m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT03115
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[1] | |||
m6A modification
SENP1
SENP1
IGF2BP3
: m6A sites
Indirect
Enhancement
Histone modification
EGFR
HDAC2
Downstream Gene
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| m6A Modification: | |||||
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| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) | READER | |||
| m6A Target | SUMO specific peptidase 1 (SENP1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | Histone modification (HistMod) | ||||
| Epigenetic Regulator | Histone deacetylase 2 (HDAC2) | ERASER | View Details | ||
| Regulated Target | Epidermal growth factor receptor (EGFR) | View Details | |||
| Crosstalk Relationship | m6A → Histone modification | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly regulates histone modification through downstream signaling pathways | ||||
| Crosstalk Summary | SUMO specific peptidase 1 (SENP1) can desumoylate HDAC2, which enhances Epidermal growth factor receptor (EGFR) transcription and activates the AKT pathway. In addition, we found that IGF2BP3 expression was upregulated in high-risk AML patients and was positively correlated with SENP1 expression. MERIP-qPCR and RIP-qPCR showed that IGF2BP3 binds SENP1 3-UTR in an m6A manner, enhances SENP1 expression, and promotes AKT pathway conduction. | ||||
| Responsed Disease | Acute myeloid leukaemia | ICD-11: 2A60 | |||
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
| Epidermal growth factor receptor (EGFR) | 222 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
| Necitumumab | Approved | [2] | ||
| Synonyms |
LY3012211
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| MOA | Modulator | |||
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| HEGF | Approved | [3] | ||
| MOA | Activator | |||
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| Erlotinib | Approved | [4] | ||
| Synonyms |
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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| MOA | Inhibitor | |||
| Activity | Ki = 0.1 nM | |||
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| Gefitinib | Approved | [5] | ||
| Synonyms |
Gefitini; IRE; Iressa; Irressat; Gefitinib [USAN]; ZD 1839; ZD1839; Iressa (TN); Iressa(TM); ZD-1839; CU-00000000396-1; Gefitinib,Iressa, ZD1839; Gefitinib (JAN/USAN/INN); ZD-1839, Iressa, Gefitinib; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine; N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; 6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.1 nM | |||
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| Panitumumab | Approved | [6] | ||
| Synonyms |
Vectibix; Panitumumab (genetical recombination); Vectibix (TN); Panitumumab (USAN/INN); Panitumumab (genetical recombination) (JAN); Panitumumab (EGFR mAb inhibitor)
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| MOA | Suppressor | |||
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| Cetuximab | Approved | [7] | ||
| Synonyms |
Erbitux; Cetuximab (genetical recombination); Erbitux (TN); Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN); novel EGFR mAb inhibitors
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| BIBW 2992 | Approved | [8] | ||
| Synonyms |
Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.19 nM | |||
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| Nitroglycerin | Approved | [3] | ||
| Synonyms |
Glyceryl trinitrate; Trinitroglycerin; Nitroglycerol; Nitrostat; Nitroglycerine; Nitro-dur; Minitran; Trinitroglycerol; 55-63-0; Nitroderm; Nitroglyn; Nitrospan; Nitronet; Tridil; Glycerol trinitrate; Transderm-nitro; Transderm Nitro; Epinitril; Susadrin; Perlinganit; Nitrolingual; Nitrolan; Sustonit; Nitrocine; Trinitrin; Natispray; Lenitral; Nitrong; Niong; Nitro-Bid; Nitroderm TTS; Trinitrosan; Rectogesic; Nitroglicerina; Cordipatch; Perglottal; Nitrorectal; Gilustenon; Nitroretard; Nitroplast; Corditrine; Trinitrolong; Adesitrin; Aldonitrin; Angibid; Angiolingual; Angiplex; Anglix; Angonist; Angorin; Anogesic; Buccal; Buccard; Cardabid; Cardamist; Cardinit; Cardiodisco; Cellegesic; Chitamite; Colenitral; Dauxona; Deponit; Diafusor; Discotrine; Dynamite; GTN; Glonoin; Glycerintrinitrate; Glyceroltrinitraat; Glyceryl; Glycerylnitrat; Glytrin; Herwicard; Herzer; Klavikordal; Lentonitrina; Millisrol; Minitram; Minitro; Mionitrat; Myocon; Myoglycerin; Myovin; NTG; Niglin; Niglycon; Nirmin; Nitora; Nitradisc; Nitrangin; Nitrek; Nitriderm; NitroBid; NitroCor; NitroDur; NitroMist; NitroQuick; NitroQuik; Nitroard; Nitrobaat; Nitrobukal; Nitrocap; Nitrocard; Nitrocerin; Nitroclyn; Nitrocontin; Nitrocot; Nitrodisc; Nitrodyl; Nitrogard; Nitrogliceryna; Nitroglin; Nitroject; Nitroletten; Nitrolin; Nitrolowe; Nitromel; Nitromex; Nitromint; Nitropatch; Nitropen; Nitropercuten; Nitroperlinit; Nitroprol; Nitropront; Nitroprontan; Nitrorex; Nitrostabilin; Nitrovis; Nysconitrine; Percutol; Perganit; Plastranit; Polnitrin; Ratiopharm; Soup; Suscard; Sustac; Sustak; TNG; Temponitrin; Trinalgon; Trinipatch; Triniplas; Trinitrol; Trinitron; Turicard; Vascana; Vasoglyn; Vasolator; Vernies; Willong; Blasting gelatin; Blasting oil; Gepan Nitroglicerin; Gilucor nitro; Glycerin trinitrate; Glycerine trinitrate; Glyceryl nitrate; NITRO IV; Neos nitro OPT; Niong Retard; Nitradisc Pad; Nitradisc TTS; Nitriderm TTS; Nitro Bid; Nitro Dur; Nitro Dur TTS; Nitro Mack Retard; Nitro Retard; Nitro Rorer; Nitrobid Oint; Nitrocontin Continus; Nitroderm TTS Ext; Nitrodyl TTS; Nitrol Ointment; Nitrolingual Spray; Nitromack Retard; Nitromint Aerosol; Nitromint Retard; Nitronal Aqueous; Nitrong Retard; Nitrong parenteral; Nitrozell retard; Percutol Oint; Spirit of glonoin; Tridil sublin; Trinitrin Tablets; Trinitrina Erba; Deponit 5; Deponit TTS 10; Deponit TTS 5; Nitrocine 5; Aquo-Trimitrosan; Coro-Nitro; Deponit-5; GTN-Pohl; IMX-150; MED-2002; MQX-503; Mi-Trates; Minitran (TN); NK-843; Natispray (TN); Nit-Ret; Nitrine-TDC; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Span; Nitro-Time; Nitro-lent; NitrocapTD; Nitroderm TTS-5; Nitrogard-SR; Nitroglycerin (NG); Nitroglycerin-ACC; Nitrolingual Pump Spray (TN); Nitromist (TN); Nitrong-SR; Nitrospan (TN); Nitrostat (TN); SDM No 17; SK-106N; SK-866; SK-878; Top-Nitro; Transderm Nitro (TN); Transderm-N TTS; Transderm-Nitro TTS; Transiderm-nitro; Tridil (TN); Trinipatch (TN); Trinitrate, Glyceryl; Nitro-Dur (TN); Nitro-M-Bid; Nitro-bid (TN); Transderm-nitro (TN); DWP-401
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| MOA | Activator | |||
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| Epidermal growth factor | Approved | [9] | ||
| Synonyms |
62229-50-9; Urogastrone; Uroenterone; Uroanthelone; Urogastron; Kutrol; beta-Urogastrone; Anthelone U; Urogastrone [JAN]; Gastrone, gamma-uro-; Gastrone, beta-uro- (human); Epidermal growth factor (egf); CCRIS 7234; EINECS 263-468-7; EPIDERMAL GROWTH FACTOR-UROGASTRONE; Gastrone, uro- (9CI); 9010-53-1; Gentel (TN); EGF
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| MOA | Modulator | |||
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| Osimertinib | Approved | [10] | ||
| Synonyms |
Tagrisso
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.421 nM | |||
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| NERATINIB MALEATE | Approved | [11] | ||
| Synonyms |
UNII-9RM7XY23ZS; 9RM7XY23ZS; Neratinib maleate [MI]; hki-272 maleate; Nerlynx (TN); SCHEMBL2180998; MolPort-044-561-003; AKOS030524209; DS-19892
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| MOA | Antagonist | |||
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| Amivantamab | Approved | [12] | ||
| MOA | Inhibitor | |||
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| SKI-758 | Approved | [13] | ||
| Synonyms |
SCHEMBL3992463; CHEMBL219557; BDBM13047; 3-quinolinecarbonitrile analog 10; ANUHLKPVOXDYSK-UHFFFAOYSA-N; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]furan-3-yl}quinoline-3-carbonitrile; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6 methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile
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| MOA | Inhibitor | |||
| Activity | IC50 = 230 nM | |||
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| Dacomitinib | Approved | [9] | ||
| Synonyms |
PF-00299804
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| MOA | Antagonist | |||
| Activity | IC50 = 1.8 nM | |||
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| Lapatinib | Approved | [14] | ||
| Synonyms |
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
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| MOA | Inhibitor | |||
| Activity | Ki = 3 nM | |||
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| Merimepodib | Approved | [15] | ||
| Synonyms |
Merimebodib; Merimepodib [USAN:INN]; Tyverb/Tykerb; MMPD; 198821-22-6; 2ZL2BA06FU; C23H24N4O6; CHEMBL304087; MERIMEPODIB, VI-21497, VX-497; UNII-2ZL2BA06FU; VI-21497; VX-497; VX497; Vx 497; carbamic acid
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| MOA | Inhibitor | |||
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| Vandetanib | Approved | [16] | ||
| Synonyms |
Zactima; Vandetanib [INN]; CH 331; ZD 6474; ZD6474; AZD-6474; CH-331; F9995-0087; ZD-6474; Zactima, ZD6474; Vandetanib (JAN/INN); Vandetanib, Zactima, ZD6474; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib (Pan-TK inhibitor)
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| MOA | Inhibitor | |||
| Activity | IC50 = 200 nM | |||
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| Sorafenib | Approved | [17] | ||
| Synonyms |
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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| MOA | Inhibitor | |||
| Activity | IC50 = 43.5 nM | |||
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| Icotinib hydrochloride | Registered | [18] | ||
| Synonyms |
Conmana; Conmanna; Icotinib; BPI-2009-H
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| MOA | Antagonist | |||
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| Rindopepimut | Phase 3 | [2] | ||
| MOA | Modulator | |||
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| SYM-004 | Phase 3 | [19] | ||
| Synonyms |
Chimeric IgG1 antibody 1024 (cancer), Symphogen; Chimeric IgG1 antibody 992 (cancer), Symphogen; Chimeric IgG1 antibodies992 + 1024 (cancer), Symphogen
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| DE-766 | Phase 3 | [9] | ||
| MOA | Modulator | |||
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| EGF816 | Phase 3 | [20] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 160.6 nM | |||
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| CO-1686 | Phase 3 | [21] | ||
| Synonyms |
1374640-70-6; AVL-301; CO1686; UNII-72AH61702G; CNX-419; CO-1686 (AVL-301); Rociletinib(AVL-301,CNX-419,CO-1686); 72AH61702G; N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; CO 1686; Rociletinib (CO-1686, AVL-301); Rociletinib [USAN:INN]; Tube721; Rociletinib (USAN/INN); Rociletinib (CO-1686); SCHEMBL4177736; GTPL7966; CHEMBL3545308; EX-A228; MolPort-035-395-816; C27H28F3N7O3; HMS3653G08; BDBM149404; BCP07085; AOB87314; ZINC98043800; s7284
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| MOA | Modulator | |||
| Activity | IC50 = 1.6 nM | |||
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| Zalutumumab | Phase 3 | [9] | ||
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| Almonertinib | Phase 3 | [22] | ||
| Synonyms |
HS-10296; Ameile; 1899921-05-1; Egfr T790M inhibitor HS-10296; N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide; UNII-T4RS462G19; SCHEMBL17683063; GTPL11136; T4RS462G19; EX-A3721; HS 10296 [WHO-DD]; s8817; HS10296; example 26 [WO2016054987A1]; HY-112823; CS-0066162; 2-Propenamide, N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-((2-(dimethylamino)ethyl)methylamino)-4-methoxyphenyl)-; C1(CC1)N1C=C(C2=CC=CC=C12)C1=NC(=NC=C1)NC=1C(=CC(=C(C=1)NC(C=C)=O)N(C)CCN(C)C)OC; N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
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| MOA | Inhibitor | |||
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| ASP1929 | Phase 3 | [23] | ||
| Synonyms |
Cetuximab sarotalocan
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| MOA | Inhibitor | |||
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| A140 | Phase 3 | [24] | ||
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| Bevacizumab + Erlotinib | Phase 3 | [25] | ||
| MOA | Inhibitor | |||
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| HKI-272 | Phase 3 | [26] | ||
| Synonyms |
Neratinib (ERBB2 inhibitor)
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.08 nM | |||
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| Indium-111 | Phase 2/3 | [27] | ||
| Synonyms |
ABT-806
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| Varlitinib | Phase 2/3 | [28] | ||
| Synonyms |
845272-21-1; ARRY-334543; ARRY334543; ARRY 334543; ARRY-543; UNII-846Y8197W1; ASLAN-001; 846Y8197W1; (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine; Varlitinib [USAN:INN]; Varlitinib (ARRY334543); Varlitinib free base; Varlitinib (USAN/INN); MLS006011274; GTPL7645; SCHEMBL1384578; CHEMBL2103842; SYN1192; MolPort-028-720-424; EX-A1005; 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
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| MOA | Modulator | |||
| Activity | IC50 = 7 nM | |||
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| ASP8273 | Phase 2 | [29] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 8 nM | |||
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| ABT-414 | Phase 2 | [30] | ||
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| Depatuxizumab | Phase 2 | [31] | ||
| MOA | Antagonist | |||
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| Matuzumab | Phase 2 | [32] | ||
| Synonyms |
EMD-62000; EMD-72000; Anti-EGF receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-EGFR humanized mAb (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-epidermal growth factor receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals
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| HER1-VSSP vaccine | Phase 2 | [33] | ||
| Synonyms |
HER1-VSSP vaccine (cancer)
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| RM-1929 | Phase 2 | [34] | ||
| MOA | Antagonist | |||
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| CetuGEX | Phase 2 | [35] | ||
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| ABX-EGF | Phase 2 | [36] | ||
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| Pelitinib | Phase 2 | [37] | ||
| Synonyms |
EKB-569; EKI-569; WAY-EKB-569
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| MOA | Modulator | |||
| Activity | IC50 = 8.02 nM | |||
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| HM-78136B | Phase 2 | [34] | ||
| Synonyms |
Pan-Her/EGFR inhibitors (cancer), Hanmi
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.218 nM | |||
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| Pazopanib + Tyverb/Tykerb | Phase 2 | [15] | ||
| MOA | Inhibitor | |||
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| MEHD-7945A | Phase 2 | [28] | ||
| Synonyms |
RG-7597; EGFR/HER3 dual monoclonal antibody, Genentech
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| MOA | Modulator | |||
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| TT-100 | Phase 2 | [38] | ||
| Synonyms |
TT-100, TriAct; Dual IGF-1/EGFR inhibitor (non-small-cell lung cancer), TriAct
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| MOA | Inhibitor | |||
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| BMS-599626 | Phase 2 | [39] | ||
| Synonyms |
714971-09-2; AC480; AC-480; BMS 599626; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate; UNII-2252724U5N; CHEMBL1645462; BMS599626; AC480 (BMS-599626); 2252724U5N; J-502499; C27H27FN8O3; AC 480; AC1480 (free base); PubChem22432; GTPL7647; SCHEMBL12065349; CTK8B6780; DTXSID60221714; SYN1142; AOB5594; MolPort-023-279-418; EX-A2296; ZINC6717782; KS-000008GE; BDBM50333373; s1056; C27H44O11; ANW-54337; AKOS015999853; CS-0407; RL05125; BCP9000428; SB21703
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| MOA | Inhibitor | |||
| Activity | IC50 = 32 nM | |||
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| Tarloxotinib | Phase 2 | [40] | ||
| Synonyms |
Tarloxotinib cation; UNII-H8768UL06V; H8768UL06V; [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium; Tarloxotinib ion; GTPL9409; CHEMBL4297661; SCHEMBL19733352; PR610; DB14944; TH-4000; Q27279755; 1636938-13-0
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| MOA | Inhibitor | |||
| External Link | ||||
| VATALANIB | Phase 2 | [26] | ||
| Synonyms |
212141-54-3; Vatalanib base; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK787; Pynasunate; CGP 79787; Vatalanib free base; PTK-787; Vatalanib (free base); Vatalinib; ZK-232934; CGP-79787; ZK222584; PTK/ZK; CHEMBL101253; N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine; UNII-5DX9U76296; CHEBI:90620; YCOYDOIWSSHVCK-UHFFFAOYSA-N; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine; 5DX9U76296; NCGC00181350-01; 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-; DSSTox_CID_26919
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| MOA | Inhibitor | |||
