Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03115
[1]
m6A modification SENP1 SENP1 IGF2BP3 : m6A sites Indirect Enhancement Histone modification EGFR HDAC2 Downstream Gene
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) READER
m6A Target SUMO specific peptidase 1 (SENP1)
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone deacetylase 2 (HDAC2) ERASER View Details
Regulated Target Epidermal growth factor receptor (EGFR) View Details
Crosstalk Relationship m6A  →  Histone modification Enhancement
Crosstalk Mechanism m6A modification indirectly regulates histone modification through downstream signaling pathways
Crosstalk Summary SUMO specific peptidase 1 (SENP1) can desumoylate HDAC2, which enhances Epidermal growth factor receptor (EGFR) transcription and activates the AKT pathway. In addition, we found that IGF2BP3 expression was upregulated in high-risk AML patients and was positively correlated with SENP1 expression. MERIP-qPCR and RIP-qPCR showed that IGF2BP3 binds SENP1 3-UTR in an m6A manner, enhances SENP1 expression, and promotes AKT pathway conduction.
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Epidermal growth factor receptor (EGFR) 222 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Necitumumab Approved [2]
Synonyms
LY3012211
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MOA Modulator
External Link
 Compound Name HEGF Approved [3]
MOA Activator
External Link
 Compound Name Erlotinib Approved [4]
Synonyms
Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
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MOA Inhibitor
Activity Ki = 0.1 nM
External Link
 Compound Name Gefitinib Approved [5]
Synonyms
Gefitini; IRE; Iressa; Irressat; Gefitinib [USAN]; ZD 1839; ZD1839; Iressa (TN); Iressa(TM); ZD-1839; CU-00000000396-1; Gefitinib,Iressa, ZD1839; Gefitinib (JAN/USAN/INN); ZD-1839, Iressa, Gefitinib; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine; N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; 6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine
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MOA Inhibitor
Activity IC50 = 0.1 nM
External Link
 Compound Name Panitumumab Approved [6]
Synonyms
Vectibix; Panitumumab (genetical recombination); Vectibix (TN); Panitumumab (USAN/INN); Panitumumab (genetical recombination) (JAN); Panitumumab (EGFR mAb inhibitor)
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MOA Suppressor
External Link
 Compound Name Cetuximab Approved [7]
Synonyms
Erbitux; Cetuximab (genetical recombination); Erbitux (TN); Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN); novel EGFR mAb inhibitors
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External Link
 Compound Name BIBW 2992 Approved [8]
Synonyms
Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens
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MOA Inhibitor
Activity IC50 = 0.19 nM
External Link
 Compound Name Nitroglycerin Approved [3]
Synonyms
Glyceryl trinitrate; Trinitroglycerin; Nitroglycerol; Nitrostat; Nitroglycerine; Nitro-dur; Minitran; Trinitroglycerol; 55-63-0; Nitroderm; Nitroglyn; Nitrospan; Nitronet; Tridil; Glycerol trinitrate; Transderm-nitro; Transderm Nitro; Epinitril; Susadrin; Perlinganit; Nitrolingual; Nitrolan; Sustonit; Nitrocine; Trinitrin; Natispray; Lenitral; Nitrong; Niong; Nitro-Bid; Nitroderm TTS; Trinitrosan; Rectogesic; Nitroglicerina; Cordipatch; Perglottal; Nitrorectal; Gilustenon; Nitroretard; Nitroplast; Corditrine; Trinitrolong; Adesitrin; Aldonitrin; Angibid; Angiolingual; Angiplex; Anglix; Angonist; Angorin; Anogesic; Buccal; Buccard; Cardabid; Cardamist; Cardinit; Cardiodisco; Cellegesic; Chitamite; Colenitral; Dauxona; Deponit; Diafusor; Discotrine; Dynamite; GTN; Glonoin; Glycerintrinitrate; Glyceroltrinitraat; Glyceryl; Glycerylnitrat; Glytrin; Herwicard; Herzer; Klavikordal; Lentonitrina; Millisrol; Minitram; Minitro; Mionitrat; Myocon; Myoglycerin; Myovin; NTG; Niglin; Niglycon; Nirmin; Nitora; Nitradisc; Nitrangin; Nitrek; Nitriderm; NitroBid; NitroCor; NitroDur; NitroMist; NitroQuick; NitroQuik; Nitroard; Nitrobaat; Nitrobukal; Nitrocap; Nitrocard; Nitrocerin; Nitroclyn; Nitrocontin; Nitrocot; Nitrodisc; Nitrodyl; Nitrogard; Nitrogliceryna; Nitroglin; Nitroject; Nitroletten; Nitrolin; Nitrolowe; Nitromel; Nitromex; Nitromint; Nitropatch; Nitropen; Nitropercuten; Nitroperlinit; Nitroprol; Nitropront; Nitroprontan; Nitrorex; Nitrostabilin; Nitrovis; Nysconitrine; Percutol; Perganit; Plastranit; Polnitrin; Ratiopharm; Soup; Suscard; Sustac; Sustak; TNG; Temponitrin; Trinalgon; Trinipatch; Triniplas; Trinitrol; Trinitron; Turicard; Vascana; Vasoglyn; Vasolator; Vernies; Willong; Blasting gelatin; Blasting oil; Gepan Nitroglicerin; Gilucor nitro; Glycerin trinitrate; Glycerine trinitrate; Glyceryl nitrate; NITRO IV; Neos nitro OPT; Niong Retard; Nitradisc Pad; Nitradisc TTS; Nitriderm TTS; Nitro Bid; Nitro Dur; Nitro Dur TTS; Nitro Mack Retard; Nitro Retard; Nitro Rorer; Nitrobid Oint; Nitrocontin Continus; Nitroderm TTS Ext; Nitrodyl TTS; Nitrol Ointment; Nitrolingual Spray; Nitromack Retard; Nitromint Aerosol; Nitromint Retard; Nitronal Aqueous; Nitrong Retard; Nitrong parenteral; Nitrozell retard; Percutol Oint; Spirit of glonoin; Tridil sublin; Trinitrin Tablets; Trinitrina Erba; Deponit 5; Deponit TTS 10; Deponit TTS 5; Nitrocine 5; Aquo-Trimitrosan; Coro-Nitro; Deponit-5; GTN-Pohl; IMX-150; MED-2002; MQX-503; Mi-Trates; Minitran (TN); NK-843; Natispray (TN); Nit-Ret; Nitrine-TDC; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Span; Nitro-Time; Nitro-lent; NitrocapTD; Nitroderm TTS-5; Nitrogard-SR; Nitroglycerin (NG); Nitroglycerin-ACC; Nitrolingual Pump Spray (TN); Nitromist (TN); Nitrong-SR; Nitrospan (TN); Nitrostat (TN); SDM No 17; SK-106N; SK-866; SK-878; Top-Nitro; Transderm Nitro (TN); Transderm-N TTS; Transderm-Nitro TTS; Transiderm-nitro; Tridil (TN); Trinipatch (TN); Trinitrate, Glyceryl; Nitro-Dur (TN); Nitro-M-Bid; Nitro-bid (TN); Transderm-nitro (TN); DWP-401
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MOA Activator
External Link
 Compound Name Epidermal growth factor Approved [9]
Synonyms
62229-50-9; Urogastrone; Uroenterone; Uroanthelone; Urogastron; Kutrol; beta-Urogastrone; Anthelone U; Urogastrone [JAN]; Gastrone, gamma-uro-; Gastrone, beta-uro- (human); Epidermal growth factor (egf); CCRIS 7234; EINECS 263-468-7; EPIDERMAL GROWTH FACTOR-UROGASTRONE; Gastrone, uro- (9CI); 9010-53-1; Gentel (TN); EGF
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MOA Modulator
External Link
 Compound Name Osimertinib Approved [10]
Synonyms
Tagrisso
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MOA Inhibitor
Activity IC50 = 0.421 nM
External Link
 Compound Name NERATINIB MALEATE Approved [11]
Synonyms
UNII-9RM7XY23ZS; 9RM7XY23ZS; Neratinib maleate [MI]; hki-272 maleate; Nerlynx (TN); SCHEMBL2180998; MolPort-044-561-003; AKOS030524209; DS-19892
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MOA Antagonist
External Link
 Compound Name Amivantamab Approved [12]
MOA Inhibitor
External Link
 Compound Name SKI-758 Approved [13]
Synonyms
SCHEMBL3992463; CHEMBL219557; BDBM13047; 3-quinolinecarbonitrile analog 10; ANUHLKPVOXDYSK-UHFFFAOYSA-N; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]furan-3-yl}quinoline-3-carbonitrile; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6 methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile
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MOA Inhibitor
Activity IC50 = 230 nM
External Link
 Compound Name Dacomitinib Approved [9]
Synonyms
PF-00299804
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MOA Antagonist
Activity IC50 = 1.8 nM
External Link
 Compound Name Lapatinib Approved [14]
Synonyms
FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor)
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MOA Inhibitor
Activity Ki = 3 nM
External Link
 Compound Name Merimepodib Approved [15]
Synonyms
Merimebodib; Merimepodib [USAN:INN]; Tyverb/Tykerb; MMPD; 198821-22-6; 2ZL2BA06FU; C23H24N4O6; CHEMBL304087; MERIMEPODIB, VI-21497, VX-497; UNII-2ZL2BA06FU; VI-21497; VX-497; VX497; Vx 497; carbamic acid
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MOA Inhibitor
External Link
 Compound Name Vandetanib Approved [16]
Synonyms
Zactima; Vandetanib [INN]; CH 331; ZD 6474; ZD6474; AZD-6474; CH-331; F9995-0087; ZD-6474; Zactima, ZD6474; Vandetanib (JAN/INN); Vandetanib, Zactima, ZD6474; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib (Pan-TK inhibitor)
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MOA Inhibitor
Activity IC50 = 200 nM
External Link
 Compound Name Sorafenib Approved [17]
Synonyms
Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor)
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MOA Inhibitor
Activity IC50 = 43.5 nM
External Link
 Compound Name Icotinib hydrochloride Registered [18]
Synonyms
Conmana; Conmanna; Icotinib; BPI-2009-H
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MOA Antagonist
External Link
 Compound Name Rindopepimut Phase 3 [2]
MOA Modulator
External Link
 Compound Name SYM-004 Phase 3 [19]
Synonyms
Chimeric IgG1 antibody 1024 (cancer), Symphogen; Chimeric IgG1 antibody 992 (cancer), Symphogen; Chimeric IgG1 antibodies992 + 1024 (cancer), Symphogen
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External Link
 Compound Name DE-766 Phase 3 [9]
MOA Modulator
External Link
 Compound Name EGF816 Phase 3 [20]
MOA Inhibitor
Activity IC50 = 160.6 nM
External Link
 Compound Name CO-1686 Phase 3 [21]
Synonyms
1374640-70-6; AVL-301; CO1686; UNII-72AH61702G; CNX-419; CO-1686 (AVL-301); Rociletinib(AVL-301,CNX-419,CO-1686); 72AH61702G; N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; CO 1686; Rociletinib (CO-1686, AVL-301); Rociletinib [USAN:INN]; Tube721; Rociletinib (USAN/INN); Rociletinib (CO-1686); SCHEMBL4177736; GTPL7966; CHEMBL3545308; EX-A228; MolPort-035-395-816; C27H28F3N7O3; HMS3653G08; BDBM149404; BCP07085; AOB87314; ZINC98043800; s7284
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MOA Modulator
Activity IC50 = 1.6 nM
External Link
 Compound Name Zalutumumab Phase 3 [9]
External Link
 Compound Name Almonertinib Phase 3 [22]
Synonyms
HS-10296; Ameile; 1899921-05-1; Egfr T790M inhibitor HS-10296; N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide; UNII-T4RS462G19; SCHEMBL17683063; GTPL11136; T4RS462G19; EX-A3721; HS 10296 [WHO-DD]; s8817; HS10296; example 26 [WO2016054987A1]; HY-112823; CS-0066162; 2-Propenamide, N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-((2-(dimethylamino)ethyl)methylamino)-4-methoxyphenyl)-; C1(CC1)N1C=C(C2=CC=CC=C12)C1=NC(=NC=C1)NC=1C(=CC(=C(C=1)NC(C=C)=O)N(C)CCN(C)C)OC; N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide
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MOA Inhibitor
External Link
 Compound Name ASP1929 Phase 3 [23]
Synonyms
Cetuximab sarotalocan
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MOA Inhibitor
External Link
 Compound Name A140 Phase 3 [24]
External Link
 Compound Name Bevacizumab + Erlotinib Phase 3 [25]
MOA Inhibitor
External Link
 Compound Name HKI-272 Phase 3 [26]
Synonyms
Neratinib (ERBB2 inhibitor)
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MOA Inhibitor
Activity IC50 = 0.08 nM
External Link
 Compound Name Indium-111 Phase 2/3 [27]
Synonyms
ABT-806
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External Link
 Compound Name Varlitinib Phase 2/3 [28]
Synonyms
845272-21-1; ARRY-334543; ARRY334543; ARRY 334543; ARRY-543; UNII-846Y8197W1; ASLAN-001; 846Y8197W1; (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine; Varlitinib [USAN:INN]; Varlitinib (ARRY334543); Varlitinib free base; Varlitinib (USAN/INN); MLS006011274; GTPL7645; SCHEMBL1384578; CHEMBL2103842; SYN1192; MolPort-028-720-424; EX-A1005; 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine
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MOA Modulator
Activity IC50 = 7 nM
External Link
 Compound Name ASP8273 Phase 2 [29]
MOA Inhibitor
Activity IC50 = 8 nM
External Link
 Compound Name ABT-414 Phase 2 [30]
External Link
 Compound Name Depatuxizumab Phase 2 [31]
MOA Antagonist
External Link
 Compound Name Matuzumab Phase 2 [32]
Synonyms
EMD-62000; EMD-72000; Anti-EGF receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-EGFR humanized mAb (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-epidermal growth factor receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals
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External Link
 Compound Name HER1-VSSP vaccine Phase 2 [33]
Synonyms
HER1-VSSP vaccine (cancer)
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External Link
 Compound Name RM-1929 Phase 2 [34]
MOA Antagonist
External Link
 Compound Name CetuGEX Phase 2 [35]
External Link
 Compound Name ABX-EGF Phase 2 [36]
External Link
 Compound Name Pelitinib Phase 2 [37]
Synonyms
EKB-569; EKI-569; WAY-EKB-569
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MOA Modulator
Activity IC50 = 8.02 nM
External Link
 Compound Name HM-78136B Phase 2 [34]
Synonyms
Pan-Her/EGFR inhibitors (cancer), Hanmi
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MOA Inhibitor
Activity IC50 = 0.218 nM
External Link
 Compound Name Pazopanib + Tyverb/Tykerb Phase 2 [15]
MOA Inhibitor
External Link
 Compound Name MEHD-7945A Phase 2 [28]
Synonyms
RG-7597; EGFR/HER3 dual monoclonal antibody, Genentech
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MOA Modulator
External Link
 Compound Name TT-100 Phase 2 [38]
Synonyms
TT-100, TriAct; Dual IGF-1/EGFR inhibitor (non-small-cell lung cancer), TriAct
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MOA Inhibitor
External Link
 Compound Name BMS-599626 Phase 2 [39]
Synonyms
714971-09-2; AC480; AC-480; BMS 599626; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate; UNII-2252724U5N; CHEMBL1645462; BMS599626; AC480 (BMS-599626); 2252724U5N; J-502499; C27H27FN8O3; AC 480; AC1480 (free base); PubChem22432; GTPL7647; SCHEMBL12065349; CTK8B6780; DTXSID60221714; SYN1142; AOB5594; MolPort-023-279-418; EX-A2296; ZINC6717782; KS-000008GE; BDBM50333373; s1056; C27H44O11; ANW-54337; AKOS015999853; CS-0407; RL05125; BCP9000428; SB21703
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MOA Inhibitor
Activity IC50 = 32 nM
External Link
 Compound Name Tarloxotinib Phase 2 [40]
Synonyms
Tarloxotinib cation; UNII-H8768UL06V; H8768UL06V; [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium; Tarloxotinib ion; GTPL9409; CHEMBL4297661; SCHEMBL19733352; PR610; DB14944; TH-4000; Q27279755; 1636938-13-0
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MOA Inhibitor
External Link
 Compound Name VATALANIB Phase 2 [26]
Synonyms
212141-54-3; Vatalanib base; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK787; Pynasunate; CGP 79787; Vatalanib free base; PTK-787; Vatalanib (free base); Vatalinib; ZK-232934; CGP-79787; ZK222584; PTK/ZK; CHEMBL101253; N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine; UNII-5DX9U76296; CHEBI:90620; YCOYDOIWSSHVCK-UHFFFAOYSA-N; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine; 5DX9U76296; NCGC00181350-01; 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-; DSSTox_CID_26919
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MOA Inhibitor
Activity IC50 = 457.7 nM
External Link
 Compound Name BMS-690514 Phase 2 [41]
Synonyms
BMS 690514; BMS690514
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MOA Inhibitor
External Link
 Compound Name CI-1033 Phase 2 [16]
Synonyms
