beta-Casomorphine(1-4) amide; NH(4)-Tyr-pro-phe-pro-conh(2); Tyr-Pro-Phe-Pro-NH2; Tyrosyl-prolyl-phenylalanyl-D-prolinamide; UNII-97TZA8ANPC; H-Tyr-Pro-Phe-Pro-NH2; L-Tyrosyl-L-prolyl-L-phenylalanyl-L-prolinamide; 74135-04-9; b-Casomorphin-4-amide; 97TZA8ANPC; CHEMBL362991; L-Prolinamide, L-tyrosyl-L-prolyl-L-phenylalanyl-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 150 nM
External Link
CID: 119303
TTD: D0R0OZ
 Compound Name DIHYDROAKUAMMINE Investigative [78]
MOA Inhibitor
External Link
CID: 44576039
TTD: D0R1MB
 Compound Name 6-(2-benzylisoindolin-5-yloxy)nicotinamide Investigative [58]
Synonyms
CHEMBL238362; SCHEMBL3690327; GGVSFVBTUMOASO-UHFFFAOYSA-N; BDBM50226248
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1008 nM
External Link
CID: 44434060
TTD: D0R2VL
 Compound Name Tyr-Pro-Trp-Gly-Bn Investigative [84]
Synonyms
CHEMBL570634
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 56.23 nM
External Link
CID: 45487601
TTD: D0R6VX
 Compound Name CYPRODIME Investigative [92]
Synonyms
CHEMBL322796; N-(Cyclopropylmethyl)-4,14-dimethoxymorphinan-6-one; SCHEMBL3619261; BDBM50148071; ZINC13580323; NCGC00344512-01; Morphinan-6-one, 17-(cyclopropylmethyl)-4,14-dimethoxy-; (-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6-one(Cyprodime); 17-cyclopropylmethyl-3,10-dimethoxy-(1R,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one; 17-cyclopropylmethyl-10-hydroxy-4,14-dimethoxy-(1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3-dien-6-one(cyprodime)
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 10.6 nM
External Link
CID: 5748293
TTD: D0S3TZ
 Compound Name MORPHINONE Investigative [66]
Synonyms
467-02-7; UNII-28MBK63MAW; EINECS 207-384-0; BRN 0042464; 28MBK63MAW; Didehydro-4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-one; CHEBI:16315; (5alpha)-7,8-Didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-one; Morphinan-6-one, 7,8-didehydro-4,5-epoxy-3-hydroxy-17-methyl-, (5-alpha)-; SCHEMBL427946; CHEMBL255467; CTK1D7902; DTXSID50196907; ZINC4095712; AKOS030240636; LS-92113; C01735; 3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxy-5alpha-morphinan-6-one
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 28 nM
External Link
CID: 5459823
TTD: D0S5BJ
 Compound Name PL017 Investigative [93]
Synonyms
3-N-Me-Phe-morphiceptin; PL-017; PL 017
    Click to Show/Hide
MOA Agonist
External Link
CID: 115335
TTD: D0S6BX
 Compound Name ADC-5510 Investigative [27]
Synonyms
ADC-02265510; ADL-5510; Centrally acting mu opoid receptor antagonists, Adolor
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D0TA3V
 Compound Name MM3B6S Investigative [68]
Synonyms
CHEMBL211374
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414811
TTD: D0TT5V
 Compound Name M3S Investigative [68]
MOA Inhibitor
External Link
TTD: D0V0PY
 Compound Name Tyr-Pro-Trp-D-Ala-Bn Investigative [84]
Synonyms
CHEMBL577747
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4.56 nM
External Link
CID: 44555372
TTD: D0W3PR
 Compound Name Beta-funaltrexamine Investigative [77]
Synonyms
beta-Fna; Naltrexone fumarate methyl ester; 72782-05-9; CHEMBL473136; CHEBI:81527; 2-Butenoic acid, 4-(((5alpha,6beta)-17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl)amino)-4-oxo-, methyl ester, (E)-; Beta Funaltrexamine; Beta-Funeltrexamine; SCHEMBL1240811; GTPL1631; ZINC3995756; PDSP2_001549; PDSP2_000394; BDBM50247803; NCGC00163180-01; LS-47116; C18127; methyl 3-[4-cyclopropylmethyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-ylcarbamoyl]-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.41 nM
External Link
CID: 5311018
TTD: D0WT7H
 Compound Name KRP-110 Investigative [27]
Synonyms
IDDBCP262221
    Click to Show/Hide
MOA Modulator
External Link
TTD: D0WX3N
 Compound Name H-Tyr-D-Ala-Aic-Asp-Val-Val-Gly-NH2 Investigative [82]
Synonyms
CHEMBL124435; BDBM50001462; 3-[(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-indane-2-carbonyl)-amino]-N-{1-[1-(carbamoylmethyl-carbamoyl)-2-methyl-propylcarbamoyl]-2-methyl-propyl}-succinamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10010455
TTD: D0X1SN
 Compound Name KRP-100 Investigative [27]
Synonyms
Mu opioid receptor antagonist, Kyorin
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D0X4RU
 Compound Name [Tyr-Pro-Phe-NH-]2 Investigative [67]
Synonyms
CHEMBL179946
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44390663
TTD: D0Z9YE
 Compound Name H-Aba-ser-Gly-Phe-Leu-Thr-OH Investigative [37]
Synonyms
CHEMBL246479
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 640 nM
External Link
CID: 44439907
TTD: D00FXL
 Compound Name Tyr-(R)-Aba-Gly-Phe-NH2 Investigative [89]
Synonyms
CHEMBL250448
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24755140
TTD: D00FZN
 Compound Name H-Dmt-Tic-Lys-NH-Ph Investigative [94]
Synonyms
SCHEMBL8224099
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050067
TTD: D00LLO
 Compound Name H-Dmt-Tic-Gly-NH-CH2-Bid Investigative [95]
Synonyms
(3S)-N-[(1H-Benzimidazole-2-ylmethyl)carbamoylmethyl]-2-[(S)-3-(2,6-dimethyl-4-hydroxyphenyl)-2-aminopropionyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44375729
TTD: D00MEM
 Compound Name H-Dmt-Tic-D-Asp-N(Me)-Ph Investigative [96]
Synonyms
CHEMBL502302
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25033947
TTD: D00QLH
 Compound Name H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid Investigative [96]
Synonyms
CHEMBL444197
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25033951
TTD: D00WBU
 Compound Name H-Dmt-Tic-Glu-Dap(6DMN)-NH(2) Investigative [97]
Synonyms
CHEMBL208916
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44412290
TTD: D00WEV
 Compound Name Tyr-Pro-D-Phe-Pro-NH2 Investigative [71]
Synonyms
CHEMBL162564
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44376104
TTD: D00XQV
 Compound Name H-mCpa-ala-Gly-Phe-leu-OH Investigative [37]
Synonyms
CHEMBL246682
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 560 nM
External Link
CID: 44439875
TTD: D01HOP
 Compound Name H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-NH2 Investigative [98]
Synonyms
CHEMBL371856
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44399141
TTD: D01JSA
 Compound Name H-Dmt-D-Arg(NO2)-Phe-Lys(Z)-OH Investigative [98]
Synonyms
CHEMBL370701
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44399025
TTD: D01MFM
 Compound Name H-Aba-ala-Gly-Phe-Met-OH Investigative [37]
Synonyms
CHEMBL246572
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 100 nM
External Link
CID: 44439910
TTD: D01SDX
 Compound Name Tyr-D-Ala-Gly-Phe-Met-NH2 Investigative [62]
Synonyms
Tyr-DAla-Gly-Phe-Met-NH2
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10371120
TTD: D01TKS
 Compound Name Tyr-Pro-3,5Dmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL413892
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736272
TTD: D02GMU
 Compound Name H-Dmt-Tic-NH-CH2-CH2-NH2 Investigative [100]
Synonyms
CHEMBL241010
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44436392
TTD: D02IQG
 Compound Name Ac-RYYRIK-GGG-K-(NH2)-YRFB-GGGGG Investigative [81]
Synonyms
CHEMBL441930
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416445
TTD: D02TPK
 Compound Name Tyr-Pro-Phe-Phe-OCH2CH3 Investigative [101]
Synonyms
CHEMBL505502
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44586191
TTD: D02WUZ
 Compound Name N-alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2 Investigative [87]
Synonyms
CHEMBL243189; BDBM50201412; N alpha-amidino-Tyr(Me)-Pro-Trp-p-Cl-Phe-NH2
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44428304
TTD: D03BFH
 Compound Name (H-Dmt-Tic-Glu-NH-(CH(2))(5)-CO-Dap(6DMN)-NH(2) Investigative [97]
Synonyms
CHEMBL426320
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44412158
TTD: D03BRB
 Compound Name H-Tyr-c[D-Orn-Aic-Glu]-NH2 Investigative [102]
Synonyms
CHEMBL106849
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44336496
TTD: D03CKF
 Compound Name 3,6-bis(Dmt-Tic-NH-methyl)-2(1H)-pyrazinone Investigative [103]
Synonyms
CHEMBL200890
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405233
TTD: D03HXN
 Compound Name 2-Benzylaminomethyl-3-hydroxymorphinan Investigative [104]
Synonyms
CHEMBL578173
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 190 nM
External Link
CID: 44626544
TTD: D03KAQ
 Compound Name PTI-601 Investigative [27]
MOA Modulator
External Link
TTD: D03PMB
 Compound Name M6S Investigative [68]
MOA Inhibitor
External Link
TTD: D03RSA
 Compound Name Antanal 1 Investigative [105]
Synonyms
CHEMBL507442
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44568843
TTD: D03VSJ
 Compound Name KETOCYCLAZOCINE Investigative [106]
MOA Inhibitor
External Link
CID: 23724935
TTD: D03WYO
 Compound Name UFP-502 Investigative [107]
Synonyms
CHEMBL109390; H-Dmt-Tic-NH-CH2-Bid; 2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (1H-benzoimidazol-2-ylmethyl)-amide; BDBM50179191; (S)-N-((1H-benzo[d]imidazol-2-yl)methyl)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10345770
TTD: D03YDG
 Compound Name H-Dmt-Tic-D-Asp-NH-Ph Investigative [96]
Synonyms
CHEMBL498799
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25033945
TTD: D04BII
 Compound Name Dimethylthiambutene Investigative [108]
Synonyms
Dimethibutin; Ohton; Dimetiltiambuteno; Aminobutene; Dimethylthiambutenum; Kobaton; N,N,1-Trimethyl-3,3-di-2-thienylallylamine; 3-Dimethylamino-1,1-bis(2-thienyl)-1-butene; 524-84-5; 3-Dimethylamino-1,1-di-(2'-thienyl)-1-butene; Dimetiltiambutene [DCIT]; N,N,1-Trimethyl-3,3-di(2-thienyl)-2-propenylamine; Dimetiltiambuteno [INN-Spanish]; Dimethylthiambutenum [INN-Latin]; Dimethylthiambutene [INN:BAN:DCF]; 338C48; Allylamine, N,N,1-trimethyl-3,3-di-2-thienyl-; BRN 0084891; DEA No. 9619; CHEBI:59781; NIH4542
    Click to Show/Hide
MOA Agonist
External Link
CID: 10668
TTD: D04EZN
DrugBank: DB01444
 Compound Name H-Dmt-Tic-Asp-NH-Bzl Investigative [96]
Synonyms
CHEMBL450566
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25034010
TTD: D04IIB
 Compound Name Etorphine Investigative [109]
Synonyms
19-Propylorvinol; 6,14-Ethenomorphinan-7-methanol, 4,5-epoxy-3-hydroxy-6-methoxy-.alpha.,17-dimethyl-.alpha.-propyl-, [5.alpha.,7.alpha.(R)]-; 7.alpha.-Etorphine; AC1LARGT; ETORPHINE - HCI; GTPL1625; SCHEMBL10031275; Oripavine, 6,14-endo-ethylenetetrahydro-7-(1-hydroxy-1-methylbutyl)-; BDBM82425; CAHCBJPUTCKATP-UHFFFAOYSA-N; M99; CAS_61677; NSC_61677; FT-0668440; L024016; Tetrahydro-7-.alpha.-(1-hydroxy-1-methylbutyl)-6,14-endo-ethenooripavine; 6,14-endo-Ethenotetrahydrooripavine, 7.alpha.-(1-hydroxy-1-methylbuty
    Click to Show/Hide
MOA Agonist
External Link
CID: 644209
TTD: D04JCK
 Compound Name H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H Investigative [100]
Synonyms
CHEMBL392469
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44436371
TTD: D04KHE
 Compound Name Tyr-Pro-L-Phe-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44375782
TTD: D04POA
 Compound Name Tyr-D-Ala-Phe-Asp-Val-Val-Thr[Beta-D-Glc]-Gly-NH2 Investigative [83]
MOA Inhibitor
External Link
CID: 73346987
TTD: D04QXM
 Compound Name Dmt-Pro-Trp-D-2-Nal-NH2 Investigative [110]
Synonyms
CHEMBL218433
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16105563
TTD: D04RPI
 Compound Name H-Tyr-Tic-Phe-Phe-OH Investigative [111]
Synonyms
Tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-phenylalanyl-phenylalanine; TIPP; 146369-65-5; Tyr-tic-phe-phe-OH; CHEMBL191751; L-Phenylalanine, L-tyrosyl-L-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-phenylalanyl-; Tyr-Tic-Phe-PheOH; AC1LD8RR; TIPP (opioid antagonist); DTXSID60163362; ZINC3942635; BDBM50068664; tyrosyl-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl- phenylalanyl-phenylalanine; L-Tyrosyl-L-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L- phenylalanyl-L-phenylalanine; 147780-77-6
    Click to Show/Hide
MOA Inhibitor
Activity Ki > 4500 nM
External Link
CID: 644210
TTD: D04SFK
 Compound Name 6-(2-phenethylisoindolin-5-yloxy)nicotinamide Investigative [58]
Synonyms
CHEMBL235154; SCHEMBL3696847
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 658.8 nM
External Link
CID: 44434061
TTD: D04VJE
 Compound Name UFP-512 Investigative [107]
Synonyms
CHEMBL442577; GTPL9006; BDBM50272169; H-Dmt-Tic-NH-CH(CH2-COOH)-Bid; H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid; (3S)-3-[[(3S)-2-[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-3-(1H-benzimidazol-2-yl)propanoic acid; (S)-3-((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-3-(1H-benzo[d]imidazol-2-yl)propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10918703
TTD: D05AFV
 Compound Name SPIROINDANYLOXYMORPHONE Investigative [112]
Synonyms
7-Spiroindanyloxymorphone; SIOM; 7-(Spiroindano)Oxymorphone; CHEMBL399708; 150380-34-0; SCHEMBL12013205; 7-(2'-spiroindanyl)oxymorphone; 7-(2''-spiroindanyl)oxymorphone; BDBM50297170; 1',3',7,7a,8,9-Hexahydro-3,7a-dihydroxy-12-methylspiro(6H-8,9c-(iminoethano)phenanthro(4,5-bcd)furan-6,2'-(2H)inden)-5(4aH)-one (4aR-(4aalpha,7aalpha,8alpha,9calpha))-; Spiro(6H-8,9c-(iminoethano)phenanthro(4,5-bcd)furan-6,2'-(2H)inden)-5(4aH)-one, 1',3',7,7a,8,9-hexahydro-3,7a-dihydroxy-12-methyl-, (4aR-(4aalpha
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 14.3 nM
External Link
CID: 44444966
TTD: D05EWZ
 Compound Name Tyr-(NMe)Ala-L-Phe-D-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44376180
TTD: D05GFM
 Compound Name H-Dmt-Tic-Gly-N(Me)-Ph Investigative [96]
Synonyms
CHEMBL500937
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25034012
TTD: D05KIQ
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Phe-D-Asp-D-Nle-Trp-H Investigative [113]
Synonyms
CHEMBL375359
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16100411
TTD: D05KIS
 Compound Name H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-OH Investigative [111]
Synonyms
CHEMBL375094
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418912
TTD: D05NYR
 Compound Name NalBzOH Investigative [68]
Synonyms
Naloxone benzoylhydrazone; 119630-94-3; 6-Desoxy-6-benzoylhydrazido-N-allyl-14-hydroxydihydronormorphinone; Benzoic acid, ((5alpha)-4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)morphinan-6-ylidene)hydrazide; Lopac0_000882; [(5alpha)-4,5-Epoxy-; MLS000860072; Naloxone benzoylhydrazone, solid; SCHEMBL15423902; CHEMBL1256836; MolPort-003-958-927; MFCD05662358; AKOS024456586; CCG-204964; NCGC00092281-03; NCGC00092281-02; NCGC00092281-04; NCGC00092281-01; SMR000326930; N-165; EU-0100882; SR-01000075513; SR-01000075513-1