| Activity | IC50 = 457.7 nM | |||
| External Link | ||||
| BMS-690514 | Phase 2 | [41] | ||
| Synonyms |
BMS 690514; BMS690514
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| MOA | Inhibitor | |||
| External Link | ||||
| CI-1033 | Phase 2 | [16] | ||
| Synonyms |
Canertinib; Canertinib HCl; Canertinib dihydrochloride; Canertinib dihydrochloride [USAN]; CI1033; PD 183805; Canertinib dihydrochloride (USAN); PD-0183805; PD-183805; Canertinib, PD-183805, CI1033, PD183805; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride; N-(4-(3-chloro-4-fluorophenyl)amino)-7-(3-morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide dihydrochloride; N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl) amino)-7-(3-(4-morpholinyl) propoxy)-6-quinazolinyl)-, dihydrochloride; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-, dihydrochloride
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| MOA | Inhibitor | |||
| Activity | Ki = 0.11 nM | |||
| External Link | ||||
| CART-EGFR | Phase 1/2 | [42] | ||
| MOA | CAR-T-Cell-Therapy | |||
| External Link | ||||
| SN-32793 | Phase 1/2 | [9] | ||
| Synonyms |
PR-509; PR-610; SN-32807; Hypoxia-activated irreversible pan-erbb inhibitors, Proacta; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer); Hypoxia-selective multi-kinase inhibitors (lung cancer), Proacta; Hypoxia-selective multi-kinase inhibitors(lung cancer), Proacta/ Yakult Honsha; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer), Proacta/ Yakult Honsha
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| MOA | Inhibitor | |||
| External Link | ||||
| EGFR CART | Phase 1/2 | [43] | ||
| MOA | CAR-T-Cell-Therapy | |||
| External Link | ||||
| EMD 55900 | Phase 1/2 | [36] | ||
| Synonyms |
27686-84-6; 4,4'-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol); UNII-7BO8G1BYQU; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)-; EINECS 248-606-6; 7BO8G1BYQU; CHEMBL313972; erythro-nordihydroguaiaretic acid; CHEBI:73468
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| External Link | ||||
| TAK-186 | Phase 1/2 | [44] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| ZN-e4 | Phase 1/2 | [45] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| EMB-01 | Phase 1/2 | [46] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| Sym015 | Phase 1/2 | [31] | ||
| MOA | Antagonist | |||
| External Link | ||||
| BDTX-189 | Phase 1/2 | [47] | ||
| Synonyms |
2414572-47-5; EX-A4379
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| MOA | Inhibitor | |||
| External Link | ||||
| AFM24 | Phase 1/2 | [48] | ||
| External Link | ||||
| Sym013 | Phase 1/2 | [31] | ||
| MOA | Antagonist | |||
| External Link | ||||
| S-222611 | Phase 1b | [49] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| SYN004 | Phase 1 | [31] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| BIBX-1382 | Phase 1 | [50] | ||
| Synonyms |
Falnidamol; BIBX 1382; 196612-93-8; BIBX1382; UNII-0MU316797D; CHEMBL258940; FTFRZXFNZVCRSK-UHFFFAOYSA-N; 0MU316797D; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine; Bibx 1382bs; Falnidamol [INN]; NCGC00161422-01; AC1OCFIP; BIBX-1382BX; BIBX-1382BS; SCHEMBL158563; GTPL7646; DTXSID0048399; CHEBI:93243; EX-A570; AOB5489; MolPort-039-136-623; ZINC1494443; KS-00001CR9; BCP09515; BDBM50375639; AKOS025396660; API0007916; DB12966; CS-0691; NCGC00161422-03; AS-16894; HY-10322; AK174047
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| MOA | Antagonist | |||
| Activity | IC50 = 3 nM | |||
| External Link | ||||
| IMGN289 | Phase 1 | [51] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| AST-1306 | Phase 1 | [52] | ||
| Synonyms |
Allitinib; Allitinib tosylate
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| MOA | Modulator | |||
| External Link | ||||
| AMG 595 | Phase 1 | [53] | ||
| MOA | Modulator | |||
| External Link | ||||
| HER-2/HER-1 vaccine | Phase 1 | [9] | ||
| Synonyms |
HER-2/HER-1 vaccine (solid tumors)
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| External Link | ||||
| EGFR806-specific CAR T cell | Phase 1 | [54] | ||
| MOA | CAR-T-Cell-Therapy | |||
| External Link | ||||
| PF-05230907 | Phase 1 | [55] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| MR1-1 | Phase 1 | [56] | ||
| Synonyms |
MR1-1KDEL; EGFR-specific immunotoxin, IVAX; Anticancer immunotoxin (EGFR-specific), IVAX
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| MOA | Modulator | |||
| External Link | ||||
| Anti-EGFR CAR T | Phase 1 | [57] | ||
| MOA | CAR-T-Cell-Therapy | |||
| External Link | ||||
| AP32788 | Phase 1 | [34] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| CLN-081 | Phase 1 | [58] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| LY3164530 | Phase 1 | [59] | ||
| MOA | Modulator | |||
| External Link | ||||
| MM-151 | Phase 1 | [31] | ||
| MOA | Antagonist | |||
| External Link | ||||
| Cipatinib | Phase 1 | [28] | ||
| Synonyms |
HER-1/HER-2 inhibitor (oral, cancer), Jiangsu Hengrui
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| MOA | Modulator | |||
| External Link | ||||
| Anti-HER3/EGFR DAF | Phase 1 | [60] | ||
| MOA | Modulator | |||
| External Link | ||||
| BCA101 | Phase 1 | [61] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| CUDC-101 | Phase 1 | [62] | ||
| Synonyms |
1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149
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| MOA | Modulator | |||
| Activity | IC50 = 2.4 nM | |||
| External Link | ||||
| SI-B001 | Phase 1 | [63] | ||
| External Link | ||||
| CX-904 | Phase 1 | [64] | ||
| Synonyms |
AMG 651
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| External Link | ||||
| AZD9592 | Phase 1 | [65] | ||
| External Link | ||||
| D2C7 | Phase 1 | [66] | ||
| External Link | ||||
| MCLA-158 | Phase 1 | [67] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| JNJ-26483327 | Phase 1 | [68] | ||
| Synonyms |
MTKI (cancer), J&J; MTKI (cancer), Johnson & Johnson; Multi-targeted kinase inhibitor (cancer), J&J; Multi-targeted kinase inhibitor (cancer), Johnson & Johnson
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| MOA | Inhibitor | |||
| External Link | ||||
| Pyrrolo[2,3-d]pyrimidine derivative 24 | Patented | [69] | ||
| Synonyms |
PMID28705083-Compound-22
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| MOA | Inhibitor | |||
| External Link | ||||
| PKI166 | Discontinued in Phase 2 | [70] | ||
| Synonyms |
PKI-166; CGP-75166; 187724-61-4; NVP-PKI166; CHEMBL1914653; AC1OCFE0; UNII-9RIE5HW38P; 9RIE5HW38P; SCHEMBL177814; GTPL7642; CHEMBL1963502; ZINC23255; AOB1619; PKI-75166; BDBM50358046; NCGC00387215-02; AS-16676; KB-275097; PKI-166, > 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[4,5-e]pyrimidin-6-yl]phenol
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| MOA | Modulator | |||
| Activity | IC50 = 3.7 nM | |||
| External Link | ||||
| RG7160 | Discontinued in Phase 2 | [71] | ||
| MOA | Modulator | |||
| External Link | ||||
| PD-153035 | Discontinued in Phase 1 | [72] | ||
| Synonyms |
183322-45-4; PD153035 hydrochloride; N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride; PD153035 HCl; PD 153035 HYDROCHLORIDE; PD-153035 hydrochloride; PD153035 (Hydrochloride); Tyrphostin AG 1517; AG 1517 hydrochloride; SU-5271 hydrochloride; UNII-AHJ252P69N; ZM 252868; SU 5271; AG 1517; 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; AHJ252P69N; pd 153035; PD153035.HCl; CHEMBL1204168; 6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride; C16H15BrClN3O2; 4-Quinazolinamine, N-(3-bromo
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| MOA | Modulator | |||
| Activity | Ki = 0.006 nM | |||
| External Link | ||||
| AZD4769 | Discontinued in Phase 1 | [73] | ||
| Synonyms |
Acetic acid, ((4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)-; 127481-29-2; L-674573; ((4-Phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid; {[4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl]thio}acetic acid; L 674573; L-674,573; AC1L3YFJ; SCHEMBL9460146; CHEMBL422872; JOIXGLLMSDPZDN-UHFFFAOYSA-N; AZD-4769; 2-[[4-phenyl-1-[4-(2-quinolinylmethoxy)phenyl]butyl]thio]Acetic acid; DA-13018; FT-0734991; AZ-12096971; 2-[4-phenyl-1-[4-(quinolin-2-ylmethoxy)phenyl]butyl]sulfanylacetic
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| MOA | Inhibitor | |||
| External Link | ||||
| TAK165 | Discontinued in Phase 1 | [16] | ||
| Synonyms |
Mubritinib; TAK 165; Mubritinib (USAN/INN); 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole
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| MOA | Inhibitor | |||
| External Link | ||||
| 111In-hEGF | Preclinical | [74] | ||
| Synonyms |
Indium-111-hEGF; Indium-111-labeled human epithelial growth factor (breast cancer), University of Toronto; 111In-labeledhuman epithelial growth factor (breast cancer), University of Toronto
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| MOA | Modulator | |||
| External Link | ||||
| EGFR/IGFR tandem adnectin | Preclinical | [75] | ||
| Synonyms |
BMS-964210
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| MOA | Inhibitor | |||
| External Link | ||||
| Heparin-EGF-like factor | Terminated | [76] | ||
| Synonyms |
HB-EGF, Scios Nova; Heparin-EGF-like factor, Scios Nova
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| MOA | Modulator | |||
| External Link | ||||
| CGP-52411 | Terminated | [77] | ||
| Synonyms |
DAPH
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| MOA | Inhibitor | |||
| Activity | Ki = 160 nM | |||
| External Link | ||||
| CGP-53353 | Terminated | [78] | ||
| Synonyms |
145915-60-2; CGP 53353; DAPH 2; DAPH-7; CGP53353; PKCbetaII/EGFR Inhibitor; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; CHEMBL7939; CGP 53 353; 4,5-bis(4-Fluoroanilino)-phthalimide; CG53353; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; MolMap_000016; DAPH-2; CGP-53353, solid; SCHEMBL230492
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| MOA | Inhibitor | |||
| Activity | IC50 = 700 nM | |||
| External Link | ||||
| AZD-9935 | Terminated | [79] | ||
| MOA | Antagonist | |||
| External Link | ||||
| N4-(3-chlorophenyl)quinazoline-4,6-diamine | Investigative | [80] | ||
| Synonyms |
CHEMBL343352; Anilinoquinazoline, 4c; SCHEMBL1262804; AWAYNEMCHILZCF-UHFFFAOYSA-N; ZINC13527446; BDBM50133382; AKOS013915036; 6-amino-4-(3'-chloroanilino)quinazoline; N4-(3-chlorophenyl)-4,6-quinazolinediamine; 6-amino-4[(3-chlorophenyl)amino]quinazoline
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| MOA | Inhibitor | |||
| Activity | IC50 = 3.38 nM | |||
| External Link | ||||
| 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile | Investigative | [81] | ||
| Synonyms |
Tyrphostin deriv. 29; AC1NS5AC; CHEMBL56132; BDBM4296; ZINC12352646; 2-(Benzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile; (E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
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| MOA | Inhibitor | |||
| Activity | IC50 = 1000 nM | |||
| External Link | ||||
| 6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL250523; BDBM50222432
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| MOA | Inhibitor | |||
| Activity | IC50 = 15 nM | |||
| External Link | ||||
| 2-cyano-3-(3,4-dihydroxyphenyl)acrylamide | Investigative | [81] | ||
| Synonyms |
Tyrphostin 46; Tyrphostin A46; AG 99; Tyrphostin B40; 122520-85-8; alpha-Cyano-(3,4-dihydroxy)cinnamide; AG-99; 3,4-Dihydroxy-alpha-cyanocinnamamide; UNII-ARL2OF9022; CHEMBL296407; ARL2OF9022; 118409-59-9; Tyrphostin AG 99; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; NSC666250; NSC-666250; 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-; (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide; Tyrphostin AG99; 3,4-Dihydroxy-alpha-cyanocinnamide; NSC 666250; Tocris-0497; Tyrphostin deriv. 40; BiomolKI_000013; AC1NS5AR
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| MOA | Inhibitor | |||
| Activity | Ki = 3500 nM | |||
| External Link | ||||
| HM-61713B | Investigative | [9] | ||
| Synonyms |
EGFR mutant selective inhibitor (cancer), Hanmi; EMSI (cancer), Hanmi
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| MOA | Inhibitor | |||
| External Link | ||||
| Benzyl-quinazolin-4-yl-amine | Investigative | [83] | ||
| Synonyms |
N-Benzylquinazolin-4-amine; N-benzyl-N-(4-quinazolinyl)amine; 4-(Benzylamino)quinazoline; 100818-54-0; 4-Benzylaminoquinazoline; AC1LDDI3; benzylquinazolin-4-ylamine; ChemDiv2_003678; N-benzyl-4-quinazolineamine; Oprea1_089836; MLS000701321; N-Benzyl-4-quinazolinamine #; cid_616573; CHEMBL102726; BDBM3256; SCHEMBL7612718; CHEBI:92768; MolPort-001-960-903; FVWANTDQRFSCAL-UHFFFAOYSA-N; HMS2233F15; HMS3373H15; HMS1379H04; ZINC109589; 4-[(phenylmethyl)amino]quinazoline; N-(phenylmethyl)-4-quinazolinamine
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| MOA | Inhibitor | |||
| External Link | ||||
| 6,7-diethoxy-4-styrylquinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL250925
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| MOA | Inhibitor | |||
| Activity | IC50 = 15 nM | |||
| External Link | ||||
| AFM-21 | Investigative | [9] | ||
| Synonyms |
Anti-EGFR antibody (RECRUIT-TandAb, colon/solid tumors), Affimed
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| External Link | ||||
| PD182905 | Investigative | [84] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| AG 112 | Investigative | [85] | ||
| Synonyms |
tyrphostin A48; tyrphostin AG 112; AG-112; AG112
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| MOA | Inhibitor | |||
| Activity | IC50 = 125 nM | |||
| External Link | ||||
| 2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile | Investigative | [86] | ||
| Synonyms |
(4,5-Dihydroxyindanylidene)malononitrile; Tyrphostin deriv. 17; AC1NS59O; CHEMBL57300; BDBM4286; 133550-13-7; 2-(4,5-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; 2-(4,5-dihydroxy-2,3-dihydro-1H-inden-1-ylidene)propanedinitrile
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| MOA | Inhibitor | |||
| Activity | IC50 = 7000 nM | |||
| External Link | ||||
| (3-Bromo-phenyl)-quinazolin-4-yl-amine | Investigative | [87] | ||
| Synonyms |
N-(3-bromophenyl)quinazolin-4-amine; CHEMBL290096; AC1LEF72; SCHEMBL2992623; BDBM3264; 4-Anilino quinazoline deriv. 15; ZINC151213; (3-bromophenyl)quinazolin-4-ylamine; N-(3-Bromophenyl)-4-quinazolinamine; AKOS002264782; MCULE-4660970870; 4-Quinazolinamine, N-(3-bromophenyl)-
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| MOA | Inhibitor | |||
| Activity | IC50 = 27 nM | |||
| External Link | ||||
| PD-158780 | Investigative | [88] | ||
| Synonyms |
171179-06-9; PD158780; pd 158780; N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AC1L1IRV; CHEMBL53753; 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AK160389; 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine; 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine; 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine; Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl-
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.008 nM | |||
| External Link | ||||
| EGFR inhibitor | Investigative | [89] | ||
| Synonyms |
879127-07-8; CHEMBL387187; N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; K00598a; N-{3-[(6-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}cyclopropanecarboxamide; EGFR Inhibitor 324674; SCHEMBL242230; GTPL5963; CTK8E9808; DTXSID40429554; MolPort-042-665-758; HMS3229E03; BDBM50200394; ZINC13831337; API0010446; CCG-206749; NCGC00167954-01
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| MOA | Inhibitor | |||
| Activity | IC50 = 21 nM | |||
| External Link | ||||
| 6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL399371
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| MOA | Inhibitor | |||
| Activity | IC50 = 5 nM | |||
| External Link | ||||
| LA22-radioimmunoconjugates | Investigative | [9] | ||
| Synonyms |
LA22-radioimmunoconjugates (cancer); Lutetium177-DOTA-LA22; LA22-radioimmunoconjugates (cancer), Welson/PekingUniversity; MAb-conjugated radioimmunotherapeutics (cancer), Welson/Peking University; 177Lu-DOTA-LA22; 177Lu-DTPA-LA22
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| MOA | Modulator | |||
| External Link | ||||
| 5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide | Investigative | [90] | ||
| Synonyms |
CHEMBL382537
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| MOA | Inhibitor | |||
| External Link | ||||
| ICR 62 | Investigative | [36] | ||
| External Link | ||||
| Bmab-200 | Investigative | [9] | ||
| Synonyms |
Anti-EGFR mAb (cancer), Biocon; Anti-epidermal growth factor receptor monoclonal antibody (cancer), Biocon
Click to Show/Hide
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| External Link | ||||
| HTS-00213 | Investigative | [91] | ||
| Synonyms |
CHEMBL461781; AC1MDDFE; MolPort-002-900-007; ZINC1028479; BDBM50292742; MCULE-3257779074; 3-((2,6-dichlorophenoxy)methyl)-5-((4-(4-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 6300 nM | |||
| External Link | ||||
| 6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL251123
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| MOA | Inhibitor | |||
| Activity | IC50 = 140 nM | |||
| External Link | ||||
| N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine | Investigative | [88] | ||