Canertinib; Canertinib HCl; Canertinib dihydrochloride; Canertinib dihydrochloride [USAN]; CI1033; PD 183805; Canertinib dihydrochloride (USAN); PD-0183805; PD-183805; Canertinib, PD-183805, CI1033, PD183805; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride; N-(4-(3-chloro-4-fluorophenyl)amino)-7-(3-morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide dihydrochloride; N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl) amino)-7-(3-(4-morpholinyl) propoxy)-6-quinazolinyl)-, dihydrochloride; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-, dihydrochloride
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 0.11 nM
External Link
 Compound Name CART-EGFR Phase 1/2 [42]
MOA CAR-T-Cell-Therapy
External Link
 Compound Name SN-32793 Phase 1/2 [9]
Synonyms
PR-509; PR-610; SN-32807; Hypoxia-activated irreversible pan-erbb inhibitors, Proacta; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer); Hypoxia-selective multi-kinase inhibitors (lung cancer), Proacta; Hypoxia-selective multi-kinase inhibitors(lung cancer), Proacta/ Yakult Honsha; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer), Proacta/ Yakult Honsha
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name EGFR CART Phase 1/2 [43]
MOA CAR-T-Cell-Therapy
External Link
 Compound Name EMD 55900 Phase 1/2 [36]
Synonyms
27686-84-6; 4,4'-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol); UNII-7BO8G1BYQU; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)-; EINECS 248-606-6; 7BO8G1BYQU; CHEMBL313972; erythro-nordihydroguaiaretic acid; CHEBI:73468
    Click to Show/Hide
External Link
 Compound Name TAK-186 Phase 1/2 [44]
MOA Inhibitor
External Link
 Compound Name ZN-e4 Phase 1/2 [45]
MOA Inhibitor
External Link
 Compound Name EMB-01 Phase 1/2 [46]
MOA Inhibitor
External Link
 Compound Name Sym015 Phase 1/2 [31]
MOA Antagonist
External Link
 Compound Name BDTX-189 Phase 1/2 [47]
Synonyms
2414572-47-5; EX-A4379
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name AFM24 Phase 1/2 [48]
External Link
 Compound Name Sym013 Phase 1/2 [31]
MOA Antagonist
External Link
 Compound Name S-222611 Phase 1b [49]
MOA Inhibitor
External Link
 Compound Name SYN004 Phase 1 [31]
MOA Inhibitor
External Link
 Compound Name BIBX-1382 Phase 1 [50]
Synonyms
Falnidamol; BIBX 1382; 196612-93-8; BIBX1382; UNII-0MU316797D; CHEMBL258940; FTFRZXFNZVCRSK-UHFFFAOYSA-N; 0MU316797D; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine; Bibx 1382bs; Falnidamol [INN]; NCGC00161422-01; AC1OCFIP; BIBX-1382BX; BIBX-1382BS; SCHEMBL158563; GTPL7646; DTXSID0048399; CHEBI:93243; EX-A570; AOB5489; MolPort-039-136-623; ZINC1494443; KS-00001CR9; BCP09515; BDBM50375639; AKOS025396660; API0007916; DB12966; CS-0691; NCGC00161422-03; AS-16894; HY-10322; AK174047
    Click to Show/Hide
MOA Antagonist
Activity IC50 = 3 nM
External Link
 Compound Name IMGN289 Phase 1 [51]
MOA Inhibitor
External Link
 Compound Name AST-1306 Phase 1 [52]
Synonyms
Allitinib; Allitinib tosylate
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MOA Modulator
External Link
 Compound Name AMG 595 Phase 1 [53]
MOA Modulator
External Link
 Compound Name HER-2/HER-1 vaccine Phase 1 [9]
Synonyms
HER-2/HER-1 vaccine (solid tumors)
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External Link
 Compound Name EGFR806-specific CAR T cell Phase 1 [54]
MOA CAR-T-Cell-Therapy
External Link
 Compound Name PF-05230907 Phase 1 [55]
MOA Inhibitor
External Link
 Compound Name MR1-1 Phase 1 [56]
Synonyms
MR1-1KDEL; EGFR-specific immunotoxin, IVAX; Anticancer immunotoxin (EGFR-specific), IVAX
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MOA Modulator
External Link
 Compound Name Anti-EGFR CAR T Phase 1 [57]
MOA CAR-T-Cell-Therapy
External Link
 Compound Name AP32788 Phase 1 [34]
MOA Inhibitor
External Link
 Compound Name CLN-081 Phase 1 [58]
MOA Inhibitor
External Link
 Compound Name LY3164530 Phase 1 [59]
MOA Modulator
External Link
 Compound Name MM-151 Phase 1 [31]
MOA Antagonist
External Link
 Compound Name Cipatinib Phase 1 [28]
Synonyms
HER-1/HER-2 inhibitor (oral, cancer), Jiangsu Hengrui
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name Anti-HER3/EGFR DAF Phase 1 [60]
MOA Modulator
External Link
 Compound Name BCA101 Phase 1 [61]
MOA Inhibitor
External Link
 Compound Name CUDC-101 Phase 1 [62]
Synonyms
1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149
    Click to Show/Hide
MOA Modulator
Activity IC50 = 2.4 nM
External Link
 Compound Name SI-B001 Phase 1 [63]
External Link
 Compound Name CX-904 Phase 1 [64]
Synonyms
AMG 651
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External Link
 Compound Name AZD9592 Phase 1 [65]
External Link
 Compound Name D2C7 Phase 1 [66]
External Link
 Compound Name MCLA-158 Phase 1 [67]
MOA Inhibitor
External Link
 Compound Name JNJ-26483327 Phase 1 [68]
Synonyms
MTKI (cancer), J&J; MTKI (cancer), Johnson & Johnson; Multi-targeted kinase inhibitor (cancer), J&J; Multi-targeted kinase inhibitor (cancer), Johnson & Johnson
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MOA Inhibitor
External Link
 Compound Name Pyrrolo[2,3-d]pyrimidine derivative 24 Patented [69]
Synonyms
PMID28705083-Compound-22
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MOA Inhibitor
External Link
 Compound Name PKI166 Discontinued in Phase 2 [70]
Synonyms
PKI-166; CGP-75166; 187724-61-4; NVP-PKI166; CHEMBL1914653; AC1OCFE0; UNII-9RIE5HW38P; 9RIE5HW38P; SCHEMBL177814; GTPL7642; CHEMBL1963502; ZINC23255; AOB1619; PKI-75166; BDBM50358046; NCGC00387215-02; AS-16676; KB-275097; PKI-166, > 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[4,5-e]pyrimidin-6-yl]phenol
    Click to Show/Hide
MOA Modulator
Activity IC50 = 3.7 nM
External Link
 Compound Name RG7160 Discontinued in Phase 2 [71]
MOA Modulator
External Link
 Compound Name PD-153035 Discontinued in Phase 1 [72]
Synonyms
183322-45-4; PD153035 hydrochloride; N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride; PD153035 HCl; PD 153035 HYDROCHLORIDE; PD-153035 hydrochloride; PD153035 (Hydrochloride); Tyrphostin AG 1517; AG 1517 hydrochloride; SU-5271 hydrochloride; UNII-AHJ252P69N; ZM 252868; SU 5271; AG 1517; 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; AHJ252P69N; pd 153035; PD153035.HCl; CHEMBL1204168; 6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride; C16H15BrClN3O2; 4-Quinazolinamine, N-(3-bromo
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MOA Modulator
Activity Ki = 0.006 nM
External Link
 Compound Name AZD4769 Discontinued in Phase 1 [73]
Synonyms
Acetic acid, ((4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)-; 127481-29-2; L-674573; ((4-Phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid; {[4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl]thio}acetic acid; L 674573; L-674,573; AC1L3YFJ; SCHEMBL9460146; CHEMBL422872; JOIXGLLMSDPZDN-UHFFFAOYSA-N; AZD-4769; 2-[[4-phenyl-1-[4-(2-quinolinylmethoxy)phenyl]butyl]thio]Acetic acid; DA-13018; FT-0734991; AZ-12096971; 2-[4-phenyl-1-[4-(quinolin-2-ylmethoxy)phenyl]butyl]sulfanylacetic
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MOA Inhibitor
External Link
 Compound Name TAK165 Discontinued in Phase 1 [16]
Synonyms
Mubritinib; TAK 165; Mubritinib (USAN/INN); 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 111In-hEGF Preclinical [74]
Synonyms
Indium-111-hEGF; Indium-111-labeled human epithelial growth factor (breast cancer), University of Toronto; 111In-labeledhuman epithelial growth factor (breast cancer), University of Toronto
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MOA Modulator
External Link
 Compound Name EGFR/IGFR tandem adnectin Preclinical [75]
Synonyms
BMS-964210
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MOA Inhibitor
External Link
 Compound Name Heparin-EGF-like factor Terminated [76]
Synonyms
HB-EGF, Scios Nova; Heparin-EGF-like factor, Scios Nova
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MOA Modulator
External Link
 Compound Name CGP-52411 Terminated [77]
Synonyms
DAPH
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MOA Inhibitor
Activity Ki = 160 nM
External Link
 Compound Name CGP-53353 Terminated [78]
Synonyms
145915-60-2; CGP 53353; DAPH 2; DAPH-7; CGP53353; PKCbetaII/EGFR Inhibitor; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; CHEMBL7939; CGP 53 353; 4,5-bis(4-Fluoroanilino)-phthalimide; CG53353; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; MolMap_000016; DAPH-2; CGP-53353, solid; SCHEMBL230492
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 700 nM
External Link
 Compound Name AZD-9935 Terminated [79]
MOA Antagonist
External Link
 Compound Name N4-(3-chlorophenyl)quinazoline-4,6-diamine Investigative [80]
Synonyms
CHEMBL343352; Anilinoquinazoline, 4c; SCHEMBL1262804; AWAYNEMCHILZCF-UHFFFAOYSA-N; ZINC13527446; BDBM50133382; AKOS013915036; 6-amino-4-(3'-chloroanilino)quinazoline; N4-(3-chlorophenyl)-4,6-quinazolinediamine; 6-amino-4[(3-chlorophenyl)amino]quinazoline
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3.38 nM
External Link
 Compound Name 2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile Investigative [81]
Synonyms
Tyrphostin deriv. 29; AC1NS5AC; CHEMBL56132; BDBM4296; ZINC12352646; 2-(Benzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile; (E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-enenitrile
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
 Compound Name 6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline Investigative [82]
Synonyms
CHEMBL250523; BDBM50222432
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MOA Inhibitor
Activity IC50 = 15 nM
External Link
 Compound Name 2-cyano-3-(3,4-dihydroxyphenyl)acrylamide Investigative [81]
Synonyms
Tyrphostin 46; Tyrphostin A46; AG 99; Tyrphostin B40; 122520-85-8; alpha-Cyano-(3,4-dihydroxy)cinnamide; AG-99; 3,4-Dihydroxy-alpha-cyanocinnamamide; UNII-ARL2OF9022; CHEMBL296407; ARL2OF9022; 118409-59-9; Tyrphostin AG 99; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; NSC666250; NSC-666250; 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-; (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide; Tyrphostin AG99; 3,4-Dihydroxy-alpha-cyanocinnamide; NSC 666250; Tocris-0497; Tyrphostin deriv. 40; BiomolKI_000013; AC1NS5AR
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 3500 nM
External Link
 Compound Name HM-61713B Investigative [9]
Synonyms
EGFR mutant selective inhibitor (cancer), Hanmi; EMSI (cancer), Hanmi
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MOA Inhibitor
External Link
 Compound Name Benzyl-quinazolin-4-yl-amine Investigative [83]
Synonyms
N-Benzylquinazolin-4-amine; N-benzyl-N-(4-quinazolinyl)amine; 4-(Benzylamino)quinazoline; 100818-54-0; 4-Benzylaminoquinazoline; AC1LDDI3; benzylquinazolin-4-ylamine; ChemDiv2_003678; N-benzyl-4-quinazolineamine; Oprea1_089836; MLS000701321; N-Benzyl-4-quinazolinamine #; cid_616573; CHEMBL102726; BDBM3256; SCHEMBL7612718; CHEBI:92768; MolPort-001-960-903; FVWANTDQRFSCAL-UHFFFAOYSA-N; HMS2233F15; HMS3373H15; HMS1379H04; ZINC109589; 4-[(phenylmethyl)amino]quinazoline; N-(phenylmethyl)-4-quinazolinamine
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6,7-diethoxy-4-styrylquinazoline Investigative [82]
Synonyms
CHEMBL250925
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 15 nM
External Link
 Compound Name AFM-21 Investigative [9]
Synonyms
Anti-EGFR antibody (RECRUIT-TandAb, colon/solid tumors), Affimed
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External Link
 Compound Name PD182905 Investigative [84]
MOA Inhibitor
External Link
 Compound Name AG 112 Investigative [85]
Synonyms
tyrphostin A48; tyrphostin AG 112; AG-112; AG112
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MOA Inhibitor
Activity IC50 = 125 nM
External Link
 Compound Name 2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile Investigative [86]
Synonyms
(4,5-Dihydroxyindanylidene)malononitrile; Tyrphostin deriv. 17; AC1NS59O; CHEMBL57300; BDBM4286; 133550-13-7; 2-(4,5-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; 2-(4,5-dihydroxy-2,3-dihydro-1H-inden-1-ylidene)propanedinitrile
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MOA Inhibitor
Activity IC50 = 7000 nM
External Link
 Compound Name (3-Bromo-phenyl)-quinazolin-4-yl-amine Investigative [87]
Synonyms
N-(3-bromophenyl)quinazolin-4-amine; CHEMBL290096; AC1LEF72; SCHEMBL2992623; BDBM3264; 4-Anilino quinazoline deriv. 15; ZINC151213; (3-bromophenyl)quinazolin-4-ylamine; N-(3-Bromophenyl)-4-quinazolinamine; AKOS002264782; MCULE-4660970870; 4-Quinazolinamine, N-(3-bromophenyl)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 27 nM
External Link
 Compound Name PD-158780 Investigative [88]
Synonyms
171179-06-9; PD158780; pd 158780; N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AC1L1IRV; CHEMBL53753; 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AK160389; 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine; 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine; 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine; Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.008 nM
External Link
 Compound Name EGFR inhibitor Investigative [89]
Synonyms
879127-07-8; CHEMBL387187; N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; K00598a; N-{3-[(6-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}cyclopropanecarboxamide; EGFR Inhibitor 324674; SCHEMBL242230; GTPL5963; CTK8E9808; DTXSID40429554; MolPort-042-665-758; HMS3229E03; BDBM50200394; ZINC13831337; API0010446; CCG-206749; NCGC00167954-01
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MOA Inhibitor
Activity IC50 = 21 nM
External Link
 Compound Name 6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline Investigative [82]
Synonyms
CHEMBL399371
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MOA Inhibitor
Activity IC50 = 5 nM
External Link
 Compound Name LA22-radioimmunoconjugates Investigative [9]
Synonyms
LA22-radioimmunoconjugates (cancer); Lutetium177-DOTA-LA22; LA22-radioimmunoconjugates (cancer), Welson/PekingUniversity; MAb-conjugated radioimmunotherapeutics (cancer), Welson/Peking University; 177Lu-DOTA-LA22; 177Lu-DTPA-LA22
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name 5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide Investigative [90]
Synonyms
CHEMBL382537
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MOA Inhibitor
External Link
 Compound Name ICR 62 Investigative [36]
External Link
 Compound Name Bmab-200 Investigative [9]
Synonyms
Anti-EGFR mAb (cancer), Biocon; Anti-epidermal growth factor receptor monoclonal antibody (cancer), Biocon
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External Link
 Compound Name HTS-00213 Investigative [91]
Synonyms
CHEMBL461781; AC1MDDFE; MolPort-002-900-007; ZINC1028479; BDBM50292742; MCULE-3257779074; 3-((2,6-dichlorophenoxy)methyl)-5-((4-(4-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6300 nM
External Link
 Compound Name 6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline Investigative [82]
Synonyms
CHEMBL251123
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MOA Inhibitor
Activity IC50 = 140 nM
External Link
 Compound Name N*4*-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine Investigative [88]
Synonyms
CHEMBL300083; 4-N-benzylpyrido[4,3-d]pyrimidine-4,7-diamine; 7-Aminopyrido[4,3-d]pyrimidine 8a; AC1NS3PZ; SCHEMBL6839398; BDBM3331; pyrido[4,3-d]pyrimidine-4,7-diamine,n4-(phenylmethyl)-; ZINC3815364; 171178-89-5; PD-69896; KB-302882
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 578 nM
External Link
 Compound Name Epitinib Investigative [9]
Synonyms
HMPL-813; EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma
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MOA Inhibitor
External Link
 Compound Name OSI-75 Investigative [92]
MOA Inhibitor
External Link
 Compound Name (E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin Investigative [93]
Synonyms
