m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03143
|
[1] | |||
Histone modification
H3K27ac
KAT2A
METTL3
Direct
Enhancement
m6A modification
BECN1
BECN1
METTL3
Methylation
 : m6A sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Beclin-1 (BECN1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Histone acetyltransferase KAT2A (KAT2A) | WRITER | View Details | ||
| Regulated Target | Histone H3 lysine 27 acetylation (H3K27ac) | View Details | |||
| Downstream Gene | METTL3 | View Details | |||
| Crosstalk Relationship | Histone modification → m6A | Enhancement | |||
| Crosstalk Mechanism | histone modification directly impacts m6A modification through modulating the level of m6A regulator | ||||
| Crosstalk Summary | CAT upregulated NRF1, NRF1 activated METTL3 via Kat2a transcription, and METTL3 inhibited Beclin-1 (BECN1) via m6A modification. KAT2A could increase the Histone H3 lysine 27 acetylation (H3K27ac) level in the METTL3 promoter region to activate METTL3 transcription. | ||||