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9601084
TTD: D05ZYZ
 Compound Name CTAP Investigative [93]
MOA Antagonist
External Link
CID: 44309215
TTD: D06BAU
 Compound Name Leucine-enkephalin Investigative [114]
Synonyms
YGGFL; URLZCHNOLZSCCA-UHFFFAOYSA-N; 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid; Spectrum_001429; AC1L1GYW; Spectrum5_000656; Spectrum4_001048; Spectrum2_001177; Spectrum3_001521; AC1Q1P3H; KBioSS_001909; KBioGR_001316; BSPBio_002902
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 1.3 nM
External Link
CID: 461776
TTD: D06EES
 Compound Name MCL-457 Investigative [115]
Synonyms
CHEMBL242967; BDBM50210558
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 160 nM
External Link
CID: 44429060
TTD: D06SZI
 Compound Name DADLE Investigative [116]
Synonyms
63631-40-3; H-TYR-D-ALA-GLY-PHE-D-LEU-OH; DADL; (D-Ala2,D-Leu5)-Enkephalin; [D-Ala2, D-Leu5]-enkephalin; CHEMBL340032; BW-180C; Tyr-D-Ala-Gly-Phe-D-Leu; (2R,5S,11R,14S)-14-Amino-5-benzyl-15-(4-hydroxyphenyl)-2-isobutyl-11-methyl-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecan-1-oic acid; (2R)-2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoic acid; UNII-HB4QD9GL6F; HB4QD9GL6F; DADLE-OH; AC1OCEJN; ZINC14952092; H-Tyr-D-Ala-Gly-Phe-D-Leu
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 128.82 nM
External Link
CID: 6917707
TTD: D06YMS
DrugBank: DB08856
 Compound Name H-D-Trp-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 Investigative [117]
Synonyms
CHEMBL384571
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44369487
TTD: D07AUG
 Compound Name 1-[3-(4-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol Investigative [118]
Synonyms
CHEMBL208801
    Click to Show/Hide
MOA Inhibitor
Activity Ki > 10000 nM
External Link
CID: 11645313
TTD: D07BPA
 Compound Name Tyr-Pro-Dmt-Phe-NH2 Investigative [99]
Synonyms
CHEMBL228512
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44424809
TTD: D07BXN
 Compound Name H-Tyr-c[D-Orn-(D or L)Atc-Glu]-NH2 Investigative [102]
MOA Inhibitor
External Link
CID: 15088039
TTD: D07DTN
 Compound Name Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH2 Investigative [119]
Synonyms
CHEMBL29078; Tyr-Ala-Phe-Asp-Val-Val-Gly; GTPL1615
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10033203
TTD: D07GQE
 Compound Name H-Aba-Gly-Gly-Phe-Leu-OH Investigative [37]
Synonyms
CHEMBL247759
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1200 nM
External Link
CID: 44439882
TTD: D07JIQ
 Compound Name Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2 Investigative [119]
Synonyms
CHEMBL32202; BDBM50009180; 3-(2-{2-[2-(2-{2-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-4-methylsulfanyl-butyrylamino}-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-4-methyl-pentanoylamino}-4-methylsulfanyl-butyrylamino)-succinamic ac
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 14504437
TTD: D07LXZ
 Compound Name C[L-Phe-D-pro-L-Tyr(OMe)-D-trp] Investigative [74]
Synonyms
CHEMBL506211
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 43 nM
External Link
CID: 44583388
TTD: D07QUY
 Compound Name D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2(CTAP) Investigative [90]
Synonyms
CHEMBL413950
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44316483
TTD: D08BOD
 Compound Name N-isobutylnoroxymorphone Investigative [120]
Synonyms
CHEMBL490418; 17-Isobutyl-4,5alpha-epoxy-3,14-dihydroxymorphinan-6-one; SCHEMBL3835355; OEQLILQNMUXCHV-XFWGSAIBSA-N
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25178033
TTD: D08BST
 Compound Name H-Dmt-Tic-NH-(CH2)6-NH-Dmt-H Investigative [121]
Synonyms
CHEMBL372130
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405653
TTD: D08CJB
 Compound Name 1,10-bis-(Dmt-Tic-amino)decane Investigative [103]
Synonyms
CHEMBL373192
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405160
TTD: D08COK
 Compound Name H-Dmt-Tic-NH-CH2-Bta Investigative [122]
Synonyms
CHEMBL258704
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451667
TTD: D08CXZ
 Compound Name Tyr-Pro-D-Phg-Phe-NH2 Investigative [69]
Synonyms
CHEMBL210247
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44413216
TTD: D08FGQ
 Compound Name KNT-63 Investigative [26]
Synonyms
CHEMBL593980
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46225291
TTD: D08FYQ
 Compound Name SB-0304 Investigative [123]
Synonyms
CHEMBL409225
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 5.17 nM
External Link
CID: 11641503
TTD: D08LIT
 Compound Name H-Dmt-Aba-Gly-NH-CH2-Ph Investigative [95]
Synonyms
CHEMBL208683; BDBM50189920
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.46 nM
External Link
CID: 11664525
TTD: D08SCK
 Compound Name Tyr-Pro-L-(NMe)Phe-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44375819
TTD: D08STW
 Compound Name 3,6-bis(Dmt-Tic-NH-propyl)-2(1H)-pyrazinone Investigative [103]
Synonyms
CHEMBL381874
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405208
TTD: D08VOC
 Compound Name C[L-Phe-D-pro-L-Phe-D-trp] Investigative [74]
Synonyms
CHEMBL502411; SCHEMBL7980647
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 21 nM
External Link
CID: 44583373
TTD: D09BWX
 Compound Name Ac-RYYRIK-K-(NH2)-YRFB Investigative [81]
Synonyms
CHEMBL412939
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416444
TTD: D09CTG
 Compound Name H-Dmt-Tic-Lys(Ac)-NH-CH2-Ph Investigative [94]
Synonyms
SCHEMBL8222648
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050225
TTD: D09DAM
 Compound Name H-2',6'-dimethyltyrosine-Tic-OH Investigative [124]
Synonyms
CHEMBL571492; 2,6-Dimethyl-L-Tyr-L-Tic-OH; BDBM50299565; H-2'',6''-dimethyltyrosine-Tic-OH; (S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 894 nM
External Link
CID: 15384271
TTD: D09GQP
 Compound Name H-Dmt-Aba-Gly-NH-CH2-Bid Investigative [95]
Synonyms
CHEMBL211543
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 19.9 nM
External Link
CID: 11721803
TTD: D09GSD
 Compound Name FLUPERAMIDE Investigative [125]
Synonyms
UNII-6H13T09362; 53179-10-5; CHEMBL421665; 6H13T09362; R-18910; Fluperamide [USAN:INN]; AC1L2ZCI; AC1Q4JI5; SCHEMBL120826; ZINC4216287; BDBM50017686; R 18,910; 4-[4-[4-chloro-3-(trifluoromethyl)phenyl]-4-hydroxypiperidin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide; 4-(4-Chloro-alpha,alpha,alpha-trifluoro-m-tolyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-1-piperidinebutyramide; 4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-4-hydroxy-piperidin-1-yl]-N,N-dimethyl-2,2-diphenyl-butyramide; 1-Piperidinebutanamide, 4-(4-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.11 nM
External Link
CID: 131534
TTD: D09KBQ
 Compound Name H-Dmt-Tic-NH-(S)CH(CH2-COOH)-Bid(N1-Me) Investigative [96]
Synonyms
XFKPEXYNTQLONY-MPYJOUPCSA-N; CHEMBL450263
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25033949
TTD: D09MBV
 Compound Name C[L-Ala-D-pro-L-Phe-D-trp] Investigative [74]
Synonyms
CHEMBL499595; SCHEMBL7991248
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 22 nM
External Link
CID: 44583393
TTD: D09SBU
 Compound Name H-mCpa-ser-Gly-Phe-Leu-Thr-OH Investigative [37]
Synonyms
CHEMBL393867
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1100 nM
External Link
CID: 44439901
TTD: D0A9AJ
 Compound Name H-Dmt-Tic-Lys(Z)-NH-Ph Investigative [94]
MOA Inhibitor
External Link
CID: 25050066
TTD: D0AJ9D
 Compound Name Tyr-Pro-Phe-Phe-N(CH3)2 Investigative [101]
Synonyms
CHEMBL505975
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44586190
TTD: D0B1JC
 Compound Name Tyr-Pro-Mmp-Phe-NH Investigative [99]
Synonyms
CHEMBL413676
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736675
TTD: D0C4QH
 Compound Name N-alpha-amidino-Tyr(Me)-Pro-Trp-Phe-NH2 Investigative [87]
Synonyms
CHEMBL390271; BDBM50201414; N alpha-amidino-Tyr(Me)-Pro-Trp-Phe-NH2
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44428305
TTD: D0C5RC
 Compound Name D-PhGly-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2 Investigative [90]
Synonyms
CHEMBL384284
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44316656
TTD: D0C9XB
 Compound Name Dynorphin(1-8) Investigative [114]
MOA Inhibitor
External Link
CID: 44273338
TTD: D0D1WB
 Compound Name C[L-Phe-D-pro-L-Tyr-D-trp] Investigative [74]
Synonyms
CHEMBL486388
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 120 nM
External Link
CID: 44583375
TTD: D0D5VD
 Compound Name KNT-62 Investigative [26]
Synonyms
CHEMBL594654
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46906981
TTD: D0D6KZ
 Compound Name DM6S Investigative [68]
Synonyms
CHEMBL385448
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414783
TTD: D0D6OA
 Compound Name H-Dmt-Tic-NH-CH[(CH2)4-NH-Z]-Bid Investigative [94]
Synonyms
CHEMBL386309; SCHEMBL8228625
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050223
TTD: D0D8DZ
 Compound Name (-)-eseroline Investigative [78]
Synonyms
Eseroline; UNII-Q22H41O18D; CHEMBL310934; CHEBI:48845; C13H18N2O; HKGWQUVGHPDEBZ-OLZOCXBDSA-N; Q22H41O18D; (3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-ol; 469-22-7; (3as-cis)-1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol; Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-; (3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol; Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, (3aS,8aR)-
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 119198
TTD: D0D9RL
 Compound Name 1,4-bis-(Dmt-Tic-amino)butane Investigative [103]
Synonyms
CHEMBL370197
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405158
TTD: D0DN6A
 Compound Name MR-2034 Investigative [106]
Synonyms
MR 2034; (-)-alpha-(1R,5R,9R)-5,9-Dimethyl-2-(L-tetrahydrofurfuryl)-2'-hydroxy-6,7-benzomorphan; 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-((tetrahydro-2-furanyl)methyl)-, (2R-(2-alpha,3(R*),6-alpha,11R*))-; 57236-85-8; AC1Q7AHJ; (2r,6r)-6,11-dimethyl-3-[(2r)-tetrahydrofuran-2-ylmethyl]-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol; BDBM81932; MR2034; LS-90624; CAS_57236-85-8
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 123980
TTD: D0DO6P
 Compound Name Ac-RYYRIK-GGG-K-(NH2)-YAFGYPS-GG Investigative [81]
Synonyms
CHEMBL414736
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416159
TTD: D0E3RQ
 Compound Name H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-OH Investigative [111]
Synonyms
CHEMBL219482
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418911
TTD: D0E7NL
 Compound Name H-Dmt-Tic-Gly-NH-Ph Investigative [96]
Synonyms
CHEMBL501451; BDBM50272081; (3S)-N-(Phenylcarbamoylmethyl)-2-[(S)-3-(2,6-dimethyl-4-hydroxyphenyl)-2-aminopropionyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; 2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid phenylcarbamoylmethyl-amide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.16 nM
External Link
CID: 11016572
TTD: D0ED2I
 Compound Name H-Dmt-Tic-Lys(Ac)-NH-Ph Investigative [94]
Synonyms
SCHEMBL8228366
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050226
TTD: D0EG7I
 Compound Name DSLET Investigative [27]
Synonyms
DSTLE; Dislet; [D-Ser2, Leu5, Thr6]-enkephalin
    Click to Show/Hide
MOA Agonist
External Link
CID: 107847
TTD: D0EM9A
 Compound Name H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-NH2 Investigative [111]
Synonyms
CHEMBL415426
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418917
TTD: D0ES7P
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-Boc Investigative [126]
Synonyms
CHEMBL413644
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408590
TTD: D0F1XY
 Compound Name 1-benzhydryl-4-cyclopropylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL398039
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 18365 nM
External Link
CID: 44430024
TTD: D0F8AX
 Compound Name Tyr-Pro-Tmp-Phe-NH Investigative [99]
Synonyms
CHEMBL389023
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736706
TTD: D0FT9J
 Compound Name H-Dmt-Tic-Gly-NH-Bzl Investigative [96]
Synonyms
CHEMBL458631; H-Dmt-Tic-Gly-NH-CH2-Ph; GTPL9838; BDBM50266025; 2-[2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (benzylcarbamoyl-methyl)-amide; (S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-N-(2-(benzylamino)-2-oxoethyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide; (3S)-N-(Benzylcarbamoylmethyl)-2-[(S)-3-(2,6-dimethyl-4-hydroxyphenyl)-2-aminopropionyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.16 nM
External Link
CID: 10864183
TTD: D0H1BU
 Compound Name Tyr-Pro-Imp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL434559
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736710
TTD: D0H2RF
 Compound Name AMINOFENTANYL Investigative [128]
Synonyms
CHEMBL385168; BDBM50191054
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416393
TTD: D0H3QK
 Compound Name M3Pr6S Investigative [68]
Synonyms
CHEMBL385048; 3-Propionylmorphine 6-sulfate
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414843
TTD: D0H6AA
 Compound Name Tyr-D-Ala-Phe-Gly-Tyr-Pro-Thr(Beta-D-Glc)-Gly-NH2 Investigative [83]
MOA Inhibitor
External Link
CID: 44331204
TTD: D0H8WV
 Compound Name Tyr-Pro-Phe-Phe-NHCH3 Investigative [101]
Synonyms
CHEMBL453689
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44586189
TTD: D0HF0I
 Compound Name Dmt-Pro-Phe-D-1-Nal-NH2 Investigative [110]
Synonyms
CHEMBL385583
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16105560
TTD: D0I1BJ
 Compound Name Tyr-D-Ala-Phe-Thr(-D-Glc)-Tyr-Pro-Ser-NH2 Investigative [83]
MOA Inhibitor
External Link
CID: 73345456
TTD: D0I9IX
 Compound Name 3,6-bis(Dmt-Tic-NH-ethyl)-2(1H)-pyrazinone Investigative [103]
Synonyms
CHEMBL198800
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405192
TTD: D0J2IK
 Compound Name DELTORPHIN-II Investigative [107]
Synonyms
Delt II; Delt-II; (Ala(2))deltorphin II; deltorphin II, Ala(2)-; (Ala(2),glu(4))deltorphin; Deltorphin, ala(2)-glu(4)-; Tyr-ala-phe-glu-val-val-gly-NH2; Deltorphin, alanyl(2)-glutamyl(4)-; Glycinamide, L-tyrosyl-D-alanyl-L-phenylalanyl-L-alpha-glutamyl-L-valyl-L-valyl-; AC1L3XB1; LS-72217
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 123795
TTD: D0J7XM
 Compound Name MR-1029 Investigative [129]
MOA Inhibitor
External Link
CID: 71716573
TTD: D0K0XT
 Compound Name Tyr-Pro-Dmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL266122
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10371367
TTD: D0K2OK
 Compound Name DELTORPHIN Investigative [130]
Synonyms
Dermenkephalin; Deltorphin A; 119975-64-3; CHEMBL20775; CHEBI:81455; Tyr-met-phe-his-leu-met-asp-NH2; AC1MHYOS; DTXSID60152630; BDBM50000518; Tyrosyl-methionyl-phenylalanyl-histidyl-leucyl-methionyl-aspartamide; ZINC169301619