CHEMBL213560; SCHEMBL16693054; BDBM50187134
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MOA Inhibitor
Activity IC50 = 710 nM
External Link
 Compound Name HTS-02876 Investigative [91]
Synonyms
AC1MDGL2; CHEMBL460914; MolPort-002-900-576; ZINC1030761; MCULE-7093116609
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MOA Inhibitor
External Link
 Compound Name 2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile Investigative [86]
Synonyms
133550-11-5; Propanedinitrile, (2,3-dihydro-5,6-dihydroxy-1H-inden-1-ylidene)-; Tyrphostin deriv. 15; ACMC-20muzh; AC1NS59I; SCHEMBL6285970; CHEMBL293584; BDBM4284; CTK0C0328; DTXSID30416170; 2-(5,6-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; (5,6-Dihydroxyindanylidene)malononitrile; [(2,3-Dihydro-5,6-dihydroxy-1H-inden)-1-ylidene]malononitrile
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MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name PMID8568816C56 Investigative [94]
Synonyms
PD153035 Analog 56; 171745-13-4; AC1L1EMN; K00042; BDBM3556; GTPL5956; CTK6G1384; DTXSID40274389; MolPort-019-910-218; HMS3229C09; BCP08039; ZINC2572485; IN1496; CCG-206742; QC-8197; ACM171745134; RT-012080; SR-02000000170; SR-02000000170-1; J-010
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MOA Inhibitor
Activity IC50 = 0.006 nM
External Link
 Compound Name MT-062 Investigative [9]
Synonyms
EGFR inhibitor (melanoma), Medisyn Technologies
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MOA Inhibitor
External Link
 Compound Name Anti-EGFR mab Investigative [9]
External Link
 Compound Name RG-50810 Investigative [81]
Synonyms
Tyrphostin 23; 118409-57-7; Tyrphostin A23; AG 18; (3,4-Dihydroxybenzylidene)malononitrile; AG-18; Tyrphostin AG18; Tyrphostin RG50810; 2-(3,4-dihydroxybenzylidene)malononitrile; UNII-RV0GCD31OJ; alpha-Cyano-(3,4-dihydroxy)cinnamonitrile; 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; RG 50810; Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-; ag18; (3,4-Dihydroxyphenyl)methylene propanedinitrile; RV0GCD31OJ; C10H6N2O2; NCGC00016043-03; (3,4-dihydroxybenzylidene)propanedinitrile; DSSTox_CID_25215
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MOA Inhibitor
Activity Ki = 11000 nM
External Link
 Compound Name IPS-01003 Investigative [9]
Synonyms
EGFR kinase antagonist (cancer), InnoPharmaScreen
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MOA Antagonist
External Link
 Compound Name RM-6427 Investigative [9]
Synonyms
RM-6428; EGFR tyrosine kinase inhibitors (parasitic infection), Romark
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N*4*-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine Investigative [87]
Synonyms
bpdq; CHEMBL328216; 4-N-(3-bromophenyl)quinazoline-4,6,7-triamine; 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline; 169205-87-2; AC1L1DNE; N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine; K00041; SCHEMBL7221302; BDBM3303; 4-Anilinoquinazoline deriv. 54; CTK8F8323; ADXSZLCTQCWMTE-UHFFFAOYSA-N; IN1401; HSCI1_000040; AKOS025149794; 4-(3-bromoanilino)-6,7-diaminoquinazoline; N-(3-Bromophenyl)quinazoline-4,6,7-triamine; 4[ (3-Bromophenyl)aminol-6,7-diaminoquinazoline; J-010514
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.12 nM
External Link
 Compound Name 3-Pyridin-4-yl-quinoline-6,7-diol Investigative [95]
MOA Inhibitor
Activity IC50 = 5000 nM
External Link
 Compound Name AGT-2000 Investigative [9]
Synonyms
Gene therapy (intravenous, brain cancer), ArmaGen
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name 3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one Investigative [96]
Synonyms
CHEMBL7827; SCHEMBL3355884; 62845-10-7; CTK2B1467; ZINC23489; DTXSID10445847; BDBM50074745; AKOS030553076; 5,7-Dihydroxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-(3-chlorophenyl)-5,7-dihydroxy-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 95 nM
External Link
 Compound Name ON-128 Investigative [9]
Synonyms
ON-128060; ON-128 series (cancer); HER1/EGFR inhibitors (cancer), Onconova; Human epidermal growth factor receptor 1/epidermal growth factor receptor inhibitors (cancer), Onconova; ON-128 series (cancer), Onconova
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name FHT-2107 Investigative [9]
Synonyms
EGFR-targeting siRNA agent, ForHumanTech
    Click to Show/Hide
External Link
 Compound Name GI-3000 Investigative [9]
Synonyms
GI-3001; GI-6200; GlioVax-1; EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen); EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen), GlobeImmune
    Click to Show/Hide
External Link
 Compound Name 6,7-dimethoxy-N-m-tolylquinazolin-4-amine Investigative [91]
Synonyms
CHEMBL56802; AC1MDC5E; Oprea1_570563; SCHEMBL5482883; ZINC5857; 4-Quinazolinamine,6,7-dimethoxy-N-(3-methylphenyl)-; MolPort-001-734-434; BDBM50102093; MCULE-3929709513; 666839-07-2; (6,7-Dimethoxy-quinazolin-4-yl)-m-tolyl-amine; SR-02000000178; SR-02000000178-1; 6,7-dimethoxy-N-(3-methylphenyl)quinazolin-4-amine
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4.6 nM
External Link
 Compound Name 5,6-Bis-p-tolylamino-isoindole-1,3-dione Investigative [78]
Synonyms
CHEMBL7914; SCHEMBL8834183; BDBM50040920
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4500 nM
External Link
 Compound Name HTS-05058 Investigative [89]
Synonyms
MLS000327715; SMR000180717; 3-(1H-imidazol-5-ylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(1H-imidazol-5-ylmethylidene)-1H-indol-2-one; Angiogenesis Inhibitor; 372164-79-9; AC1NWWY9; CHEMBL261692; SCHEMBL2998484; REGID_for_CID_667701; BDBM41079; cid_5714572; REGID_for_CID_5714572; MolPort-002-870-304; MolPort-002-901-109; HMS2463B12; ZINC4693510; AKOS015992864; (3Z)-3-(1H-imidazol-5-ylmethylene)oxindole; 4X-0884; J-011988
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide Investigative [97]
Synonyms
CHEMBL297968; SCHEMBL2994207; FAGJCAQBJKSOOS-UHFFFAOYSA-N; BDBM50077245; N-[4-(3-Methylanilino)quinazoline-7-yl]acrylamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 90 nM
External Link
 Compound Name 4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid Investigative [81]
Synonyms
CHEMBL76958; BDBM50007075; 4-[4-(2-Nitro-vinyl)-phenoxysulfonyl]-benzoic acid; 4-[4-[(E)-2-Nitroethenyl]phenoxysulfonyl]benzoic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
 Compound Name Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine Investigative [87]
Synonyms
CHEMBL63786; N-(3-bromophenyl)benzo[g]quinazolin-4-amine; Benzoquinazoline deriv. 23; AC1NS43R; SCHEMBL4348523; BDBM3585; BUVKJPOCMOXSSQ-UHFFFAOYSA-; ZINC3815025; 4-[(3-Bromophenyl)amino]benzo[g]quinazoline; N-(3-Bromophenyl)benzo[g]quinazoline-4-amine
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.003 nM
External Link
 Compound Name ARX-AHD Investigative [9]
Synonyms
Dolastatin-conjugated HER2 antibody (breast cancer), Ambrx
    Click to Show/Hide
External Link
 Compound Name TGF alpha Investigative [9]
Synonyms
TGF alpha (neurological damage)
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name AG 9 Investigative [85]
Synonyms
tyrphostin 1; tyrphostin A1; AG9; AG-9
    Click to Show/Hide
MOA Inhibitor
Activity Ki > 400000 nM
External Link
 Compound Name N*4*-(3-Bromo-phenyl)-quinazoline-4,6-diamine Investigative [98]
Synonyms
N4-(3-Bromophenyl)quinazoline-4,6-diamine; 169205-78-1; 4-N-(3-bromophenyl)quinazoline-4,6-diamine; CHEMBL52765; AK-25174; N4-(3-bromophenyl)-4,6-quinazolinediamine; 4,6-Quinazolinediamine, N4-(3-bromophenyl)-; C14H11BrN4; nchembio866-comp32; Anilinoquinazoline, 4b; AC1NS3N2; BDBM3294; SCHEMBL1417740; 4-Anilinoquinazoline deriv. 45; KS-00000HMR; CTK4D3225; DTXSID40416141; IZQHULBHKPGOAP-UHFFFAOYSA-N; MolPort-009-198-483; ZINC3815034; BCP18882; ANW-50332; AKOS013915836; 6-amino 4-(3-bromoanilino)quinazoline; GS-4221
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.78 nM
External Link
 Compound Name 4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline Investigative [99]
Synonyms
CHEMBL473320; SCHEMBL5616932
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 131 nM
External Link
 Compound Name Theliatinib Investigative [9]
Synonyms
HMPL-309; Second EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-(3-Bromo-phenylamino)-quinazoline-6,7-diol Investigative [87]
MOA Inhibitor
External Link
 Compound Name 6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline Investigative [82]
Synonyms
CHEMBL250318; BDBM50222435
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 14 nM
External Link
 Compound Name 4-(2-nitroprop-1-enyl)benzene-1,2-diol Investigative [81]
Synonyms
13662-96-9; 1,2-Benzenediol, 4-(2-nitro-1-propenyl)-; AC1MMGH2; Oprea1_551147; CTK0F3796; DTXSID20390758; AKOS017269192
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name EDP-13 Investigative [9]
Synonyms
Epidermal growth factor receptor antagonist (cancer), BiolineRx/Matrix Pharma
    Click to Show/Hide
MOA Antagonist
External Link
 Compound Name N*4*-(3-Bromo-phenyl)-quinazoline-4,7-diamine Investigative [83]
Synonyms
CHEMBL420624; 7-amino-4-[(3-bromophenyl)amino]quinazoline; 4-N-(3-bromophenyl)quinazoline-4,7-diamine; 4-Anilinoquinazoline deriv. 48; AC1NS3NB; BDBM3297; SCHEMBL2986298; GHVBIROTJQDRQB-UHFFFAOYSA-N; ZINC3815072; AKOS014671983; 7-Amino-4-(3-bromoanilino)quinazoline; 7-amino-4(3-bromoanilino)-quinazoline; 7-amino-4-(3-bromoanilino)-quinazoline; 169205-81-6; N-(3-Bromophenyl)quinazoline-4,7-diamine; 7-Amino-4-[(3-bromophenyl)aminolquinazoline; FT-0768311; 7-amino-4-[(3-bromophenyl)-amino]quinazoline
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.1 nM
External Link
 Compound Name (S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate Investigative [81]
Synonyms
Z-L-Ala-chloromethylketone; 41036-43-5; Benzyloxycarbonylalanine chloromethyl ketone; Z-Ala-chloromethyl ketone; AC1NUSRJ; PubChem11548; Benzyloxycarbonyl-ala-chloromethyl ketone; CHEMBL483443; SCHEMBL6437509; DTXSID50194009; ZINC34206665; AKOS027382196; FT-0603930; benzyl N-[(2S)-4-chloro-3-oxobutan-2-yl]carbamate; [(S)-1-Methyl-2-oxo-3-chloropropyl]carbamic acid benzyl ester; Carbamic acid, (3-chloro-1-methyl-2-oxopropyl)-, phenylmethyl ester, (S)-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-(2-nitrovinyl)benzene-1,2-diol Investigative [81]
Synonyms
SL-1; CHEMBL78224; 108074-44-8; SL-1 Pigment; 1,2-Dihydroxy-4-(nitroethenyl)benzene; 4-[(E)-2-nitroethenyl]benzene-1,2-diol; AC1O5R3K; SCHEMBL2052283; SCHEMBL2052285; beta-Nitro-3,4-dihydroxystyrene; LLJASJHXECDHOM-ONEGZZNKSA-N; BDBM50007069; AKOS010878666; 4-(2-Nitro-vinyl)-benzene-1,2-diol; 1,2-Benzenediol, 4-(2-nitroethenyl)-, (E)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 8800 nM
External Link
 Compound Name AG-538 Investigative [81]
Synonyms
Tyrphostin AG 538; AG 538; NSC676485; (E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile; alpha-Cyano-(3,4-dihydroxy)cinnamoyl-(3& -dihydroxyphenyl)ketone; Tyrphostin deriv. 24; Lopac-T-7822; AC1NS5A3; Lopac0_001261; MLS002153408; CHEMBL56393; SCHEMBL2678764; SCHEMBL2678765; BDBM4293; REGID_for_CID_660907; CHEBI:92138; cid_5328760; REGID_for_CID_5328760; HMS3263N04; HMS2233K10; ZINC3871438; 133550-18-2; Tox21_501261; HSCI1_000189; CCG-205335; NSC-676485; LP01261; NCGC00094499-02
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 370 nM
External Link
 Compound Name WZ-3146 Investigative [9]
Synonyms
WZ-4002; WZ-8040; EGFR-T790M kinase inhibitors (lung cancer); EGFR-T790M kinase inhibitors (lung cancer), Gatekeeper Pharmaceuticals
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 2-methoxy-4-(2-nitrovinyl)phenol Investigative [81]
Synonyms
6178-42-3; 2-Methoxy-4-[(E)-2-nitroethenyl]phenol; 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE; (E)-2-methoxy-4-(2-nitrovinyl)phenol; trans-4-Hydroxy-3-methoxy-beta-nitrostyrene; 2-methoxy-4-[(E)-2-nitrovinyl]phenol; CHEMBL309016; 22568-51-0; AF-467/00017042; 2-methoxy-4-(2-nitroethenyl)phenol; 2-Methoxy-4-(2-nitro-vinyl)-phenol; 4-((1E)-2-nitrovinyl)-2-methoxyphenol; 4-{2-nitrovinyl}-2-methoxyphenol; 4-Hydroxy-3-methoxy-beta-nitrostyrene; AC1LCWDN; PubChem19447; AC1Q1WR9; MLS000574924
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7900 nM
External Link
 Compound Name MG-111 Investigative [100]
Synonyms
134865-04-6; EGF, Hitachi
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name 6,7-dimethoxy-4-(2-phenylethynyl)quinazoline Investigative [82]
Synonyms
CHEMBL250315; SCHEMBL6180450; BDBM50222433
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 5600 nM
External Link
 Compound Name Anti-EGFR humanized mabs Investigative [9]
Synonyms
Anti-EGFR humanized mAbs (cancer); Anti-EGFR humanized mAbs (cancer), Xencor; Anti-EGFR humanized monoclonal antibodies (cancer), Xencor
    Click to Show/Hide
External Link
 Compound Name 4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline Investigative [82]
Synonyms
CHEMBL250924; BDBM50222419
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 26 nM
External Link
 Compound Name AL-6802 Investigative [9]
Synonyms
EGFR modulators (cancer), Advenchen/Simcere
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name BPIQ-I Investigative [87]
Synonyms
174709-30-9; N-(3-bromophenyl)-3-methyl-3H-imidazo[4,5-g]quinazolin-8-amine; 8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline; Imidazoquinazoline deriv. 12; AC1L1DNH; GTPL5939; CHEMBL174426; BDBM3574; SCHEMBL17931472; CTK8E6742; DTXSID60274366; MolPort-044-561-412; HMS3229C05; ZINC2391775; IN1402; HSCI1_000090; AKOS025394452; CCG-206740; ACM174709309; RT-011807; J-011030; BRD-K72211743-001-01-1
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.025 nM
External Link
 Compound Name mabionHER2 Investigative [9]
Synonyms
Humanized monoclonal antibody (breast cancer), Mabion
    Click to Show/Hide
External Link
 Compound Name 4-(2-nitrovinyl)phenol Investigative [81]
Synonyms
4-Hydroxy-b-nitrostyrene; (E)-4-(2-nitrovinyl)phenol; 4-hydroxy-beta-nitrostyrene; trans-4-Hydroxy-beta-nitrostyrene; 22568-49-6; Phenol, p-(2-nitrovinyl)-; 4-[(E)-2-Nitroethenyl]phenol; 4-[(E)-2-nitrovinyl]phenol; CHEMBL307481; CTJKRKMPTRJAIT-AATRIKPKSA-N; NSC81594; 1-(4-hydroxyphenyl)-2-nitroethene; 4-(2-(Hydroxy(oxido)amino)vinyl)phenol; 4-(2-Nitro-vinyl)-phenol; NSC30299; AC1LCWDH; 4-Hydroxy--nitrostyrene; 4'-hydroxy-beta-nitrostyrene; Phenol,4-(2-nitroethenyl)-
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10000 nM
External Link
 Compound Name 4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide Investigative [90]
Synonyms
CHEMBL200958
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name MDP-01 Investigative [9]
Synonyms
Peptabody-EGF (anticancer), Med Discovery
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N4-(3-methylphenyl)-4,6-quinazolinediamine Investigative [101]
Synonyms
CHEMBL336113; Anilinoquinazoline, 4a; 6-amino-4-[(3-methylphenyl)amino]quinazoline; SMA52; SCHEMBL159209; ZINC6328; SMA-52; NFBCSWGEYDCCDW-UHFFFAOYSA-N; BDBM50133384; AKOS013914431; N*4*-m-Tolyl-quinazoline-4,6-diamine; 153436-70-5; 6-amino-4-(3'-methylanilino)quinazoline; 6-amino-4-(3-methylphenylamino)-quinazoline; FT-0765557; 6-amino-4[(3-methylphenyl)amino]quinazoline
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1000 nM
External Link
 Compound Name RX-1792 Investigative [9]
Synonyms
EGF antagonist, Rexahn; RX-0183
    Click to Show/Hide
MOA Antagonist
External Link
 Compound Name (3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine Investigative [83]
Synonyms
N-(3-bromophenyl)-5-nitroquinazolin-4-amine; AC1NS3MQ; BDBM3290; CHEMBL116308; 4-Anilinoquinazoline deriv. 41
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 355 nM
External Link
 Compound Name NRC-2694 Investigative [9]
MOA Inhibitor
External Link
 Compound Name Cochliobolic acid Investigative [102]
Synonyms