| Synonyms |
CHEMBL300083; 4-N-benzylpyrido[4,3-d]pyrimidine-4,7-diamine; 7-Aminopyrido[4,3-d]pyrimidine 8a; AC1NS3PZ; SCHEMBL6839398; BDBM3331; pyrido[4,3-d]pyrimidine-4,7-diamine,n4-(phenylmethyl)-; ZINC3815364; 171178-89-5; PD-69896; KB-302882
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 578 nM | |||
| External Link | ||||
| Epitinib | Investigative | [9] | ||
| Synonyms |
HMPL-813; EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| OSI-75 | Investigative | [92] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| (E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin | Investigative | [93] | ||
| Synonyms |
CHEMBL213560; SCHEMBL16693054; BDBM50187134
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 710 nM | |||
| External Link | ||||
| HTS-02876 | Investigative | [91] | ||
| Synonyms |
AC1MDGL2; CHEMBL460914; MolPort-002-900-576; ZINC1030761; MCULE-7093116609
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| 2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile | Investigative | [86] | ||
| Synonyms |
133550-11-5; Propanedinitrile, (2,3-dihydro-5,6-dihydroxy-1H-inden-1-ylidene)-; Tyrphostin deriv. 15; ACMC-20muzh; AC1NS59I; SCHEMBL6285970; CHEMBL293584; BDBM4284; CTK0C0328; DTXSID30416170; 2-(5,6-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; (5,6-Dihydroxyindanylidene)malononitrile; [(2,3-Dihydro-5,6-dihydroxy-1H-inden)-1-ylidene]malononitrile
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| PMID8568816C56 | Investigative | [94] | ||
| Synonyms |
PD153035 Analog 56; 171745-13-4; AC1L1EMN; K00042; BDBM3556; GTPL5956; CTK6G1384; DTXSID40274389; MolPort-019-910-218; HMS3229C09; BCP08039; ZINC2572485; IN1496; CCG-206742; QC-8197; ACM171745134; RT-012080; SR-02000000170; SR-02000000170-1; J-010
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.006 nM | |||
| External Link | ||||
| MT-062 | Investigative | [9] | ||
| Synonyms |
EGFR inhibitor (melanoma), Medisyn Technologies
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| Anti-EGFR mab | Investigative | [9] | ||
| External Link | ||||
| RG-50810 | Investigative | [81] | ||
| Synonyms |
Tyrphostin 23; 118409-57-7; Tyrphostin A23; AG 18; (3,4-Dihydroxybenzylidene)malononitrile; AG-18; Tyrphostin AG18; Tyrphostin RG50810; 2-(3,4-dihydroxybenzylidene)malononitrile; UNII-RV0GCD31OJ; alpha-Cyano-(3,4-dihydroxy)cinnamonitrile; 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; RG 50810; Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-; ag18; (3,4-Dihydroxyphenyl)methylene propanedinitrile; RV0GCD31OJ; C10H6N2O2; NCGC00016043-03; (3,4-dihydroxybenzylidene)propanedinitrile; DSSTox_CID_25215
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| MOA | Inhibitor | |||
| Activity | Ki = 11000 nM | |||
| External Link | ||||
| IPS-01003 | Investigative | [9] | ||
| Synonyms |
EGFR kinase antagonist (cancer), InnoPharmaScreen
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| MOA | Antagonist | |||
| External Link | ||||
| RM-6427 | Investigative | [9] | ||
| Synonyms |
RM-6428; EGFR tyrosine kinase inhibitors (parasitic infection), Romark
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| MOA | Inhibitor | |||
| External Link | ||||
| N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine | Investigative | [87] | ||
| Synonyms |
bpdq; CHEMBL328216; 4-N-(3-bromophenyl)quinazoline-4,6,7-triamine; 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline; 169205-87-2; AC1L1DNE; N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine; K00041; SCHEMBL7221302; BDBM3303; 4-Anilinoquinazoline deriv. 54; CTK8F8323; ADXSZLCTQCWMTE-UHFFFAOYSA-N; IN1401; HSCI1_000040; AKOS025149794; 4-(3-bromoanilino)-6,7-diaminoquinazoline; N-(3-Bromophenyl)quinazoline-4,6,7-triamine; 4[ (3-Bromophenyl)aminol-6,7-diaminoquinazoline; J-010514
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.12 nM | |||
| External Link | ||||
| 3-Pyridin-4-yl-quinoline-6,7-diol | Investigative | [95] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 5000 nM | |||
| External Link | ||||
| AGT-2000 | Investigative | [9] | ||
| Synonyms |
Gene therapy (intravenous, brain cancer), ArmaGen
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| MOA | Modulator | |||
| External Link | ||||
| 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one | Investigative | [96] | ||
| Synonyms |
CHEMBL7827; SCHEMBL3355884; 62845-10-7; CTK2B1467; ZINC23489; DTXSID10445847; BDBM50074745; AKOS030553076; 5,7-Dihydroxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-(3-chlorophenyl)-5,7-dihydroxy-
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 95 nM | |||
| External Link | ||||
| ON-128 | Investigative | [9] | ||
| Synonyms |
ON-128060; ON-128 series (cancer); HER1/EGFR inhibitors (cancer), Onconova; Human epidermal growth factor receptor 1/epidermal growth factor receptor inhibitors (cancer), Onconova; ON-128 series (cancer), Onconova
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| FHT-2107 | Investigative | [9] | ||
| Synonyms |
EGFR-targeting siRNA agent, ForHumanTech
Click to Show/Hide
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| External Link | ||||
| GI-3000 | Investigative | [9] | ||
| Synonyms |
GI-3001; GI-6200; GlioVax-1; EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen); EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen), GlobeImmune
Click to Show/Hide
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| External Link | ||||
| 6,7-dimethoxy-N-m-tolylquinazolin-4-amine | Investigative | [91] | ||
| Synonyms |
CHEMBL56802; AC1MDC5E; Oprea1_570563; SCHEMBL5482883; ZINC5857; 4-Quinazolinamine,6,7-dimethoxy-N-(3-methylphenyl)-; MolPort-001-734-434; BDBM50102093; MCULE-3929709513; 666839-07-2; (6,7-Dimethoxy-quinazolin-4-yl)-m-tolyl-amine; SR-02000000178; SR-02000000178-1; 6,7-dimethoxy-N-(3-methylphenyl)quinazolin-4-amine
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 4.6 nM | |||
| External Link | ||||
| 5,6-Bis-p-tolylamino-isoindole-1,3-dione | Investigative | [78] | ||
| Synonyms |
CHEMBL7914; SCHEMBL8834183; BDBM50040920
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| MOA | Inhibitor | |||
| Activity | IC50 = 4500 nM | |||
| External Link | ||||
| HTS-05058 | Investigative | [89] | ||
| Synonyms |
MLS000327715; SMR000180717; 3-(1H-imidazol-5-ylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(1H-imidazol-5-ylmethylidene)-1H-indol-2-one; Angiogenesis Inhibitor; 372164-79-9; AC1NWWY9; CHEMBL261692; SCHEMBL2998484; REGID_for_CID_667701; BDBM41079; cid_5714572; REGID_for_CID_5714572; MolPort-002-870-304; MolPort-002-901-109; HMS2463B12; ZINC4693510; AKOS015992864; (3Z)-3-(1H-imidazol-5-ylmethylene)oxindole; 4X-0884; J-011988
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide | Investigative | [97] | ||
| Synonyms |
CHEMBL297968; SCHEMBL2994207; FAGJCAQBJKSOOS-UHFFFAOYSA-N; BDBM50077245; N-[4-(3-Methylanilino)quinazoline-7-yl]acrylamide
Click to Show/Hide
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 90 nM | |||
| External Link | ||||
| 4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid | Investigative | [81] | ||
| Synonyms |
CHEMBL76958; BDBM50007075; 4-[4-(2-Nitro-vinyl)-phenoxysulfonyl]-benzoic acid; 4-[4-[(E)-2-Nitroethenyl]phenoxysulfonyl]benzoic acid
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 1000 nM | |||
| External Link | ||||
| Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine | Investigative | [87] | ||
| Synonyms |
CHEMBL63786; N-(3-bromophenyl)benzo[g]quinazolin-4-amine; Benzoquinazoline deriv. 23; AC1NS43R; SCHEMBL4348523; BDBM3585; BUVKJPOCMOXSSQ-UHFFFAOYSA-; ZINC3815025; 4-[(3-Bromophenyl)amino]benzo[g]quinazoline; N-(3-Bromophenyl)benzo[g]quinazoline-4-amine
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.003 nM | |||
| External Link | ||||
| ARX-AHD | Investigative | [9] | ||
| Synonyms |
Dolastatin-conjugated HER2 antibody (breast cancer), Ambrx
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| External Link | ||||
| TGF alpha | Investigative | [9] | ||
| Synonyms |
TGF alpha (neurological damage)
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| MOA | Modulator | |||
| External Link | ||||
| AG 9 | Investigative | [85] | ||
| Synonyms |
tyrphostin 1; tyrphostin A1; AG9; AG-9
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| MOA | Inhibitor | |||
| Activity | Ki > 400000 nM | |||
| External Link | ||||
| N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine | Investigative | [98] | ||
| Synonyms |
N4-(3-Bromophenyl)quinazoline-4,6-diamine; 169205-78-1; 4-N-(3-bromophenyl)quinazoline-4,6-diamine; CHEMBL52765; AK-25174; N4-(3-bromophenyl)-4,6-quinazolinediamine; 4,6-Quinazolinediamine, N4-(3-bromophenyl)-; C14H11BrN4; nchembio866-comp32; Anilinoquinazoline, 4b; AC1NS3N2; BDBM3294; SCHEMBL1417740; 4-Anilinoquinazoline deriv. 45; KS-00000HMR; CTK4D3225; DTXSID40416141; IZQHULBHKPGOAP-UHFFFAOYSA-N; MolPort-009-198-483; ZINC3815034; BCP18882; ANW-50332; AKOS013915836; 6-amino 4-(3-bromoanilino)quinazoline; GS-4221
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.78 nM | |||
| External Link | ||||
| 4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline | Investigative | [99] | ||
| Synonyms |
CHEMBL473320; SCHEMBL5616932
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 131 nM | |||
| External Link | ||||
| Theliatinib | Investigative | [9] | ||
| Synonyms |
HMPL-309; Second EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| 4-(3-Bromo-phenylamino)-quinazoline-6,7-diol | Investigative | [87] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| 6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL250318; BDBM50222435
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| MOA | Inhibitor | |||
| Activity | IC50 = 14 nM | |||
| External Link | ||||
| 4-(2-nitroprop-1-enyl)benzene-1,2-diol | Investigative | [81] | ||
| Synonyms |
13662-96-9; 1,2-Benzenediol, 4-(2-nitro-1-propenyl)-; AC1MMGH2; Oprea1_551147; CTK0F3796; DTXSID20390758; AKOS017269192
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| EDP-13 | Investigative | [9] | ||
| Synonyms |
Epidermal growth factor receptor antagonist (cancer), BiolineRx/Matrix Pharma
Click to Show/Hide
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| MOA | Antagonist | |||
| External Link | ||||
| N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine | Investigative | [83] | ||
| Synonyms |
CHEMBL420624; 7-amino-4-[(3-bromophenyl)amino]quinazoline; 4-N-(3-bromophenyl)quinazoline-4,7-diamine; 4-Anilinoquinazoline deriv. 48; AC1NS3NB; BDBM3297; SCHEMBL2986298; GHVBIROTJQDRQB-UHFFFAOYSA-N; ZINC3815072; AKOS014671983; 7-Amino-4-(3-bromoanilino)quinazoline; 7-amino-4(3-bromoanilino)-quinazoline; 7-amino-4-(3-bromoanilino)-quinazoline; 169205-81-6; N-(3-Bromophenyl)quinazoline-4,7-diamine; 7-Amino-4-[(3-bromophenyl)aminolquinazoline; FT-0768311; 7-amino-4-[(3-bromophenyl)-amino]quinazoline
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.1 nM | |||
| External Link | ||||
| (S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate | Investigative | [81] | ||
| Synonyms |
Z-L-Ala-chloromethylketone; 41036-43-5; Benzyloxycarbonylalanine chloromethyl ketone; Z-Ala-chloromethyl ketone; AC1NUSRJ; PubChem11548; Benzyloxycarbonyl-ala-chloromethyl ketone; CHEMBL483443; SCHEMBL6437509; DTXSID50194009; ZINC34206665; AKOS027382196; FT-0603930; benzyl N-[(2S)-4-chloro-3-oxobutan-2-yl]carbamate; [(S)-1-Methyl-2-oxo-3-chloropropyl]carbamic acid benzyl ester; Carbamic acid, (3-chloro-1-methyl-2-oxopropyl)-, phenylmethyl ester, (S)-
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| 4-(2-nitrovinyl)benzene-1,2-diol | Investigative | [81] | ||
| Synonyms |
SL-1; CHEMBL78224; 108074-44-8; SL-1 Pigment; 1,2-Dihydroxy-4-(nitroethenyl)benzene; 4-[(E)-2-nitroethenyl]benzene-1,2-diol; AC1O5R3K; SCHEMBL2052283; SCHEMBL2052285; beta-Nitro-3,4-dihydroxystyrene; LLJASJHXECDHOM-ONEGZZNKSA-N; BDBM50007069; AKOS010878666; 4-(2-Nitro-vinyl)-benzene-1,2-diol; 1,2-Benzenediol, 4-(2-nitroethenyl)-, (E)-
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 8800 nM | |||
| External Link | ||||
| AG-538 | Investigative | [81] | ||
| Synonyms |
Tyrphostin AG 538; AG 538; NSC676485; (E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile; alpha-Cyano-(3,4-dihydroxy)cinnamoyl-(3& -dihydroxyphenyl)ketone; Tyrphostin deriv. 24; Lopac-T-7822; AC1NS5A3; Lopac0_001261; MLS002153408; CHEMBL56393; SCHEMBL2678764; SCHEMBL2678765; BDBM4293; REGID_for_CID_660907; CHEBI:92138; cid_5328760; REGID_for_CID_5328760; HMS3263N04; HMS2233K10; ZINC3871438; 133550-18-2; Tox21_501261; HSCI1_000189; CCG-205335; NSC-676485; LP01261; NCGC00094499-02
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| MOA | Inhibitor | |||
| Activity | IC50 = 370 nM | |||
| External Link | ||||
| WZ-3146 | Investigative | [9] | ||
| Synonyms |
WZ-4002; WZ-8040; EGFR-T790M kinase inhibitors (lung cancer); EGFR-T790M kinase inhibitors (lung cancer), Gatekeeper Pharmaceuticals
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| MOA | Inhibitor | |||
| External Link | ||||
| 2-methoxy-4-(2-nitrovinyl)phenol | Investigative | [81] | ||
| Synonyms |
6178-42-3; 2-Methoxy-4-[(E)-2-nitroethenyl]phenol; 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE; (E)-2-methoxy-4-(2-nitrovinyl)phenol; trans-4-Hydroxy-3-methoxy-beta-nitrostyrene; 2-methoxy-4-[(E)-2-nitrovinyl]phenol; CHEMBL309016; 22568-51-0; AF-467/00017042; 2-methoxy-4-(2-nitroethenyl)phenol; 2-Methoxy-4-(2-nitro-vinyl)-phenol; 4-((1E)-2-nitrovinyl)-2-methoxyphenol; 4-{2-nitrovinyl}-2-methoxyphenol; 4-Hydroxy-3-methoxy-beta-nitrostyrene; AC1LCWDN; PubChem19447; AC1Q1WR9; MLS000574924
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| MOA | Inhibitor | |||
| Activity | IC50 = 7900 nM | |||
| External Link | ||||
| MG-111 | Investigative | [100] | ||
| Synonyms |
134865-04-6; EGF, Hitachi
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| MOA | Modulator | |||
| External Link | ||||
| 6,7-dimethoxy-4-(2-phenylethynyl)quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL250315; SCHEMBL6180450; BDBM50222433
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 5600 nM | |||
| External Link | ||||
| Anti-EGFR humanized mabs | Investigative | [9] | ||
| Synonyms |
Anti-EGFR humanized mAbs (cancer); Anti-EGFR humanized mAbs (cancer), Xencor; Anti-EGFR humanized monoclonal antibodies (cancer), Xencor
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| External Link | ||||
| 4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline | Investigative | [82] | ||
| Synonyms |
CHEMBL250924; BDBM50222419
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| MOA | Inhibitor | |||
| Activity | IC50 = 26 nM | |||
| External Link | ||||
| AL-6802 | Investigative | [9] | ||
| Synonyms |
EGFR modulators (cancer), Advenchen/Simcere
Click to Show/Hide
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| MOA | Modulator | |||
| External Link | ||||
| BPIQ-I | Investigative | [87] | ||
| Synonyms |
174709-30-9; N-(3-bromophenyl)-3-methyl-3H-imidazo[4,5-g]quinazolin-8-amine; 8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline; Imidazoquinazoline deriv. 12; AC1L1DNH; GTPL5939; CHEMBL174426; BDBM3574; SCHEMBL17931472; CTK8E6742; DTXSID60274366; MolPort-044-561-412; HMS3229C05; ZINC2391775; IN1402; HSCI1_000090; AKOS025394452; CCG-206740; ACM174709309; RT-011807; J-011030; BRD-K72211743-001-01-1
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.025 nM | |||
| External Link | ||||
| mabionHER2 | Investigative | [9] | ||
| Synonyms |
Humanized monoclonal antibody (breast cancer), Mabion
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| External Link | ||||
| 4-(2-nitrovinyl)phenol | Investigative | [81] | ||
| Synonyms |
4-Hydroxy-b-nitrostyrene; (E)-4-(2-nitrovinyl)phenol; 4-hydroxy-beta-nitrostyrene; trans-4-Hydroxy-beta-nitrostyrene; 22568-49-6; Phenol, p-(2-nitrovinyl)-; 4-[(E)-2-Nitroethenyl]phenol; 4-[(E)-2-nitrovinyl]phenol; CHEMBL307481; CTJKRKMPTRJAIT-AATRIKPKSA-N; NSC81594; 1-(4-hydroxyphenyl)-2-nitroethene; 4-(2-(Hydroxy(oxido)amino)vinyl)phenol; 4-(2-Nitro-vinyl)-phenol; NSC30299; AC1LCWDH; 4-Hydroxy--nitrostyrene; 4'-hydroxy-beta-nitrostyrene; Phenol,4-(2-nitroethenyl)-
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 10000 nM | |||
| External Link | ||||
| 4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide | Investigative | [90] | ||
| Synonyms |
CHEMBL200958
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| MOA | Inhibitor | |||
| External Link | ||||
| MDP-01 | Investigative | [9] | ||
| Synonyms |
Peptabody-EGF (anticancer), Med Discovery
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| MOA | Inhibitor | |||
| External Link | ||||
| N4-(3-methylphenyl)-4,6-quinazolinediamine | Investigative | [101] | ||
| Synonyms |
CHEMBL336113; Anilinoquinazoline, 4a; 6-amino-4-[(3-methylphenyl)amino]quinazoline; SMA52; SCHEMBL159209; ZINC6328; SMA-52; NFBCSWGEYDCCDW-UHFFFAOYSA-N; BDBM50133384; AKOS013914431; N*4*-m-Tolyl-quinazoline-4,6-diamine; 153436-70-5; 6-amino-4-(3'-methylanilino)quinazoline; 6-amino-4-(3-methylphenylamino)-quinazoline; FT-0765557; 6-amino-4[(3-methylphenyl)amino]quinazoline
Click to Show/Hide
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 1000 nM | |||
| External Link | ||||
| RX-1792 | Investigative | [9] | ||
| Synonyms |
EGF antagonist, Rexahn; RX-0183
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| MOA | Antagonist | |||