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 3035060
TTD: D0K4AC
 Compound Name Tyr-Pro-D-Phe-D-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44375820
TTD: D0L3DM
 Compound Name H-Dmt-Tic-NH-CH2-ImidPh Investigative [122]
Synonyms
CHEMBL259917
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451637
TTD: D0L9NB
 Compound Name MR-2266 Investigative [129]
Synonyms
Mrz 2266 BS; MR 2266; MR-2266-BS; (-)-Mr 2266; (-)-2-(3-Furylmethyl)-5,9-diethyl-2'-hydroxy-6,7-benzomorphan; 56649-76-4; (+/-)-2-(3-Furylmethyl)-2'-hydroxy-5,9alpha-diethyl-6,7-benzomorphan hydrochloride; 2,6-Methano-3-benzazocin-8-ol, 6,11-diethyl-3-(3-furanylmethyl)-1,2,3,4,5,6-hexahydro-, (2R,6R,11R)-; 2,6-Methano-3-benzazocin-8-ol, 6,11-diethyl-3-(3-furanylmethyl)-1,2,3,4,5,6-hexahydro-, (2R-(2alpha,6alpha,11R*))-; Mr1302 MS; Mr2267; Mr 2267; SCHEMBL4404993; BDBM82508; Mr2266; ZINC5492542; CAS_56649-76-4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 3034816
TTD: D0M4DI
 Compound Name H-Tyr-Pro-Phe-Phe-NH-(CH2)5-(C=O)-Dap(6DMN)-NH2 Investigative [97]
Synonyms
CHEMBL411335
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44412234
TTD: D0M6BL
 Compound Name H-2',6'-dimethyltyrosine-Tic-Phe-Phe-OH Investigative [124]
Synonyms
CHEMBL555206; BDBM50299557; H-2'',6''-dimethyltyrosine-Tic-Phe-Phe-OH; (S)-2-((S)-2-((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-3-phenylpropanamido)-3-phenylpropanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 45273695
TTD: D0M6CZ
 Compound Name Dmt-Pro-Phe-D-2-Nal-NH2 Investigative [110]
MOA Inhibitor
External Link
TTD: D0MP7Z
 Compound Name CTOP Investigative [85]
Synonyms
Ctop-NH2; CTOPA; CHEMBL507214; 103429-31-8; AC1NSJX5; H-D-Phe-c[Cys-Tyr-DTrp-Orn-Thr-Pen]-Thr-NH2; GTPL1674; CTOP, &gt; BDBM50252861; (4R,7S,10S,13R,16S,19R)-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-10-(3-aminopropyl)-7-[(1R)-1-hydroxyethyl]-16-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
    Click to Show/Hide
MOA Antagonist
External Link
CID: 2884
TTD: D0MZ2A
 Compound Name H-Dmt-Tic-NH-CH2-Indn Investigative [122]
Synonyms
CHEMBL260127
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451639
TTD: D0N1AO
 Compound Name Antanal 2 Investigative [105]
Synonyms
CHEMBL454035
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44568844
TTD: D0N5TL
 Compound Name Tyr-Pro-Phe-Phe-OC(CH3)3 Investigative [101]
Synonyms
CHEMBL500195
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44586192
TTD: D0NB7S
 Compound Name DERMORPHIN Investigative [81]
Synonyms
77614-16-5; H-Tyr-D-ala-phe-gly-tyr-pro-ser-NH2; UNII-2SEC01B703; DERMORPHIN ACETATE; Tyrosyl-alanyl-phenylalanyl-glycyl-tyrosyl-prolyl-serinamide; CHEMBL278789; 2SEC01B703; Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2; AC1NUNYZ; YAFGYPS-NH2; SCHEMBL237169; Tyr-Ala-Phe-Gly-Tyr-Pro-Ser; DTXSID40228281; HY-P0244
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.585 nM
External Link
CID: 5485199
TTD: D0NE3U
 Compound Name Tyr-Pro-Phe-Phe-OCH3 Investigative [101]
Synonyms
CHEMBL361922; Tyr-Pro-Phe-Phe-OMe
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44390652
TTD: D0O4KY
 Compound Name H-Dmt-Tic-NH-CH[(CH2)4-NH2]-Bid Investigative [94]
Synonyms
SCHEMBL8230993; CHEMBL377960
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050224
TTD: D0O7NC
 Compound Name H-Dmt-Tic-(2S,3S)-beta-MeCha-Phe-NH2 Investigative [111]
Synonyms
CHEMBL269314
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418915
TTD: D0P1CP
 Compound Name MR-1526 Investigative [129]
MOA Inhibitor
External Link
CID: 73352838
TTD: D0P2GB
 Compound Name H-Dmt-Tic-Asp-N(Me)-Ph Investigative [96]
Synonyms
CHEMBL448360
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25034014
TTD: D0P2KV
 Compound Name 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide Investigative [131]
Synonyms
CHEMBL594511
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44596230
TTD: D0P2LE
 Compound Name H-Dmt-Tic-(2R,3R)-beta-MeCha-Phe-NH2 Investigative [111]
Synonyms
CHEMBL218781
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418916
TTD: D0P4PM
 Compound Name H-Dmt-Tic-Glu-NH-(CH2)5-NH2 Investigative [132]
Synonyms
CHEMBL225479
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44421433
TTD: D0P5EI
 Compound Name C[L-Tyr(OMe)-D-pro-L-Phe-D-trp] Investigative [74]
Synonyms
CHEMBL507127
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 170 nM
External Link
CID: 44583387
TTD: D0P5IH
 Compound Name Tyr-Pro-L-(NMe)Phe-D-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44376060
TTD: D0P6AR
 Compound Name H-Dmt-Tic-NH-CH2-Indl Investigative [122]
Synonyms
CHEMBL408975
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451665
TTD: D0P8NZ
 Compound Name H-Dmt-Tic-Asp-NH-Ph Investigative [96]
Synonyms
CHEMBL501202
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25033885
TTD: D0PN1A
 Compound Name H-Aba-ala-Gly-Phe-leu-OH Investigative [37]
Synonyms
CHEMBL247064
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1200 nM
External Link
CID: 44439877
TTD: D0PN3P
 Compound Name H-D-Tca-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 Investigative [117]
MOA Inhibitor
External Link
CID: 91931233
TTD: D0Q0UQ
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-(NMe)Phe-Asp-Nle-Trp-Ac Investigative [126]
Synonyms
CHEMBL408889
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408417
TTD: D0Q1PN
 Compound Name H-Dmt-Tic-NH-(R)CH(CH2-COOH)-Bid(N1-Me) Investigative [96]
Synonyms
CHEMBL499099; BDBM50272228
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25034016
TTD: D0Q2HZ
 Compound Name C[L-Tyr-D-pro-L-Phe-D-trp] Investigative [74]
Synonyms
CHEMBL506217
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 670 nM
External Link
CID: 44583374
TTD: D0Q6CF
 Compound Name Tyr-(S)-Aba-Gly-Phe-NH2 Investigative [89]
Synonyms
CHEMBL399796
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24755070
TTD: D0Q7SS
 Compound Name H-Dmt-Tic-Lys-NH-CH2-Ph Investigative [94]
MOA Inhibitor
External Link
CID: 44415604
TTD: D0R1DY
 Compound Name H-Dmt-Tic-NH-(D)-CH[(CH2)4-NH-Z]-Bid Investigative [94]
Synonyms
CHEMBL212172
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16082947
TTD: D0R3GD
 Compound Name H-Dmt-Tic-(2S,3R)-beta-MeCha-Phe-OH Investigative [111]
Synonyms
CHEMBL375095
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418913
TTD: D0R4KJ
 Compound Name H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-OH Investigative [111]
Synonyms
CHEMBL376453
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418914
TTD: D0R4YD
 Compound Name H-Apa-ala-Gly-Phe-leu-OH Investigative [37]
Synonyms
CHEMBL247363
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1400 nM
External Link
CID: 44439872
TTD: D0R9AP
 Compound Name 1,6-bis-(N,N-dimethyl-Dmt-Tic-NH)hexane Investigative [103]
Synonyms
CHEMBL370399
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405153
TTD: D0R9LV
 Compound Name H-Dmt-Tic-Lys(Z)-NH-CH2-Ph Investigative [94]
MOA Inhibitor
External Link
CID: 44415603
TTD: D0R9XD
 Compound Name H-D-Tic-c[Cys-Tyr-D-Trp-Arg-Thr-Pen]-Thr-NH2 Investigative [117]
Synonyms
CHEMBL268162
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44369523
TTD: D0RR4X
 Compound Name 1,6-bis-(Dmt-Tic-amino)hexane Investigative [103]
Synonyms
CHEMBL197185
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405159
TTD: D0S3LK
 Compound Name ZYKLOPHIN Investigative [133]
Synonyms
GTPL9193; CHEMBL574568
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 45483651
TTD: D0S9UH
 Compound Name M3P6S Investigative [68]
Synonyms
CHEMBL213228
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414864
TTD: D0TH8E
 Compound Name CARBOXYFENTANYL Investigative [134]
Synonyms
CHEBI:61106; CHEMBL216239; 4-oxo-4-{phenyl[1-(2-phenylethyl)piperidin-4-yl]amino}butanoic acid; 4-anilidopiperidine, 8; Epitope ID:153518; SCHEMBL5163413; BDBM21114; ZINC14975441; 4-Oxo-4-[N-(1-phenethylpiperidine-4-yl)anilino]butyric acid; 3-{phenyl[1-(2-phenylethyl)piperidin-4-yl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23635044
TTD: D0U3ZL
 Compound Name H-Dmt-Tic-NH-(CH2)6-NH-Phe-H Investigative [121]
Synonyms
CHEMBL198909
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405656
TTD: D0U4LU
 Compound Name 1-[3-(3-biphenyl)-(1,2,4-triazol-4-yl) ]-3-phenol Investigative [118]
Synonyms
CHEMBL212743; SCHEMBL14506371
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1000 nM
External Link
CID: 11580459
TTD: D0U5OP
 Compound Name Tyr-Pro-Phe-Phe-OCH2OH Investigative [101]
Synonyms
CHEMBL522293
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24857893
TTD: D0U8YU
 Compound Name 3,6-bis(Dmt-Tic-NH-butyl)-2(1H)-pyrazinone Investigative [103]
Synonyms
CHEMBL373668
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405182
TTD: D0UV1C
 Compound Name H-Dmt-Tic-NH-CH2-Imid Investigative [122]
Synonyms
CHEMBL407957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451610
TTD: D0V2PM
 Compound Name Tyr-Pro-Phe-Phe-NHNH2 Investigative [101]
Synonyms
CHEMBL180777
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24857892
TTD: D0V3GN
 Compound Name [3H]U69593 Investigative [68]
Synonyms
U-69593; U69593; 96744-75-1; U 69593; UNII-J5S4K6TKTG; U 69,593; J5S4K6TKTG; N-Methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(4,5)dec-8-yl)benzeneacetamide; CHEBI:73357; n-methyl-2-phenyl-n-[(5r,7s,8s)-7-(pyrrolidin-1-yl)-1-oxaspiro[45]dec-8-yl]acetamide; Benzeneacetamide, N-methyl-N-(7-(1-pyrrolidinyl)-1-oxaspiro(45)dec-8-yl)-, (5alpha,7alpha,8beta)-(-)-; NCGC00163179-01; DSSTox_CID_26326; DSSTox_RID_81542; U69,593; DSSTox_GSID_46326; [3H]-U69593
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 105104
TTD: D0V3OY
 Compound Name H-Dmt-Tic-NH-CH2-Boa Investigative [122]
Synonyms
CHEMBL258458
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44451689
TTD: D0V8UG
 Compound Name H-Dmt-Tic-Glu-NH2 Investigative [132]
MOA Inhibitor
External Link
CID: 11156202
TTD: D0W8MP
 Compound Name M3A6S Investigative [68]
Synonyms
CHEMBL214040; 3-Acetylmorphine 6-sulfate; 3-O-acetylmorphine-6-sulfate
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414842
TTD: D0WZ7J
 Compound Name H-Dmt-Tic-NH-CH[(CH2)4-NH-Ac]-Bid Investigative [94]
Synonyms
CHEMBL378082
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25050370
TTD: D0X2HA
 Compound Name M3IBu6S Investigative [68]
Synonyms
CHEMBL211576
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44414863
TTD: D0X2HT
 Compound Name H-Dmt-Tic-NH-(CH2)6-NH-Tic-H Investigative [121]
Synonyms
CHEMBL380590
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44405654
TTD: D0X4YC
 Compound Name H-Cdp-ser-Gly-Phe-Leu-Thr-OH Investigative [37]
Synonyms
CHEMBL247760
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 19 nM
External Link
CID: 44439905
TTD: D0X5TB
 Compound Name D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Pen-Thr-NH2(CTP) Investigative [90]
Synonyms
CHEMBL437283
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44316364
TTD: D0X9SP
 Compound Name Tyr-(S)-spiro-Aba-Gly-Phe-NH2 Investigative [89]
Synonyms
CHEMBL401143
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24755069
TTD: D0X9TT
 Compound Name H-Dmt-Aba-Gly-NH-Ph Investigative [95]
Synonyms
CHEMBL377392
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.48 nM
External Link
CID: 11635818
TTD: D0Y2HI
 Compound Name Ac-RYYRIK-K-(NH2)-YAFGYPS Investigative [81]
Synonyms
CHEMBL404792
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44416158
TTD: D0Y2MT
 Compound Name Tyr-Pro-Emp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL375274
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736708
TTD: D0Y5TF
 Compound Name Tyr-Pro-L-Phe-D-Pro-NH2 Investigative [71]
MOA Inhibitor
External Link
CID: 44376061
TTD: D0Y5UN
 Compound Name H-Tyr-Pro-Ala-Phe-NH2 Investigative [76]
Synonyms
YPAF-NH2
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 225.9 nM
External Link
CID: 44428865
TTD: D0Y9RD
 Compound Name Oxymorphone semicarbazone hydrochloride Investigative [114]
Synonyms
CHEMBL1202432; Oxymorphone Semicarbazone HCl
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 49860169
TTD: D0YK5E
 Compound Name H-Tyr-Tic-Cha-Phe-OH Investigative [111]
Synonyms
CHEMBL197937
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9809581
TTD: D0Z5UG
 Compound Name H-Tyr-Pro-Dap(6DMN)-Phe-NH2 Investigative [97]
Synonyms
CHEMBL207661
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44412206
TTD: D0ZI5Z
 Compound Name H-Dmt-Tic-(2R,3S)-beta-MeCha-Phe-NH2 Investigative [111]
Synonyms
CHEMBL218782
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44418918
TTD: D0ZQ7L
 Compound Name 3-Methylthiofentanyl Investigative [135]
Synonyms
3-Methyl-thiofentanyl; UNII-C9C204973M; 86052-04-2; CHEBI:53763; N-(3-Methyl-1-(2-thienyl)ethyl-4-piperidinyl)-N-phenylpropanamide; C9C204973M; Propanamide, N-(3-methyl-1-(2-(2-thienyl)ethyl)-4-piperidinyl)-N-phenyl-; N-{3-methyl-1-[2-(2-thienyl)ethyl]piperidin-4-yl}-N-phenylpropanamide; DEA No. 9833; 3-Methylthiofentanil; Epitope ID:153515; AC1Q5I8I; AC1L1WU2; SCHEMBL1742151; CHEMBL2365680; DB01439; FT-0672232
    Click to Show/Hide
MOA Agonist
External Link
CID: 62296
TTD: D00HIG
DrugBank: DB01439
 Compound Name (-)-cyclorphan Investigative [136]
Synonyms
CHEMBL291468; BDBM50105483; 17-cyclopropylmethyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-4-ol; 17-cyclopropylmethyl-(1R,9R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44299063
TTD: D00JAT
 Compound Name 5-(4-((phenethylamino)methyl)phenoxy)picolinamide Investigative [72]
Synonyms
CHEMBL236376; SCHEMBL3771658
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.44 nM
External Link
CID: 44434951
TTD: D00JPB
 Compound Name MCL-117 Investigative [136]
Synonyms
CHEMBL1790045; (-)3-hydroxy-N-propargylmorphinan; BDBM50366764
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.003 nM
External Link
CID: 6602241
TTD: D00NRB
 Compound Name 17-(Cyclopropylmethyl)-N-phenylmorphinan-3-amine Investigative [104]
Synonyms
CHEMBL568757
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.08 nM
External Link
CID: 44627900
TTD: D00SDP
 Compound Name 1-benzhydryl-4-isopropylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL233721
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 13230 nM
External Link
CID: 44430025
TTD: D00XZH
 Compound Name Tyr-D-Pro-Gly-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 4; CHEMBL205965; BDBM21134; (3S)-3-[(2S)-2-[(2S)-2-(2-{[(2R)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]pyrrolidin-2-yl]formamido}acetamido)-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11693641