CHEMBL464721; 185846-15-5; AC1O516J; BDBM50292386; 2-Furancarboxylic acid, tetrahydro-3-hydroxy-5-(17-methyl-13,14-dioxo-1,3,5,7,9,11,15-nonadecaheptaenyl)-, (2alpha,3beta,5alpha(1E,3E,5E,7E,9E,11E,15E))-(partial)-; (2R,3R,5S)-3-hydroxy-5-[(1E,3E,5E,7E,9E,11E,15E)-17-methyl-13,14-dioxononadeca-1,3,5,7,9,11,15-heptaenyl]oxolane-2-carboxylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1600 nM
External Link
 Compound Name PD-168393 Investigative [103]
Synonyms
PD168393; 194423-15-9; pd 168393; UNII-3R996Y9T0I; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide; N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide; CHEMBL285063; 3R996Y9T0I; C17H13BrN4O; N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-acrylamide; 2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-; 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-; nchembio866-comp2; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.08 nM
External Link
 Compound Name N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide Investigative [97]
Synonyms
CHEMBL31815; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl]acrylamide; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl)acrylamide; SCHEMBL2991796; AWQLTDUXGVCRBV-UHFFFAOYSA-N; BDBM50077244
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.42 nM
External Link
 Compound Name 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline Investigative [104]
Synonyms
CHEMBL98798
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 70 nM
External Link
 Compound Name 4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline Investigative [104]
Synonyms
CHEMBL101581
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2500 nM
External Link
 Compound Name YH013 Investigative [105]
External Link
 Compound Name LAVENDUSTIN A Investigative [106]
Synonyms
125697-92-9; RG14355; UNII-3Y0G32G2RV; CHEMBL103552; 3Y0G32G2RV; C21H19NO6; Lavendustin A, from Streptomyces griseolavendus; Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-; RG 14355; 5-(((2,5-Dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxybenzoic acid; Benzoic acid, 5-(((2,5-dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxy-; 5-Amino-((N-2,5-dihydroxybenzyl)-N -2-hydroxybenzyl)salicylic acid
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.004 ug.mL-1
External Link
 Compound Name PF 5208766 Investigative [107]
Synonyms
WAY-178357
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name 6-chloro-N-(3-chlorophenyl)quinazolin-4-amine Investigative [108]
Synonyms
4-Anilidoquinazoline deriv. 12a; AC1NS5EY; SCHEMBL4355658; BDBM4397
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2700 nM
External Link
 Compound Name N-(4-(phenylamino)quinazolin-6-yl)acrylamide Investigative [103]
Synonyms
CHEMBL1221699; N-[4-(phenylamino)quinazolin-6-yl]prop-2-enamide; nchembio866-comp4; SCHEMBL614989; BDBM50324687; DB08462; N-(4-Anilinoquinazoline-6-yl)acrylamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 < 1 nM
External Link
 Compound Name AG-213 Investigative [99]
MOA Inhibitor
Activity Ki = 850 nM
External Link
 Compound Name SYM-011 Investigative [9]
Synonyms
Dimercept; Hermodulins; Herstatin; RB-200; RBLX-200; RBLX-242; RBLX-242h; RBLX-642h
    Click to Show/Hide
MOA Modulator
External Link
 Compound Name 10-hydroxy-18-methoxybetaenone Investigative [109]
Synonyms
CHEMBL498247; BDBM50269144
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10500 nM
External Link
 Compound Name 4557W Investigative [110]
Synonyms
EGFR/ErbB-2 Inhibitor; 179248-61-4; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; SCHEMBL242224; GTPL5964; CHEMBL563845; CTK8E8822; DTXSID40431718; MolPort-018-661-221; HMS3229C21; ZINC1485577; IN1350; HSCI1_000238; AKOS002350936; CCG-206748; RT-012453; J-011438; BRD-K76819286-001-01-0; N-[4-(Benzyloxy)phenyl]-6,7-dimethoxyquinazoline-4-amine; N-[4-(benzyloxy)phenyl]-6,7-dimethoxyquinazolin-4-amine
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Tyrphostin ag-1478 Investigative [96]
Synonyms
AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 120 nM
External Link
 Compound Name CL-387785 Investigative [91]
Synonyms
194423-06-8; EKI-785; CL-387785 (EKI-785); CL-387,785; UNII-B4W27J1Z8B; CL-387785(EKI785; WAY-EKI 785); EKB-785; CHEMBL91867; B4W27J1Z8B; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide; CHEBI:90180; C18H13BrN4O; N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide; N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]but-2-ynamide; N-[4-[(3-bromophenyl)amino]-6-quinazolinyl)-2-butynamide; N-{4-[(3-bromophenyl)amino]-6-quinazolinyl}-2-butynamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.37 nM
External Link
 Compound Name HDS-029 Investigative [111]
Synonyms
HDS 029
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.3 nM
External Link
 Compound Name WHI-P154 Investigative [112]
MOA Inhibitor
External Link
 Compound Name PMID24915291C38 Investigative [113]
Synonyms
GTPL8145; PLS-123; BDBM50020476; 1431727-04-6
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 7 nM
External Link
 Compound Name HKI-9924129 Investigative [114]
MOA Inhibitor
Activity IC50 = 390 nM
External Link
 Compound Name PD-0173956 Investigative [114]
Synonyms
UNII-YR2DP5GJ1Y; YR2DP5GJ1Y; PD173956; PD-173956; AC1NS9BQ; 305820-76-2; SCHEMBL1334768; BDBM6569; CHEMBL574059; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-; 6-(2,6-dichlorophenyl)-2-(4-fluoroanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one; 6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 380 nM
External Link
 Compound Name PD-0166326 Investigative [114]
Synonyms
PD-166326
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 90 nM
External Link
 Compound Name PP121 Investigative [115]
Synonyms
PP-121; PP 121
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 260 nM
External Link
 Compound Name 3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [116]
Synonyms
CHEMBL380598; SCHEMBL3148490; HVQJGNALTWNDMX-UHFFFAOYSA-N; BDBM50375058; 2-(1H-Indole-3-yl)-3-phenylmaleimide
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Ro-4396686 Investigative [117]
Synonyms
SCHEMBL5809947; CHEMBL606964
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 545 nM
External Link
 Compound Name 3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione Investigative [116]
Synonyms
1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 3,4-diphenyl-1H-pyrrole-2,5-dione Investigative [116]
Synonyms
2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione Investigative [116]
Synonyms
CHEMBL372076; SCHEMBL3822337
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Osimertinib Approved [10]
Synonyms
Tagrisso
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.421 nM
External Link
 Compound Name PMID27774824-Compound-Figure9Example2down Patented [118]
External Link
 Compound Name Mobocertinib Approved [118]
Synonyms
1847461-43-1; TAK-788; TAK788; AP32788; UNII-39HBQ4A67L; 39HBQ4A67L; propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Mobocertinib [INN]; Mobocertinib [USAN]; AP-32788; Mobocertinib (TAK788); Mobocertinib(TAK-788); SCHEMBL17373133; GTPL10468; BDBM368374; BCP31045; EX-A3392; US10227342, Example 10; MFCD32669806; NSC825519; s6813; TAK-788;AP32788; WHO 11183; NSC-825519; example 94 [WO2015195228A1]; HY-135815; CS-0114256; TAK-788;TAK 788; AP 32788; 5-Pyrimidinecarboxylic acid, 2-((4-((2-(dimethylamino)ethyl)methylamino)-2-methoxy-5-((1-oxo-2-propen-1-yl)amino)phenyl)amino)-4-(1-methyl-1H-indol-3-yl)-, 1-methylethyl ester; C(C=C)(=O)NC=1C(=CC(=C(C=1)NC1=NC=C(C(=N1)C1=CN(C2=CC=CC=C12)C)C(=O)OC(C)C)OC)N(C)CCN(C)C; Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate
    Click to Show/Hide
External Link
 Compound Name DZD9008 Phase 1/2 [118]
External Link
 Compound Name AC0010 Phase 3 [118]
Synonyms
Avitinib; 1557267-42-1; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Avitinib free base; SCHEMBL15453394; KS-00000TON; EX-A783; MolPort-042-663-560; Avitinib(AC0010/AC0010MA); ZINC142081723; AKOS030632728; CS-W008904; N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide; DS-19269; AK543905; 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-
    Click to Show/Hide
External Link
 Compound Name EGFR antisense DNA Phase 1/2 [118]
Synonyms
Antisense therapy, UPCI; EGFR antisense DNA, University of Pittsburgh
    Click to Show/Hide
External Link
 Compound Name CK-101 Phase 1/2 [118]
Synonyms
IDRGFNPZDVBSSE-UHFFFAOYSA-N; 1660963-42-7; RX-518; N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide; EGFR-IN-3; UNII-708TLB8J3Y; 708TLB8J3Y; AK543910; N-[3-[2-[[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl]amino]quinazolin-8-yl]phenyl]acrylamide; GTPL9863; SCHEMBL16514522; KS-00000TOQ; MolPort-042-663-562; RX518; CK101; EX-A1142; BCP19075; RX 518; ZINC514250913; AKOS030632731; DS-19272; HY-19815; CS-0016788; Example 153 [US20170050936A1]; J-690231; 2-Propena
    Click to Show/Hide
External Link
 Compound Name Pyrotinib Phase 1 [118]
Synonyms
UNII-CJN36EQM0H; SHR-1258; CJN36EQM0H; SHR1258; 1269662-73-8; SCHEMBL9948753; GTPL9662; SADXACCFNXBCFY-IYNHSRRRSA-N; BDBM139991; AKOS032946680; CS-7940; compound 12 [PMID: 28115222]; 2-Propenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-3-((2R)-1-methyl-2-pyrrolidinyl)-, (2E)-; HY-104065; US8901140, 5; (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide; (E)-N-[4-[3-chloro-4-(pyridin-2-ylmetho
    Click to Show/Hide
External Link
 Compound Name Anti-EGFRvIII CAR transduced PBL Phase 1/2 [118]
External Link
 Compound Name EGFRvIII CAR Phase 1/2 [118]
External Link
 Compound Name Anti-EGFR V III CAR-T cells Phase 1/2 [118]
External Link
 Compound Name EGFRvIII CAR T cells Phase 1 [118]
External Link
 Compound Name CAR-T cells targeting EGFRviii Phase 1 [118]
External Link
 Compound Name Anti-EGFRvIII CAR T cells Phase 1 [118]
External Link
 Compound Name CART-EGFRvIII T cells Phase 1 [118]
External Link
 Compound Name EGFRvIII-CARs Phase 1 [118]
External Link
 Compound Name CAR-T Cells targeting EGFRvIII Phase 1 [118]
External Link
 Compound Name RG6156 Phase 1 [118]
External Link
 Compound Name AMG 596 Phase 1 [118]
External Link
 Compound Name D2C7 Phase 1 [66]
External Link
Histone deacetylase 2 (HDAC2) 113 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name CHR-3996 Phase 1/2 [119]
Synonyms
CCT-075453; CHR-2504; HDAC inhibitors, Chroma Therapeutics; Histone deacetylase inhibitors, Chroma
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 4 nM
External Link
 Compound Name PMID29671355-Compound-74 Patented [120]
MOA Inhibitor
Activity IC50 = 119 nM
External Link
 Compound Name PMID29671355-Compound-59 Patented [120]
MOA Inhibitor
Activity IC50 = 10 nM
External Link
 Compound Name PMID29671355-Compound-55 Patented [120]
MOA Inhibitor
Activity IC50 < 1000 nM
External Link
 Compound Name PMID29671355-Compound-11 Patented [120]
MOA Inhibitor
Activity IC50 = 24 nM
External Link
 Compound Name PMID29671355-Compound-9 Patented [120]
MOA Inhibitor
Activity IC50 = 128 nM
External Link
 Compound Name PMID29671355-Compound-8 Patented [120]
MOA Inhibitor
Activity IC50 = 123000 nM
External Link
 Compound Name PMID29671355-Compound-61 Patented [120]
MOA Inhibitor
Activity IC50 = 45.9 nM
External Link
 Compound Name PMID29671355-Compound-23 Patented [120]
MOA Inhibitor
Activity IC50 = 7450 nM
External Link
 Compound Name PMID29671355-Compound-44 Patented [120]
MOA Inhibitor
Activity IC50 < 150 nM
External Link
 Compound Name PMID29671355-Compound-56 Patented [120]
MOA Inhibitor
Activity IC50 = 54.4 nM
External Link
 Compound Name PMID29671355-Compound-67 Patented [120]
MOA Inhibitor
Activity IC50 > 50000 nM
External Link
 Compound Name PMID29671355-Compound-31 Patented [120]
MOA Inhibitor
Activity IC50 = 2 nM
External Link
 Compound Name PMID29671355-Compound-21 Patented [120]
MOA Inhibitor
Activity IC50 = 4880 nM
External Link
 Compound Name PMID29671355-Compound-62 Patented [120]
MOA Inhibitor
Activity IC50 = 100 to 500 nM
External Link
 Compound Name PMID29671355-Compound-43 Patented [120]
MOA Inhibitor
Activity IC50 = 124 nM
External Link
 Compound Name PMID29671355-Compound-25 Patented [120]
MOA Inhibitor
Activity IC50 = 5400 nM
External Link
 Compound Name N8-hydroxy-2-methoxy-N1-phenyloctanediamide Investigative [121]
Synonyms
CHEMBL251010; SCHEMBL8158442
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name N-(4'-acetyl-4-aminobiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1099078; BDBM50317997
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3800 nM
External Link
 Compound Name N-Hydroxy-E-3-(4'-chlorobiphenyl-4-yl)-acrylamide Investigative [123]
Synonyms
CHEMBL557066; SCHEMBL3292989; SCHEMBL3292983; BDBM50293365
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1860 nM
External Link
 Compound Name N7-hydroxy-2-methoxy-N1-phenylheptanediamide Investigative [121]
Synonyms
CHEMBL251206; SCHEMBL8143763
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name N7-hydroxy-N1-phenyl-2-propoxyheptanediamide Investigative [121]
Synonyms
CHEMBL251406; SCHEMBL8144856
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name N-(4-amino-4'-vinylbiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1096397; BDBM50318002
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 800 nM
External Link
 Compound Name N-(4-amino-3'-methoxybiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1097747; BDBM50317991
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
 Compound Name KAR-1880 Investigative [124]
Synonyms
Anti-inflammatory OS-HDI; OS-HDI-2; HDAC 2 inhibitors (topical, dermatitis/psoriasis), Karus
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide Investigative [122]
Synonyms
CHEMBL1095096
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3900 nM
External Link
 Compound Name N-(4-amino-3'-methylbiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1094108; BDBM50317995
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3100 nM
External Link
 Compound Name N-(3'-acetyl-4-aminobiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1097746; BDBM50317992
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 13000 nM
External Link
 Compound Name N-(4-amino-4'-fluorobiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1098337; SCHEMBL15398027; BDBM50317988
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1400 nM
External Link
 Compound Name N8,2-dihydroxy-N1-phenyloctanediamide Investigative [121]
Synonyms
CHEMBL251009; SCHEMBL8144564
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name N-(2-amino-5-(furan-3-yl)phenyl)benzamide Investigative [122]
Synonyms
CHEMBL1095095; Benzamide, N-[2-amino-5-(3-furanyl)phenyl]-; BDBM50318000
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 39 nM
External Link
 Compound Name N-Hydroxy-E-3-(biphenyl-4-yl)-acrylamide Investigative [123]
Synonyms
CHEMBL556532; SCHEMBL3292226; SCHEMBL3290139
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 820 nM
External Link
 Compound Name 2-(allyloxy)-N8-hydroxy-N1-phenyloctanediamide Investigative [121]
Synonyms
CHEMBL402719; SCHEMBL8150833
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name 2-(benzyloxy)-N7-hydroxy-N1-phenylheptanediamide Investigative [121]
Synonyms
CHEMBL402718; SCHEMBL8152458
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 500 nM
External Link
 Compound Name N-(4-amino-4'-bromobiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1097748; BDBM50317990
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 600 nM
External Link
 Compound Name N-(2-amino-5-(furan-2-yl)phenyl)benzamide Investigative [122]
Synonyms
CHEMBL1097651
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 43 nM
External Link
 Compound Name 5-(Biphenyl-4-yl)-pentanoic acid N-hydroxyamide Investigative [123]
Synonyms
CHEMBL541239; SCHEMBL7045815