| External Link | ||||
| (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine | Investigative | [83] | ||
| Synonyms |
N-(3-bromophenyl)-5-nitroquinazolin-4-amine; AC1NS3MQ; BDBM3290; CHEMBL116308; 4-Anilinoquinazoline deriv. 41
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| MOA | Inhibitor | |||
| Activity | IC50 = 355 nM | |||
| External Link | ||||
| NRC-2694 | Investigative | [9] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| Cochliobolic acid | Investigative | [102] | ||
| Synonyms |
CHEMBL464721; 185846-15-5; AC1O516J; BDBM50292386; 2-Furancarboxylic acid, tetrahydro-3-hydroxy-5-(17-methyl-13,14-dioxo-1,3,5,7,9,11,15-nonadecaheptaenyl)-, (2alpha,3beta,5alpha(1E,3E,5E,7E,9E,11E,15E))-(partial)-; (2R,3R,5S)-3-hydroxy-5-[(1E,3E,5E,7E,9E,11E,15E)-17-methyl-13,14-dioxononadeca-1,3,5,7,9,11,15-heptaenyl]oxolane-2-carboxylic acid
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| MOA | Inhibitor | |||
| Activity | IC50 = 1600 nM | |||
| External Link | ||||
| PD-168393 | Investigative | [103] | ||
| Synonyms |
PD168393; 194423-15-9; pd 168393; UNII-3R996Y9T0I; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide; N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide; CHEMBL285063; 3R996Y9T0I; C17H13BrN4O; N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-acrylamide; 2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-; 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-; nchembio866-comp2; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.08 nM | |||
| External Link | ||||
| N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide | Investigative | [97] | ||
| Synonyms |
CHEMBL31815; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl]acrylamide; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl)acrylamide; SCHEMBL2991796; AWQLTDUXGVCRBV-UHFFFAOYSA-N; BDBM50077244
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.42 nM | |||
| External Link | ||||
| 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | Investigative | [104] | ||
| Synonyms |
CHEMBL98798
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 70 nM | |||
| External Link | ||||
| 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline | Investigative | [104] | ||
| Synonyms |
CHEMBL101581
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| MOA | Inhibitor | |||
| Activity | IC50 = 2500 nM | |||
| External Link | ||||
| YH013 | Investigative | [105] | ||
| External Link | ||||
| LAVENDUSTIN A | Investigative | [106] | ||
| Synonyms |
125697-92-9; RG14355; UNII-3Y0G32G2RV; CHEMBL103552; 3Y0G32G2RV; C21H19NO6; Lavendustin A, from Streptomyces griseolavendus; Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-; RG 14355; 5-(((2,5-Dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxybenzoic acid; Benzoic acid, 5-(((2,5-dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxy-; 5-Amino-((N-2,5-dihydroxybenzyl)-N -2-hydroxybenzyl)salicylic acid
Click to Show/Hide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.004 ug.mL-1 | |||
| External Link | ||||
| PF 5208766 | Investigative | [107] | ||
| Synonyms |
WAY-178357
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| MOA | Modulator | |||
| External Link | ||||
| 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine | Investigative | [108] | ||
| Synonyms |
4-Anilidoquinazoline deriv. 12a; AC1NS5EY; SCHEMBL4355658; BDBM4397
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| MOA | Inhibitor | |||
| Activity | IC50 = 2700 nM | |||
| External Link | ||||
| N-(4-(phenylamino)quinazolin-6-yl)acrylamide | Investigative | [103] | ||
| Synonyms |
CHEMBL1221699; N-[4-(phenylamino)quinazolin-6-yl]prop-2-enamide; nchembio866-comp4; SCHEMBL614989; BDBM50324687; DB08462; N-(4-Anilinoquinazoline-6-yl)acrylamide
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| MOA | Inhibitor | |||
| Activity | IC50 < 1 nM | |||
| External Link | ||||
| AG-213 | Investigative | [99] | ||
| MOA | Inhibitor | |||
| Activity | Ki = 850 nM | |||
| External Link | ||||
| SYM-011 | Investigative | [9] | ||
| Synonyms |
Dimercept; Hermodulins; Herstatin; RB-200; RBLX-200; RBLX-242; RBLX-242h; RBLX-642h
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| MOA | Modulator | |||
| External Link | ||||
| 10-hydroxy-18-methoxybetaenone | Investigative | [109] | ||
| Synonyms |
CHEMBL498247; BDBM50269144
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| MOA | Inhibitor | |||
| Activity | IC50 = 10500 nM | |||
| External Link | ||||
| 4557W | Investigative | [110] | ||
| Synonyms |
EGFR/ErbB-2 Inhibitor; 179248-61-4; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; SCHEMBL242224; GTPL5964; CHEMBL563845; CTK8E8822; DTXSID40431718; MolPort-018-661-221; HMS3229C21; ZINC1485577; IN1350; HSCI1_000238; AKOS002350936; CCG-206748; RT-012453; J-011438; BRD-K76819286-001-01-0; N-[4-(Benzyloxy)phenyl]-6,7-dimethoxyquinazoline-4-amine; N-[4-(benzyloxy)phenyl]-6,7-dimethoxyquinazolin-4-amine
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| MOA | Inhibitor | |||
| External Link | ||||
| Tyrphostin ag-1478 | Investigative | [96] | ||
| Synonyms |
AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255
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| MOA | Inhibitor | |||
| Activity | IC50 = 120 nM | |||
| External Link | ||||
| CL-387785 | Investigative | [91] | ||
| Synonyms |
194423-06-8; EKI-785; CL-387785 (EKI-785); CL-387,785; UNII-B4W27J1Z8B; CL-387785(EKI785; WAY-EKI 785); EKB-785; CHEMBL91867; B4W27J1Z8B; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide; CHEBI:90180; C18H13BrN4O; N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide; N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]but-2-ynamide; N-[4-[(3-bromophenyl)amino]-6-quinazolinyl)-2-butynamide; N-{4-[(3-bromophenyl)amino]-6-quinazolinyl}-2-butynamide
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.37 nM | |||
| External Link | ||||
| HDS-029 | Investigative | [111] | ||
| Synonyms |
HDS 029
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.3 nM | |||
| External Link | ||||
| WHI-P154 | Investigative | [112] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| PMID24915291C38 | Investigative | [113] | ||
| Synonyms |
GTPL8145; PLS-123; BDBM50020476; 1431727-04-6
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| MOA | Inhibitor | |||
| Activity | IC50 = 7 nM | |||
| External Link | ||||
| HKI-9924129 | Investigative | [114] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 390 nM | |||
| External Link | ||||
| PD-0173956 | Investigative | [114] | ||
| Synonyms |
UNII-YR2DP5GJ1Y; YR2DP5GJ1Y; PD173956; PD-173956; AC1NS9BQ; 305820-76-2; SCHEMBL1334768; BDBM6569; CHEMBL574059; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-; 6-(2,6-dichlorophenyl)-2-(4-fluoroanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one; 6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
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| MOA | Inhibitor | |||
| Activity | IC50 = 380 nM | |||
| External Link | ||||
| PD-0166326 | Investigative | [114] | ||
| Synonyms |
PD-166326
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| MOA | Inhibitor | |||
| Activity | IC50 = 90 nM | |||
| External Link | ||||
| PP121 | Investigative | [115] | ||
| Synonyms |
PP-121; PP 121
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| MOA | Inhibitor | |||
| Activity | IC50 = 260 nM | |||
| External Link | ||||
| 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione | Investigative | [116] | ||
| Synonyms |
CHEMBL380598; SCHEMBL3148490; HVQJGNALTWNDMX-UHFFFAOYSA-N; BDBM50375058; 2-(1H-Indole-3-yl)-3-phenylmaleimide
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| MOA | Inhibitor | |||
| External Link | ||||
| Ro-4396686 | Investigative | [117] | ||
| Synonyms |
SCHEMBL5809947; CHEMBL606964
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| MOA | Inhibitor | |||
| Activity | IC50 = 545 nM | |||
| External Link | ||||
| 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione | Investigative | [116] | ||
| Synonyms |
1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388
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| MOA | Inhibitor | |||
| External Link | ||||
| 3,4-diphenyl-1H-pyrrole-2,5-dione | Investigative | [116] | ||
| Synonyms |
2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556
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| MOA | Inhibitor | |||
| External Link | ||||
| 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione | Investigative | [116] | ||
| Synonyms |
CHEMBL372076; SCHEMBL3822337
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| MOA | Inhibitor | |||
| External Link | ||||
| Osimertinib | Approved | [10] | ||
| Synonyms |
Tagrisso
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.421 nM | |||
| External Link | ||||
| PMID27774824-Compound-Figure9Example2down | Patented | [118] | ||
| External Link | ||||
| Mobocertinib | Approved | [118] | ||
| Synonyms |
1847461-43-1; TAK-788; TAK788; AP32788; UNII-39HBQ4A67L; 39HBQ4A67L; propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Mobocertinib [INN]; Mobocertinib [USAN]; AP-32788; Mobocertinib (TAK788); Mobocertinib(TAK-788); SCHEMBL17373133; GTPL10468; BDBM368374; BCP31045; EX-A3392; US10227342, Example 10; MFCD32669806; NSC825519; s6813; TAK-788;AP32788; WHO 11183; NSC-825519; example 94 [WO2015195228A1]; HY-135815; CS-0114256; TAK-788;TAK 788; AP 32788; 5-Pyrimidinecarboxylic acid, 2-((4-((2-(dimethylamino)ethyl)methylamino)-2-methoxy-5-((1-oxo-2-propen-1-yl)amino)phenyl)amino)-4-(1-methyl-1H-indol-3-yl)-, 1-methylethyl ester; C(C=C)(=O)NC=1C(=CC(=C(C=1)NC1=NC=C(C(=N1)C1=CN(C2=CC=CC=C12)C)C(=O)OC(C)C)OC)N(C)CCN(C)C; Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
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| External Link | ||||
| DZD9008 | Phase 1/2 | [118] | ||
| External Link | ||||
| AC0010 | Phase 3 | [118] | ||
| Synonyms |
Avitinib; 1557267-42-1; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Avitinib free base; SCHEMBL15453394; KS-00000TON; EX-A783; MolPort-042-663-560; Avitinib(AC0010/AC0010MA); ZINC142081723; AKOS030632728; CS-W008904; N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide; DS-19269; AK543905; 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-
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| External Link | ||||
| EGFR antisense DNA | Phase 1/2 | [118] | ||
| Synonyms |
Antisense therapy, UPCI; EGFR antisense DNA, University of Pittsburgh
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| External Link | ||||
| CK-101 | Phase 1/2 | [118] | ||
| Synonyms |
IDRGFNPZDVBSSE-UHFFFAOYSA-N; 1660963-42-7; RX-518; N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide; EGFR-IN-3; UNII-708TLB8J3Y; 708TLB8J3Y; AK543910; N-[3-[2-[[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl]amino]quinazolin-8-yl]phenyl]acrylamide; GTPL9863; SCHEMBL16514522; KS-00000TOQ; MolPort-042-663-562; RX518; CK101; EX-A1142; BCP19075; RX 518; ZINC514250913; AKOS030632731; DS-19272; HY-19815; CS-0016788; Example 153 [US20170050936A1]; J-690231; 2-Propena
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| External Link | ||||
| Pyrotinib | Phase 1 | [118] | ||
| Synonyms |
UNII-CJN36EQM0H; SHR-1258; CJN36EQM0H; SHR1258; 1269662-73-8; SCHEMBL9948753; GTPL9662; SADXACCFNXBCFY-IYNHSRRRSA-N; BDBM139991; AKOS032946680; CS-7940; compound 12 [PMID: 28115222]; 2-Propenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-3-((2R)-1-methyl-2-pyrrolidinyl)-, (2E)-; HY-104065; US8901140, 5; (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide; (E)-N-[4-[3-chloro-4-(pyridin-2-ylmetho
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| External Link | ||||
| Anti-EGFRvIII CAR transduced PBL | Phase 1/2 | [118] | ||
| External Link | ||||
| EGFRvIII CAR | Phase 1/2 | [118] | ||
| External Link | ||||
| Anti-EGFR V III CAR-T cells | Phase 1/2 | [118] | ||
| External Link | ||||
| EGFRvIII CAR T cells | Phase 1 | [118] | ||
| External Link | ||||
| CAR-T cells targeting EGFRviii | Phase 1 | [118] | ||
| External Link | ||||
| Anti-EGFRvIII CAR T cells | Phase 1 | [118] | ||
| External Link | ||||
| CART-EGFRvIII T cells | Phase 1 | [118] | ||
| External Link | ||||
| EGFRvIII-CARs | Phase 1 | [118] | ||
| External Link | ||||
| CAR-T Cells targeting EGFRvIII | Phase 1 | [118] | ||
| External Link | ||||
| RG6156 | Phase 1 | [118] | ||
| External Link | ||||
| AMG 596 | Phase 1 | [118] | ||
| External Link | ||||
| D2C7 | Phase 1 | [66] | ||
| External Link | ||||
| Histone deacetylase 2 (HDAC2) | 113 Compound(s) Regulating the Target | Click to Show/Hide the Full List | ||
| CHR-3996 | Phase 1/2 | [119] | ||
| Synonyms |
CCT-075453; CHR-2504; HDAC inhibitors, Chroma Therapeutics; Histone deacetylase inhibitors, Chroma
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| MOA | Inhibitor | |||
| Activity | IC50 = 4 nM | |||
| External Link | ||||
| PMID29671355-Compound-74 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 119 nM | |||
| External Link | ||||
| PMID29671355-Compound-59 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 10 nM | |||
| External Link | ||||
| PMID29671355-Compound-55 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 < 1000 nM | |||
| External Link | ||||
| PMID29671355-Compound-11 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 24 nM | |||
| External Link | ||||
| PMID29671355-Compound-9 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 128 nM | |||
| External Link | ||||
| PMID29671355-Compound-8 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 123000 nM | |||
| External Link | ||||
| PMID29671355-Compound-61 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 45.9 nM | |||
| External Link | ||||
| PMID29671355-Compound-23 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 7450 nM | |||
| External Link | ||||
| PMID29671355-Compound-44 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 < 150 nM | |||
| External Link | ||||
| PMID29671355-Compound-56 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 54.4 nM | |||
| External Link | ||||
| PMID29671355-Compound-67 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 > 50000 nM | |||
| External Link | ||||
| PMID29671355-Compound-31 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 2 nM | |||
| External Link | ||||
| PMID29671355-Compound-21 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 4880 nM | |||
| External Link | ||||
| PMID29671355-Compound-62 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 100 to 500 nM | |||
| External Link | ||||
| PMID29671355-Compound-43 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 124 nM | |||
| External Link | ||||
| PMID29671355-Compound-25 | Patented | [120] | ||
| MOA | Inhibitor | |||
| Activity | IC50 = 5400 nM | |||
| External Link | ||||
| N8-hydroxy-2-methoxy-N1-phenyloctanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL251010; SCHEMBL8158442
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1099078; BDBM50317997
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| MOA | Inhibitor | |||
| Activity | IC50 = 3800 nM | |||
| External Link | ||||
| N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide | Investigative | [123] | ||
| Synonyms |
CHEMBL557066; SCHEMBL3292989; SCHEMBL3292983; BDBM50293365
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| MOA | Inhibitor | |||
| Activity | IC50 = 1860 nM | |||
| External Link | ||||
| N7-hydroxy-2-methoxy-N1-phenylheptanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL251206; SCHEMBL8143763
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| N7-hydroxy-N1-phenyl-2-propoxyheptanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL251406; SCHEMBL8144856
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1096397; BDBM50318002
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| MOA | Inhibitor | |||
| Activity | IC50 = 800 nM | |||
| External Link | ||||
| N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097747; BDBM50317991
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| MOA | Inhibitor | |||
| Activity | IC50 = 1300 nM | |||
| External Link | ||||
| KAR-1880 | Investigative | [124] | ||
| Synonyms |
Anti-inflammatory OS-HDI; OS-HDI-2; HDAC 2 inhibitors (topical, dermatitis/psoriasis), Karus
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| MOA | Inhibitor | |||
| External Link | ||||
| N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1095096
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| MOA | Inhibitor | |||
| Activity | IC50 = 3900 nM | |||
| External Link | ||||
| N-(4-amino-3'-methylbiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1094108; BDBM50317995
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 3100 nM | |||
| External Link | ||||
| N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097746; BDBM50317992
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 13000 nM | |||
| External Link | ||||
| N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1098337; SCHEMBL15398027; BDBM50317988
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| MOA | Inhibitor | |||
| Activity | IC50 = 1400 nM | |||
| External Link | ||||
| N8,2-dihydroxy-N1-phenyloctanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL251009; SCHEMBL8144564