TTD: D01ADK
 Compound Name BUTORPHAN Investigative [137]
Synonyms
CHEMBL301160; MCL-101; SCHEMBL11805323; ZINC3982790; 3-Hydroxy-N-cyclobutylmethylmorphinan; BDBM50135808; 3-hydroxy-n-cyclobutylmethyl morphinan
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.12 nM
External Link
CID: 9804450
TTD: D01EPU
 Compound Name 1-benzhydryl-4-tert-butylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL234771
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3599 nM
External Link
CID: 10314141
TTD: D01MUV
 Compound Name 8-carboxamidocyclazocine Investigative [138]
Synonyms
CHEMBL58646; 8-CAC; SCHEMBL12014004; (6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocine-8-carboxylic acid amide; PDSP1_000954; PDSP2_000939
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.31 nM
External Link
CID: 10086063
TTD: D01RFG
 Compound Name quadazocine Investigative [27]
Synonyms
(-)-WIN 44,441; (-)-quadazocine
    Click to Show/Hide
MOA Antagonist
External Link
CID: 115077
TTD: D02BER
 Compound Name 17-methyl-4'-methyldihydromorphinone Investigative [139]
Synonyms
CHEMBL607018
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44415081
TTD: D02FZW
 Compound Name MCL-443 Investigative [140]
Synonyms
CHEMBL394624
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.7 nM
External Link
CID: 44427184
TTD: D02IMZ
 Compound Name H-Cpa-Gly-Gly-Phe-Met-OH Investigative [37]
Synonyms
CHEMBL391580
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 28 nM
External Link
CID: 11250396
TTD: D02PIG
 Compound Name MCL-450 Investigative [141]
Synonyms
CHEMBL373984; BDBM50194274
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.69 nM
External Link
CID: 16083055
TTD: D02RYZ
 Compound Name Dcp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 Investigative [142]
Synonyms
CHEMBL373489
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44415255
TTD: D03QWP
 Compound Name OXYMORPHINDOLE Investigative [143]
Synonyms
ACMC-20di42; AC1L9G6X; CHEMBL1985511; CTK7J9928; 4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol,5,6,7,8,14,14b-hexahydro-7-methyl-, (4bS,8R,8aS,14bR)-; NSC707844; NSC-707844; NCI60_038277
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 105 nM
External Link
CID: 5491897
TTD: D03UFD
 Compound Name MCL-458 Investigative [115]
Synonyms
CHEMBL390912; BDBM50210556
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.8 nM
External Link
CID: 44429061
TTD: D03UHT
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Ac Investigative [126]
Synonyms
CHEMBL442483
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408525
TTD: D03WGS
 Compound Name Naltrexone-6-alpha-ol Investigative [106]
Synonyms
CHEMBL468469; 20410-98-4; SCHEMBL679581; ZINC1656961; BDBM50254511; FT-0672601; 17-(Cyclopropylmethyl)-4,5; A-epoxy-morphinan-3,6; A,14-triol; A)-17-(Cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol; 6alpha-Naltrexol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.21 nM
External Link
CID: 16099582
TTD: D04JFL
 Compound Name MCL-139 Investigative [136]
Synonyms
CHEMBL203251
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.16 nM
External Link
CID: 44406697
TTD: D04PPP
 Compound Name Dmt-Pro-Dmt-Phe-NH2 Investigative [99]
Synonyms
CHEMBL388800
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44424810
TTD: D04UFM
 Compound Name MCL-429 Investigative [140]
Synonyms
CHEMBL397035
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.11 nM
External Link
CID: 44427178
TTD: D04UIK
 Compound Name naltriben Investigative [27]
Synonyms
Naltrindole benzofuran; 4,8-Methano-5H-bisbenzofuro(3,2-e:2',3'-g)isoquinoline-1,8a(9H)-diol, 7-(cyclopropylmethyl)-6,7,8,14b-tetrahydro-, (8R-(4bS*,8alpha,8beta,14bbeta))-; 111555-58-9; C26H25NO4; [3H]naltriben; [3H]-naltriben; NTB; naltrindolebenzofuran; GTPL1640; SCHEMBL1240717; CHEMBL100940; GTPL3828; BDBM82552; HMS2089G18; ZINC3874478; PDSP2_001551; LS-172157; CAS_111555-58-9; C20166; AB00691672-07
    Click to Show/Hide
MOA Antagonist
External Link
CID: 5486827
TTD: D05ANN
 Compound Name Dmt-Pro-Phe-Phe-NH2 Investigative [99]
Synonyms
CHEMBL331325; 596792-36-8; Dmt-endomorphin-2; CTK1E6813; DTXSID10435187; BDBM50149384; AKOS030610408; L-Phenylalaninamide, 2,6-dimethyl-L-tyrosyl-L-prolyl-L-phenylalanyl-; (S)-1-[(S)-2-Amino-3-(4-hydroxy-2,6-dimethyl-phenyl)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-1-((S)-1-carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethyl]-amide
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 0.1 nM
External Link
CID: 10077295
TTD: D05EZE
 Compound Name CYCLORPHAN Investigative [137]
Synonyms
17-(Cyclopropylmethyl)morphinan-3-ol; 4163-15-9; UNII-U6Z73N36V0; EINECS 224-007-5; CHEMBL49269; (-)-3-Hydroxy-N-cyclopropylmethylmorphinan; U6Z73N36V0; Morphinan, (-)-3-hydroxy-N-cyclopropylmethyl-; Morphinan-3-ol, 17-(cyclopropylmethyl)- (8CI,9CI); SCHEMBL159134; CTK4I5050; ZINC4215487; PDSP2_000668; BDBM50135800; N-cyclopropylmethyl 3-hydroxymorphinan; 3-Hydroxy-N-cyclopropylmethylmorphinan; LS-91818; (-)-17-(Cyclopropylmethyl)morphinan-3-ol; (-)-3-Hydroxy-N-cycloproypylmethylmorphinan Mandelate
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.062 nM
External Link
CID: 5359966
TTD: D05FEQ
 Compound Name MCL-145 Investigative [136]
MOA Inhibitor
Activity Ki = 0.2 nM
External Link
CID: 10462426
TTD: D05JSY
 Compound Name NORBINALTORPHIMINE Investigative [144]
Synonyms
nor-Binaltorphimine; UNII-36OOQ86QM1; 36OOQ86QM1; CHEBI:81529; C18130; 4,8:11,15-Dimethano-20H-bisbenzofuro(2,3-a:3',2'-i)dipyrido(4,3-b:3',4'-h)carbazole-1,8a,10a,18-tetrol, 7,12-bis(cyclopropylmethyl)-5,6,7,8,9,10,11,12,13,14,19a,20b-dodecahydro-20-methyl-, (8R-(4bR*,8alpha,8abeta,10aalpha,11beta,14aR*,19aalpha,20bbeta))-; Nor-Binaltorphamine; (-)-norbinaltorphimine; NOR-BNI (HCI)2; Lopac0_000806; GTPL1642; CHEMBL573214; SCHEMBL12013206; BDBM82551; APSUXPSYBJVPPS-YAUKWVCOSA-N
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.94 nM
External Link
CID: 5480230
TTD: D05QJS
 Compound Name 3-(1-benzylpiperidin-4-yl)-5-chloro-1H-indole Investigative [145]
Synonyms
CHEMBL210770; SCHEMBL14280723; NRIVFQIOYWIUPX-UHFFFAOYSA-N; BDBM50185792
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 230 nM
External Link
CID: 44413409
TTD: D05RII
 Compound Name Dmt-Pro-3,5Dmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL389949
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736676
TTD: D05TOY
 Compound Name [3H]diprenorphine Investigative [85]
Synonyms
[15,16-3H]diprenorphine
    Click to Show/Hide
MOA Antagonist
External Link
CID: 6858272
TTD: D05YNT
 Compound Name 6beta-naltrexol HCl Investigative [146]
Synonyms
CHEMBL558140; UNII-765G11MG24; 765G11MG24; 55488-86-3; Naltrexone metabolite 6; A-Naltrexol (hydrochloride); 6beta-Naltrexol hydrochloride; HY-G0019; 6beta-Hydroxynaltrexone hydrochloride; Morphinan-3,6,14-triol, 17-(cyclopropylmethyl)-4,5-epoxy-, hydrochloride, (5alpha,6beta)-; Naltrexone metabolite 6AfAE'A centa' notA inverted exclamation markAfasA'A; AfAE'Adaggeratrade markAfA centA centasA notA em leaderA inverted exclamation mark-Naltrexol (hydrochloride)
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2.12 nM
External Link
CID: 45110000
TTD: D05ZIH
 Compound Name MCL-153 Investigative [147]
MOA Inhibitor
Activity Ki = 29 nM
External Link
CID: 11411315
TTD: D06IXE
 Compound Name C[L-Phe-D-pro-L-Phe-L-trp] Investigative [74]
Synonyms
CHEMBL506616; CJ-15208; SCHEMBL12368055
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 25 nM
External Link
CID: 44583372
TTD: D06KFX
 Compound Name Dmt-Pro-Mmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL389948
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16737287
TTD: D06MWG
 Compound Name CYCLAZOCINE Investigative [137]
Synonyms
(-)-cyclazocine; 7313-86-2; l-Cyclazocine; (-)-cis-Cyclazocine; A-Cyclazocine; AC1L55DZ; GTPL1604; CTK8F1400; DTXSID20617937; MCV 4512; (2R,6R,11R)-3-(Cyclopropylmethyl)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-2,6-methano-3-benzazocin-8-ol; NIH 10450; AKOS030242899; FT-0665329
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.16 nM
External Link
CID: 19143
TTD: D06NST
 Compound Name MCL-433 Investigative [140]
Synonyms
CHEMBL245049
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.4 nM
External Link
CID: 44427174
TTD: D06OKE
 Compound Name 4-phenyl-1-(1-phenylpropyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL433814; SCHEMBL9520650
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2298 nM
External Link
CID: 44426806
TTD: D06PVO
 Compound Name NRP290 Investigative [27]
MOA Agonist
External Link
TTD: D06WTI
 Compound Name M6G thiosaccharide analogue Investigative [149]
MOA Inhibitor
External Link
TTD: D07AAK
 Compound Name MCL-434 Investigative [140]
Synonyms
CHEMBL241824
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.3 nM
External Link
CID: 44427176
TTD: D07DFD
 Compound Name 4-phenyl-1-(1-phenylethyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL230249
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 6265 nM
External Link
CID: 9925737
TTD: D07FCB
 Compound Name MCL-446 Investigative [115]
Synonyms
CHEMBL428038; BDBM50210549
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 12 nM
External Link
CID: 44429064
TTD: D07HFU
 Compound Name H-Tyr-c[D-Allylgly-Gly-Phe-L-Allylgly]NH2 Investigative [150]
Synonyms
CHEMBL220333
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16116088
TTD: D07JZS
 Compound Name MCL-435 Investigative [140]
Synonyms
CHEMBL242046
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.2 nM
External Link
CID: 44427180
TTD: D08IWF
 Compound Name H-Tyr-D-Ala-Gly Phe-Pro-Leu-Trp-O-3,5-Bzl(CF3)2 Investigative [151]
Synonyms
CHEMBL261390; BDBM21007; C-terminal modified bifunctional peptide, 1; [3,5-bis(trifluoromethyl)phenyl]methyl (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}-4-methylpentanamido]-3-(1H-indol-3-yl)propanoate
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24768351
TTD: D08KSJ
 Compound Name Trans-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH Investigative [152]
Synonyms
tDADAE(9); CHEMBL229440; BDBM21126; (5S,8R,10E,13R)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-5-benzyl-3,6,14-trioxo-1,4,7-triazacyclotetradec-10-ene-8-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 2.65 nM
External Link
CID: 16733487
TTD: D08NJB
 Compound Name 6-(Allyl-methyl-amino)-4,4-diphenyl-heptan-3-ol Investigative [153]
Synonyms
CHEMBL171118
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44382932
TTD: D08ORS
 Compound Name Tyr-D-Nle-Gly-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 3; CHEMBL408330; BDBM21133; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]hexanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11528076
TTD: D08QKT
 Compound Name MCL-182 Investigative [115]
Synonyms
CHEMBL49143; 3-aminobutorphan; 3-Amino-N-cyclobutylmethylmorphinan
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.7 nM
External Link
CID: 11255361
TTD: D08RPH
 Compound Name TQ-1017 Investigative [154]
MOA Agonist
External Link
TTD: D08YCS
 Compound Name MCL-447 Investigative [115]
Synonyms
CHEMBL394573; BDBM50210555
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.2 nM
External Link
CID: 44429063
TTD: D09DUE
 Compound Name 17-Methylmorphinan-3-yl 4-Iodophenyl Carbamate Investigative [104]
Synonyms
CHEMBL568989
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.34 nM
External Link
CID: 44627904
TTD: D09FLC
 Compound Name N-Benzyl-17-(cyclopropylmethyl)morphinan-3-amine Investigative [104]
Synonyms
CHEMBL571998; MCL-610
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.26 nM
External Link
CID: 44627790
TTD: D09RUY
 Compound Name MCL-183 Investigative [115]
Synonyms
CHEMBL390866; SCHEMBL14419223
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 7.1 nM
External Link
CID: 11303119
TTD: D09UKS
 Compound Name Deprotected cogener of M6G Investigative [149]
Synonyms
CHEMBL362202
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.5 nM
External Link
CID: 44390358
TTD: D0A5MU
 Compound Name MCL-144 Investigative [155]
Synonyms
CHEMBL147511; BDBM50135806; di[17-cyclobutylmethyl-(1R,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-yl] sebacate
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.09 nM
External Link
CID: 9897164
TTD: D0B8MY
 Compound Name MCL-428 Investigative [140]
Synonyms
CHEMBL242048
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.12 nM
External Link
CID: 44427183
TTD: D0C2UQ
 Compound Name H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-3,5-Bzl(CF3)2 Investigative [151]
Synonyms
CHEMBL406030; BDBM21013; C-terminal modified bifunctional peptide, 6
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24768356
TTD: D0C6RQ
 Compound Name MCL-448 Investigative [115]
Synonyms
CHEMBL242968; BDBM50210550
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.4 nM
External Link
CID: 44429062
TTD: D0C7MP
 Compound Name H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-O-Bzl Investigative [151]
Synonyms
CHEMBL261608; BDBM21009; C-terminal modified bifunctional peptide, 2; benzyl (2S)-2-[(2S)-2-{[(2S)-1-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-phenylpropanoyl]pyrrolidin-2-yl]formamido}-4-methylpentanamido]-3-(1H-indol-3-yl)propanoate
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24768352
TTD: D0CK8C
 Compound Name [Dcp1]Dyn A(1-11)-NH2 Investigative [142]
Synonyms
CHEMBL412997
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44415282
TTD: D0CX0I
 Compound Name SN-23 Investigative [63]
Synonyms
CHEMBL564538
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 45270599
TTD: D0D3UB
 Compound Name 6-desoxonaltrexone Investigative [36]
Synonyms
CHEMBL511816; SCHEMBL3825815; XBPQMXFKKJADMC-WOUAJJJCSA-N; BDBM50278385; 3,14-Dihydroxy-17-cyclopropylmethyl-4,5alpha-epoxymorphinan
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.24 nM
External Link
CID: 13374610
TTD: D0D8AN
 Compound Name 1-benzhydryl-4-(pyridin-2-yl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL393971
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11540 nM
External Link
CID: 10427620
TTD: D0D9BB
 Compound Name 4-(4-((phenethylamino)methyl)phenoxy)benzamide Investigative [72]
Synonyms
CHEMBL238317; SCHEMBL3692341; FARQYUHOSNLRKV-UHFFFAOYSA-N; BDBM50219921
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.15 nM
External Link
CID: 44434950
TTD: D0E0TD