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 720 nM
External Link
 Compound Name N-(4-aminobiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL271741; 3max; SCHEMBL16380794; BDBM50232053; N-(4-amino-biphenyl-3-yl)-benzamide
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 27 nM
External Link
 Compound Name N-(2-amino-5-(benzofuran-2-yl)phenyl)benzamide Investigative [122]
Synonyms
CHEMBL1097063
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 10000 nM
External Link
 Compound Name N-(2-aminophenyl)benzamide Investigative [122]
Synonyms
2'-AMINOBENZANILIDE; 721-47-1; CHEMBL405072; AC1LFSYX; AC1Q5NOK; ACMC-1AE0C; Oprea1_478192; MLS000084661; SCHEMBL407834; N-(2-amino-phenyl)-benzamide; AC1Q514U; Benzamide, N-(2-aminophenyl)-; CTK2H2825; DTXSID60353948; RFDVMOUXHKTCDO-UHFFFAOYSA-N; MolPort-001-783-352; ZINC225957; HMS2355D18; STL497474; BDBM50232046; AKOS000133162; MCULE-5545982713; NE17312; SMR000019009; TC-170926; KB-298435; ST51030142; EN300-31745; SR-01000389415; AE-641/00785046
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 3100 nM
External Link
 Compound Name N-(4-amino-4'-methoxybiphenyl-3-yl)benzamide Investigative [122]
Synonyms
CHEMBL1095412; BDBM50317998
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 140 nM
External Link
 Compound Name N-Hydroxy-E-3-(4'-cyanobiphenyl-4-yl)-acrylamide Investigative [123]
Synonyms
CHEMBL538710; SCHEMBL3292721; SCHEMBL3292715; BDBM50293355
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 330 nM
External Link
 Compound Name N-(2-amino-5-(thiazol-2-yl)phenyl)benzamide Investigative [122]
Synonyms
CHEMBL1097278
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 390 nM
External Link
 Compound Name N-(2-aminophenyl)quinoxaline-6-carboxamide Investigative [125]
Synonyms
benzamide-type inhibitor, 20; CHEMBL236060; BDBM19424
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2000 nM
External Link
 Compound Name 7-Biphenyl-4-yl-heptanoic acid hydroxyamide Investigative [126]
Synonyms
CHEMBL125098; BDBM50222335; 7-(4-Biphenylyl)heptanehydroximic acid
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 8-(Biphenyl-4-yloxy)-2-oxo-octanoic acid Investigative [127]
Synonyms
CHEMBL115049; 436150-72-0; SCHEMBL7368556; CTK1D2674; DTXSID40658342; BDBM50221807; 8-[([1,1'-Biphenyl]-4-yl)oxy]-2-oxooctanoic acid; Octanoic acid, 8-([1,1'-biphenyl]-4-yloxy)-2-oxo-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 1,1,1-Trifluoro-8-phenoxy-octan-2-one Investigative [128]
Synonyms
CHEMBL114796; BDBM50217940
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-(Biphenyl-4-yloxy)-heptanoic acid hydroxyamide Investigative [127]
Synonyms
CHEMBL114184; SCHEMBL3383144
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-Phenoxy-heptanoic acid hydroxyamide Investigative [126]
Synonyms
CHEMBL124322; N-hydroxy-7-phenoxyheptanamide; 7-Phenoxyheptanehydroximic acid
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 1,1,1-Trifluoro-8-(4-phenoxy-phenoxy)-octan-2-one Investigative [128]
Synonyms
CHEMBL117916; SCHEMBL7366611; BDBM50217945
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(4-hydroxybiphenyl-3-yl)benzamide Investigative [129]
Synonyms
CHEMBL269935; SCHEMBL5724398; BDBM50232005
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 200 nM
External Link
 Compound Name 8-Phenyl-octanoic acid hydroxyamide Investigative [126]
Synonyms
CHEMBL123624; N-Hydroxy-8-phenyloctanamide; SCHEMBL5807174
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 8-(Biphenyl-3-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [128]
Synonyms
CHEMBL116023; SCHEMBL7368359; BDBM50218558
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(2-aminophenyl)nicotinamide Investigative [129]
Synonyms
N-(2-Amino-phenyl)-nicotinamide; 436089-31-5; N-(2-aminophenyl)pyridine-3-carboxamide; CHEMBL236678; AC1LMN6K; SCHEMBL18086514; CTK4I7538; DTXSID50360661; CHEBI:125506; ZINC873967; BDBM50220259; 3463AE; AKOS000129725; RTR-042156; MCULE-7933541910; N-(2-aminophenyl)-3-pyridylcarboxamide; ZB014940; ACM436089315; ST086607; ASN 01337807; KB-298440; TR-042156; BC4148434; SR-01000329900; SR-01000329900-1; BRD-K20880473-001-04-6
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 6980 nM
External Link
 Compound Name santacruzamate A Investigative [130]
Synonyms
CAY10683
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 0.112 nM
External Link
 Compound Name N-(4-aminobiphenyl-3-yl)nicotinamide Investigative [129]
Synonyms
CHEMBL255805; BDBM50232035
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 900 nM
External Link
 Compound Name N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide Investigative [129]
Synonyms
CHEMBL256440; SCHEMBL1066609
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 390 nM
External Link
 Compound Name N-(2-aminophenyl)-4-methoxybenzamide Investigative [125]
Synonyms
AC1LFX2W; Cambridge id 5129152; Oprea1_722128; benzamide-type inhibitor, 22; CHEMBL236061; SCHEMBL5226034; BDBM19426; CTK7A1998; MolPort-001-019-504; BDYVCYUXCNZYRW-UHFFFAOYSA-N; ZINC281656; STK156256; AKOS000130378; MCULE-9183453747; N-(2-Amino-phenyl)4-methoxy-benzamide; N-(2-amino-phenyl)-4-methoxy-benzamide; NCGC00240897-01; N1-(4-methoxybenzoyl)-1,2-benzenediamine; N1-(4-methoxy-benzoyl)-1,2-benzenediamine; ST50908739; N-(2-aminophenyl)(4-methoxyphenyl)carboxamide; SR-01000196394
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 900 nM
External Link
 Compound Name 4-Phenylbutyrohydroxamic acid Investigative [131]
Synonyms
N-Hydroxy-4-phenylbutanamide; 32153-46-1; NSC131300; UNII-QX182FOM5S; QX182FOM5S; 4-phenylbutanehydroxamic acid; CHEMBL55895; Benzenebutanamide, N-hydroxy-; NSC 131300; AC1Q7DIW; AC1L5RDX; Phenylbutyrylhydroxamic Acid; AC1Q5QD1; N-Hydroxy-4-phenyl-butyramide; 4-Phenylbutyryl hydroxamic acid; SCHEMBL1350853; CTK4G8310; DTXSID60185943; MolPort-011-492-164; UPHXPXYRKPCXHK-UHFFFAOYSA-N; ZINC4962622; STL301752; BDBM50015142; AKOS009266186; MCULE-9765156954; NSC-131300; NE28489; BCB03_000829; EN300-68596
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 430 nM
External Link
 Compound Name 8-Oxo-8-phenyl-octanoic acid hydroxyamide Investigative [132]
Synonyms
CHEMBL95959; SCHEMBL3383197; N-hydroxy-8-oxo-8-phenyloctanamide
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Octanedioic acid bis-hydroxyamide Investigative [133]
Synonyms
Suberohydroxamic acid
    Click to Show/Hide
MOA Inhibitor
Activity Ki = 29 nM
External Link
 Compound Name ST-2986 Investigative [134]
Synonyms
CHEMBL471041; SCHEMBL3444455; BDBM50278219
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 11000 nM
External Link
 Compound Name 9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide Investigative [128]
Synonyms
9,9,9-Trifluoro-8-Oxo-N-Phenylnonanamide; CHEMBL113537; 2gh6; SCHEMBL2702892; KRCXZGYVOZSCSF-UHFFFAOYSA-N; BDBM50121062; DB07553
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1400 nM
External Link
 Compound Name 7-Mercapto-heptanoic acid phenylamide Investigative [135]
Synonyms
Thiol-SAHA (t-SAHA); CHEMBL325676; SCHEMBL14821761; BDBM152692
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 1300 nM
External Link
 Compound Name 6-benzenesulfinylhexanoic acid hydroxamide Investigative [136]
Synonyms
6-(benzenesulfinyl)hexanoic acid hydroxyamide; 875737-03-4
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-succinamide Investigative [137]
Synonyms
CHEMBL193959
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-Mercapto-heptanoic acid biphenyl-4-ylamide Investigative [135]
Synonyms
CHEMBL112311
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-phenylacetylamino-benzamide Investigative [138]
Synonyms
CHEMBL356824; 656261-23-3; SCHEMBL675578; CTK1J6158; DTXSID40458440; ZINC13533297; AKOS030583151; Benzeneacetamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6-(2-Bromo-acetylamino)-hexanoic acid phenylamide Investigative [135]
Synonyms
CHEMBL344920; 651767-99-6; SCHEMBL3736839; CTK1J8444; DTXSID50432973; HWYLREOMBVUGJQ-UHFFFAOYSA-N; BDBM50222416; ZINC13587789; AKOS030603042; N-Phenyl-6-(bromoacetylamino)hexanamide; Hexanamide, 6-[(bromoacetyl)amino]-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide Investigative [139]
Synonyms
CHEMBL143674; SCHEMBL673760
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [140]
Synonyms
CHEMBL126355; BDBM50222394
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Octanedioic acid hydroxyamide pyridin-4-ylamide Investigative [141]
Synonyms
SCHEMBL8082656; CHEMBL165162; ZINC13472304
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(6-Mercapto-hexyl)-benzamide Investigative [135]
Synonyms
CHEMBL112364; BDBM50223650
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [141]
Synonyms
CHEMBL167455
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Investigative [138]
Synonyms
SCHEMBL675474
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6-benzenesulfonylhexanoic acid hydroxamide Investigative [136]
Synonyms
CHEMBL203207
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Investigative [128]
Synonyms
SCHEMBL7373122; CHEMBL116578
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester Investigative [135]
Synonyms
CHEMBL111806; SCHEMBL14812153
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-Butyrylamino-N-hydroxy-benzamide Investigative [139]
Synonyms
CHEMBL142254; 656261-22-2; Benzamide, N-hydroxy-4-[(1-oxobutyl)amino]-; SCHEMBL675234; CTK1J6159; DTXSID90461262
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [140]
Synonyms
CHEMBL127328
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-Mercapto-heptanoic acid biphenyl-3-ylamide Investigative [135]
Synonyms
CHEMBL320323
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione Investigative [142]
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide Investigative [138]
Synonyms
SCHEMBL676079
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide Investigative [135]
Synonyms
CHEMBL324126
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-Mercapto-heptanoic acid pyridin-3-ylamide Investigative [135]
Synonyms
CHEMBL332246; Heptanamide, 7-mercapto-N-3-pyridinyl-; BDBM50223653
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6-Phenoxy-hexane-1-thiol Investigative [135]
Synonyms
CHEMBL109796; 6-phenoxyhexane-1-thiol; 1-Hexanethiol, 6-phenoxy-; SCHEMBL5679745; MolPort-020-180-823; BDBM50223652; AKOS018584222; MCULE-9521857089
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-Benzoylamino-N-hydroxy-benzamide Investigative [138]
Synonyms
SCHEMBL673678; CHEMBL191227
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide Investigative [132]
Synonyms
CHEMBL143734; NSC718168; AC1L8L82; SCHEMBL13039735; ZINC5579677; BDBM50082664; NSC-718168; NCI60_040737; 6-(4-Chlorobenzoylamino)hexanehydroxamic acid
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Investigative [128]
Synonyms
CHEMBL112148; SCHEMBL7364383; BDBM50218532
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Investigative [140]
Synonyms
CHEMBL127351; SCHEMBL7365180; HWZHDGRMABBYOV-UHFFFAOYSA-N; BDBM50222367; 7-((1,1'-biphenyl)-3-yloxy)-1-(1 ,3-oxazol-2-yl)-1-heptanone
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6-Mercapto-hexanoic acid phenylamide Investigative [135]
Synonyms
CHEMBL109654; Hexanamide, 6-mercapto-N-phenyl-; SCHEMBL14254925; BDBM50027600
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2220 nM
External Link
 Compound Name Cyclostellettamine derivative Investigative [143]
Synonyms
CHEMBL88332
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide Investigative [132]
Synonyms
CHEMBL139999; SCHEMBL1232700; BDBM50082661; ZINC13472309
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 5-Mercapto-pentanoic acid phenylamide Investigative [135]
Synonyms
N-Phenyl-5-mercaptovaleramide; CHEMBL114344; Pentanamide, 5-mercapto-N-phenyl-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name Octanedioic acid hydroxyamide pyridin-2-ylamide Investigative [141]
Synonyms
SCHEMBL8090513; CHEMBL164872; ZINC13472303
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide Investigative [137]
Synonyms
CHEMBL193979
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 2-(methylsulfonylthio)ethyl 2-propylpentanoate Investigative [142]
Synonyms
CHEMBL271677; SCHEMBL4156413
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name (E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Investigative [140]
Synonyms
CHEMBL126465; SCHEMBL7368197; SCHEMBL7368201
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Investigative [138]
Synonyms
SCHEMBL676080
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide Investigative [144]
Synonyms
N-hydroxy-4-(3-phenylpropanamido)benzamide
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Investigative [138]
Synonyms
SCHEMBL7311087
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 8-Oxo-8-phenyl-octanoic acid Investigative [141]
Synonyms
8-Oxo-8-phenyloctanoic acid; 7-Benzoylheptanoic acid; 24314-23-6; Benzeneoctanoic acid, h-oxo-; 7-BENZOYL HEPTANOIC ACID; AC1L6TSB; SCHEMBL3381106; 8-keto-8-phenyl-caprylic acid; CHEMBL162423; 8-Oxo-8-phenyloctanoic acid #; CTK4F3363; DTXSID40305602; UMCSRRHQLAVYRS-UHFFFAOYSA-N; ZINC2168376; 7009f; NSC171230; AKOS016022495; NSC-171230; MCULE-7202530747; ACM24314236; ST50825837
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide Investigative [138]
Synonyms
CHEMBL143336; 656261-24-4; SCHEMBL674421; CTK1J6157; DTXSID30433908; ZINC13533300; AKOS030583673; n-hydroxy-4-(4-phenylbutyryl-amino)benzamide; Benzenebutanamide, N-[4-[(hydroxyamino)carbonyl]phenyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 6-phenylsulfanylhexanoic acid hydroxamide Investigative [136]
Synonyms
Hexanamide, N-hydroxy-6-(phenylthio)-; CHEMBL203028; SCHEMBL7317658
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name ST-2987 Investigative [134]
Synonyms
CHEMBL471042; SCHEMBL3444989; SCHEMBL3444984; BDBM50278220
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 2670 nM
External Link
 Compound Name 7-Mercapto-heptanoic acid quinolin-3-ylamide Investigative [135]
Synonyms
CHEMBL112234
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide Investigative [145]
Synonyms
CHEMBL84288
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 8-Mercapto-octanoic acid phenylamide Investigative [135]
Synonyms
8-mercapto-N-phenyloctanamide; CHEMBL326433; ZINC13609343
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 754 nM
External Link
 Compound Name N-(6-Hydroxycarbamoyl-hexyl)-benzamide Investigative [141]
Synonyms
CHEMBL57107; 174664-71-2; SCHEMBL573254; CTK0A7470; DTXSID00433435; BDBM50220823; ZINC13490043; 7-(Benzoylamino)heptanehydroxamic acid; AKOS030580013; Benzamide, N-[7-(hydroxyamino)-7-oxoheptyl]-
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Investigative [128]
Synonyms
CHEMBL326529; SCHEMBL7365237; BDBM50217957
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name 7-Mercapto-heptanoic acid benzothiazol-2-ylamide Investigative [135]
Synonyms
CHEMBL178779
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name N-Hydroxy-4-(pentanoylamino-methyl)-benzamide Investigative [139]
Synonyms
CHEMBL143102
    Click to Show/Hide
MOA Inhibitor
External Link
 Compound Name PSAMMAPLIN A Investigative [132]
Synonyms
110659-91-1; Bisprasin; NSC614495; AC1O46WI; SCHEMBL364511; ZINC150352860; NSC-614495; B723735K022; J-002461; Benzenepropanamide, N,N'-(dithiodi-2,1-ethanediyl)bis(3-bromo-4-hydroxy-alpha-(hydroxyimino)-
    Click to Show/Hide
MOA Inhibitor
External Link
2A60: Acute myeloid leukaemia 283 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Atezolizumab Approved [34]
External Link
 Compound Name ENASIDENIB MESYLATE Approved [11]
Synonyms
UNII-UF6PC17XAV; AG-221 mesylate; Enasidenib (mesylate); UF6PC17XAV; Enasidenib mesylate [USAN]; Enasidenib mesylate (USAN); Enasidenib mesilate; Enasidenib methanesulfonate; Idhifa (TN); SCHEMBL16448052; HY-18690A; CS-7541