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| N-(2-amino-5-(furan-3-yl)phenyl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1095095; Benzamide, N-[2-amino-5-(3-furanyl)phenyl]-; BDBM50318000
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 39 nM | |||
| External Link | ||||
| N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide | Investigative | [123] | ||
| Synonyms |
CHEMBL556532; SCHEMBL3292226; SCHEMBL3290139
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| MOA | Inhibitor | |||
| Activity | IC50 = 820 nM | |||
| External Link | ||||
| 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL402719; SCHEMBL8150833
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide | Investigative | [121] | ||
| Synonyms |
CHEMBL402718; SCHEMBL8152458
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 500 nM | |||
| External Link | ||||
| N-(4-amino-4'-bromobiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097748; BDBM50317990
Click to Show/Hide
|
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| MOA | Inhibitor | |||
| Activity | IC50 = 600 nM | |||
| External Link | ||||
| N-(2-amino-5-(furan-2-yl)phenyl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097651
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 43 nM | |||
| External Link | ||||
| 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide | Investigative | [123] | ||
| Synonyms |
CHEMBL541239; SCHEMBL7045815
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 720 nM | |||
| External Link | ||||
| N-(4-aminobiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL271741; 3max; SCHEMBL16380794; BDBM50232053; N-(4-amino-biphenyl-3-yl)-benzamide
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 27 nM | |||
| External Link | ||||
| N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097063
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 10000 nM | |||
| External Link | ||||
| N-(2-aminophenyl)benzamide | Investigative | [122] | ||
| Synonyms |
2'-AMINOBENZANILIDE; 721-47-1; CHEMBL405072; AC1LFSYX; AC1Q5NOK; ACMC-1AE0C; Oprea1_478192; MLS000084661; SCHEMBL407834; N-(2-amino-phenyl)-benzamide; AC1Q514U; Benzamide, N-(2-aminophenyl)-; CTK2H2825; DTXSID60353948; RFDVMOUXHKTCDO-UHFFFAOYSA-N; MolPort-001-783-352; ZINC225957; HMS2355D18; STL497474; BDBM50232046; AKOS000133162; MCULE-5545982713; NE17312; SMR000019009; TC-170926; KB-298435; ST51030142; EN300-31745; SR-01000389415; AE-641/00785046
Click to Show/Hide
|
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| MOA | Inhibitor | |||
| Activity | IC50 = 3100 nM | |||
| External Link | ||||
| N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1095412; BDBM50317998
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 140 nM | |||
| External Link | ||||
| N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide | Investigative | [123] | ||
| Synonyms |
CHEMBL538710; SCHEMBL3292721; SCHEMBL3292715; BDBM50293355
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|
|||
| MOA | Inhibitor | |||
| Activity | IC50 = 330 nM | |||
| External Link | ||||
| N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide | Investigative | [122] | ||
| Synonyms |
CHEMBL1097278
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 390 nM | |||
| External Link | ||||
| N-(2-aminophenyl)quinoxaline-6-carboxamide | Investigative | [125] | ||
| Synonyms |
benzamide-type inhibitor, 20; CHEMBL236060; BDBM19424
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|
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| MOA | Inhibitor | |||
| Activity | IC50 = 2000 nM | |||
| External Link | ||||
| 7-Biphenyl-4-yl-heptanoic acid hydroxyamide | Investigative | [126] | ||
| Synonyms |
CHEMBL125098; BDBM50222335; 7-(4-Biphenylyl)heptanehydroximic acid
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|
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| MOA | Inhibitor | |||
| External Link | ||||
| 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid | Investigative | [127] | ||
| Synonyms |
CHEMBL115049; 436150-72-0; SCHEMBL7368556; CTK1D2674; DTXSID40658342; BDBM50221807; 8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acid; Octanoic acid, 8-([1,1'-biphenyl]-4-yloxy)-2-oxo-
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| 1,1,1-Trifluoro-8-phenoxy-octan-2-one | Investigative | [128] | ||
| Synonyms |
CHEMBL114796; BDBM50217940
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|
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| MOA | Inhibitor | |||
| External Link | ||||
| 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide | Investigative | [127] | ||
| Synonyms |
CHEMBL114184; SCHEMBL3383144
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|
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| MOA | Inhibitor | |||
| External Link | ||||
| 7-Phenoxy-heptanoic acid hydroxyamide | Investigative | [126] | ||
| Synonyms |
CHEMBL124322; N-hydroxy-7-phenoxyheptanamide; 7-Phenoxyheptanehydroximic acid
Click to Show/Hide
|
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| MOA | Inhibitor | |||
| External Link | ||||
| 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one | Investigative | [128] | ||
| Synonyms |
CHEMBL117916; SCHEMBL7366611; BDBM50217945
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| MOA | Inhibitor | |||
| External Link | ||||
| N-(4-hydroxybiphenyl-3-yl)benzamide | Investigative | [129] | ||
| Synonyms |
CHEMBL269935; SCHEMBL5724398; BDBM50232005
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| MOA | Inhibitor | |||
| Activity | IC50 = 200 nM | |||
| External Link | ||||
| 8-Phenyl-octanoic acid hydroxyamide | Investigative | [126] | ||
| Synonyms |
CHEMBL123624; N-Hydroxy-8-phenyloctanamide; SCHEMBL5807174
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| MOA | Inhibitor | |||
| External Link | ||||
| 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one | Investigative | [128] | ||
| Synonyms |
CHEMBL116023; SCHEMBL7368359; BDBM50218558
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| MOA | Inhibitor | |||
| External Link | ||||
| N-(2-aminophenyl)nicotinamide | Investigative | [129] | ||
| Synonyms |
N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6
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| MOA | Inhibitor | |||
| Activity | IC50 = 6980 nM | |||
| External Link | ||||
| santacruzamate A | Investigative | [130] | ||
| Synonyms |
CAY10683
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| MOA | Inhibitor | |||
| Activity | IC50 = 0.112 nM | |||
| External Link | ||||
| N-(4-aminobiphenyl-3-yl)nicotinamide | Investigative | [129] | ||
| Synonyms |
CHEMBL255805; BDBM50232035
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| MOA | Inhibitor | |||
| Activity | IC50 = 900 nM | |||
| External Link | ||||
| N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide | Investigative | [129] | ||
| Synonyms |
CHEMBL256440; SCHEMBL1066609
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| MOA | Inhibitor | |||
| Activity | IC50 = 390 nM | |||
| External Link | ||||
| N-(2-aminophenyl)-4-methoxybenzamide | Investigative | [125] | ||
| Synonyms |
AC1LFX2W; Cambridge id 5129152; Oprea1_722128; benzamide-type inhibitor, 22; CHEMBL236061; SCHEMBL5226034; BDBM19426; CTK7A1998; MolPort-001-019-504; BDYVCYUXCNZYRW-UHFFFAOYSA-N; ZINC281656; STK156256; AKOS000130378; MCULE-9183453747; N-(2-Amino-phenyl)4-methoxy-benzamide; N-(2-amino-phenyl)-4-methoxy-benzamide; NCGC00240897-01; N1-(4-methoxybenzoyl)-1,2-benzenediamine; N1-(4-methoxy-benzoyl)-1,2-benzenediamine; ST50908739; N-(2-aminophenyl)(4-methoxyphenyl)carboxamide; SR-01000196394
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| MOA | Inhibitor | |||
| Activity | IC50 = 900 nM | |||
| External Link | ||||
| 4-Phenylbutyrohydroxamic acid | Investigative | [131] | ||
| Synonyms |
N-Hydroxy-4-phenylbutanamide; 32153-46-1; NSC131300; UNII-QX182FOM5S; QX182FOM5S; 4-phenylbutanehydroxamic acid; CHEMBL55895; Benzenebutanamide, N-hydroxy-; NSC 131300; AC1Q7DIW; AC1L5RDX; Phenylbutyrylhydroxamic Acid; AC1Q5QD1; N-Hydroxy-4-phenyl-butyramide; 4-Phenylbutyryl hydroxamic acid; SCHEMBL1350853; CTK4G8310; DTXSID60185943; MolPort-011-492-164; UPHXPXYRKPCXHK-UHFFFAOYSA-N; ZINC4962622; STL301752; BDBM50015142; AKOS009266186; MCULE-9765156954; NSC-131300; NE28489; BCB03_000829; EN300-68596
Click to Show/Hide
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|||
| MOA | Inhibitor | |||
| Activity | Ki = 430 nM | |||
| External Link | ||||
| 8-Oxo-8-phenyl-octanoic acid hydroxyamide | Investigative | [132] | ||
| Synonyms |
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
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|||
| MOA | Inhibitor | |||
| External Link | ||||
| Octanedioic acid bis-hydroxyamide | Investigative | [133] | ||
| Synonyms |
Suberohydroxamic acid
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| MOA | Inhibitor | |||
| Activity | Ki = 29 nM | |||
| External Link | ||||
| ST-2986 | Investigative | [134] | ||
| Synonyms |
CHEMBL471041; SCHEMBL3444455; BDBM50278219
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 11000 nM | |||
| External Link | ||||
| 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide | Investigative | [128] | ||
| Synonyms |
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
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|||
| MOA | Inhibitor | |||
| Activity | IC50 = 1400 nM | |||
| External Link | ||||
| 7-Mercapto-heptanoic acid phenylamide | Investigative | [135] | ||
| Synonyms |
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
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| MOA | Inhibitor | |||
| Activity | IC50 = 1300 nM | |||
| External Link | ||||
| 6-benzenesulfinylhexanoic acid hydroxamide | Investigative | [136] | ||
| Synonyms |
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-(2-Mercapto-ethyl)-N'-phenyl-succinamide | Investigative | [137] | ||
| Synonyms |
CHEMBL193959
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|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-Mercapto-heptanoic acid biphenyl-4-ylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL112311
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| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-phenylacetylamino-benzamide | Investigative | [138] | ||
| Synonyms |
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
Click to Show/Hide
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| MOA | Inhibitor | |||
| External Link | ||||
| 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
Click to Show/Hide
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|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide | Investigative | [139] | ||
| Synonyms |
CHEMBL143674; SCHEMBL673760
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|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one | Investigative | [140] | ||
| Synonyms |
CHEMBL126355; BDBM50222394
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| Octanedioic acid hydroxyamide pyridin-4-ylamide | Investigative | [141] | ||
| Synonyms |
SCHEMBL8082656; CHEMBL165162; ZINC13472304
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-(6-Mercapto-hexyl)-benzamide | Investigative | [135] | ||
| Synonyms |
CHEMBL112364; BDBM50223650
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide | Investigative | [141] | ||
| Synonyms |
CHEMBL167455
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide | Investigative | [138] | ||
| Synonyms |
SCHEMBL675474
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 6-benzenesulfonylhexanoic acid hydroxamide | Investigative | [136] | ||
| Synonyms |
CHEMBL203207
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one | Investigative | [128] | ||
| Synonyms |
SCHEMBL7373122; CHEMBL116578
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester | Investigative | [135] | ||
| Synonyms |
CHEMBL111806; SCHEMBL14812153
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 4-Butyrylamino-N-hydroxy-benzamide | Investigative | [139] | ||
| Synonyms |
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one | Investigative | [140] | ||
| Synonyms |
CHEMBL127328
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-Mercapto-heptanoic acid biphenyl-3-ylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL320323
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione | Investigative | [142] | ||
| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide | Investigative | [138] | ||
| Synonyms |
SCHEMBL676079
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide | Investigative | [135] | ||
| Synonyms |
CHEMBL324126
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-Mercapto-heptanoic acid pyridin-3-ylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
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|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 6-Phenoxy-hexane-1-thiol | Investigative | [135] | ||
| Synonyms |
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 4-Benzoylamino-N-hydroxy-benzamide | Investigative | [138] | ||
| Synonyms |
SCHEMBL673678; CHEMBL191227
Click to Show/Hide
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|||
| MOA | Inhibitor | |||
| External Link | ||||
| 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide | Investigative | [132] | ||
| Synonyms |
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one | Investigative | [128] | ||
| Synonyms |
CHEMBL112148; SCHEMBL7364383; BDBM50218532
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one | Investigative | [140] | ||
| Synonyms |
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 6-Mercapto-hexanoic acid phenylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| Activity | IC50 = 2220 nM | |||
| External Link | ||||
| Cyclostellettamine derivative | Investigative | [143] | ||
| Synonyms |
CHEMBL88332
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide | Investigative | [132] | ||
| Synonyms |
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 5-Mercapto-pentanoic acid phenylamide | Investigative | [135] | ||
| Synonyms |
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| Octanedioic acid hydroxyamide pyridin-2-ylamide | Investigative | [141] | ||
| Synonyms |
SCHEMBL8090513; CHEMBL164872; ZINC13472303
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide | Investigative | [137] | ||
| Synonyms |
CHEMBL193979
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| 2-(methylsulfonylthio)ethyl 2-propylpentanoate | Investigative | [142] | ||
| Synonyms |
CHEMBL271677; SCHEMBL4156413
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one | Investigative | [140] | ||
| Synonyms |
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
Click to Show/Hide
|
|||
| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide | Investigative | [138] | ||
| Synonyms |
SCHEMBL676080
Click to Show/Hide
|
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| MOA | Inhibitor | |||
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| N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide | Investigative | [144] | ||
| Synonyms |
N-hydroxy-4-(3-phenylpropanamido)benzamide
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| MOA | Inhibitor | |||
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| N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide | Investigative | [138] | ||
| Synonyms |
SCHEMBL7311087
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| MOA | Inhibitor | |||
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| 8-Oxo-8-phenyl-octanoic acid | Investigative | [141] | ||
| Synonyms |
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
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| MOA | Inhibitor | |||
| External Link | ||||
| N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide | Investigative | [138] | ||
| Synonyms |
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
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| MOA | Inhibitor | |||
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| 6-phenylsulfanylhexanoic acid hydroxamide | Investigative | [136] | ||
| Synonyms |
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
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| MOA | Inhibitor | |||
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| ST-2987 | Investigative | [134] | ||
| Synonyms |
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
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| MOA | Inhibitor | |||
| Activity | IC50 = 2670 nM | |||
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| 7-Mercapto-heptanoic acid quinolin-3-ylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL112234
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| MOA | Inhibitor | |||
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| 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide | Investigative | [145] | ||
| Synonyms |
CHEMBL84288
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| MOA | Inhibitor | |||
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| 8-Mercapto-octanoic acid phenylamide | Investigative | [135] | ||
| Synonyms |
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
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| MOA | Inhibitor | |||
| Activity | IC50 = 754 nM | |||
| External Link | ||||
| N-(6-Hydroxycarbamoyl-hexyl)-benzamide | Investigative | [141] | ||
| Synonyms |