 Compound Name Dmt-Pro-Imp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL228516
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16737137
TTD: D0E1FQ
 Compound Name 14-O-phenylpropylnaltrexone Investigative [156]
Synonyms
CHEMBL514774; SCHEMBL3167650; BDBM50249017
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.34 nM
External Link
CID: 44565511
TTD: D0E6GH
 Compound Name MC-CAM Investigative [157]
Synonyms
CHEMBL386272; BDBM50195674; BDBM50091405; 14-[(4-Chlorocinnamoyl)amino]-4,5alpha-epoxy-17-(cyclopropylmethyl)-3-methoxymorphinan-6-one; 1N-[4-cyclopropylmethyl-10-methoxy-14-oxo-(17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7,9,11(18)-trien-17-yl]-3-(4-chlorophenyl)-(E)-2-propenamide(Methyoclocinnamox (MC-CAM))
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.46 nM
External Link
CID: 44417373
TTD: D0F1EB
 Compound Name MCL-432 Investigative [140]
Synonyms
CHEMBL242047
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.7 nM
External Link
CID: 44427182
TTD: D0F4AN
 Compound Name DAMGO Investigative [158]
Synonyms
DAGO; glyol; Dagol; DAMGE; 78123-71-4; 2-Ala-4-mephe-5-gly-enkephalin; Tyr-ala-gly-(nme)phe-gly-ol; Enkephalin, ala(2)-mephe(4)-gly(5)-; RX 783006; (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin; Ala(2)-mephe(4)-gly-ol(5) enkephalin; CHEBI:272; CHEMBL38874; Tyr-D-Ala-Gly-MePhe-Gly-ol; Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)-; H-Tyr-D-Ala-Gly-N-Me-Phe-Glycinol; Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-; [3H]DAMGO; L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.28 nM
External Link
CID: 5462471
TTD: D0F8CV
 Compound Name DPDPE Investigative [158]
Synonyms
2,5-Pen-enkephalin; (D-Pen2,D-Pen5)-Enkephalin; Enkephalin, D-penicillamine (2,5)-; (4s,7s,13s)-7-benzyl-3,3,14,14-tetramethyl-6,9,12-trioxo-13-(l-tyrosylamino)-1,2-dithia-5,8,11-triazacyclotetradecane-4-carboxylic acid; DPLPE; c[D-Pen(2,5)]-enkephalin; CHEMBL31421; CHEBI:73356; Enkephalin, penicillamine(2,5)-; cyclo-[D-Pen(2,5)]-enkephalin; 88373-73-3; D-penicillamine-(2,5)-enkephalin; H-Tyr-c(D-Pen-Gly-Phe-D-Pen)-OH; [D-Pen(2)-D-Pen(5)]-enkephaline; H-Tyr-cyclo-(D-Pen-Gly-Phe-D-Pen)-OH; [3H]DPDPE; D-Valine, L-tyros
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1.6 nM
External Link
CID: 104787
TTD: D0G4NM
DrugBank: DB08861
 Compound Name Tyr-D-Ala-Gly-Phe-Met-Pro-Leu-Trp-NH-Bzl Investigative [159]
Synonyms
CHEMBL448998
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25129135
TTD: D0G6GC
 Compound Name MCL-147 Investigative [115]
Synonyms
CHEMBL242756; SCHEMBL14419222; Aminothiazolo-N-Cyclopropylmorphinan
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.5 nM
External Link
CID: 9798655
TTD: D0G7FB
 Compound Name 6-(4-(3-(benzylamino)propyl)phenoxy)nicotinamide Investigative [72]
Synonyms
CHEMBL236170; SCHEMBL3697663; FZBJOVYOONJNIG-UHFFFAOYSA-N; BDBM50219917
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 22.26 nM
External Link
CID: 44434946
TTD: D0H0KP
 Compound Name dynorphin B Investigative [27]
Synonyms
rimorphin
    Click to Show/Hide
MOA Agonist
External Link
CID: 25075991
TTD: D0H0OO
 Compound Name H-Cdp-Gly-Gly-Phe-Leu-OH Investigative [37]
Synonyms
CHEMBL246739
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 9.8 nM
External Link
CID: 44439880
TTD: D0HB6O
 Compound Name Dimepheptanol Investigative [153]
Synonyms
Methadol; Racemethadol; Pangerin; Bimethadol; 545-90-4; NIH 2933; Betamethadol; Betametadol; 6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEPTANOL; 3-HEPTANOL, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-; Dimepheptanolum; Dimefeptanol; Dimefeptanolo; Bimethadolum; (-)-beta-Methadol; Betametadolo [DCIT]; (3S,6R)-Methadol; beta-Methadol, (-)-; Betametadol [INN-Spanish]; Dimefeptanolo [DCIT]; Betamethadolum [INN-Latin]; 3-Heptanol,4-diphenyl-, hydrochloride; Betamethadol [INN:BAN:DCF]; DEA No. 9609; Dimefeptanol [INN-Spanish]; Dimepheptanolum [IN
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 28397
TTD: D0HC3H
 Compound Name H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]NH2 Investigative [150]
Synonyms
CHEMBL220219
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16116220
TTD: D0HV6H
 Compound Name 6-(4-((phenethylamino)methyl)phenoxy)nicotinamide Investigative [58]
Synonyms
CHEMBL238361; SCHEMBL3702187
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.07 nM
External Link
CID: 44434058
TTD: D0I1NG
 Compound Name C[L-mTyr-D-pro-L-Phe-D-trp] Investigative [74]
Synonyms
CHEMBL510506
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 37 nM
External Link
CID: 44583376
TTD: D0I2CE
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-Trp-D-Nle-D-Asp-D-Phe-H Investigative [113]
Synonyms
CHEMBL218651
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16100409
TTD: D0I9PH
 Compound Name PHENAZOCINE Investigative [106]
Synonyms
PHENAZOCINE HYDROBROMIDE; Narphen; Phenazocine (+-)- hydrobromide; EINECS 214-982-5; 1239-04-9; 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocin-8-ol hydrobromide; 2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan hydrobromide; 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-, hydrobromide; NIH 7519 hydrobromide; AC1L24DX; C22H27NO.HBr; SCHEMBL396395; PHENETHYLAZOCINE BROMIDE; 127-35-5 (Parent); CHEMBL2107297; DTXSID20872382; AKOS022180090; LS-90611
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 14707
TTD: D0I9SX
 Compound Name 1-benzhydryl-4-(4-propylphenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL393675
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11430 nM
External Link
CID: 44430013
TTD: D0IL9H
 Compound Name MCL-445 Investigative [115]
Synonyms
CHEMBL243195; BDBM50210553
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 22 nM
External Link
CID: 44429065
TTD: D0IY2V
 Compound Name MCL-449 Investigative [140]
Synonyms
CHEMBL427862
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.29 nM
External Link
CID: 44427177
TTD: D0J3NK
 Compound Name N-(17-Methylmorphinan-3-yl)-N'-phenylurea Investigative [104]
Synonyms
CHEMBL568829; BDBM50303599
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11 nM
External Link
CID: 44628003
TTD: D0K1BV
 Compound Name MCL-431 Investigative [140]
Synonyms
CHEMBL241823
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4.8 nM
External Link
CID: 44427175
TTD: D0K4XQ
 Compound Name Dmt-Pro-Tmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL228503
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16737135
TTD: D0KL5N
 Compound Name Dhp-c[D-Cys-Gly-Phe(pNO2)-D-Cys]NH2 Investigative [142]
Synonyms
CHEMBL386043
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44415281
TTD: D0L0NI
 Compound Name H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-3,5-Bzl(CF3)2 Investigative [151]
Synonyms
CHEMBL438389; BDBM21012; C-terminal modified bifunctional peptide, 5
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 9.5 nM
External Link
CID: 24768355
TTD: D0L2CT
 Compound Name MCL-149 Investigative [115]
Synonyms
CHEMBL299220; 3-aminocyclorphan; SCHEMBL13383188; 3-Amino-N-cyclopropylmethylmorphinan; ZINC13532322
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.3 nM
External Link
CID: 11392313
TTD: D0L5DN
 Compound Name LOFENTANIL Investigative [160]
Synonyms
Lofentanil oxalate; Lofentanil oxalate [USAN]; Lofentanil oxalate (USAN); 61380-41-4; Lofentaniloxalat; R 34995; EINECS 262-750-7; cis-(-)-4-(Methoxycarbonyl)-3-methyl-1-phenethyl-4-(N-phenylpropionylamino)piperidinium hydrogen oxalate; R 34,995; AC1L23D4; (-)-Methyl cis-3-methyl-1-phenethyl-4-(N-phenylpropionamido)isonipecotate oxalate (1:1); FT-0670830; D04764; UNII-6C1599T3OQ component CBKLICUQYUTWQL-XWGBWKJCSA-N; methyl (3S,4R)-3-methyl-1-phenethyl-4-(N-propanoylanilino)piperidine-4-carboxylate
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.14 nM
External Link
CID: 10070040
TTD: D0L6QN
DrugBank: DB09174
 Compound Name H-Tyr-Gly-Gly-Phe-Met-NH2 Investigative [37]
Synonyms
[Met5]-Enkephalin Amide; [Met5]-Enkephalin, amide; CHEMBL247368; 60117-17-1; Tyr-Gly-Gly-Phe-Met-NH2; Met-enkephalinamide; L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-; Enkephalinamide-met-; Methionine enkephalinamide; AC1L3X5D; CTK2F3118; HY-P1467; ZINC28893234; BDBM50207823; AKOS030610304; CS-0044396; A833448; (2S)-2-[[(2S)-2-[2-[2-[[(2S)-2-azanyl-3-(4-hydroxyphenyl)propanoyl]amino]ethanoylamino]ethanoylamino]-3-phenyl-propanoyl]amino]-4-methylsulfanyl-butanamide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 12 nM
External Link
CID: 123704
TTD: D0L8LX
 Compound Name ELAEOCARPENINE Investigative [161]
MOA Inhibitor
Activity Ki = 18000 nM
External Link
CID: 16747727
TTD: D0M1YV
 Compound Name Beta-endorphin Investigative [162]
Synonyms
UNII-3S51P4W3XQ; 3S51P4W3XQ; 61214-51-5; LPH (61-91); beta-Endorphin, human; SCHEMBL6238339; CHEMBL1866903; EINECS 262-330-3; beta-Endorphin human, &gt; NCGC00163196-01; NCGC00163196-02; 27-L-Tyrosine-31-L-glutamic acid-beta-endorphin (sheep); beta-Endorphin (sheep), 27-L-tyrosine-31-L-glutamic acid-
    Click to Show/Hide
MOA Antagonist
External Link
CID: 16132316
TTD: D0N8LP
 Compound Name MCL-451 Investigative [141]
Synonyms
CHEMBL384915; H-Dmt-Tic-beta-Ala-OH
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1100 nM
External Link
CID: 16083058
TTD: D0NA7G
 Compound Name normorphine Investigative [27]
Synonyms
466-97-7; Desmethylmorphine; UNII-XUI1Y24IMI; Demethylmorphine; N-Normorphine; XUI1Y24IMI; NSC 270042; CHEBI:7633; ONBWJWYUHXVEJS-ZTYRTETDSA-N; Normorfina [INN-Spanish]; Normorphinum [INN-Latin]; 4,5-Epoxy-3,6-dihydroxymorphin-7-ene; Normorphine [INN:BAN:DCF]; Normorfina; Normorphinum; EINECS 207-381-4; N-Demethylmorphine; BRN 5297209; CHEMBL1227; DEA No. 9313; Normorphine (7,8-Didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol)
    Click to Show/Hide
MOA Agonist
External Link
CID: 5462508
TTD: D0NV5N
 Compound Name 6-(4-(2-(benzylamino)ethyl)phenoxy)nicotinamide Investigative [58]
Synonyms
CHEMBL237066; 6-[4-(2-benzylamino-ethyl)-phenoxy]-nicotinamide; SCHEMBL3698270; FCDWJNPFPYAKET-UHFFFAOYSA-N; BDBM50219925
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2.25 nM
External Link
CID: 44434057
TTD: D0O1JD
 Compound Name Diprenorphine Investigative [163]
Synonyms
14357-78-9; UNII-1F0L5N25ZZ; CHEMBL281786; CHEBI:4650; 1F0L5N25ZZ; DEA No. 9058; M50-50 Injection; Diprenorphine [INN:BAN]; Diprenorphinum [INN-Latin]; Diprenorfina [INN-Spanish]; Diprenorphinum; Diprenorfina; EINECS 238-325-7; 21-Cyclopropyl-6,7,8,14-tetrahydro-7alpha-(1-hydroxy-1-methylethyl)-6,14-endo-ethanooripavine; Diprenorfin; (5 ,7 )-17-(Cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy- , -dimethyl-6,14-ethenomorphinan-7-methanol; 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-4
    Click to Show/Hide
MOA Antagonist
Activity Ki = 0.07 nM
External Link
CID: 443408
TTD: D0O6SB
DrugBank: DB01548
 Compound Name H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NMe-Bzl Investigative [151]
Synonyms
CHEMBL272665; BDBM21011; C-terminal modified bifunctional peptide, 4
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24768354
TTD: D0P0RB
 Compound Name 2-Hydroxymethyl-3-hydroxymorphinan Investigative [104]
Synonyms
CHEMBL570449
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 15 nM
External Link
CID: 44626540
TTD: D0P5QI
 Compound Name N-Benzyl-17-(cyclobutylmethyl)morphinan-3-amine Investigative [104]
Synonyms
CHEMBL571560; MCL-630
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.7 nM
External Link
CID: 44627901
TTD: D0P6FF
 Compound Name MCL-154 Investigative [147]
Synonyms
CHEMBL151872; BDBM50135811; (1R,9R,10R)-17-(cyclobutylmethyl)-4-[(10-{[(1R,9R,10R)-17-(cyclobutylmethyl)-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-trien-4-yl]oxy}decyl)oxy]-17-azatetracyclo[7.5.3.0^{1,10}.0^{2,7}]heptadeca-2(7),3,5-triene
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 66 nM
External Link
CID: 44365804
TTD: D0Q5AJ
 Compound Name H-Tyr-D-Ala-Gly-Phe-Pro-Leu-Trp-NH-Bzl Investigative [151]
Synonyms
CHEMBL271619; BDBM21010; C-terminal modified bifunctional peptide, 3
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 24768353
TTD: D0Q7HG
 Compound Name H-Tyr-c[D-Allylgly-Gly-Phe-D-Allylgly]-OH Investigative [152]
Synonyms
rDADAE (11); CHEMBL229441; BDBM21127; single bond H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH; reduced bond-c[2-D-allylglycine, 5-D-allylglycine]enkephalin; (5S,8R,13R)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-5-benzyl-3,6,14-trioxo-1,4,7-triazacyclotetradecane-8-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16733489
TTD: D0R1AB
 Compound Name HERKINORIN Investigative [46]
Synonyms
CHEMBL363324; 862073-77-6; BF3DNCA methyl ester; 9-(benzoyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho(2,1-c)pyran-7-carboxylic acid methyl ester; SCHEMBL3540059; DTXSID30235444; MolPort-003-983-869; PYDQMXRFUVDCHC-XAGHGKQISA-N; ZINC28461930; BDBM50170678; (3S,4aR,4bS,6S,8R,8aR,10aR)-6-Benzoyloxy-3-furan-3-yl-4a,8a-dimethyl-1,5-dioxo-dodecahydro-2-oxa-phenanthrene-8-carboxylic acid methyl ester
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 12 nM
External Link
CID: 11431898
TTD: D0R4QF
 Compound Name ENDOMORPHIN-1 Investigative [164]
Synonyms
Endomorphin 1; 189388-22-5; Tyr-Pro-Trp-Phe-Nh2; H-Tyr-Pro-Trp-Phe-NH2; CHEMBL316446; L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-tryptophyl-; (S)-N-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamide; (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 0.001 nM
External Link
CID: 5311080
TTD: D0R5TA
 Compound Name Clocinnamox Investigative [156]
Synonyms
Methoclocinnamox; C-CAM; 14-beta-(4-Chlorocinnamoylamino)-7,8-dihydro-N-cyclopropylmethylnorpmorphine mesylate; Clocinnamox mesylate; 117332-69-1; 2-Propenamide, 3-(4-chlorophenyl)-N-((5alpha)-17-(cyclopropylmethyl)-4,5-epoxy-3-hydroxy-6-oxomorphinan-14-yl)-, monomethanesulfonate; NIH 10443 mesylate; NIH 10989; SCHEMBL4404383; AKOS024259103
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.25 nM
External Link
CID: 6540640
TTD: D0R6VF
 Compound Name Cis-H-Tyr-c[D-AllylGly-Gly-Phe-D-Allylgly]-OH Investigative [152]
Synonyms
cDADAE(8); CHEMBL375025; BDBM21125; (5S,8R,10Z,13R)-13-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-5-benzyl-3,6,14-trioxo-1,4,7-triazacyclotetradec-10-ene-8-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 2.35 nM
External Link
CID: 16733485
TTD: D0R7LY
 Compound Name H-Cdp-ala-Gly-Phe-leu-OH Investigative [37]
Synonyms
CHEMBL247758
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 9.8 nM