    Click to Show/Hide
External Link
 Compound Name Lestaurtinib Approved (orphan drug) [146]
Synonyms
A 1544750; CEP 701; KT 5555; KT5555; SP 924; CEP-701; KT-5555; SPM-924; Lestaurtinib (USAN/INN)
    Click to Show/Hide
External Link
 Compound Name Motixafortide Approved [147]
External Link
 Compound Name ARN-509 Approved [148]
Synonyms
Arn-509 (AR inhibitor)
    Click to Show/Hide
External Link
 Compound Name DEOXYCYTIDINE Approved [149]
Synonyms
Cytosine deoxyribonucleoside; 2'-dC; bmse000323; ACMC-209rv6; CYTIDINE, 2'-DEOXY-; Cytosine deoxy nucleoside hydrochloride; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; Desoxycytidine; 4-amino-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; 3h-deoxycytidine; 4-amino-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 40093-94-5; AC1L19OG; TimTec1_003892; NCIOpen2_004589; Oprea1_817993
    Click to Show/Hide
External Link
 Compound Name Bestatin Approved [150]
Synonyms
Bestatin (TN); CHEBI:3070; UPCMLD-DP116; CHEMBL476869; SureCN25971; Ubenimex (JP16/INN); Ubenimex (JP17/INN); SCHEMBL25971; GTPL5151; AC1L972Z; UPCMLD-DP116:001; DTXSID4048430; CHEBI:140702; ZINC1532730; ZINC01532730; BDBM50010142; AKOS026750073; NCGC00161660-01; C00732; D00087; ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-D-leucine; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
    Click to Show/Hide
External Link
 Compound Name Tagraxofusp Approved [148]
Synonyms
Tagraxofusp [INN]; Molecule 129; Tagraxofusp [USAN]; UNII-8ZHS5657EH; 8ZHS5657EH; Diphtheria toxin-il-3 fusion protein targeting IL-3 receptor
    Click to Show/Hide
External Link
 Compound Name Uracil mustard Approved [151]
Synonyms
Chlorethaminacil; Demethyldopan; Desmethyldopan; Nordopan; Uracillost; Uracilmostaza; Uramustin; Uramustina; Uramustine; Uramustinum; Aminouracil mustard; Uracil lost; Uracil lost [German]; Uracil mustard [USAN]; Uracil nitrogen mustard; ENT 50439; U 8344; CB-4835; SK-19849; U-8344; Uracil mustard (TN); Uracil mustard (USAN); Uramustina [INN-Spanish]; Uramustine (INN); Uramustinum [INN-Latin]; URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY); 2,6-Dihydroxy-5-bis(2-chloroethyl)aminopyrimidine; 2,6-Dihydroxy-5-bis[2-chloroethyl]aminopyrimidine; 5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)uracil; 5-(Di-(beta-chloroethyl)amino)uracil; 5-(Di-2-chloroethyl)aminouracil; 5-Aminouracil mustard; 5-N,N-Bis(2-chloroethyl)aminouracil; 5-[Bis(2-chlorethyl)amino]-2,4(1H,3H)pyrimidinedione; 5-[Bis(2-chloroethyl)amino]uracil; 5-[Di(2-chloroethyl)amino]uracil; 5-[Di(beta-chloroethyl)amino]uracil; 5-[Di(beta.-chloroethyl)amino]uracil; 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione; 5-[bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4(1H,3H)-dione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol
    Click to Show/Hide
External Link
 Compound Name Tisagenlecleucel Application submitted [31]
Synonyms
Tisagenlecleucel-T
    Click to Show/Hide
External Link
 Compound Name Olutasidenib Approved [34]
Synonyms
NEQYWYXGTJDAKR-JTQLQIEISA-N; Olutasidenib; UNII-0T4IMT8S5Z; 0T4IMT8S5Z; (S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; Olutasidenib [USAN]; SCHEMBL17603134; HY-114226; CS-0080183; 5-(((1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-(((1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro-1-methyl-6-oxo-; 1887014-12-1
    Click to Show/Hide
External Link
 Compound Name Midostaurin Approved [152]
Synonyms
PKC412; 120685-11-2; Cgp 41251; 4'-N-Benzoylstaurosporine; CGP-41251; Benzoylstaurosporine; PKC-412; RYDAPT; PKC 412; UNII-ID912S5VON; N-Benzoylstaurosporine; ID912S5VON; CHEMBL608533; CHEBI:63452; Cgp 41 251; N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide; PKC-412(Midostaurin); Midostaurin (PKC412); Midostaurin (USAN/INN); Midostaurin [USAN:INN]; CGP 41231; Rydapt (TN); CPG 41251
    Click to Show/Hide
External Link
 Compound Name Quizartinib Approved [55]
Synonyms
Quizartinib
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External Link
 Compound Name Ivosidenib Approved [55]
Synonyms
UNII-Q2PCN8MAM6; Q2PCN8MAM6; Ivosidenib [INN]; Ivosidenib [USAN]; Ivosidenib [WHO-DD]; GTPL9217; SCHEMBL15122512; EX-A992; MolPort-044-560-317; RG120; s8206; 1448347-49-6 (Ivosidenib); AKOS028113340; ZINC205136523; CS-5122; AS-35058; HY-18767
    Click to Show/Hide
External Link
 Compound Name Gemtuzumab ozogamicin Approved [153]
Synonyms
Mylotarg (TN)
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External Link
 Compound Name Gilteritinib Approved [148]
Synonyms
UNII-66D92MGC8M; 66D92MGC8M; Gilteritinib [USAN:INN]; Gilteritinib(ASP2215); Gilteritinib (USAN/INN); Gilteritinib (ASP2215); Gilteritinib (ASP-2215); SCHEMBL282229; GTPL8708; MolPort-038-934-933; BDBM144315; C29H44N8O3; 3694AH; s7754; AKOS030234455; ZINC113476229; DB12141; CS-3885; KS-0000064E; AS-35199
    Click to Show/Hide
External Link
 Compound Name Thioguanine Approved [154]
Synonyms
6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog)
    Click to Show/Hide
External Link
 Compound Name Daunorubicin Approved [155]
Synonyms
Daunomycin; 20830-81-3; Rubidomycin; Cerubidine; Daunorubicine; Acetyladriamycin; Leukaemomycin C; Daunorubicinum; Daunarubicinum; Daunorrubicina; Daunamycin; Cerubidin; DaunoXome; Rubomycin C; (+)-Daunomycin; Daunoblastin; Anthracyline; Rubomycin; Daunorubicinum [INN-Latin]; RP 13057; Daunorubicin [INN:BAN]; RCRA waste no U059; FI6339; NSC-82151; DAUNORUBICIN HCL; DaunoXome (TN); UNII-ZS7284E0ZP; CCRIS 914; ZS7284E0ZP; CHEBI:41977; HSDB 5095; C27H29NO10; NCI-C04693; EINECS 244-069-7; Ondena; NSC 83142; Daunoblastine; Antibiotics from Streptomyces coeruleorubidus; DM1; FI 6339; Dauno-Rubidomycine; Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin, Hydrochloride; VS-103; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Anthracycline
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 Compound Name Idarubicin Approved [156]
Synonyms
DMDR; Idamycin; Idarubicina; Idarubicine; Idarubicinum; Zavedos; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin hydrochloride; DM5; I 1656; IMI 30; IMI-30; Idamycin (TN); Idarubicin (INN); Idarubicin [INN:BAN]; Idarubicina [INN-Spanish]; Idarubicine [INN-French]; Idarubicinum [INN-Latin]; Zavedos (TN); (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-A-l-lyxo-hexopyranoside; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 4-DMD; 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; 4-Desmethoxydaunorubicin
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 Compound Name Aclarubicin Approved [157]
Synonyms
Aclacin; Aclacur; Aclarubicine; Aclarubicino; Aclarubicinum; Jaclacin; Aclacinomycin A; Aclucinomycin A; Antibiotic MA 144A; Antibiotic MA 144A1; Antibiotic MA 144G1; MA 144G1; Aclarubicine [INN-French]; Aclarubicino [INN-Spanish]; Aclarubicinum [INN-Latin]; Antibiotic MA144-A1; MA 144-A1; MA-144A1; Acene-1-carboxylate; Aclarubicin (USAN/INN); Aclarubicin [USAN:BAN:INN]; Alpha-L-lyxo-hexopyranosyl]-oxy]-1-naphthacenecarboxalic acid methyl ester; 10-epi-Aclacinomycin A
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 Compound Name Magrolimab Phase 3 [158]
Synonyms
GS-4721
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 Compound Name DSP-7888 Phase 2 [34]
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 Compound Name 131I-labelled aCD45 Phase 3 [159]
External Link
 Compound Name ATIR101 Phase 3 [160]
External Link
 Compound Name Dociparstat sodium Phase 3 [161]
Synonyms
DSTAT
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 Compound Name Iomab-B CD45 Phase 3 [34]
External Link
 Compound Name Tasisulam Phase 3 [162]
Synonyms
Tasisulam sodium; LY-573636; LY-573636 sodium; LY-573636Na; Apoptosis stimulator (cancer), Lilly
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 Compound Name Vadastuximab talirine Phase 3 [31]
Synonyms
Vadastuximab talirine [INN]; Vadastuximab talirine [USAN]; Vadastuximab talirine [WHO-DD]; UNII-T13V17U431; T13V17U431; UNII-X1TW58ZV0U component BNJNAEJASPUJTO-DUOHOMBCSA-N; 1436390-64-5
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 Compound Name Abexinostat Phase 3 [34]
Synonyms
PCI-24781; 783355-60-2; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide
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 Compound Name Peginterferon lambda-1a Phase 3 [163]
Synonyms
BMS-914143; IFN lambda, ZymoGenetics/Novo Nordisk; Interferon lambda 1, ZymoGenetics/Novo Nordisk; PEG-IL-29; PEG-rIL-29; Interleukin-29, ZymoGenetics/Novo Nordisk; PEG-IFN lambda, ZymoGenetics/Novo Nordisk; PEG-interferon lambda, ZymoGenetics/Novo Nordisk; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk; Peginterferon lambda-1a, ZymoGenetics/Bristol-Myers Squibb; PEG-IFN lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; PEG-interferon lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; Recombinant PEG-interferon lambda-1, ZymoGenetics/Bristol-Myers Squibb; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb
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 Compound Name CPX-351 Phase 3 [55]
Synonyms
Vyxeos; Cytarabine / daunonubicin; Daunonubicin / cytarabine; CPX 351; Cytarabine mixture with daunonubicin; Daunonubicin mixture with cytarabine; Daunonubicin and cytarabine liposomal injection; SCHEMBL3959238; 1256639-86-7; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-, mixt. with 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
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 Compound Name BYM338 Phase 2/3 [164]
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 Compound Name SGI110 Phase 3 [165]
External Link
 Compound Name Elacytarabine Phase 3 [166]
Synonyms
Elacyt (TN)
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 Compound Name RG7388 Phase 3 [167]
Synonyms
Idasanutlin; 1229705-06-9; Idasanutlin (RG-7388); RG-7388; UNII-QSQ883V35U; QSQ883V35U; CHEMBL2402737; Benzoic acid, 4-((((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl)carbonyl)amino)-3-methoxy-; RO5503781; Idasanutlin [USAN:INN]; Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-; RG-7388;Idasanutlin; RO-5503781; SCHEMBL442856
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 Compound Name Galinpepimut-S Phase 3 [168]
External Link
 Compound Name Pracinostat Phase 3 [55]
Synonyms
929016-96-6; SB939; SB 939; Pracinostat (SB939); SB-939; UNII-GPO2JN4UON; GPO2JN4UON; CHEMBL1851943; (E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide; 2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-; Pracinostat [INN]; (2E)-3-(2-Butyl-1-[2-(diethylamino)ethyl]-1h-1,3-benzodiazol-5-yl)-n-hydroxyprop-2-enamide; 2-Propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzimidazol-5-yl)-N-hydroxy-, (2E)-
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 Compound Name DFP-10917 Phase 3 [34]
External Link
 Compound Name AG-881 Phase 1 [34]
Synonyms
Vorasidenib; 1644545-52-7; UNII-789Q85GA8P; 789Q85GA8P; AG881; 9UO; 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine; Vorasidenib [INN]; Vorasidenib (AG-881); SCHEMBL16393139; AG 881 [WHO-DD]; QCZAWDGAVJMPTA-RNFRBKRXSA-N; BDBM279948; EX-A2574; US10028961, Compound 101; AG 881; s8611; CS-8033; HY-104042; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoro propan-2-yl)-1,3,5-triazine-2,4-diamine; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoroprop
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 Compound Name AG-221 Phase 1/2 [169]
Synonyms
AG-221 (IDH2 inhibitor)
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 Compound Name CP-868596 Phase 3 [34]
Synonyms
Crenolanib; 670220-88-9; Crenolanib (CP-868596); ARO-002; UNII-LQF7I567TQ; LQF7I567TQ; CP-868596 (Crenolanib); CP-868,596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP868569; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine; J-502712; 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
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 Compound Name Rydaptmidostaurin Phase 3 [34]
External Link
 Compound Name Sapacitabine Phase 3 [170]
Synonyms
CYC682
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 Compound Name S-110 Phase 3 [165]
Synonyms
DNA demethylating agent (myelodysplastic syndrome), Supergen
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 Compound Name VAL-083 Phase 1/2 [171]
Synonyms
Dianhydrogalactitol; 23261-20-3; UNII-4S465RYF7M; 1,2:5,6-DIANHYDROGALACTITOL; Dulcitoldiepoxide; 4S465RYF7M; Dianhydrogalactitol [USAN:INN]; SCHEMBL4306431; Dianhydrogalactitol (USAN/INN); CHEMBL3137322; AAFJXZWCNVJTMK-GUCUJZIJSA-N; ZINC4963497; CS-1358; DB12873; NSC-1323313; HY-16513; BC657197; D10623; W-5268; J-015059; 457899-38-6
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 Compound Name CC-486 Phase 3 [34]
Synonyms
AG-14361; AG14361; 328543-09-5; UNII-48N0U0K50I; AG 14361; CHEMBL65892; 48N0U0K50I; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; AG-014361; 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; Imidazo(4,5,1-jk)(1,4)benzodiazepin-7(4H)-one, 2-(4-((dimethylamino)methyl)phenyl)-5,6-dihydro-; 2-[4-[(Dimethylamino)methyl]phenyl]-5,6-dihydroimidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one; SMR000486393; MLS006011157; MLS001065917; Nucleoside analogue
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 Compound Name Hu5F9-G4 Phase 3 [31]
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 Compound Name Iomab-B Phase 3 [172]
Synonyms
Iomab-B (TN)
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 Compound Name PEG arginine deiminase Phase 1 [34]
Synonyms
ADI-PEG 20
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 Compound Name CPI-613 Phase 3 [55]
Synonyms
95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874
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 Compound Name Zarnestra Phase 3 [173]
Synonyms
JAN; Tipifarnib; Tipifarnib [USAN]; R 115777; R115777; R-11577; R-115777; Tipifarnib (USAN/INN); Zarnestra, IND 58359, R115777, Tipifarnib; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-R115777; 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone; 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE
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 Compound Name LMT-X Phase 3 [174]
Synonyms
Second-generation tau aggregation inhibitor (Alzheimer's disease); Second-generation tau aggregation inhibitor (Alzheimer's disease), TauRx
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 Compound Name Elesclomol Phase 3 [175]
Synonyms
488832-69-5; Elesclomol (STA-4783); STA-4783; UNII-6UK191M53P; CHEBI:79369; 6UK191M53P; Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]; 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid; N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; J-503879; C19H20N4O2S2; 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide; Elesclomol [USAN:INN]; elesclomolum
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 Compound Name GMI-1271 Phase 3 [176]
Synonyms
Uproleselan
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 Compound Name AT-406 Phase 3 [177]
Synonyms
1071992-99-8; SM 406; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; CHEMBL2158051; QCR-136; UNII-N65WC8PXDD; N65WC8PXDD; AT406 (SM-406, ARRY-334543); J-501625; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; AT-406/Debio-1143
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 Compound Name PR1 peptide antigen vaccine Phase 3 [178]
Synonyms
PR1 peptide antigen vaccine (leukemia); PR1 peptide antigen vaccine (leukemia), MD Anderson; PR1 peptide antigen vaccine (leukemia), Vaccine Company
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 Compound Name CPI-0610 Phase 3 [34]
External Link
 Compound Name SNS-595 Phase 3 [179]
Synonyms
Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
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 Compound Name Selinexor Phase 3 [55]
Synonyms
Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
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 Compound Name Volasertib Phase 3 [55]
Synonyms
755038-65-4; BI 6727; BI-6727; BI6727 (Volasertib); Volasertib (BI 6727); UNII-6EM57086EA; 6EM57086EA; BI6727; N-{trans-4-[4-(Cyclopropylmethyl)piperazin-1-Yl]cyclohexyl}-4-{[(7r)-7-Ethyl-5-Methyl-8-(1-Methylethyl)-6-Oxo-5,6,7,8-Tetrahydropteridin-2-Yl]amino}-3-Methoxybenzamide; Volasertib [USAN:INN]; IBI; Volasertib (USAN); BI6727,Volasertib; Volasertib(BI6727); BI6727 - Volasertib; Volasertib (BI6727); BI6727 (Volasertib)/; BI 6727 (Volasertib); MLS006011195; SCHEMBL738946; SCHEMBL9888052; SCHEMBL2169101; GTPL7947
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 Compound Name Rivo-cel Phase 2/3 [180]
Synonyms
BPX-501
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 Compound Name CLL1 CAR-T Cell Phase 2/3 [181]
External Link
 Compound Name NLG8189 Phase 2/3 [34]
Synonyms
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
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 Compound Name CD123/CLL1 CAR-T Cells Phase 2/3 [181]
External Link
 Compound Name K-NK002 Phase 2 [182]
Synonyms
CSTD-002-NK
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 Compound Name Dilanubicel Phase 2 [183]
Synonyms
NLA101
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External Link
 Compound Name DS-3201b Phase 2 [184]
Synonyms
Valemetostat; 1809336-39-7; UNII-60RD0234VE; 60RD0234VE; 1809336-39-7 (free base); DS-3201; (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide; Valemetostat 2HCl; Valemetostat [INN]; Valemetostat (DS-3201); CHEMBL4597193; EZH1/2 inhibitor DS-3201; SCHEMBL18393626; SCHEMBL18393627; SCHEMBL18639210; EX-A3423; DS3201; NSC813381; s8926; NSC-813381; HY-109108; CS-0039740; D11551
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 Compound Name BST-236 Phase 2 [185]
Synonyms
Aspacytarabine; UNII-JL7V54Z2BR; JL7V54Z2BR; 2098942-53-9; N4-(1-beta-D-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)-; Astarabine; Aspacytarabine [INN]; CHEMBL4297599; L-Asparagine, N-(1-beta-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-; N4-(1-N2-D-Arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)- L-asparagine
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 Compound Name Zelenoleucel Phase 2 [186]
External Link
 Compound Name CX-01 Phase 2 [34]
External Link
 Compound Name LY2090314 Phase 2 [187]
Synonyms
603288-22-8; LY-2090314; UNII-822M3GYM67; Kinome_3681; LY 2090314; CHEMBL362558; 822M3GYM67; 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione; SCHEMBL633455; GTPL7958; DTXSID90209085; MolPort-035-944-332; EX-A2214; ZINC3817327; BCP07855; s7063; BDBM50150699; AKOS032950045; AKOS026750195; CS-1633; DB11913; SB16558; NCGC00378942-05; NCGC00378942-02; BC600682; QC-11735; HY-16294; KB-78238; FT-0698670; LY2090314, &gt
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 Compound Name Flotetuzumab Phase 2 [188]
External Link
 Compound Name BGB-324 Phase 1/2 [55]
Synonyms
BGB-001; SiRNA therapeutic (metastasis cancer), BiobergenBio
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 Compound Name PTX-200 Phase 2 [34]
Synonyms
Plant-derived antiparkinsonian, Phytrix
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 Compound Name LY2523355 Phase 2 [189]
Synonyms
Litronesib
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 Compound Name Prexigebersen Phase 2 [34]
Synonyms
Prexigebersen [INN]; Prexigebersen [USAN:INN]; UNII-8W1O4Y961B; 8W1O4Y961B; BP-100-1.01/L-Grb2; DNA, d(A-T-A-T-T-T-G-G-C-G-A-T-G-G-C-T-T-C); 202484-91-1; 1352967-54-4
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External Link
 Compound Name ALT-801 Phase 2 [190]
Synonyms
ALT-801 (donor lymphocyte infusion, cancer); ALT-801 (donor lymphocyte infusion, cancer), Altor; STAR IL-2 conjugate (donor lymphocyte infusion, cancer), Altor; STAR-Ck (donor lymphocyte infusion, cancer), Altor; Soluble T-cell Antigen Receptor IL-2 conjugate (donor lymphocyte infusion, cancer), Altor
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External Link
 Compound Name ENMD-2076 Phase 2 [191]
Synonyms
934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; UNII-J6U9WP10T7; ENMD2076; J6U9WP10T7; CHEMBL482968; 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine; 6-(4-METHYL-1-PIPERAZINYL)-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-[(1E)-2-PHENYLETHENYL]-4-PYRIMIDINAMINE; ENMD-981693; MLS006011042; SCHEMBL596481; GTPL7885; SCHEMBL15668060; SCHEMBL10122872; ENND-2076; EX-A235; DTXSID60239430; MolPort-009-679-391; AOB87159
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External Link
 Compound Name FPI-01 Phase 2 [192]
Synonyms
WT-1 therapeutic vaccine (cancer), Formula Pharmaceuticals
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External Link
 Compound Name Inecalcitol oral Phase 2 [34]
Synonyms
Inecalcitol; TX-522; UNII-05FZV98342; TX 522; 163217-09-2; AC1OCD0K; 19-Nor-14-epi-23-yne-1,25 dihydroxyvitamin D3; 05FZV98342; (1R,3R)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; (7E)-(1R,3R,14R)-19-nor-23-yne-9,10-seco-5,7-cholestadiene-1,3,25-triol; Inecalcitol [INN]; SCHEMBL754593; GTPL7747; CHEMBL2105107; LMST03020649; 8151AH; ZINC12504514; AKOS025312295; AN-7569; DB04796; TX-527; Vitamin D analogs, Catholic University of Leuven; Vitamin D analogs, KULeuven; Inecalcitol (oral, hyperthyroidism), Hybrigenics; Inecalcitol (sc, psoriasis), Hybrigenics; Vitamin D analog (sc, psoriasis), Hybrigenics; Inecalcitol (oral, prostate cancer/psoriasis), Hybrigenics
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External Link
 Compound Name Eryaspase Phase 2 [34]
External Link
 Compound Name ALXN6000 Phase 2 [31]
Synonyms
Samalizumab
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External Link
 Compound Name BI 2536 Phase 2 [193]
Synonyms
BI2536, BI 2536
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External Link
 Compound Name MK8242 Phase 2 [194]
External Link
 Compound Name Leukemia DNA vaccine Phase 2 [195]
External Link
 Compound Name Anti-CD45 mAb 131I-BC8 Phase 2 [55]
External Link
 Compound Name BREQUINAR Phase 1/2 [196]
Synonyms
96187-53-0; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; Brequinar [INN]; Biphenquinate; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinarum [INN-Latin]; UNII-5XL19F49H6; C23H15F2NO2; NSC-368390; NSC 368390; 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid; PHEZJEYUWHETKO-UHFFFAOYSA-N; Dup 785; 5XL19F49H6; 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID; brequinarum
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External Link
 Compound Name Leukemia cancer vaccine Phase 2 [197]
External Link
 Compound Name ADCT-301 Phase 1 [34]
Synonyms
camidanlumab tesirine
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External Link
 Compound Name Flavopiridol Phase 2 [55]
Synonyms
FLAVO; Alvocidib [INN]; Flavopiridol hydrochloride; L 868275; HMR-1275; L-868275; L86-8275; HMR-1275, Alvocidib, L868275, Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
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External Link
 Compound Name BP-100-1-01 Phase 2 [198]
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 Compound Name IRX-2 Phase 2 [199]
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 Compound Name Cenersen Phase 2 [200]
External Link
 Compound Name Lirilumab Phase 2 [201]
External Link
 Compound Name LOR-2040 Phase 2 [202]
External Link
 Compound Name Sodium butyrate Phase 2 [203]
Synonyms
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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External Link
 Compound Name GRNVAC1 Phase 2 [204]
External Link
 Compound Name H3B-8800 Phase 1 [34]
External Link
 Compound Name GS-9973 Phase 2 [34]
Synonyms
Entospletinib; 1229208-44-9; Entospletinib (GS-9973); gs9973; UNII-6I3O3W6O3B; 6-(1H-Indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine; GS 9973; 6I3O3W6O3B; CHEMBL3265032; C23H21N7O; 6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine; Entospletinib [INN]; Entospletinib [USAN:INN]; 4puz; 6-(1h-Indazol-6-Yl)-N-[4-(Morpholin-4-Yl)phenyl]imidazo[1,2-A]pyrazin-8-Amine; SCHEMBL2483776; GTPL7889; MolPort-035-395-879; HMS3653D13; EX-A1120; BCP09582; AOB87385
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External Link
 Compound Name ALT-803 Phase 2 [205]
Synonyms
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
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External Link
 Compound Name CHR-2797 Phase 2 [206]
Synonyms
Tosedostat; Tosedostat, CHR2797, CHR-2797
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External Link
 Compound Name HTERT RNA vaccine Phase 2 [207]
External Link
 Compound Name MB-102 Phase 2 [31]
Synonyms
Relmapirazin; UNII-Q3UQB8PQ6H; Q3UQB8PQ6H; Relmapirazin [INN]; CHEMBL1949708; SCHEMBL16738795; N,N'-((3,6-Diamino-2,5-pyrazinediyl)dicarbonyl)bis(D-serine); D-Serine, N,N'-((3,6-diamino-2,5-pyrazinediyl)dicarbonyl)bis-; 1313706-17-0
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External Link
 Compound Name phorbol 12-myristate 13-acetate Phase 2 [34]
Synonyms
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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External Link
 Compound Name AEB1102 Phase 1 [34]
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 Compound Name Ifabotuzumab Phase 2 [31]
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 Compound Name BP1001 Phase 2 [55]
External Link
 Compound Name AS-101 Phase 2 [208]
Synonyms
Ossirene; Tellaxium trichloride glycol; IVX-Q-101
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External Link
 Compound Name ALRN-6924 Phase 2 [34]
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 Compound Name GO-203-2c Phase 2 [34]
External Link
 Compound Name Talacotuzumab Phase 2 [31]
Synonyms
JNJ 473; JNJ 56022473; TAL
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External Link
 Compound Name AST-VAC1 Phase 2 [209]
External Link
 Compound Name Lomab B Phase 2 [210]
Synonyms
BCS-I-131 construct
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External Link
 Compound Name Fipamezole Phase 2 [211]
Synonyms
150586-58-6; JP-1730; 1H-Imidazole,5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-; Fipamezole [INN]; ACMC-1BZQD; AC1Q4NYS; SCHEMBL935549; AC1L4U51; SCHEMBL18826053; CHEMBL1255582; CTK4C6705; 5-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-1H-imidazole; KXSUAWAUCNFBQJ-UHFFFAOYSA-N; 5-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole; BDBM50417007; SB17014; 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole; L001472; 4-((2RS)-2-Ethyl-5-fluoroindan-2-yl)-1H-imidazole
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External Link
 Compound Name PR104 Phase 2 [212]
Synonyms
851627-62-8; PR-104; UNII-V16D2ZT7DT; V16D2ZT7DT; 2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate; 2-[(2-bromoethyl)(2,4-dinitro-6-{[2-(phosphonooxy)ethyl]carbamoyl}phenyl)amino]ethyl methanesulfonate; PR 104; SCHEMBL367963; ZINC43131754; AKOS022174966; RL05275; KB-80083; 4CA-1041; AX8282408; J-507569; Benzamide, 2-((2-bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-3,5- dinitro-N-(2-(phosphonooxy)ethyl)-
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External Link
 Compound Name BI-836858 Phase 1/2 [34]
External Link
 Compound Name Ficlatuzumab Phase 2 [34]
Synonyms
AV-299
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External Link
 Compound Name K562/GM-CSF Phase 2 [213]
Synonyms
GM-CSF-secreting cells+tumor cell vaccine, Cell Genesys/Johns Hopkins
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External Link
 Compound Name PCM-075 Phase 2 [34]
Synonyms
Onvansertib
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External Link
 Compound Name Actimab-A Phase 2 [31]
External Link
 Compound Name IMG-7289 Phase 2 [34]
Synonyms
KQKBMHGOHXOHTD-KKUQBAQOSA-N; UNII-Y2T4ALDEAT; Y2T4ALDEAT; SCHEMBL17984236; Benzamide, N-((1S)-4-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-4-(1H-1,2,3-triazol-1-yl)-; 1990504-34-1; N-[(2S)-1-(4-(methyl)piperazin-1-yl)-5-[[(1R,2S)-2-(4-fluorophenyl)-cyclopropyl]amino]-1-oxopentan-2-yl]-4-(1H-1,2,3-triazol-1-yl)benzamide
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External Link
 Compound Name WT1-targeted autologous dendritic cell vaccine Phase 2 [214]
Synonyms
WT1-targeted autologous dendritic cell vaccine (cancer)
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External Link
 Compound Name AZD-4877 Phase 2 [215]
Synonyms
Anticancer therapeutic (solid tumors), AstraZeneca
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External Link
 Compound Name IPH-2102 Phase 2 [216]
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 Compound Name ASP7517 Phase 1/2 [217]
External Link
 Compound Name CG-806 Phase 1/2 [218]
Synonyms
1370466-81-1; UNII-7W3FGR71NN; 7W3FGR71NN; 1-(3-fluoro-4-(7-(4-methyl-1H-imidazol-2-yl)-1-oxoisoindolin-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea; SCHEMBL1292507; EX-A2932; NSC810717; CG'806; NSC-810717; CG-026806; HY-112646; CS-0058852; 1-(3-Fluoro-4-(7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindo-1-4-yl)-phenyl)-3-(3-trifluoromethyl-phenyl)urea; Urea, N-(4-(2,3-dihydro-7-(5-methyl-1H-imidazol-2-yl)-1-oxo-1H-isoindol-4-yl)-3-fluorophenyl)-N'-(3-(trifluoromethyl)phenyl)-
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External Link
 Compound Name KO-539 Phase 1/2 [219]
Synonyms
UNII-4MOD1F4ENC; 4MOD1F4ENC; SCHEMBL20846943; KO539; Menin-mll interaction inhibitor KO 539; (S)-4-Methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile; 2134675-36-6
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External Link
 Compound Name SAR440234 Phase 1/2 [220]
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 Compound Name HM43239 Phase 1/2 [221]
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 Compound Name Annamycin Phase 1/2 [34]
Synonyms
92689-49-1; UNII-SNU299M83Q; 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; SNU299M83Q; (7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-Dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione; AR-522; SCHEMBL19368; (7S,9S)-7-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione; ZINC3918134; DB06420; 5,12-Naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-L-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S-cis)-; 689A491; Q4767903
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External Link
 Compound Name ONO-7475 Phase 1/2 [222]
Synonyms
1646839-59-9; UNII-0VCB95RHRV; N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide; N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide; SCHEMBL16426362; ONO7475; BCP33232; MFCD32689448; s8933; ONO 7475; HY-114358; CS-0083699; 3-Quinolinecarboxamide, N-(5-((6,7-dimethoxy-4-quinolinyl)oxy)-2-pyridinyl)-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-; N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
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External Link
 Compound Name FF-10101 Phase 1/2 [223]
Synonyms
1472797-69-5; UNII-7V7IHI0SYG; 7V7IHI0SYG; (S,E)-N-(1-((5-(2-((4-Cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide; SCHEMBL15584726; SCHEMBL16443760; BDBM397428; BCP23613; s8899; US9987278, Compound Reference 38; HY-109584; CS-0032038; FF 10101; FF10101; (E)-N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-4-(dimethylamino)-N-methylbut-2-enamide; 2-Butenamide, N-((1S)-2-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)-5-pyrimidinyl)-4-pentyn-1-yl)amino)-1-methyl-2-oxoethyl)-4-(dimethylamino)-N-methyl-, (2E)-