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
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| MOA | Inhibitor | |||
| External Link | ||||
| 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one | Investigative | [128] | ||
| Synonyms |
CHEMBL326529; SCHEMBL7365237; BDBM50217957
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| MOA | Inhibitor | |||
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| 7-Mercapto-heptanoic acid benzothiazol-2-ylamide | Investigative | [135] | ||
| Synonyms |
CHEMBL178779
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| MOA | Inhibitor | |||
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| N-Hydroxy-4-(pentanoylamino-methyl)-benzamide | Investigative | [139] | ||
| Synonyms |
CHEMBL143102
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| MOA | Inhibitor | |||
| External Link | ||||
| PSAMMAPLIN A | Investigative | [132] | ||
| Synonyms |
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
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| MOA | Inhibitor | |||
| External Link | ||||
| 2A60: Acute myeloid leukaemia | 283 Compound(s) Regulating the Disease | Click to Show/Hide the Full List | ||
| Atezolizumab | Approved | [34] | ||
| External Link | ||||
| ENASIDENIB MESYLATE | Approved | [11] | ||
| Synonyms |
UNII-UF6PC17XAV; AG-221 mesylate; Enasidenib (mesylate); UF6PC17XAV; Enasidenib mesylate [USAN]; Enasidenib mesylate (USAN); Enasidenib mesilate; Enasidenib methanesulfonate; Idhifa (TN); SCHEMBL16448052; HY-18690A; CS-7541
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| Lestaurtinib | Approved (orphan drug) | [146] | ||
| Synonyms |
A 1544750; CEP 701; KT 5555; KT5555; SP 924; CEP-701; KT-5555; SPM-924; Lestaurtinib (USAN/INN)
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| Motixafortide | Approved | [147] | ||
| External Link | ||||
| ARN-509 | Approved | [148] | ||
| Synonyms |
Arn-509 (AR inhibitor)
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| DEOXYCYTIDINE | Approved | [149] | ||
| Synonyms |
Cytosine deoxyribonucleoside; 2'-dC; bmse000323; ACMC-209rv6; CYTIDINE, 2'-DEOXY-; Cytosine deoxy nucleoside hydrochloride; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; Desoxycytidine; 4-amino-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; 3h-deoxycytidine; 4-amino-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 40093-94-5; AC1L19OG; TimTec1_003892; NCIOpen2_004589; Oprea1_817993
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| Bestatin | Approved | [150] | ||
| Synonyms |
Bestatin (TN); CHEBI:3070; UPCMLD-DP116; CHEMBL476869; SureCN25971; Ubenimex (JP16/INN); Ubenimex (JP17/INN); SCHEMBL25971; GTPL5151; AC1L972Z; UPCMLD-DP116:001; DTXSID4048430; CHEBI:140702; ZINC1532730; ZINC01532730; BDBM50010142; AKOS026750073; NCGC00161660-01; C00732; D00087; ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-D-leucine; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
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| Tagraxofusp | Approved | [148] | ||
| Synonyms |
Tagraxofusp [INN]; Molecule 129; Tagraxofusp [USAN]; UNII-8ZHS5657EH; 8ZHS5657EH; Diphtheria toxin-il-3 fusion protein targeting IL-3 receptor
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| Uracil mustard | Approved | [151] | ||
| Synonyms |
Chlorethaminacil; Demethyldopan; Desmethyldopan; Nordopan; Uracillost; Uracilmostaza; Uramustin; Uramustina; Uramustine; Uramustinum; Aminouracil mustard; Uracil lost; Uracil lost [German]; Uracil mustard [USAN]; Uracil nitrogen mustard; ENT 50439; U 8344; CB-4835; SK-19849; U-8344; Uracil mustard (TN); Uracil mustard (USAN); Uramustina [INN-Spanish]; Uramustine (INN); Uramustinum [INN-Latin]; URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY); 2,6-Dihydroxy-5-bis(2-chloroethyl)aminopyrimidine; 2,6-Dihydroxy-5-bis[2-chloroethyl]aminopyrimidine; 5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)uracil; 5-(Di-(beta-chloroethyl)amino)uracil; 5-(Di-2-chloroethyl)aminouracil; 5-Aminouracil mustard; 5-N,N-Bis(2-chloroethyl)aminouracil; 5-[Bis(2-chlorethyl)amino]-2,4(1H,3H)pyrimidinedione; 5-[Bis(2-chloroethyl)amino]uracil; 5-[Di(2-chloroethyl)amino]uracil; 5-[Di(beta-chloroethyl)amino]uracil; 5-[Di(beta.-chloroethyl)amino]uracil; 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione; 5-[bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4(1H,3H)-dione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol
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| Tisagenlecleucel | Application submitted | [31] | ||
| Synonyms |
Tisagenlecleucel-T
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| Olutasidenib | Approved | [34] | ||
| Synonyms |
NEQYWYXGTJDAKR-JTQLQIEISA-N; Olutasidenib; UNII-0T4IMT8S5Z; 0T4IMT8S5Z; (S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; Olutasidenib [USAN]; SCHEMBL17603134; HY-114226; CS-0080183; 5-(((1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-(((1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro-1-methyl-6-oxo-; 1887014-12-1
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| Midostaurin | Approved | [152] | ||
| Synonyms |
PKC412; 120685-11-2; Cgp 41251; 4'-N-Benzoylstaurosporine; CGP-41251; Benzoylstaurosporine; PKC-412; RYDAPT; PKC 412; UNII-ID912S5VON; N-Benzoylstaurosporine; ID912S5VON; CHEMBL608533; CHEBI:63452; Cgp 41 251; N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide; PKC-412(Midostaurin); Midostaurin (PKC412); Midostaurin (USAN/INN); Midostaurin [USAN:INN]; CGP 41231; Rydapt (TN); CPG 41251
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| Quizartinib | Approved | [55] | ||
| Synonyms |
Quizartinib
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| Ivosidenib | Approved | [55] | ||
| Synonyms |
UNII-Q2PCN8MAM6; Q2PCN8MAM6; Ivosidenib [INN]; Ivosidenib [USAN]; Ivosidenib [WHO-DD]; GTPL9217; SCHEMBL15122512; EX-A992; MolPort-044-560-317; RG120; s8206; 1448347-49-6 (Ivosidenib); AKOS028113340; ZINC205136523; CS-5122; AS-35058; HY-18767
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| Gemtuzumab ozogamicin | Approved | [153] | ||
| Synonyms |
Mylotarg (TN)
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| Gilteritinib | Approved | [148] | ||
| Synonyms |
UNII-66D92MGC8M; 66D92MGC8M; Gilteritinib [USAN:INN]; Gilteritinib(ASP2215); Gilteritinib (USAN/INN); Gilteritinib (ASP2215); Gilteritinib (ASP-2215); SCHEMBL282229; GTPL8708; MolPort-038-934-933; BDBM144315; C29H44N8O3; 3694AH; s7754; AKOS030234455; ZINC113476229; DB12141; CS-3885; KS-0000064E; AS-35199
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| Thioguanine | Approved | [154] | ||
| Synonyms |
6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog)
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| Daunorubicin | Approved | [155] | ||
| Synonyms |
Daunomycin; 20830-81-3; Rubidomycin; Cerubidine; Daunorubicine; Acetyladriamycin; Leukaemomycin C; Daunorubicinum; Daunarubicinum; Daunorrubicina; Daunamycin; Cerubidin; DaunoXome; Rubomycin C; (+)-Daunomycin; Daunoblastin; Anthracyline; Rubomycin; Daunorubicinum [INN-Latin]; RP 13057; Daunorubicin [INN:BAN]; RCRA waste no U059; FI6339; NSC-82151; DAUNORUBICIN HCL; DaunoXome (TN); UNII-ZS7284E0ZP; CCRIS 914; ZS7284E0ZP; CHEBI:41977; HSDB 5095; C27H29NO10; NCI-C04693; EINECS 244-069-7; Ondena; NSC 83142; Daunoblastine; Antibiotics from Streptomyces coeruleorubidus; DM1; FI 6339; Dauno-Rubidomycine; Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin, Hydrochloride; VS-103; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Anthracycline
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| Idarubicin | Approved | [156] | ||
| Synonyms |
DMDR; Idamycin; Idarubicina; Idarubicine; Idarubicinum; Zavedos; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin hydrochloride; DM5; I 1656; IMI 30; IMI-30; Idamycin (TN); Idarubicin (INN); Idarubicin [INN:BAN]; Idarubicina [INN-Spanish]; Idarubicine [INN-French]; Idarubicinum [INN-Latin]; Zavedos (TN); (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-A-l-lyxo-hexopyranoside; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 4-DMD; 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; 4-Desmethoxydaunorubicin
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| Aclarubicin | Approved | [157] | ||
| Synonyms |
Aclacin; Aclacur; Aclarubicine; Aclarubicino; Aclarubicinum; Jaclacin; Aclacinomycin A; Aclucinomycin A; Antibiotic MA 144A; Antibiotic MA 144A1; Antibiotic MA 144G1; MA 144G1; Aclarubicine [INN-French]; Aclarubicino [INN-Spanish]; Aclarubicinum [INN-Latin]; Antibiotic MA144-A1; MA 144-A1; MA-144A1; Acene-1-carboxylate; Aclarubicin (USAN/INN); Aclarubicin [USAN:BAN:INN]; Alpha-L-lyxo-hexopyranosyl]-oxy]-1-naphthacenecarboxalic acid methyl ester; 10-epi-Aclacinomycin A
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| Magrolimab | Phase 3 | [158] | ||
| Synonyms |
GS-4721
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| DSP-7888 | Phase 2 | [34] | ||
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| 131I-labelled aCD45 | Phase 3 | [159] | ||
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| ATIR101 | Phase 3 | [160] | ||
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| Dociparstat sodium | Phase 3 | [161] | ||
| Synonyms |
DSTAT
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| Iomab-B CD45 | Phase 3 | [34] | ||
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| Tasisulam | Phase 3 | [162] | ||
| Synonyms |
Tasisulam sodium; LY-573636; LY-573636 sodium; LY-573636Na; Apoptosis stimulator (cancer), Lilly
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| Vadastuximab talirine | Phase 3 | [31] | ||
| Synonyms |
Vadastuximab talirine [INN]; Vadastuximab talirine [USAN]; Vadastuximab talirine [WHO-DD]; UNII-T13V17U431; T13V17U431; UNII-X1TW58ZV0U component BNJNAEJASPUJTO-DUOHOMBCSA-N; 1436390-64-5
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| Abexinostat | Phase 3 | [34] | ||
| Synonyms |
PCI-24781; 783355-60-2; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide
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| Peginterferon lambda-1a | Phase 3 | [163] | ||
| Synonyms |
BMS-914143; IFN lambda, ZymoGenetics/Novo Nordisk; Interferon lambda 1, ZymoGenetics/Novo Nordisk; PEG-IL-29; PEG-rIL-29; Interleukin-29, ZymoGenetics/Novo Nordisk; PEG-IFN lambda, ZymoGenetics/Novo Nordisk; PEG-interferon lambda, ZymoGenetics/Novo Nordisk; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk; Peginterferon lambda-1a, ZymoGenetics/Bristol-Myers Squibb; PEG-IFN lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; PEG-interferon lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; Recombinant PEG-interferon lambda-1, ZymoGenetics/Bristol-Myers Squibb; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb
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| CPX-351 | Phase 3 | [55] | ||
| Synonyms |
Vyxeos; Cytarabine / daunonubicin; Daunonubicin / cytarabine; CPX 351; Cytarabine mixture with daunonubicin; Daunonubicin mixture with cytarabine; Daunonubicin and cytarabine liposomal injection; SCHEMBL3959238; 1256639-86-7; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-, mixt. with 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
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| BYM338 | Phase 2/3 | [164] | ||
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| SGI110 | Phase 3 | [165] | ||
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| Elacytarabine | Phase 3 | [166] | ||
| Synonyms |
Elacyt (TN)
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| RG7388 | Phase 3 | [167] | ||
| Synonyms |
Idasanutlin; 1229705-06-9; Idasanutlin (RG-7388); RG-7388; UNII-QSQ883V35U; QSQ883V35U; CHEMBL2402737; Benzoic acid, 4-((((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl)carbonyl)amino)-3-methoxy-; RO5503781; Idasanutlin [USAN:INN]; Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-; RG-7388;Idasanutlin; RO-5503781; SCHEMBL442856
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| Galinpepimut-S | Phase 3 | [168] | ||
| External Link | ||||
| Pracinostat | Phase 3 | [55] | ||
| Synonyms |
929016-96-6; SB939; SB 939; Pracinostat (SB939); SB-939; UNII-GPO2JN4UON; GPO2JN4UON; CHEMBL1851943; (E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide; 2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-; Pracinostat [INN]; (2E)-3-(2-Butyl-1-[2-(diethylamino)ethyl]-1h-1,3-benzodiazol-5-yl)-n-hydroxyprop-2-enamide; 2-Propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzimidazol-5-yl)-N-hydroxy-, (2E)-
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| DFP-10917 | Phase 3 | [34] | ||
| External Link | ||||
| AG-881 | Phase 1 | [34] | ||
| Synonyms |
Vorasidenib; 1644545-52-7; UNII-789Q85GA8P; 789Q85GA8P; AG881; 9UO; 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine; Vorasidenib [INN]; Vorasidenib (AG-881); SCHEMBL16393139; AG 881 [WHO-DD]; QCZAWDGAVJMPTA-RNFRBKRXSA-N; BDBM279948; EX-A2574; US10028961, Compound 101; AG 881; s8611; CS-8033; HY-104042; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoro propan-2-yl)-1,3,5-triazine-2,4-diamine; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoroprop
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| AG-221 | Phase 1/2 | [169] | ||
| Synonyms |
AG-221 (IDH2 inhibitor)
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| CP-868596 | Phase 3 | [34] | ||
| Synonyms |
Crenolanib; 670220-88-9; Crenolanib (CP-868596); ARO-002; UNII-LQF7I567TQ; LQF7I567TQ; CP-868596 (Crenolanib); CP-868,596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP868569; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine; J-502712; 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
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| Rydaptmidostaurin | Phase 3 | [34] | ||
| External Link | ||||
| Sapacitabine | Phase 3 | [170] | ||
| Synonyms |
CYC682
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| S-110 | Phase 3 | [165] | ||
| Synonyms |
DNA demethylating agent (myelodysplastic syndrome), Supergen
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| VAL-083 | Phase 1/2 | [171] | ||
| Synonyms |
Dianhydrogalactitol; 23261-20-3; UNII-4S465RYF7M; 1,2:5,6-DIANHYDROGALACTITOL; Dulcitoldiepoxide; 4S465RYF7M; Dianhydrogalactitol [USAN:INN]; SCHEMBL4306431; Dianhydrogalactitol (USAN/INN); CHEMBL3137322; AAFJXZWCNVJTMK-GUCUJZIJSA-N; ZINC4963497; CS-1358; DB12873; NSC-1323313; HY-16513; BC657197; D10623; W-5268; J-015059; 457899-38-6
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| CC-486 | Phase 3 | [34] | ||
| Synonyms |
AG-14361; AG14361; 328543-09-5; UNII-48N0U0K50I; AG 14361; CHEMBL65892; 48N0U0K50I; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; AG-014361; 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; Imidazo(4,5,1-jk)(1,4)benzodiazepin-7(4H)-one, 2-(4-((dimethylamino)methyl)phenyl)-5,6-dihydro-; 2-[4-[(Dimethylamino)methyl]phenyl]-5,6-dihydroimidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one; SMR000486393; MLS006011157; MLS001065917; Nucleoside analogue
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| Hu5F9-G4 | Phase 3 | [31] | ||
| External Link | ||||
| Iomab-B | Phase 3 | [172] | ||
| Synonyms |
Iomab-B (TN)
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| PEG arginine deiminase | Phase 1 | [34] | ||
| Synonyms |
ADI-PEG 20
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| CPI-613 | Phase 3 | [55] | ||
| Synonyms |
95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874
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| Zarnestra | Phase 3 | [173] | ||
| Synonyms |
JAN; Tipifarnib; Tipifarnib [USAN]; R 115777; R115777; R-11577; R-115777; Tipifarnib (USAN/INN); Zarnestra, IND 58359, R115777, Tipifarnib; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-R115777; 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone; 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE
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| LMT-X | Phase 3 | [174] | ||
| Synonyms |
Second-generation tau aggregation inhibitor (Alzheimer's disease); Second-generation tau aggregation inhibitor (Alzheimer's disease), TauRx
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| Elesclomol | Phase 3 | [175] | ||
| Synonyms |
488832-69-5; Elesclomol (STA-4783); STA-4783; UNII-6UK191M53P; CHEBI:79369; 6UK191M53P; Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]; 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid; N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; J-503879; C19H20N4O2S2; 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide; Elesclomol [USAN:INN]; elesclomolum
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| GMI-1271 | Phase 3 | [176] | ||
| Synonyms |
Uproleselan
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| AT-406 | Phase 3 | [177] | ||
| Synonyms |
1071992-99-8; SM 406; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; CHEMBL2158051; QCR-136; UNII-N65WC8PXDD; N65WC8PXDD; AT406 (SM-406, ARRY-334543); J-501625; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; AT-406/Debio-1143
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| PR1 peptide antigen vaccine | Phase 3 | [178] | ||
| Synonyms |
PR1 peptide antigen vaccine (leukemia); PR1 peptide antigen vaccine (leukemia), MD Anderson; PR1 peptide antigen vaccine (leukemia), Vaccine Company