External Link
CID: 44439876
TTD: D0S5FN
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-Bo Investigative [113]
Synonyms
CHEMBL217957
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16100407
TTD: D0S7SO
 Compound Name Bis-((-)-N-propargylmorphinan-3-yl) sebacoylate Investigative [136]
Synonyms
CHEMBL372823
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 14 nM
External Link
CID: 44406704
TTD: D0SC3W
 Compound Name ethylketocyclazocine Investigative [27]
Synonyms
CHEMBL71301; AC1L28LJ; GTPL1602; BDBM50017232; L024009
    Click to Show/Hide
MOA Agonist
External Link
CID: 443409
TTD: D0T5EI
 Compound Name 3-desoxy-3-carboxamidonaltrexone Investigative [36]
Synonyms
CHEMBL56695; SCHEMBL2785528; QAICPHMNUHNDMC-WUHBCXKYSA-N; BDBM50128411; 6-Oxo-17-(cyclopropylmethyl)-14-hydroxy-4,5alpha-epoxymorphinan-3-carboxamide; (5a)-17-(cyclopropylmethyl)-14-hydroxy-6-oxo-4,5-epoxymorphinan-3-carboxamide
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.71 nM
External Link
CID: 10021946
TTD: D0T6OQ
 Compound Name Dmt-Pro-Emp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL374818
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736880
TTD: D0TB4A
 Compound Name METAZOCINE Investigative [75]
Synonyms
Methobenzmorphan; 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-3,6,11-trimethyl-; NSC611380; 3734-52-9; 2'-Hydroxy-2,5,9-trimethyl-6,7-benzomorphan; AC1Q7AHP; AC1L1XA2; SCHEMBL26347; CHEMBL33376; YGSVZRIZCHZUHB-UHFFFAOYSA-N; PDSP1_001246; PDSP2_001230; NSC-611380; LS-90663; LS-90665
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 62518
TTD: D0TN0D
 Compound Name SN-28 Investigative [165]
Synonyms
CHEMBL552308; SCHEMBL16248949
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44467662
TTD: D0TO0E
 Compound Name ETONITAZENE Investigative [143]
Synonyms
Etonitazine; Etonitazinum; Ciba 20-684BA; ARC 1G2; Etobedolum; 911-65-9; Etonitazenum [INN-Latin]; NIH 7607; Etonitazeno [INN-Spanish]; Etonitazene [INN:BAN:DCF]; UNII-9U3GT3353T; EINECS 213-009-1; Ba-20684; Ba 20684; BRN 0363324; CHEMBL312040; DEA No. 9624; PXDBZSCGSQSKST-UHFFFAOYSA-N; C22H28N4O3; 9U3GT3353T; 1-(2-(Diethylamino)ethyl)-2-(p-ethoxybenzyl)-5-nitrobenzimidazole; 1-(2-Diethylaminoethyl)-2-(p-ethoxybenzyl)-5-nitrobenzimidazole; 1H-Benzimidazole-1-ethanamine, 2-((4-ethoxyphenyl)methyl)-N,N-diethyl-5-nitro-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.2 nM
External Link
CID: 13493
TTD: D0U3UM
DrugBank: DB01462
 Compound Name H-Cpa-Gly-Gly-Phe-Met-NH2 Investigative [37]
Synonyms
CHEMBL246956
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 18 nM
External Link
CID: 44439866
TTD: D0U7JS
 Compound Name SN-11 Investigative [63]
Synonyms
CHEMBL559518
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 23642304
TTD: D0UG8H
 Compound Name Benzyl derivative of M6G Investigative [149]
Synonyms
CHEMBL366917
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.5 nM
External Link
CID: 44390359
TTD: D0UR7D
 Compound Name Tyr-D-Nle-Gly-D-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 15; CHEMBL205306; BDBM21145; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]hexanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11722088
TTD: D0V0RB
 Compound Name HTyr-Gly-Gly-Phe-Leu-Arg-Arg-lle-Arg-Pro-LysNH2 Investigative [133]
Synonyms
CHEMBL216640; Dynorphin A (1-11) amide; Dynorphin A(1-11) amide; 79985-48-1; Dyn A(1-11)-NH2; Linear Dyn A-(1-11)NH2; BDBM50010704; BDBM50033143; H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-NH2; Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-D-Lys-NH2; TYR-GLY-GLY-PHE-LEU-ARG-ARG-ILE-ARG-PRO-LYS-LEU-LYS-TRP-ASP-ASN-GLN-NH2
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 5.62 nM
External Link
CID: 10677974
TTD: D0VO7C
 Compound Name 17-(Cyclobutylmethyl)-N-phenylmorphinan-3-amine Investigative [104]
Synonyms
CHEMBL570225
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1.7 nM
External Link
CID: 44627903
TTD: D0W0CO
 Compound Name MCL-444 Investigative [140]
Synonyms
CHEMBL263096
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.3 nM
External Link
CID: 44427179
TTD: D0W2DN
 Compound Name H-Tyr-c[D-Cys-Gly-Phe-D-Cys]NH2 Investigative [150]
Synonyms
CHEMBL220327
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44420667
TTD: D0W6OP
 Compound Name Dmt-Pro-Dmp-Phe-NH2 Investigative [99]
Synonyms
CHEMBL228409
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16736727
TTD: D0X0XV
 Compound Name H-Tyr-c[D-Cys-Gly-Phe-L-Cys]NH2 Investigative [150]
Synonyms
CHEMBL373572
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44420674
TTD: D0X6BU
 Compound Name Tyr-Gly-Gly-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CHEMBL336381; CCK-Opioid Peptide, 6; BDBM21136; (3S)-3-[(2S)-2-[(2S)-2-(2-{2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]acetamido}acetamido)-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 610 nM
External Link
CID: 11061906
TTD: D0X7LC
 Compound Name N-(4-Iodophenyl)-N'-(17-methylmorphinan-3-yl)urea Investigative [104]
Synonyms
CHEMBL569724; BDBM50303601
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 17 nM
External Link
CID: 44626534
TTD: D0Y5ZP
 Compound Name 1-benzhydryl-4-(4-ethylphenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL234543
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3433 nM
External Link
CID: 44430012
TTD: D0Y7KE
 Compound Name RTI-5989-31 Investigative [166]
Synonyms
SCHEMBL6288083
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3.1 nM
External Link
CID: 22977851
TTD: D0Y8NO
 Compound Name 6-(4-((benzylamino)methyl)phenoxy)nicotinamide Investigative [72]
Synonyms
CHEMBL238316; SCHEMBL3700197; LUBVSQAMVPXMBJ-UHFFFAOYSA-N; BDBM50219916
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2.43 nM
External Link
CID: 44434949
TTD: D0YU5H
 Compound Name [Leu5]enkephalin Investigative [167]
Synonyms
[Leu5]-Enkephalin; 58822-25-6; Enkephalin; Enkephalin L; [Leu 5]enkephalin; UNII-RI01R707R6; [5-Leucine]Enkephalin; Tyr-Gly-Gly-Phe-Leu-OH; CHEMBL8234; H-Tyr-Gly-Gly-Phe-Leu-OH; CHEBI:89656; RI01R707R6; Enkephalins; L-Leucine, N-(N-(N-(N-L-tyrosylglycyl)glycyl)-L-phenylalanyl)-; Leucyl-enkephalin
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11.4 nM
External Link
CID: 9985128
TTD: D0Z5JD
 Compound Name C[L-Phe-D-pro-L-mTyr-D-trp] Investigative [74]
Synonyms
CHEMBL509201
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 40 nM
External Link
CID: 44583386
TTD: D0Z8JX
 Compound Name 3-Methylfentanyl Investigative [168]
Synonyms
Mefentanyl; 3-MF; 42045-86-3; N-(3-Methyl-1-(2-phenylethyl)-4-piperidinyl)-N-phenylpropanamide; F 7209; DEA No. 9813; Propanamide, N-(3-methyl-1-(2-phenylethyl)-4-piperidinyl)-N-phenyl-; CHEBI:61092; N-(3-Methyl-1-(2-phenylethyl)-4-piperidyl)-N-phenylpropanamide; N-[3-methyl-1-(2-phenylethyl)piperidin-4-yl]-N-phenylpropanamide; 3-methyl-fentanyl; C23H30N2O; 3-Methylfentanil; AC1L1WAM; Epitope ID:153511; AC1Q5I8R; SCHEMBL2337401; HSDB 8379; CTK1D6517; MLQRZXNZHAOCHQ-UHFFFAOYSA-N; DB01571; LS-119344; R-26800
    Click to Show/Hide
MOA Agonist
External Link
CID: 61996
TTD: D0ZH3G
DrugBank: DB01571
 Compound Name ENDOMORPHIN 2 Investigative [91]
Synonyms
Endomorphin-2; 141801-26-5; H-Tyr-Pro-Phe-Phe-NH2; UNII-3PH5M0466G; CHEMBL333357; 3PH5M0466G; L-Phenylalaninamide,L-tyrosyl-L-prolyl-L-phenylalanyl-; (S)-N-((S)-1-((S)-1-amino-1-oxo-3-phenylpropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-1-((S)-2-amino-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamide; (2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
    Click to Show/Hide
MOA Inhibitor
Activity EC50 = 0.04 nM
External Link
CID: 5311081
TTD: D00TNR
 Compound Name 4-phenyl-1-(1-phenylbutyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL230145
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 341 nM
External Link
CID: 44426807
TTD: D00YCW
 Compound Name Tyr-D-Phe-Gly-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 1; CHEMBL218763; BDBM21131; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 9811733
TTD: D01AQC
 Compound Name 1-(dio-tolylmethyl)-4-phenylpiperidin-4-ol Investigative [148]
Synonyms
CHEMBL389665
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2147 nM
External Link
CID: 9820782
TTD: D01WMU
 Compound Name 4-(Spiro[chromene-2,4'-piperidine]-4-yl)phenol Investigative [169]
Synonyms
CHEMBL495074; SCHEMBL471335; BDBM50252834
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 25129433
TTD: D02EIB
 Compound Name Tyr-D-Phe-Gly-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 7; CHEMBL382051; BDBM21137; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11051303
TTD: D03EPA
 Compound Name 1-benzhydryl-4-ethoxy-4-phenylpiperidine Investigative [148]
Synonyms
CHEMBL229016
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 377 nM
External Link
CID: 10022129
TTD: D03PTV
 Compound Name 8-azabicyclo[3.2.1]octan-3-yloxy-benzamide Investigative [170]
Synonyms
CHEMBL1257578; CHEMBL1223815; SCHEMBL15031381; BDBM50325848; BDBM50327244; AZ-MTAB, &gt; ZINC101363709
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 721 nM
External Link
CID: 49765077
TTD: D03RBD
 Compound Name 1-benzhydryl-4-butylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL397761; SCHEMBL13597038
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 272 nM
External Link
CID: 22970051
TTD: D03UJW
 Compound Name 4-phenyl-1-(1-phenylheptyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL231607
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 144 nM
External Link
CID: 44426812
TTD: D04ZQX
 Compound Name Tyr-D-Ala-Gly-D-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 14; CHEMBL383458; BDBM21144; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11520765
TTD: D06BRA
 Compound Name 1-benzhydryl-4-(3-methoxyphenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL233494
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2988 nM
External Link
CID: 44430018
TTD: D06MQG
 Compound Name 1-benzhydryl-4-phenylpiperidin-4-ol Investigative [171]
Synonyms
CHEMBL228690
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 207 nM
External Link
CID: 10269001
TTD: D06PHT
 Compound Name 1-benzhydryl-4-p-tolylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL393985
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 940 nM
External Link
CID: 9924923
TTD: D07CIU
 Compound Name Tyr-D-Ala-Gly-D-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 11; CHEMBL206974; BDBM21141; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 20 nM
External Link
CID: 11556976
TTD: D07ICW
 Compound Name Tyr-D-Nle-Gly-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 9; CHEMBL208479; BDBM21139; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]hexanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11564210
TTD: D07LQQ
 Compound Name 1-benzhydryl-4-(4-bromophenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL232067; BDBM50210228
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1057 nM
External Link
CID: 10093682
TTD: D07NMH
 Compound Name 1-benzhydryl-4-hexylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL234773
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 8899 nM
External Link
CID: 44430026
TTD: D08DVV
 Compound Name 1-benzhydryl-4-(3-phenylpropyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL231664
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3364 nM
External Link
CID: 44430029
TTD: D08QBU
 Compound Name 1-benzhydryl-4-cyclohexylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL394695
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 407 nM
External Link
CID: 10043439
TTD: D08TFY
 Compound Name 1-benzhydryl-4-o-tolylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL232273
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 74 nM
External Link
CID: 20481138
TTD: D09BYD
 Compound Name Tyr-D-Phe-Gly-D-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 13; CHEMBL379405; BDBM21143; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11136782
TTD: D09EMR
 Compound Name 4-phenyl-1-(phenyl(o-tolyl)methyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL388123
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 246 nM
External Link
CID: 9863568
TTD: D09FJY
 Compound Name 1-benzhydryl-4-(3-fluorophenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL395838
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 705 nM
External Link
CID: 44430008
TTD: D09LRO
 Compound Name 1-(1,2-diphenylethyl)-4-phenylpiperidin-4-ol Investigative [148]
Synonyms
CHEMBL397945
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 24 nM
External Link
CID: 44426814
TTD: D09VRT
 Compound Name Dihydromorphine Investigative [172]
Synonyms
Paramorphan; 7,8-DIHYDROMORPHINE; 6-alpha-Hydromorphol; 509-60-4; Dihydromorfin [Czech]; UNII-C3S5FRP6JW; Hydromorphine; Paramorfan; Morphine, dihydro-; EINECS 208-100-8; C3S5FRP6JW; NSC 117865; Dihydromorfin; CHEBI:4575; DEA No. 9145; Morphinan-3,6alpha-diol, 4,5alpha-epoxy-17-methyl-; Morphinan-3,6-alpha-diol, 4,5-alpha-epoxy-17-methyl-; (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol; 7,8-Dihydromorphin; 1421-28-9; dihydromorphin
    Click to Show/Hide
MOA Agonist
External Link
CID: 5359421
TTD: D0B7GU
DrugBank: DB01565
 Compound Name 1-benzhydryl-4-(thiophen-2-yl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL233323
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1734 nM
External Link
CID: 10315818
TTD: D0D0UP
 Compound Name O-DESMETHYL TRAMADOL Investigative [106]
Synonyms
O-Desmethyltramadol; CHEMBL1400; (-)-O-Desmethyl Tramadol; 80456-81-1; 2-[(Dimethylamino)methyl]-1-(3-hydroxyphenyl)cyclohexanol; CHEMBL201556; O-Demethyl tramadol; tramadol M1 metabolite; Mono-O-demethyltramadol; 144830-15-9; 3-{(1R,2R)-2-[(dimethylamino)methyl]-1-hydroxycyclohexyl}phenol; 3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol; (+)-O-Desmethyltramadol; SCHEMBL2517055; CTK8E8372; UWJUQVWARXYRCG-HIFRSBDPSA-N; ZINC2509756; BDBM50176258; BDBM50176263; Phenol, 3-(2-((dimethylamino)me
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 8.6 nM
External Link
CID: 9838803
TTD: D0D5QV
 Compound Name Tyr-D-Nle-Gly-D-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 12; CHEMBL408083; BDBM21142; (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]hexanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11614928
TTD: D0E2OG
 Compound Name 1-benzhydryl-4-(4-methoxyphenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL401234
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 11050 nM
External Link