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| CPI-0610 | Phase 3 | [34] | ||
| External Link | ||||
| SNS-595 | Phase 3 | [179] | ||
| Synonyms |
Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
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| Selinexor | Phase 3 | [55] | ||
| Synonyms |
Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
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| Volasertib | Phase 3 | [55] | ||
| Synonyms |
755038-65-4; BI 6727; BI-6727; BI6727 (Volasertib); Volasertib (BI 6727); UNII-6EM57086EA; 6EM57086EA; BI6727; N-{trans-4-[4-(Cyclopropylmethyl)piperazin-1-Yl]cyclohexyl}-4-{[(7r)-7-Ethyl-5-Methyl-8-(1-Methylethyl)-6-Oxo-5,6,7,8-Tetrahydropteridin-2-Yl]amino}-3-Methoxybenzamide; Volasertib [USAN:INN]; IBI; Volasertib (USAN); BI6727,Volasertib; Volasertib(BI6727); BI6727 - Volasertib; Volasertib (BI6727); BI6727 (Volasertib)/; BI 6727 (Volasertib); MLS006011195; SCHEMBL738946; SCHEMBL9888052; SCHEMBL2169101; GTPL7947
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| Rivo-cel | Phase 2/3 | [180] | ||
| Synonyms |
BPX-501
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| CLL1 CAR-T Cell | Phase 2/3 | [181] | ||
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| NLG8189 | Phase 2/3 | [34] | ||
| Synonyms |
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
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| CD123/CLL1 CAR-T Cells | Phase 2/3 | [181] | ||
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| K-NK002 | Phase 2 | [182] | ||
| Synonyms |
CSTD-002-NK
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| Dilanubicel | Phase 2 | [183] | ||
| Synonyms |
NLA101
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| DS-3201b | Phase 2 | [184] | ||
| Synonyms |
Valemetostat; 1809336-39-7; UNII-60RD0234VE; 60RD0234VE; 1809336-39-7 (free base); DS-3201; (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide; Valemetostat 2HCl; Valemetostat [INN]; Valemetostat (DS-3201); CHEMBL4597193; EZH1/2 inhibitor DS-3201; SCHEMBL18393626; SCHEMBL18393627; SCHEMBL18639210; EX-A3423; DS3201; NSC813381; s8926; NSC-813381; HY-109108; CS-0039740; D11551
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| BST-236 | Phase 2 | [185] | ||
| Synonyms |
Aspacytarabine; UNII-JL7V54Z2BR; JL7V54Z2BR; 2098942-53-9; N4-(1-beta-D-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)-; Astarabine; Aspacytarabine [INN]; CHEMBL4297599; L-Asparagine, N-(1-beta-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-; N4-(1-N2-D-Arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)- L-asparagine
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| Zelenoleucel | Phase 2 | [186] | ||
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| CX-01 | Phase 2 | [34] | ||
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| LY2090314 | Phase 2 | [187] | ||
| Synonyms |
603288-22-8; LY-2090314; UNII-822M3GYM67; Kinome_3681; LY 2090314; CHEMBL362558; 822M3GYM67; 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione; SCHEMBL633455; GTPL7958; DTXSID90209085; MolPort-035-944-332; EX-A2214; ZINC3817327; BCP07855; s7063; BDBM50150699; AKOS032950045; AKOS026750195; CS-1633; DB11913; SB16558; NCGC00378942-05; NCGC00378942-02; BC600682; QC-11735; HY-16294; KB-78238; FT-0698670; LY2090314, >
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| Flotetuzumab | Phase 2 | [188] | ||
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| BGB-324 | Phase 1/2 | [55] | ||
| Synonyms |
BGB-001; SiRNA therapeutic (metastasis cancer), BiobergenBio
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| PTX-200 | Phase 2 | [34] | ||
| Synonyms |
Plant-derived antiparkinsonian, Phytrix
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| LY2523355 | Phase 2 | [189] | ||
| Synonyms |
Litronesib
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| Prexigebersen | Phase 2 | [34] | ||
| Synonyms |
Prexigebersen [INN]; Prexigebersen [USAN:INN]; UNII-8W1O4Y961B; 8W1O4Y961B; BP-100-1.01/L-Grb2; DNA, d(A-T-A-T-T-T-G-G-C-G-A-T-G-G-C-T-T-C); 202484-91-1; 1352967-54-4
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| ALT-801 | Phase 2 | [190] | ||
| Synonyms |
ALT-801 (donor lymphocyte infusion, cancer); ALT-801 (donor lymphocyte infusion, cancer), Altor; STAR IL-2 conjugate (donor lymphocyte infusion, cancer), Altor; STAR-Ck (donor lymphocyte infusion, cancer), Altor; Soluble T-cell Antigen Receptor IL-2 conjugate (donor lymphocyte infusion, cancer), Altor
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| ENMD-2076 | Phase 2 | [191] | ||
| Synonyms |
934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; UNII-J6U9WP10T7; ENMD2076; J6U9WP10T7; CHEMBL482968; 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine; 6-(4-METHYL-1-PIPERAZINYL)-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-[(1E)-2-PHENYLETHENYL]-4-PYRIMIDINAMINE; ENMD-981693; MLS006011042; SCHEMBL596481; GTPL7885; SCHEMBL15668060; SCHEMBL10122872; ENND-2076; EX-A235; DTXSID60239430; MolPort-009-679-391; AOB87159
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| FPI-01 | Phase 2 | [192] | ||
| Synonyms |
WT-1 therapeutic vaccine (cancer), Formula Pharmaceuticals
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| Inecalcitol oral | Phase 2 | [34] | ||
| Synonyms |
Inecalcitol; TX-522; UNII-05FZV98342; TX 522; 163217-09-2; AC1OCD0K; 19-Nor-14-epi-23-yne-1,25 dihydroxyvitamin D3; 05FZV98342; (1R,3R)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; (7E)-(1R,3R,14R)-19-nor-23-yne-9,10-seco-5,7-cholestadiene-1,3,25-triol; Inecalcitol [INN]; SCHEMBL754593; GTPL7747; CHEMBL2105107; LMST03020649; 8151AH; ZINC12504514; AKOS025312295; AN-7569; DB04796; TX-527; Vitamin D analogs, Catholic University of Leuven; Vitamin D analogs, KULeuven; Inecalcitol (oral, hyperthyroidism), Hybrigenics; Inecalcitol (sc, psoriasis), Hybrigenics; Vitamin D analog (sc, psoriasis), Hybrigenics; Inecalcitol (oral, prostate cancer/psoriasis), Hybrigenics
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| Eryaspase | Phase 2 | [34] | ||
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| ALXN6000 | Phase 2 | [31] | ||
| Synonyms |
Samalizumab
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| BI 2536 | Phase 2 | [193] | ||
| Synonyms |
BI2536, BI 2536
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| MK8242 | Phase 2 | [194] | ||
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| Leukemia DNA vaccine | Phase 2 | [195] | ||
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| Anti-CD45 mAb 131I-BC8 | Phase 2 | [55] | ||
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| BREQUINAR | Phase 1/2 | [196] | ||
| Synonyms |
96187-53-0; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; Brequinar [INN]; Biphenquinate; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinarum [INN-Latin]; UNII-5XL19F49H6; C23H15F2NO2; NSC-368390; NSC 368390; 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid; PHEZJEYUWHETKO-UHFFFAOYSA-N; Dup 785; 5XL19F49H6; 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID; brequinarum
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| Leukemia cancer vaccine | Phase 2 | [197] | ||
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| ADCT-301 | Phase 1 | [34] | ||
| Synonyms |
camidanlumab tesirine
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| Flavopiridol | Phase 2 | [55] | ||
| Synonyms |
FLAVO; Alvocidib [INN]; Flavopiridol hydrochloride; L 868275; HMR-1275; L-868275; L86-8275; HMR-1275, Alvocidib, L868275, Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
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| BP-100-1-01 | Phase 2 | [198] | ||
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| IRX-2 | Phase 2 | [199] | ||
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| Cenersen | Phase 2 | [200] | ||
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| Lirilumab | Phase 2 | [201] | ||
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| LOR-2040 | Phase 2 | [202] | ||
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| Sodium butyrate | Phase 2 | [203] | ||
| Synonyms |
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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| GRNVAC1 | Phase 2 | [204] | ||
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| H3B-8800 | Phase 1 | [34] | ||
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| GS-9973 | Phase 2 | [34] | ||
| Synonyms |
Entospletinib; 1229208-44-9; Entospletinib (GS-9973); gs9973; UNII-6I3O3W6O3B; 6-(1H-Indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine; GS 9973; 6I3O3W6O3B; CHEMBL3265032; C23H21N7O; 6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine; Entospletinib [INN]; Entospletinib [USAN:INN]; 4puz; 6-(1h-Indazol-6-Yl)-N-[4-(Morpholin-4-Yl)phenyl]imidazo[1,2-A]pyrazin-8-Amine; SCHEMBL2483776; GTPL7889; MolPort-035-395-879; HMS3653D13; EX-A1120; BCP09582; AOB87385
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| ALT-803 | Phase 2 | [205] | ||
| Synonyms |
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
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| CHR-2797 | Phase 2 | [206] | ||
| Synonyms |
Tosedostat; Tosedostat, CHR2797, CHR-2797
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| External Link | ||||
| HTERT RNA vaccine | Phase 2 | [207] | ||
| External Link | ||||
| MB-102 | Phase 2 | [31] | ||
| Synonyms |
Relmapirazin; UNII-Q3UQB8PQ6H; Q3UQB8PQ6H; Relmapirazin [INN]; CHEMBL1949708; SCHEMBL16738795; N,N'-((3,6-Diamino-2,5-pyrazinediyl)dicarbonyl)bis(D-serine); D-Serine, N,N'-((3,6-diamino-2,5-pyrazinediyl)dicarbonyl)bis-; 1313706-17-0
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| External Link | ||||
| phorbol 12-myristate 13-acetate | Phase 2 | [34] | ||
| Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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| External Link | ||||
| AEB1102 | Phase 1 | [34] | ||
| External Link | ||||
| Ifabotuzumab | Phase 2 | [31] | ||
| External Link | ||||
| BP1001 | Phase 2 | [55] | ||
| External Link | ||||
| AS-101 | Phase 2 | [208] | ||
| Synonyms |
Ossirene; Tellaxium trichloride glycol; IVX-Q-101
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| External Link | ||||
| ALRN-6924 | Phase 2 | [34] | ||
| External Link | ||||
| GO-203-2c | Phase 2 | [34] | ||
| External Link | ||||
| Talacotuzumab | Phase 2 | [31] | ||
| Synonyms |
JNJ 473; JNJ 56022473; TAL
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| External Link | ||||
| AST-VAC1 | Phase 2 | [209] | ||
| External Link | ||||
| Lomab B | Phase 2 | [210] | ||
| Synonyms |
BCS-I-131 construct
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| Fipamezole | Phase 2 | [211] | ||
| Synonyms |
150586-58-6; JP-1730; 1H-Imidazole,5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-; Fipamezole [INN]; ACMC-1BZQD; AC1Q4NYS; SCHEMBL935549; AC1L4U51; SCHEMBL18826053; CHEMBL1255582; CTK4C6705; 5-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-1H-imidazole; KXSUAWAUCNFBQJ-UHFFFAOYSA-N; 5-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole; BDBM50417007; SB17014; 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole; L001472; 4-((2RS)-2-Ethyl-5-fluoroindan-2-yl)-1H-imidazole
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| External Link | ||||
| PR104 | Phase 2 | [212] | ||
| Synonyms |
851627-62-8; PR-104; UNII-V16D2ZT7DT; V16D2ZT7DT; 2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate; 2-[(2-bromoethyl)(2,4-dinitro-6-{[2-(phosphonooxy)ethyl]carbamoyl}phenyl)amino]ethyl methanesulfonate; PR 104; SCHEMBL367963; ZINC43131754; AKOS022174966; RL05275; KB-80083; 4CA-1041; AX8282408; J-507569; Benzamide, 2-((2-bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-3,5- dinitro-N-(2-(phosphonooxy)ethyl)-
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| BI-836858 | Phase 1/2 | [34] | ||
| External Link | ||||
| Ficlatuzumab | Phase 2 | [34] | ||
| Synonyms |
AV-299
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| K562/GM-CSF | Phase 2 | [213] | ||
| Synonyms |
GM-CSF-secreting cells+tumor cell vaccine, Cell Genesys/Johns Hopkins
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| PCM-075 | Phase 2 | [34] | ||
| Synonyms |
Onvansertib
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| Actimab-A | Phase 2 | [31] | ||
| External Link | ||||
| IMG-7289 | Phase 2 | [34] | ||
| Synonyms |
KQKBMHGOHXOHTD-KKUQBAQOSA-N; UNII-Y2T4ALDEAT; Y2T4ALDEAT; SCHEMBL17984236; Benzamide, N-((1S)-4-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-4-(1H-1,2,3-triazol-1-yl)-; 1990504-34-1; N-[(2S)-1-(4-(methyl)piperazin-1-yl)-5-[[(1R,2S)-2-(4-fluorophenyl)-cyclopropyl]amino]-1-oxopentan-2-yl]-4-(1H-1,2,3-triazol-1-yl)benzamide
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| External Link | ||||
| WT1-targeted autologous dendritic cell vaccine | Phase 2 | [214] | ||
| Synonyms |
WT1-targeted autologous dendritic cell vaccine (cancer)
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| External Link | ||||
| AZD-4877 | Phase 2 | [215] | ||
| Synonyms |
Anticancer therapeutic (solid tumors), AstraZeneca
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| External Link | ||||
| IPH-2102 | Phase 2 | [216] | ||
| External Link | ||||
| ASP7517 | Phase 1/2 | [217] | ||
| External Link | ||||
| CG-806 | Phase 1/2 | [218] | ||
| Synonyms |
1370466-81-1; UNII-7W3FGR71NN; 7W3FGR71NN; 1-(3-fluoro-4-(7-(4-methyl-1H-imidazol-2-yl)-1-oxoisoindolin-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea; SCHEMBL1292507; EX-A2932; NSC810717; CG'806; NSC-810717; CG-026806; HY-112646; CS-0058852; 1-(3-Fluoro-4-(7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindo-1-4-yl)-phenyl)-3-(3-trifluoromethyl-phenyl)urea; Urea, N-(4-(2,3-dihydro-7-(5-methyl-1H-imidazol-2-yl)-1-oxo-1H-isoindol-4-yl)-3-fluorophenyl)-N'-(3-(trifluoromethyl)phenyl)-
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| KO-539 | Phase 1/2 | [219] | ||
| Synonyms |
UNII-4MOD1F4ENC; 4MOD1F4ENC; SCHEMBL20846943; KO539; Menin-mll interaction inhibitor KO 539; (S)-4-Methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile; 2134675-36-6
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| External Link | ||||
| SAR440234 | Phase 1/2 | [220] | ||
| External Link | ||||
| HM43239 | Phase 1/2 | [221] | ||
| External Link | ||||
| Annamycin | Phase 1/2 | [34] | ||
| Synonyms |
92689-49-1; UNII-SNU299M83Q; 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; SNU299M83Q; (7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-Dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione; AR-522; SCHEMBL19368; (7S,9S)-7-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione; ZINC3918134; DB06420; 5,12-Naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-L-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S-cis)-; 689A491; Q4767903
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| ONO-7475 | Phase 1/2 | [222] | ||
| Synonyms |
1646839-59-9; UNII-0VCB95RHRV; N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide; N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide; SCHEMBL16426362; ONO7475; BCP33232; MFCD32689448; s8933; ONO 7475; HY-114358; CS-0083699; 3-Quinolinecarboxamide, N-(5-((6,7-dimethoxy-4-quinolinyl)oxy)-2-pyridinyl)-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-; N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
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| FF-10101 | Phase 1/2 | [223] | ||
| Synonyms |
1472797-69-5; UNII-7V7IHI0SYG; 7V7IHI0SYG; (S,E)-N-(1-((5-(2-((4-Cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide; SCHEMBL15584726; SCHEMBL16443760; BDBM397428; BCP23613; s8899; US9987278, Compound Reference 38; HY-109584; CS-0032038; FF 10101; FF10101; (E)-N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-4-(dimethylamino)-N-methylbut-2-enamide; 2-Butenamide, N-((1S)-2-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)-5-pyrimidinyl)-4-pentyn-1-yl)amino)-1-methyl-2-oxoethyl)-4-(dimethylamino)-N-methyl-, (2E)-
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| SL-401 | Phase 1/2 | [224] | ||
| External Link | ||||
| SEL-24 | Phase 1/2 | [34] | ||
| Synonyms |
Multikinase inhibitor (cancer), Selvita; SEL-24-1; SEL-24-11; SEL-24-20; Pim-1 kinase inhibitors (cancer), Selvita
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| SEL24 | Phase 1/2 | [225] | ||
| Synonyms |
MEN1703
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| CD38-specific gene-engineered T cells | Phase 1/2 | [226] | ||
| External Link | ||||
| HuM-195-Ac-225 | Phase 1/2 | [227] | ||
| Synonyms |
HuM-195 [225Ac]; SMART 225Ac-M195; Actinium-225-M195; SMART actinium-225-M195; Actinium-225-HuM-195; 225Ac-HuM-195; 225Ac-lintuzumab
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| NEXI-001 | Phase 1/2 | [228] | ||
| External Link | ||||
| INCB59872 | Phase 1/2 | [34] | ||
| External Link | ||||
| MG7-CART | Phase 1/2 | [229] | ||
| External Link | ||||
| PRI-724 | Phase 1/2 | [230] | ||
| External Link | ||||
| CART-123 cells | Phase 1/2 | [231] | ||
| External Link | ||||
| OXi4503 | Phase 1/2 | [34] | ||
| Synonyms |
Combretastatin A-1 phosphate; 288847-34-7; Combretastatin A1 disodium phosphate; 1,2-Benzenediol, 3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, bis(dihydrogen phosphate), tetrasodium salt
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| CIK-CAR.CD19 | Phase 1/2 | [34] | ||
| External Link | ||||
| RhH1.3 | Phase 1/2 | [232] | ||
| Synonyms |
Oncohist; Histone H1, SymbioTec; Recombinant human histone H1.3, SymbioTec; RhH1.3, SymbioTec
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| JTCR016 | Phase 1/2 | [31] | ||
| External Link | ||||
| Muc1-specific gene-engineered T cells | Phase 1/2 | [226] | ||
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| Lintuzumab Ac-225 | Phase 1/2 | [233] | ||
| Synonyms |
Actimab-A (TN)
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| CD33-specific gene-engineered T cells | Phase 1/2 | [226] | ||
| External Link | ||||
| CD19 specific CAR T cells | Phase 1/2 | [234] | ||
| External Link | ||||
| EPZ-5676 | Phase 1/2 | [235] | ||
| Synonyms |
pinometostat; 1380288-87-8; EPZ5676; UNII-8V9YR09EF3; UNII-F66X4M38G5; 8V9YR09EF3; CHEMBL3087499; CHEMBL3414626; F66X4M38G5; 1380288-88-9; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol; Pinometostat, trans-; 5'-[{cis-3-[2-(5-Tert-Butyl-1h-Benzimidazol-2-Yl)ethyl]cyclobutyl}(Propan-2-Yl)amino]-5'-Deoxyadenosine
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| BSK01 | Phase 1/2 | [31] | ||
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| CNDO-109 | Phase 1/2 | [55] | ||
| External Link | ||||
| DT388IL-3 | Phase 1/2 | [236] | ||
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| PLX2853 | Phase 1/2 | [237] | ||
| External Link | ||||
| CWP232291 | Phase 1/2 | [238] | ||
| External Link | ||||
| BPX-501 | Phase 1/2 | [34] | ||
| External Link | ||||
| RTX-240 | Phase 1/2 | [239] | ||
| External Link | ||||
| G0-203-2c | Phase 1/2 | [240] | ||
| External Link | ||||
| CD123-specific gene-engineered T cells | Phase 1/2 | [226] | ||
| External Link | ||||
| CD56-specific gene-engineered T cells | Phase 1/2 | [226] | ||
| External Link | ||||
| OTX-015 | Phase 1/2 | [241] | ||
| Synonyms |
MK 8628
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| FF-10501-01 | Phase 1/2 | [34] | ||
| External Link | ||||
| SGN-CD33A | Phase 1/2 | [55] | ||
| External Link | ||||
| CLL1-specific gene-engineered T cells | Phase 1/2 | [226] | ||
| External Link | ||||
| CLT030 | Phase 1 | [242] | ||
| External Link | ||||
| FT500 | Phase 1 | [243] | ||
| External Link | ||||
| 225Ac-labelled aCD33 | Phase 1 | [244] | ||
| External Link | ||||
| PRGN-3006 | Phase 1 | [245] | ||
| External Link | ||||
| GEM333 | Phase 1 | [246] | ||
| External Link | ||||
| VOB560 | Phase 1 | [247] | ||
| Synonyms |
S 65487
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| SEL120 | Phase 1 | [248] | ||
| Synonyms |
SEL120-34A HCl; UNII-SDM3M518PJ; SDM3M518PJ; 1609452-30-3; SEL-120; SEL120-34A (monohydrochloride); SE-120-34A; 1609452-30-3 (HCl); 7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride; CHEMBL4578881; SCHEMBL17106021; s8840; EX-A2929-1; HY-111388A; BS-16042; CS-0041061; A17086; SEL120(SEL120-34,SEL120-34A); 4H-Imidazo(4,5,1-ij)quinoline, 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-, hydrochloride (1:1); 7,8-Dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4himidazo(4,5,1-ij)quinoline hydrochloride
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| NKX101 | Phase 1 | [249] | ||
| External Link | ||||
| AMG 673 | Phase 1 | [34] | ||
| External Link | ||||
| SAR443579 | Phase 1 | [250] | ||
| External Link | ||||
| IO-202 | Phase 1 | [251] | ||
| External Link | ||||
| CYC140 | Phase 1 | [252] | ||
| Synonyms |
Telparevir; Telaprevir - VX-950; SCHEMBL6468440; CS-M3592; ZINC164377440; (1S,3aR,6aS)-2-((R)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3S,3aS,6aR)-2-[(2R)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide; Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
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| SKI-G-801 | Phase 1 | [253] | ||
| External Link | ||||
| CC-90002 | Phase 1 | [31] | ||
| External Link | ||||
| TAS-1440 | Phase 1 | [254] | ||
| External Link | ||||
| RG6007 | Phase 1 | [255] | ||
| External Link | ||||
| CB-5339 | Phase 1 | [256] | ||
| External Link | ||||
| SAR445419 | Phase 1 | [257] | ||
| External Link | ||||
| AB-110 | Phase 1 | [258] | ||
| External Link | ||||
| LP-108 | Phase 1 | [259] | ||
| External Link | ||||
| H3B-8800 | Phase 1 | [260] | ||
| Synonyms |
(2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate; 1825302-42-8; SCHEMBL17255784; DB14017
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| External Link | ||||
| CD123-CD33 Ccar | Phase 1 | [261] | ||
| External Link | ||||
| JNJ-63709178 | Phase 1 | [34] | ||
| External Link | ||||
| JNJ-67571244 | Phase 1 | [262] | ||
| External Link | ||||
| AMG 427 | Phase 1 | [263] | ||
| External Link | ||||
| AMG 330 | Phase 1 | [34] | ||
| External Link | ||||
| ABBV-184 | Phase 1 | [264] | ||
| External Link | ||||
| MIK665 | Phase 1 | [265] | ||
| Synonyms |
1799631-75-6; (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid; (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; MIK-665; S-64315; SCHEMBL16815710; EX-A2912; NSC809971; NSC-809971; HY-112218; CS-0044179; (5R)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; 1799831-02-9; OK5
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| External Link | ||||
| FT538 | Phase 1 | [266] | ||
| External Link | ||||
| BGB-11417 | Phase 1 | [267] | ||
| External Link | ||||
| SEA-CD70 | Phase 1 | [268] | ||
| External Link | ||||
| CLL1-CD33 cCART cell therapy | Phase 1 | [269] | ||
| External Link | ||||
| KITE-222 | Phase 1 | [270] | ||
| External Link | ||||
| CYAD-02 | Phase 1 | [271] | ||
| External Link | ||||
| GDX012 | Phase 1 | [272] | ||
| External Link | ||||
| APVO436 | Phase 1 | [273] | ||
| External Link | ||||
| LAM-003 | Phase 1 | [34] | ||
| External Link | ||||
| IMGN779 | Phase 1 | [34] | ||
| External Link | ||||
| BPX-701 | Phase 1 | [31] | ||
| External Link | ||||
| BMS-936564 | Phase 1 | [274] | ||
| External Link | ||||
| UCART123 | Phase 1 | [34] | ||
| External Link | ||||
| FF-10101-01 | Phase 1 | [34] | ||
| External Link | ||||
| CART-56 cells | Phase 1 | [275] | ||
| External Link | ||||
| AVB-S6-500 | Phase 1 | [34] | ||
| External Link | ||||
| BB-MPI-03 | Phase 1 | [209] | ||
| External Link | ||||
| ONO-7475 | Phase 1 | [34] | ||
| External Link | ||||
| LC-1 | Phase 1 | [276] | ||
| Synonyms |
Dimethylamino-parthenolide; Parthenolide analog (leukemia), Leuchemix
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| CART123 cells | Phase 1 | [277] | ||
| External Link | ||||
| NKR-2 cells | Phase 1 | [278] | ||
| External Link | ||||
| CART-33 cells | Phase 1 | [275] | ||
| External Link | ||||
| BI-811283 | Phase 1 | [279] | ||
| External Link | ||||
| INNO-305 | Phase 1 | [280] | ||
| External Link | ||||
| IGN523 | Phase 1 | [281] | ||
| External Link | ||||
| CART-34 cells | Phase 1 | [275] | ||
| External Link | ||||
| CM-CS1 T-cell | Phase 1 | [282] | ||
| External Link | ||||
| Mivebresib | Phase 1 | [34] | ||
| Synonyms |
ABBV-075; 1445993-26-9; UNII-VR86R11J7J; VR86R11J7J; N-[4-(2,4-Difluorophenoxy)-3-(6-Methyl-7-Oxo-6,7-Dihydro-1h-Pyrrolo[2,3-C]pyridin-4-Yl)phenyl]ethanesulfonamide; N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; 8NG; Mivebresib [INN]; ABBV-075 (Mivebresib); ABBV075; GTPL9117; SCHEMBL15068241; CHEMBL3987016; Mivebresib(ABBV-075 pound(c); MolPort-044-561-801; RDONXGFGWSSFMY-UHFFFAOYSA-N; BDBM220447; EX-A1082; s8400; ZINC146486516; AKOS030628486; CS-5815
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| AMV564 | Phase 1 | [34] | ||
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| SAR-103168 | Phase 1 | [283] | ||
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| DS-3201 | Phase 1 | [34] | ||
| Synonyms |
QTGYNKYZRZATJB-UHFFFAOYSA-N; 701899-63-0; 2-(2-(2-Methyl-1H-imidazol-5-yl)ethyl)isoindoline-1,3-dione; 2-(2-(2-Methyl-1H-imidazol-5-yl)-ethyl)isoindoline-1,3-dione; SCHEMBL7743461; MolPort-035-945-474; MolPort-035-690-353; ZINC98086069; AKOS024459002; AKOS024262663; MCULE-2708350770; FCH4077443; AK158834; AX8292467; ST2403812; 2-[2-(2-methyl-1H-imidazol-5-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione
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| PF-06747143 | Phase 1 | [31] | ||
| External Link | ||||
| DCLL9718S | Phase 1 | [34] | ||
| External Link | ||||
| CD123CAR-41BB-CD3zeta-EGFRt-expressing T cells | Phase 1 | [284] | ||
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| CSL-362 | Phase 1 | [285] | ||
| Synonyms |
CSL-360; Monoclonal antibody (acute myelogenous leukemia), CSL; Therapeutic leukaemia antibody (AML), CSL; 7G3
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| AMG 176 | Phase 1 | [286] | ||
| Synonyms |
JQNINBDKGLWYMU-GEAQBIRJSA-N; AMG-176; 1883727-34-1; AMG176; SCHEMBL17550216; EX-A2666; HY-101565; CS-0021721; Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
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| XmAb14045 | Phase 1 | [34] | ||
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| SY-1425 | Phase 1 | [34] | ||
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| AGS62P1 | Phase 1 | [34] | ||
| Synonyms |
AGS-62P1
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| CART-117 cells | Phase 1 | [275] | ||
| External Link | ||||
| CART-Muc1 cells | Phase 1 | [275] | ||
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| BAY1436032 | Phase 1 | [34] | ||
| Synonyms |
RNMAUIMMNAHKQR-QFBILLFUSA-N; BAY-1436032; 1803274-65-8; BAY 1436032; SCHEMBL17009632; EX-A1606; AKOS032946249; SB19763; HY-100020; CS-0017982; 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
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| CD33-CAR-T Cell | Phase 1 | [287] | ||
| External Link | ||||
| CART-123 cells | Phase 1 | [275] | ||
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| FATE-NK100 | Phase 1 | [34] | ||
| External Link | ||||
| CC-90009 | Phase 1 | [34] | ||
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| NKR-2 CAR-T Cells | Phase 1 | [288] | ||
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| Anti-CEA CAR-T cells | Phase 1 | [289] | ||
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| RG7775 | Phase 1 | [290] | ||
| External Link | ||||
| OTSSP167 | Phase 1 | [34] | ||
| Synonyms |
OTSSP 167; OTSSP-167; AMX10201
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| IMC-EB10 | Phase 1 | [291] | ||
| Synonyms |
Anti-Flt-3 Mab
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| TCN-P | Phase 1 | [292] | ||
| Synonyms |
TRICIRIBINE PHOSPHATE; 61966-08-3; UNII-5L5GE3DV88; Triciribine phosphate [USAN]; Tricirbine Phosphate; NSC-280594; C13H17N6O7P; NSC 280594; Pentaazaacenaphthylene-5' phosphate ester; 5L5GE3DV88; PHOSPHATE SALT OF TRICYCLIC NUCLEOSIDE; 3-Amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(dihydrogen phosphate); Triciribine phosphate (USAN); VQD-002; TCN-monophosphate; 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-; NSC280594
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| CART-38 cells | Phase 1 | [275] | ||
| External Link | ||||
| ABBV-744 | Phase 1 | [34] | ||
| Synonyms |
OEDSFMUSNZDJFD-UHFFFAOYSA-N; 2138861-99-9; N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; ABBV 744; SCHEMBL19463409; EX-A2713; ACN-054460; HY-112090; CS-0043318
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| AGS-67E | Phase 1 | [31] | ||
| External Link | ||||
| PNK-007 | Phase 1 | [31] | ||
| External Link | ||||
| GSK-2130579A | Phase 1 | [293] | ||
| Synonyms |
Leukemia vaccine, GlaxoSmithKline; WT1 ASCI, GlaxoSmithKline; WT1 antigen specific cancer immunotherapeutic, GlaxoSmithKline; WT1 vaccine, GlaxoSmithKline
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| SGN-CD123A | Phase 1 | [34] | ||
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| IM23 | Phase 1 | [294] | ||
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| Anti-CD33 | Phase 1 | [34] | ||
| External Link | ||||
| KW-2449 | Phase 1 | [295] | ||
| Synonyms |
Tumor antigen-specific mAb (cancer), Kyowa; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
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| CAR-T cells targeting CD56 | Clinical trial | [296] | ||
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| CAR-T cells targeting CD38 | Clinical trial | [296] | ||
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| Valspodar | Discontinued in Phase 3 | [297] | ||
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| LY335979 | Discontinued in Phase 3 | [298] | ||
| Synonyms |
Zosuquidar HCl; Zosuquidar Trihydrochloride; LY 335979; LY-335979; Zosuquidar (TN); Zosuquidar trihydrochloride (USAN); RS-33295-198; Zosuquidar trihydrochloride, RS-33295-198, LY335979; (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, trihydrochloride
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| Lintuzumab Bi-213 | Discontinued in Phase 1/2 | [299] | ||
| Synonyms |
Bismab-A (TN)
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| HuM-195-Bi-213 | Discontinued in Phase 1/2 | [299] | ||
| Synonyms |
SMART 213Bi-M195; SMART Y90-M195; Y90-HuM195; Bismuth-213-HuM195; SMART bismuth-213-M195; Yttrium-90-HuM195; Alpha-particle-emitting radioisotope-linked lintuzumab; 213Bi-HuM195
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| CER-227185 | Discontinued in Phase 1/2 | [300] | ||
| Synonyms |
TCTP inhibitor (cancer), Cerenis; Translationally controlled tumor protein inhibitor (acute myeloid leukemia), Cerenis
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| Autologous Anti-CD 123 CAR TCR/4-1BB-expressing T-lymphocytes | Phase 0 | [301] | ||
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| ATA2321 | Preclinical | [302] | ||
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| 2-D08 | Preclinical | [303] | ||
| Synonyms |
144707-18-6; 2',3',4'-trihydroxyflavone; 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one; SCHEMBL1772778; CHEMBL3115475; AOB4275; SYN5001; AMY31051; BCP18314; EX-A3562; MFCD27995567; s8696; ZINC97439024; CCG-267148; AC-31428; AK312791; AS-16368; HY-114166; 2D08;2 D08; CS-0077855; A16852; 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE
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| CAR-T cells targeting CD117 | Preclinical | [296] | ||
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| CAR-T cells targeting CD123 | Preclinical | [296] | ||
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| CAR-T cells targeting Mucl | Preclinical | [296] | ||
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| CAR-T cells targeting CD33 | Preclinical | [296] | ||
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| CAR-T cells targeting CD34 | Preclinical | [296] | ||
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| CAR-T cells targeting CD133 | Preclinical | [296] | ||
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| CEP-4186 | Terminated | [304] | ||
| Synonyms |
CB-1093; CEP-3265; GS-1590; Neurotrophic compounds, Cephalon/LEO Pharma; Neurotrophic factors, Cephalon/LEO Pharma
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| BI 7273 | Investigative | [305] | ||
| Synonyms |
BI-7273; 1883429-21-7; CHEMBL3823478; 4-(4-((Dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; 4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one; 4-{4-[(dimethylamino)methyl]-2,6-dimethoxyphenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one; 5SW; BI7273; GTPL9146; SCHEMBL19869878; EX-A990; BCP17545; BDBM50183448; MFCD30489736; s8179; ZINC575448880; CCG-268068; CS-5887; HY-100351; J3.533.936A; A16068; Q27075221
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| G3139 + cytarabine (ARA-C) | Investigative | [306] | ||
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| G3139 + Fludarabine | Investigative | [306] | ||
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| CG-1255 | Investigative | [307] | ||
| Synonyms |
CG-1552; Histone deacetylase inhibitors, CircaGen
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| AC-501 | Investigative | [307] | ||
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| AKN-028 | Investigative | [308] | ||
| Synonyms |
Flt3 tyrosine kinase inhibitor (AML), Akinion/Swedish Orphan Biovitrum/Karolinska
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| VLIM-88 | Investigative | [307] | ||
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| G3139 + G-CSF | Investigative | [306] | ||
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| Anti-CD44 mab | Investigative | [307] | ||
| Synonyms |
Hyaloxan; MAT-102; AML therapy (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia therapy (chimerized monoclonal antibody), MAT Biopharma; Anti-CD44 mAb (AML); Anti-CD44 mAb (AML), MAT Biopharma; Anti-CD44 monoclonal antibody (acute myeloid leukemia), MAT Biopharma
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| SB-559457 | Investigative | [309] | ||
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| COTI-001 | Investigative | [307] | ||
| Synonyms |
COTI-002; COTI-003E; Protein tyrosine kinase inhibitors (AML); Protein tyrosine kinase inhibitors (AML), Critical Outcome Technologies
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| Rebelex | Investigative | [307] | ||
| Synonyms |
Spleen tyrosine kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals; Syk kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals
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References
: m6A sites