CID: 10384734
TTD: D0G4FA
 Compound Name 4-phenyl-1-(phenyl(m-tolyl)methyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL390279
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 147 nM
External Link
CID: 44426827
TTD: D0G7DF
 Compound Name 1-benzhydryl-4-m-tolylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL437380
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 273 nM
External Link
CID: 44430009
TTD: D0J5JO
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-D-Trp-H Investigative [126]
Synonyms
CHEMBL375412
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408484
TTD: D0J7GJ
 Compound Name 1-benzhydryl-4-(2-fluorophenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL232476
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 589 nM
External Link
CID: 44430007
TTD: D0JH5D
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-Nle-Trp-Boc Investigative [126]
Synonyms
CHEMBL405192
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408524
TTD: D0N6DN
 Compound Name 4-phenyl-1-(1-phenylhexyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL230253
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 37 nM
External Link
CID: 44426810
TTD: D0O7JV
 Compound Name 4-phenyl-1-(1-phenylpentyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL390882
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 29 nM
External Link
CID: 44426808
TTD: D0P3FP
 Compound Name 1-benzhydryl-4-methoxy-4-phenylpiperidine Investigative [148]
Synonyms
CHEMBL228965
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 412 nM
External Link
CID: 10043898
TTD: D0Q9TQ
 Compound Name 1-benzhydryl-4-(4-fluorophenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL232066
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 771 nM
External Link
CID: 10089987
TTD: D0QH4A
 Compound Name Tyr-D-Ala-Gly-Phe-NH-NH-Phe-Asp-NMeNle-D-Trp-Boc Investigative [126]
Synonyms
CHEMBL374325
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44408526
TTD: D0QP2S
 Compound Name Tyr-D-Ala-Gly-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 2; CHEMBL382349; BDBM21132; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 11040230
TTD: D0R4GI
 Compound Name 1-(2-ethoxy-1-phenylethyl)-4-phenylpiperidin-4-ol Investigative [148]
Synonyms
CHEMBL228687
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 451 nM
External Link
CID: 44426817
TTD: D0T4ZY
 Compound Name 1-benzhydryl-4-(2-methoxyphenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL233493
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 983 nM
External Link
CID: 44430016
TTD: D0T9KE
 Compound Name Tyr-D-Phe-Gly-D-Trp-NMeNle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 10; CHEMBL218327; BDBM21140; H-Tyr-DPhe-Gly-DTrp-NMeNle-Asp-Phe-NH(2); (3S)-3-[(2S)-2-[(2R)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]-3-phenylpropanamido]acetamido}-3-(1H-indol-3-yl)-N-methylpropanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10942040
TTD: D0TR0U
 Compound Name Tyr-D-Ala-Gly-Trp-Nle-Asp-Phe-NH2 Investigative [64]
Synonyms
CCK-Opioid Peptide, 8; CHEMBL262172; BDBM21138; (3S)-3-[(2S)-2-[(2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl)propanamido]propanamido]acetamido}-3-(1H-indol-3-yl)propanamido]hexanamido]-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}propanoic acid
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 10909103
TTD: D0U6OA
 Compound Name H-Tyr-D-Ala-Gly-Phe-NH-NH-D-Trp-Nle-Asp-Phe-H Investigative [113]
Synonyms
CHEMBL386212
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16100410
TTD: D0V9DY
 Compound Name 1-benzhydryl-4-(4-chlorophenyl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL392753
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 936 nM
External Link
CID: 10091033
TTD: D0W3VT
 Compound Name 1-benzhydryl-4-phenyl-4-propoxypiperidine Investigative [148]
Synonyms
CHEMBL229017
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 1649 nM
External Link
CID: 10317947
TTD: D0X4SX
 Compound Name 4-phenyl-1-(phenyl(p-tolyl)methyl)piperidin-4-ol Investigative [148]
Synonyms
CHEMBL228793
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3728 nM
External Link
CID: 44426828
TTD: D0XX1Y
 Compound Name 1-benzhydryl-4-(furan-2-yl)piperidin-4-ol Investigative [127]
Synonyms
CHEMBL231874
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 4554 nM
External Link
CID: 10336926
TTD: D0Y5LJ
 Compound Name 1-benzhydryl-4-benzylpiperidin-4-ol Investigative [127]
Synonyms
CHEMBL231661
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 10390 nM
External Link
CID: 44430028
TTD: D0ZE2W
 Compound Name ICI-199441 Investigative [173]
Synonyms
115199-84-3; ICI-199,441 HYDROCHLORIDE; ICI 199,441 hydrochloride; Ici 199441; Ici 199,441; AC1MIZCX; N-(2-(N-Methyl-3,4-dichlorophenylacetamido)-2-phenylethyl)pyrrolidine; SCHEMBL7647023; CTK8E9897; MolPort-023-275-929; AKOS024458644; (S)-3,4-Dichloro-N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)benzeneacetamide monohydrochloride; RT-013313; B6448; J-003264; Benzeneacetamide, 3,4-dichloro-N-methyl-N-(1-phenyl-2-(1-pyrrolidinyl)ethyl)-, monohydrochloride, (S)-
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 53 nM
External Link
CID: 3082718
TTD: D03SAV
 Compound Name FALCARINDIOL Investigative [174]
Synonyms
55297-87-5; 1,9-Heptadecadiene-4,6-diyne-3,8-diol; Heptadeca-1,9-diene-4,6-diyne-3,8-diol; AC1L1FO2; SCHEMBL16680213; CTK1C6414; 225110-25-8; AKOS030230026; AN-40378; 4CN-1774
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 5281148
TTD: D08UOX
 Compound Name 4-(Spiro[chromene-2,4'-piperidine]-4-yl)benzamide Investigative [175]
Synonyms
CHEMBL550063; SCHEMBL10266987; BDBM50297313
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 2700 nM
External Link
CID: 44254503
TTD: D0L9YP
 Compound Name SOMATOSTATIN Investigative [90]
Synonyms
51110-01-1; Somiaton; Panhibin; Aminopan; Somatostatin acetate; SRIF; Somatotropin release-inhibiting factor; Somatotropin release-inhibiting hormone; Growth hormone release-inhibiting factor; CCRIS 7071; EINECS 256-969-7; Growth hormone release-inhibiting hormone; AY 24910; Growth hormone release inhibiting factor; Somatostatin 1-14; Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys; NCGC00181005-01; 61950-59-2; [D-Trp8]-SOMATOSTATIN; SCHEMBL3046327
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 16129706
TTD: D0T5RO
DrugBank: DB09099
 Compound Name (+/-)-nantenine Investigative [176]
MOA Inhibitor
Activity Ki = 7265 nM
External Link
CID: 181743
TTD: D0L5MW
 Compound Name 4-(4-butylpiperidin-1-yl)-1-o-tolylbutan-1-one Investigative [177]
Synonyms
AC-42; CHEMBL1242950; AC42; GTPL289; SCHEMBL4504348; ANTKBACNWQHQJE-UHFFFAOYSA-N; ZINC2022527; BDBM50326219; AKOS030284249; NCGC00485453-01; gamma-(4-Butylpiperidino)-2'-methylbutyrophenone; L019209; 4-(4-butylpiperdin-1-yl)-1-(2-methylphenyl)butan-1-one; 4-(4-butylpiperidin-1-yl)-1-(2-methylphenyl)butan-1-one
    Click to Show/Hide
MOA Inhibitor
Activity Ki >= 1000 nM
External Link
CID: 9948320
TTD: D0T2RY
8E43: Pain disorders 1 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name FMX104 Phase 2 [178]
External Link
TTD: D0Z8EA
References
Ref 1 N(6)-Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons. Adv Sci (Weinh). 2020 May 27;7(13):1902402. doi: 10.1002/advs.201902402. eCollection 2020 Jul.
Ref 2 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286. doi: 10.1038/s41573-020-00108-x. Epub 2021 Jan 19.
Ref 3 Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81. doi: 10.1016/j.molcel.2007.01.017.
Ref 4 Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9. doi: 10.1021/ml400496h. eCollection 2014 Feb 13.
Ref 5 Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57. doi: 10.1021/jm100478y.
Ref 6 A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7. doi: 10.1021/cb300139y. Epub 2012 Apr 30.
Ref 7 Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42. doi: 10.1021/jm401480r. Epub 2013 Oct 31.
Ref 8 A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74. doi: 10.1038/nchembio.599.
Ref 9 Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents. Cardiovasc Res. 1999 Dec;44(3):568-78.
Ref 10 Methadone-related opioid agonist pharmacotherapy for heroin addiction. History, recent molecular and neurochemical research and future in mainstream medicine. Ann N Y Acad Sci. 2000;909:186-216.
Ref 11 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
Ref 12 Buprenorphine is a weak partial agonist that inhibits opioid receptor desensitization. J Neurosci. 2009 Jun 3;29(22):7341-8.
Ref 13 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81. doi: 10.1038/nrd4545.
Ref 14 Alvimopan for postoperative ileus. Am J Health Syst Pharm. 2009 Jul 15;66(14):1267-77.
Ref 15 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
Ref 16 Concentration-effect relationship of intravenous alfentanil and ketamine on peripheral neurosensory thresholds, allodynia and hyperalgesia of neuropathic pain. Pain. 2001 Mar;91(1-2):177-87.
Ref 17 Acetylmethadol metabolites influence opiate receptors and adenylate cyclase in amygdala. Eur J Pharmacol. 1981 Jul 10;72(4):343-9.
Ref 18 Abstracts of Poster Presentations: CNS Summit 2013: November 14-17, 2013 Boca Raton, Florida. Innov Clin Neurosci. 2013 Nov-Dec; 10(11-12 Suppl B): 1-18.
Ref 19 Loperamide: a pharmacological review. Rev Gastroenterol Disord. 2007;7 Suppl 3:S11-8.
Ref 20 2017 FDA drug approvals. Nat Rev Drug Discov. 2018 Feb;17(2):81-85. doi: 10.1038/nrd.2018.4. Epub 2018 Jan 19.
Ref 21 The pro-nociceptive effects of remifentanil or surgical injury in mice are associated with a decrease in delta-opioid receptor mRNA levels: Prevent... Pain. 2009 Jan;141(1-2):88-96.
Ref 22 Antianalgesia: stereoselective action of dextro-morphine over levo-morphine on glia in the mouse spinal cord.J Pharmacol Exp Ther.2005 Sep;314(3):1101-8.
Ref 23 OxyContin abuse and overdose. Postgrad Med. 2009 Mar;121(2):163-7.
Ref 24 Clinical pipeline report, company report or official report of kempharm.
Ref 25 Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
Ref 26 Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology. Bioorg Med Chem Lett. 2010 Jan 1;20(1):121-4.
Ref 27 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 319).
Ref 28 2008 FDA drug approvals. Nat Rev Drug Discov. 2009 Feb;8(2):93-6. doi: 10.1038/nrd2813.
Ref 29 Clinical pipeline report, company report or official report of signaturerx.
Ref 30 Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.Biochem Pharmacol.2014 Dec 1;92(3):448-56.
Ref 31 Emerging analgesics in cancer pain management. Expert Opin Emerg Drugs. 2005 Feb;10(1):151-71.
Ref 32 Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist. Br J Anaesth. 2015 Mar;114(3):364-6.
Ref 33 A Review of Abuse-Deterrent Opioids For Chronic Nonmalignant Pain. P T. 2012 July; 37(7): 412-418.
Ref 34 The in vitro pharmacological profile of TD-1211, a neutral opioid receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2013 Jun;386(6):479-91.
Ref 35 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 36 Syntheses of novel high affinity ligands for opioid receptors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2289-94.
Ref 37 Further studies of tyrosine surrogates in opioid receptor peptide ligands. Bioorg Med Chem Lett. 2007 May 1;17(9):2656-60.
Ref 38 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
Ref 39 Wax PM, Becker CE, Curry SC: Unexpected gas casualties in Moscow: a medical toxicology perspective. Ann Emerg Med. 2003 May;41(5):700-5.
Ref 40 Molecular Mechanisms of Opioid Receptor-Dependent Signaling and Behavior. Anesthesiology. 2011 December; 115(6): 1363-1381.
Ref 41 Endomorphin-2: A Biased Agonist at the -Opioid Receptor. Mol Pharmacol. 2012 August; 82(2): 178-188.
Ref 42 Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
Ref 43 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 44 Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists. J Med Chem. 2008 Feb 28;51(4):1058-62.
Ref 45 US patent application no. 6,924,288, Enantiomerically pure opioid diarylmethylpiperzine and methods of using same.
Ref 46 Herkinorin analogues with differential beta-arrestin-2 interactions. J Med Chem. 2008 Apr 24;51(8):2421-31.
Ref 47 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009073)
Ref 48 [3H]Sufentanil, a superior ligand for mu-opiate receptors: binding properties and regional distribution in rat brain and spinal cord. Eur J Pharmacol. 1983 Feb 18;87(2-3):209-25.
Ref 49 Novel opioid antagonists for opioid-induced bowel dysfunction. Expert Opin Investig Drugs. 2011 Aug;20(8):1047-56.
Ref 50 Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin Pharmacol Ther. 1994 Sep;56(3):261-71.
Ref 51 A novel molecule (frakefamide) with peripheral opioid properties: the effects on resting ventilation compared with morphine and placebo. Anesth Analg. 2005 Mar;100(3):713-7, table of contents.
Ref 52 Mirfentanil: pharmacological profile of a novel fentanyl derivative with opioid and nonopioid effects. J Pharmacol Exp Ther. 1991 Aug;258(2):502-10.
Ref 53 DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function. J Pharmacol Exp Ther. 2003 Dec;307(3):1227-33.
Ref 54 Use of receptor chimeras to identify small molecules with high affinity for the dynorphin A binding domain of the kappa opioid receptor. Bioorg Med Chem Lett. 2008 Jun 15;18(12):3667-71.
Ref 55 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026307)
Ref 56 WO patent application no. 2007,0677,14, Treatment of sequelae of psychiatric disorders.
Ref 57 Emerging drugs for obesity: linking novel biological mechanisms to pharmaceutical pipelines. Expert Opin Emerg Drugs. 2005 Aug;10(3):643-60. doi: 10.1517/14728214.10.3.643.
Ref 58 Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6841-6.
Ref 59 Inhibition of cholinergic neurotransmission in human airways by opioids. J Appl Physiol (1985). 1992 Mar;72(3):1096-100.
Ref 60 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003724)
Ref 61 The effects on resting ventilation of intravenous infusions of morphine or sameridine, a novel molecule with both local anesthetic and opioid properties. Anesth Analg. 1999 Jan;88(1):160-5.
Ref 62 Biological and conformational evaluation of bifunctional compounds for opioid receptor agonists and neurokinin 1 receptor antagonists possessing tw... J Med Chem. 2010 Aug 12;53(15):5491-501.
Ref 63 Design and synthesis of novel delta opioid receptor agonists and their pharmacologies. Bioorg Med Chem Lett. 2009 May 15;19(10):2792-5.
Ref 64 Structure-activity relationships of bifunctional peptides based on overlapping pharmacophores at opioid and cholecystokinin receptors. J Med Chem. 2006 May 18;49(10):2868-75.
Ref 65 Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure. Bioorg Med Chem Lett. 2008 Feb 15;18(4):1350-3.
Ref 66 Live cell monitoring of mu-opioid receptor-mediated G-protein activation reveals strong biological activity of close morphine biosynthetic precursors. J Biol Chem. 2007 Sep 14;282(37):27126-32.
Ref 67 Structure-activity relationship of the novel bivalent and C-terminal modified analogues of endomorphin-2. Bioorg Med Chem Lett. 2005 Apr 1;15(7):1847-50.
Ref 68 Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5.
Ref 69 Opioid receptor binding and antinociceptive activity of the analogues of endomorphin-2 and morphiceptin with phenylalanine mimics in the position 3... Bioorg Med Chem Lett. 2006 Jul 15;16(14):3688-92.
Ref 70 Electrophilic alpha-methylene-gamma-lactone and isothiocyanate opioid ligands related to etorphine. J Med Chem. 1990 Aug;33(8):2286-96.
Ref 71 A topochemical approach to explain morphiceptin bioactivity. J Med Chem. 1993 Mar 19;36(6):708-19.
Ref 72 Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5349-52.
Ref 73 Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selecti... J Med Chem. 1999 Dec 30;42(26):5359-68.
Ref 74 Nascent structure-activity relationship study of a diastereomeric series of kappa opioid receptor antagonists derived from CJ-15,208. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3647-50.
Ref 75 Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates a... J Med Chem. 1982 Dec;25(12):1423-7.
Ref 76 Internalisation of the mu-opioid receptor by endomorphin-1 and leu-enkephalin is dependant on aromatic amino acid residues. Bioorg Med Chem. 2008 Apr 15;16(8):4341-6.
Ref 77 Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem. 2009 Dec 10;52(23):7372-5.
Ref 78 Akuammine and dihydroakuammine, two indolomonoterpene alkaloids displaying affinity for opioid receptors. J Nat Prod. 1992 Mar;55(3):380-4.
Ref 79 Phenylmorphans and analogues: opioid receptor subtype selectivity and effect of conformation on activity. J Med Chem. 1992 May 1;35(9):1521-5.
Ref 80 Respiratory effects and tolerability of Mr 2264 Cl.A new opiate partial agonist in comparison with morphine and placebo.Eur J Clin Pharmacol.1994;46(4):301-4.
Ref 81 Synthesis and receptor binding properties of chimeric peptides containing a mu-opioid receptor ligand and nociceptin/orphanin FQ receptor ligand Ac... Bioorg Med Chem Lett. 2006 Sep 15;16(18):4839-41.
Ref 82 Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. J Med Chem. 1993 Nov 26;36(24):3748-56.
Ref 83 Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides. J Med Chem. 1997 Aug 29;40(18):2948-52.
Ref 84 Molecular modeling studies to predict the possible binding modes of endomorphin analogs in mu opioid receptor. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5387-91.
Ref 85 Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors. Mol Pharmacol. 1994 Feb;45(2):330-4.
Ref 86 Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1055-8.
Ref 87 Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg Med Chem. 2007 Feb 15;15(4):1694-702.
Ref 88 Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. Br J Clin Pharmacol. 1995 Jun;39(6):611-20.
Ref 89 Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. J Med Chem. 2008 Jan 10;51(1):173-7.
Ref 90 Design and synthesis of conformationally constrained somatostatin analogues with high potency and specificity for mu opioid receptors. J Med Chem. 1986 Nov;29(11):2370-5.
Ref 91 Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2. Eur J Med Chem. 2010 Oct;45(10):4594-600.
Ref 92 Synthesis and biological evaluation of 14-alkoxymorphinans. 21. Novel 4-alkoxy and 14-phenylpropoxy derivatives of the mu opioid receptor antagonis... J Med Chem. 2004 Jun 3;47(12):3242-7.
Ref 93 Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8.
Ref 94 Effect of lysine at C-terminus of the Dmt-Tic opioid pharmacophore. J Med Chem. 2006 Sep 7;49(18):5610-7.
Ref 95 New 2',6'-dimethyl-L-tyrosine (Dmt) opioid peptidomimetics based on the Aba-Gly scaffold. Development of unique mu-opioid receptor ligands. J Med Chem. 2006 Jun 29;49(13):3990-3.
Ref 96 Further studies on lead compounds containing the opioid pharmacophore Dmt-Tic. J Med Chem. 2008 Aug 28;51(16):5109-17.
Ref 97 6-N,N-dimethylamino-2,3-naphthalimide: a new environment-sensitive fluorescent probe in delta- and mu-selective opioid peptides. J Med Chem. 2006 Jun 15;49(12):3653-8.
Ref 98 From the potent and selective mu opioid receptor agonist H-Dmt-d-Arg-Phe-Lys-NH(2) to the potent delta antagonist H-Dmt-Tic-Phe-Lys(Z)-OH. J Med Chem. 2005 Aug 25;48(17):5608-11.
Ref 99 Bifunctional [2',6'-dimethyl-L-tyrosine1]endomorphin-2 analogues substituted at position 3 with alkylated phenylalanine derivatives yield potent mi... J Med Chem. 2007 Jun 14;50(12):2753-66.
Ref 100 A new opioid designed multiple ligand derived from the micro opioid agonist endomorphin-2 and the delta opioid antagonist pharmacophore Dmt-Tic. Bioorg Med Chem. 2007 Nov 15;15(22):6876-81.
Ref 101 Structure-activity study of endomorphin-2 analogs with C-terminal modifications by NMR spectroscopy and molecular modeling. Bioorg Med Chem. 2008 Jun 15;16(12):6415-22.
Ref 102 Conformational restriction of the phenylalanine residue in a cyclic opioid peptide analogue: effects on receptor selectivity and stereospecificity. J Med Chem. 1991 Oct;34(10):3125-32.
Ref 103 Potent Dmt-Tic pharmacophoric delta- and mu-opioid receptor antagonists. J Med Chem. 2005 Dec 15;48(25):8035-44.
Ref 104 Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors. J Med Chem. 2010 Jan 14;53(1):402-18.
Ref 105 Novel opioid peptide derived antagonists containing (2S)-2-methyl-3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid [(2S)-Mdcp]. J Med Chem. 2008 Sep 25;51(18):5866-70.
Ref 106 Syntheses and opioid receptor binding properties of carboxamido-substituted opioids. Bioorg Med Chem Lett. 2009 Jan 1;19(1):203-8.
Ref 107 Role of 2',6'-dimethyl-l-tyrosine (Dmt) in some opioid lead compounds. Bioorg Med Chem. 2010 Aug 15;18(16):6024-30.
Ref 108 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 109 Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus. Neuroscience. 2001;108(3):467-77.
Ref 110 Synthesis and characterization of potent and selective mu-opioid receptor antagonists, [Dmt(1), D-2-Nal(4)]endomorphin-1 (Antanal-1) and [Dmt(1), D... J Med Chem. 2007 Feb 8;50(3):512-20.
Ref 111 Beta-methyl substitution of cyclohexylalanine in Dmt-Tic-Cha-Phe peptides results in highly potent delta opioid antagonists. J Med Chem. 2007 Jan 25;50(2):328-33.
Ref 112 Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normo... Bioorg Med Chem. 2009 Aug 15;17(16):5983-8.
Ref 113 Partial retro-inverso, retro, and inverso modifications of hydrazide linked bifunctional peptides for opioid and cholecystokinin (CCK) receptors. J Med Chem. 2007 Jan 11;50(1):165-8.
Ref 114 Peptides as receptor selectivity modulators of opiate pharmacophores. J Med Chem. 1986 Jul;29(7):1222-5.
Ref 115 In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors. Bioorg Med Chem. 2007 Jun 15;15(12):4106-12.
Ref 116 Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokini... J Med Chem. 2007 Jun 14;50(12):2779-86.
Ref 117 Opiate aromatic pharmacophore structure-activity relationships in CTAP analogues determined by topographical bias, two-dimensional NMR, and biologi... J Med Chem. 2000 Feb 24;43(4):569-80.
Ref 118 Discovery of novel triazole-based opioid receptor antagonists. J Med Chem. 2006 Jul 13;49(14):4044-7.
Ref 119 Design of cyclic deltorphins and dermenkephalins with a disulfide bridge leads to analogues with high selectivity for delta-opioid receptors. J Med Chem. 1994 Jan 7;37(1):141-5.
Ref 120 Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction. Bioorg Med Chem Lett. 2008 Sep 15;18(18):4978-81.
Ref 121 New series of potent delta-opioid antagonists containing the H-Dmt-Tic-NH-hexyl-NH-R motif. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5517-20.
Ref 122 Role of benzimidazole (Bid) in the delta-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH(2)-Bid (UFP-502). Bioorg Med Chem. 2008 Mar 15;16(6):3032-8.
Ref 123 Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility. J Med Chem. 2008 Apr 24;51(8):2571-4.
Ref 124 Agonist vs antagonist behavior of delta opioid peptides containing novel phenylalanine analogues in place of Tyr(1). J Med Chem. 2009 Nov 12;52(21):6941-5.
Ref 125 Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5275-9.
Ref 126 Design and synthesis of novel hydrazide-linked bifunctional peptides as delta/mu opioid receptor agonists and CCK-1/CCK-2 receptor antagonists. J Med Chem. 2006 Mar 9;49(5):1773-80.
Ref 127 Bioorg Med Chem Lett. 2007 Jun 1;17(11):3028-33. Epub 2007 Mar 21.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2.
Ref 128 Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4946-50.
Ref 129 Electrophilic gamma-lactone kappa-opioid receptor probes. Analogues of 2'-hydroxy-2-tetrahydrofurfuryl-5,9-dimethyl-6,7-benzomorphan diastereomers. J Med Chem. 1991 Aug;34(8):2438-44.
Ref 130 Synthesis and structure-activity relationships of deltorphin analogues. J Med Chem. 1991 May;34(5):1656-61.
Ref 131 Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic ... Bioorg Med Chem. 2009 Aug 15;17(16):5782-90.
Ref 132 Highly selective fluorescent analogue of the potent delta-opioid receptor antagonist Dmt-Tic. J Med Chem. 2004 Dec 16;47(26):6541-6.
Ref 133 The effects of C-terminal modifications on the opioid activity of [N-benzylTyr(1)]dynorphin A-(1-11) analogues. J Med Chem. 2009 Nov 12;52(21):6814-21.
Ref 134 Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors. J Med Chem. 2007 Nov 1;50(22):5528-32.
Ref 135 You HJ, Colpaert FC, Arendt-Nielsen L: The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes. Exp Neurol. 2005 Jan;191(1):174-83.
Ref 136 Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opio... J Med Chem. 2006 Jan 12;49(1):256-62.
Ref 137 Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pha... J Med Chem. 2000 Jan 13;43(1):114-22.
Ref 138 Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-c... Bioorg Med Chem. 2008 May 15;16(10):5653-64.
Ref 139 Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effect of substitution in the aromatic ring of cinnamoylaminomorp... J Med Chem. 2006 Aug 24;49(17):5333-8.
Ref 140 High-affinity carbamate analogues of morphinan at opioid receptors. Bioorg Med Chem Lett. 2007 Mar 15;17(6):1508-11.
Ref 141 New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores. J Med Chem. 2006 Sep 7;49(18):5640-3.
Ref 142 Replacement of the N-terminal tyrosine residue in opioid peptides with 3-(2,6-dimethyl-4-carbamoylphenyl)propanoic acid (Dcp) results in novel opio... J Med Chem. 2006 Aug 24;49(17):5382-5.
Ref 143 Ligand binding to nucleic acids and proteins: Does selectivity increase with strength Eur J Med Chem. 2008 Nov;43(11):2307-15.
Ref 144 Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5035-8.
Ref 145 3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor. Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8.
Ref 146 Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorg Med Chem Lett. 2009 May 15;19(10):2811-4.
Ref 147 Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1507-9.
Ref 148 Bioorg Med Chem Lett. 2007 Jun 1;17(11):3023-7. Epub 2007 Mar 23.Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1.
Ref 149 Synthesis and in vitro biological evaluation of a carbon glycoside analogue of morphine-6-glucuronide. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1583-6.
Ref 150 Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity. J Med Chem. 2007 Mar 22;50(6):1414-7.
Ref 151 A structure-activity relationship study and combinatorial synthetic approach of C-terminal modified bifunctional peptides that are delta/mu opioid ... J Med Chem. 2008 Mar 13;51(5):1369-76.
Ref 152 Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis. J Med Chem. 2007 Jun 28;50(13):3138-42.
Ref 153 Synthesis of analogues of acetylmethadol and methadol as potential narcotic antagonists. J Med Chem. 1981 Jul;24(7):903-6.
Ref 154 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 155 Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands. J Med Chem. 2009 Dec 10;52(23):7389-96.
Ref 156 14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity. J Med Chem. 2009 Mar 26;52(6):1553-7.
Ref 157 14beta-Arylpropiolylamino-17-cyclopropylmethyl-7,8-dihydronormorphinones and related opioids. Further examples of pseudoirreversible mu opioid rece... J Med Chem. 2009 Nov 12;52(21):6926-30.
Ref 158 Evaluation of N-substitution in 6,7-benzomorphan compounds. Bioorg Med Chem. 2010 Jul 15;18(14):4975-82.
Ref 159 The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokin... J Med Chem. 2008 Oct 23;51(20):6334-47.
Ref 160 Potential affinity labels for the opiate receptor based on fentanyl and related compounds. J Med Chem. 1982 Aug;25(8):913-9.
Ref 161 Synthesis and evaluation of opioid receptor-binding affinity of elaeocarpenine and its analogs. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1601-3.
Ref 162 Beta-endorphin is a potent inhibitor of thymidine incorporation into DNA via mu- and kappa-opioid receptors in fetal rat brain cell aggregates in culture. J Neurochem. 1993 Feb;60(2):765-7.
Ref 163 [6-O-methyl-11C]Diprenorphine Molecular Imaging and Contrast Agent Database (MICAD) [Internet].
Ref 164 Synthesis and evaluation of new endomorphin analogues modified at the Pro(2) residue. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4115-8.
Ref 165 Design and synthesis of KNT-127, a -opioid receptor agonist effective by systemic administration. Bioorg Med Chem Lett. 2010 Nov 1;20(21):6302-5.
Ref 166 Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an ... J Med Chem. 2007 Aug 9;50(16):3765-76.
Ref 167 Carba-analogues of fentanyl are opioid receptor agonists. J Med Chem. 2010 Apr 8;53(7):2875-81.
Ref 168 Subramanian G, Paterlini MG, Portoghese PS, Ferguson DM: Molecular docking reveals a novel binding site model for fentanyl at the mu-opioid receptor. J Med Chem. 2000 Feb 10;43(3):381-91.
Ref 169 Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-pipe... J Med Chem. 2008 Oct 9;51(19):5893-6.
Ref 170 SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2. Bioorg Med Chem Lett. 2010 Sep 15;20(18):5405-10.
Ref 171 The discovery of tropane derivatives as nociceptin receptor ligands for the management of cough and anxiety. Bioorg Med Chem Lett. 2009 May 1;19(9):2519-23.
Ref 172 Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4291-5.
Ref 173 Isothiocyanate-substituted kappa-selective opioid receptor ligands derived from N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl] phenylacetamide. J Med Chem. 1994 Sep 2;37(18):2856-64.
Ref 174 Novel coumarin glycoside and phenethyl vanillate from Notopterygium forbesii and their binding affinities for opioid and dopamine receptors. Bioorg Med Chem. 2008 Mar 15;16(6):3218-23.
Ref 175 Spirocyclic delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-3-hydroxy-4-(spiro[chromene-2,4'-piperidine]-4-yl) b... J Med Chem. 2009 Sep 24;52(18):5685-702.
Ref 176 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine. Bioorg Med Chem Lett. 2010 Jan 15;20(2):628-31.
Ref 177 Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential. J Med Chem. 2010 Sep 9;53(17):6386-97. doi: 10.1021/jm100697g.
Ref 178 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)