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 Compound Name SL-401 Phase 1/2 [224]
External Link
 Compound Name SEL-24 Phase 1/2 [34]
Synonyms
Multikinase inhibitor (cancer), Selvita; SEL-24-1; SEL-24-11; SEL-24-20; Pim-1 kinase inhibitors (cancer), Selvita
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 Compound Name SEL24 Phase 1/2 [225]
Synonyms
MEN1703
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 Compound Name CD38-specific gene-engineered T cells Phase 1/2 [226]
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 Compound Name HuM-195-Ac-225 Phase 1/2 [227]
Synonyms
HuM-195 [225Ac]; SMART 225Ac-M195; Actinium-225-M195; SMART actinium-225-M195; Actinium-225-HuM-195; 225Ac-HuM-195; 225Ac-lintuzumab
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 Compound Name NEXI-001 Phase 1/2 [228]
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 Compound Name INCB59872 Phase 1/2 [34]
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 Compound Name MG7-CART Phase 1/2 [229]
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 Compound Name PRI-724 Phase 1/2 [230]
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 Compound Name CART-123 cells Phase 1/2 [231]
External Link
 Compound Name OXi4503 Phase 1/2 [34]
Synonyms
Combretastatin A-1 phosphate; 288847-34-7; Combretastatin A1 disodium phosphate; 1,2-Benzenediol, 3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, bis(dihydrogen phosphate), tetrasodium salt
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 Compound Name CIK-CAR.CD19 Phase 1/2 [34]
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 Compound Name RhH1.3 Phase 1/2 [232]
Synonyms
Oncohist; Histone H1, SymbioTec; Recombinant human histone H1.3, SymbioTec; RhH1.3, SymbioTec
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 Compound Name JTCR016 Phase 1/2 [31]
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 Compound Name Muc1-specific gene-engineered T cells Phase 1/2 [226]
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 Compound Name Lintuzumab Ac-225 Phase 1/2 [233]
Synonyms
Actimab-A (TN)
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 Compound Name CD33-specific gene-engineered T cells Phase 1/2 [226]
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 Compound Name CD19 specific CAR T cells Phase 1/2 [234]
External Link
 Compound Name EPZ-5676 Phase 1/2 [235]
Synonyms
pinometostat; 1380288-87-8; EPZ5676; UNII-8V9YR09EF3; UNII-F66X4M38G5; 8V9YR09EF3; CHEMBL3087499; CHEMBL3414626; F66X4M38G5; 1380288-88-9; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol; Pinometostat, trans-; 5'-[{cis-3-[2-(5-Tert-Butyl-1h-Benzimidazol-2-Yl)ethyl]cyclobutyl}(Propan-2-Yl)amino]-5'-Deoxyadenosine
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External Link
 Compound Name BSK01 Phase 1/2 [31]
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 Compound Name CNDO-109 Phase 1/2 [55]
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 Compound Name DT388IL-3 Phase 1/2 [236]
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 Compound Name PLX2853 Phase 1/2 [237]
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 Compound Name CWP232291 Phase 1/2 [238]
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 Compound Name BPX-501 Phase 1/2 [34]
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 Compound Name RTX-240 Phase 1/2 [239]
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 Compound Name G0-203-2c Phase 1/2 [240]
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 Compound Name CD123-specific gene-engineered T cells Phase 1/2 [226]
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 Compound Name CD56-specific gene-engineered T cells Phase 1/2 [226]
External Link
 Compound Name OTX-015 Phase 1/2 [241]
Synonyms
MK 8628
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External Link
 Compound Name FF-10501-01 Phase 1/2 [34]
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 Compound Name SGN-CD33A Phase 1/2 [55]
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 Compound Name CLL1-specific gene-engineered T cells Phase 1/2 [226]
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 Compound Name CLT030 Phase 1 [242]
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 Compound Name FT500 Phase 1 [243]
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 Compound Name 225Ac-labelled aCD33 Phase 1 [244]
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 Compound Name PRGN-3006 Phase 1 [245]
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 Compound Name GEM333 Phase 1 [246]
External Link
 Compound Name VOB560 Phase 1 [247]
Synonyms
S 65487
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External Link
 Compound Name SEL120 Phase 1 [248]
Synonyms
SEL120-34A HCl; UNII-SDM3M518PJ; SDM3M518PJ; 1609452-30-3; SEL-120; SEL120-34A (monohydrochloride); SE-120-34A; 1609452-30-3 (HCl); 7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride; CHEMBL4578881; SCHEMBL17106021; s8840; EX-A2929-1; HY-111388A; BS-16042; CS-0041061; A17086; SEL120(SEL120-34,SEL120-34A); 4H-Imidazo(4,5,1-ij)quinoline, 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-, hydrochloride (1:1); 7,8-Dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4himidazo(4,5,1-ij)quinoline hydrochloride
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 Compound Name NKX101 Phase 1 [249]
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 Compound Name AMG 673 Phase 1 [34]
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 Compound Name SAR443579 Phase 1 [250]
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 Compound Name IO-202 Phase 1 [251]
External Link
 Compound Name CYC140 Phase 1 [252]
Synonyms
Telparevir; Telaprevir - VX-950; SCHEMBL6468440; CS-M3592; ZINC164377440; (1S,3aR,6aS)-2-((R)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3S,3aS,6aR)-2-[(2R)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide; Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
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External Link
 Compound Name SKI-G-801 Phase 1 [253]
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 Compound Name CC-90002 Phase 1 [31]
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 Compound Name TAS-1440 Phase 1 [254]
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 Compound Name RG6007 Phase 1 [255]
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 Compound Name CB-5339 Phase 1 [256]
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 Compound Name SAR445419 Phase 1 [257]
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 Compound Name AB-110 Phase 1 [258]
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 Compound Name LP-108 Phase 1 [259]
External Link
 Compound Name H3B-8800 Phase 1 [260]
Synonyms
(2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate; 1825302-42-8; SCHEMBL17255784; DB14017
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External Link
 Compound Name CD123-CD33 Ccar Phase 1 [261]
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 Compound Name JNJ-63709178 Phase 1 [34]
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 Compound Name JNJ-67571244 Phase 1 [262]
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 Compound Name AMG 427 Phase 1 [263]
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 Compound Name AMG 330 Phase 1 [34]
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 Compound Name ABBV-184 Phase 1 [264]
External Link
 Compound Name MIK665 Phase 1 [265]
Synonyms
1799631-75-6; (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid; (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; MIK-665; S-64315; SCHEMBL16815710; EX-A2912; NSC809971; NSC-809971; HY-112218; CS-0044179; (5R)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; 1799831-02-9; OK5
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 Compound Name FT538 Phase 1 [266]
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 Compound Name BGB-11417 Phase 1 [267]
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 Compound Name SEA-CD70 Phase 1 [268]
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 Compound Name CLL1-CD33 cCART cell therapy Phase 1 [269]
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 Compound Name KITE-222 Phase 1 [270]
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 Compound Name CYAD-02 Phase 1 [271]
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 Compound Name GDX012 Phase 1 [272]
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 Compound Name APVO436 Phase 1 [273]
External Link
 Compound Name LAM-003 Phase 1 [34]
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 Compound Name IMGN779 Phase 1 [34]
External Link
 Compound Name BPX-701 Phase 1 [31]
External Link
 Compound Name BMS-936564 Phase 1 [274]
External Link
 Compound Name UCART123 Phase 1 [34]
External Link
 Compound Name FF-10101-01 Phase 1 [34]
External Link
 Compound Name CART-56 cells Phase 1 [275]
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 Compound Name AVB-S6-500 Phase 1 [34]
External Link
 Compound Name BB-MPI-03 Phase 1 [209]
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 Compound Name ONO-7475 Phase 1 [34]
External Link
 Compound Name LC-1 Phase 1 [276]
Synonyms
Dimethylamino-parthenolide; Parthenolide analog (leukemia), Leuchemix
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 Compound Name CART123 cells Phase 1 [277]
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 Compound Name NKR-2 cells Phase 1 [278]
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 Compound Name CART-33 cells Phase 1 [275]
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 Compound Name BI-811283 Phase 1 [279]
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 Compound Name INNO-305 Phase 1 [280]
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 Compound Name IGN523 Phase 1 [281]
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 Compound Name CART-34 cells Phase 1 [275]
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 Compound Name CM-CS1 T-cell Phase 1 [282]
External Link
 Compound Name Mivebresib Phase 1 [34]
Synonyms
ABBV-075; 1445993-26-9; UNII-VR86R11J7J; VR86R11J7J; N-[4-(2,4-Difluorophenoxy)-3-(6-Methyl-7-Oxo-6,7-Dihydro-1h-Pyrrolo[2,3-C]pyridin-4-Yl)phenyl]ethanesulfonamide; N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; 8NG; Mivebresib [INN]; ABBV-075 (Mivebresib); ABBV075; GTPL9117; SCHEMBL15068241; CHEMBL3987016; Mivebresib(ABBV-075 pound(c); MolPort-044-561-801; RDONXGFGWSSFMY-UHFFFAOYSA-N; BDBM220447; EX-A1082; s8400; ZINC146486516; AKOS030628486; CS-5815
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 Compound Name AMV564 Phase 1 [34]
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 Compound Name SAR-103168 Phase 1 [283]
External Link
 Compound Name DS-3201 Phase 1 [34]
Synonyms
QTGYNKYZRZATJB-UHFFFAOYSA-N; 701899-63-0; 2-(2-(2-Methyl-1H-imidazol-5-yl)ethyl)isoindoline-1,3-dione; 2-(2-(2-Methyl-1H-imidazol-5-yl)-ethyl)isoindoline-1,3-dione; SCHEMBL7743461; MolPort-035-945-474; MolPort-035-690-353; ZINC98086069; AKOS024459002; AKOS024262663; MCULE-2708350770; FCH4077443; AK158834; AX8292467; ST2403812; 2-[2-(2-methyl-1H-imidazol-5-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione
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 Compound Name PF-06747143 Phase 1 [31]
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 Compound Name DCLL9718S Phase 1 [34]
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 Compound Name CD123CAR-41BB-CD3zeta-EGFRt-expressing T cells Phase 1 [284]
External Link
 Compound Name CSL-362 Phase 1 [285]
Synonyms
CSL-360; Monoclonal antibody (acute myelogenous leukemia), CSL; Therapeutic leukaemia antibody (AML), CSL; 7G3
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 Compound Name AMG 176 Phase 1 [286]
Synonyms
JQNINBDKGLWYMU-GEAQBIRJSA-N; AMG-176; 1883727-34-1; AMG176; SCHEMBL17550216; EX-A2666; HY-101565; CS-0021721; Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
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 Compound Name XmAb14045 Phase 1 [34]
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 Compound Name SY-1425 Phase 1 [34]
External Link
 Compound Name AGS62P1 Phase 1 [34]
Synonyms
AGS-62P1
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External Link
 Compound Name CART-117 cells Phase 1 [275]
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 Compound Name CART-Muc1 cells Phase 1 [275]
External Link
 Compound Name BAY1436032 Phase 1 [34]
Synonyms
RNMAUIMMNAHKQR-QFBILLFUSA-N; BAY-1436032; 1803274-65-8; BAY 1436032; SCHEMBL17009632; EX-A1606; AKOS032946249; SB19763; HY-100020; CS-0017982; 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
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 Compound Name CD33-CAR-T Cell Phase 1 [287]
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 Compound Name CART-123 cells Phase 1 [275]
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 Compound Name FATE-NK100 Phase 1 [34]
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 Compound Name CC-90009 Phase 1 [34]
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 Compound Name NKR-2 CAR-T Cells Phase 1 [288]
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 Compound Name Anti-CEA CAR-T cells Phase 1 [289]
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 Compound Name RG7775 Phase 1 [290]
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 Compound Name OTSSP167 Phase 1 [34]
Synonyms
OTSSP 167; OTSSP-167; AMX10201
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 Compound Name IMC-EB10 Phase 1 [291]
Synonyms
Anti-Flt-3 Mab
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External Link
 Compound Name TCN-P Phase 1 [292]
Synonyms
TRICIRIBINE PHOSPHATE; 61966-08-3; UNII-5L5GE3DV88; Triciribine phosphate [USAN]; Tricirbine Phosphate; NSC-280594; C13H17N6O7P; NSC 280594; Pentaazaacenaphthylene-5' phosphate ester; 5L5GE3DV88; PHOSPHATE SALT OF TRICYCLIC NUCLEOSIDE; 3-Amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(dihydrogen phosphate); Triciribine phosphate (USAN); VQD-002; TCN-monophosphate; 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-; NSC280594
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 Compound Name CART-38 cells Phase 1 [275]
External Link
 Compound Name ABBV-744 Phase 1 [34]
Synonyms
OEDSFMUSNZDJFD-UHFFFAOYSA-N; 2138861-99-9; N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; ABBV 744; SCHEMBL19463409; EX-A2713; ACN-054460; HY-112090; CS-0043318
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 Compound Name AGS-67E Phase 1 [31]
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 Compound Name PNK-007 Phase 1 [31]
External Link
 Compound Name GSK-2130579A Phase 1 [293]
Synonyms
Leukemia vaccine, GlaxoSmithKline; WT1 ASCI, GlaxoSmithKline; WT1 antigen specific cancer immunotherapeutic, GlaxoSmithKline; WT1 vaccine, GlaxoSmithKline
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 Compound Name SGN-CD123A Phase 1 [34]
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 Compound Name IM23 Phase 1 [294]
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 Compound Name Anti-CD33 Phase 1 [34]
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 Compound Name KW-2449 Phase 1 [295]
Synonyms
Tumor antigen-specific mAb (cancer), Kyowa; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
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 Compound Name CAR-T cells targeting CD56 Clinical trial [296]
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 Compound Name CAR-T cells targeting CD38 Clinical trial [296]
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 Compound Name Valspodar Discontinued in Phase 3 [297]
External Link
 Compound Name LY335979 Discontinued in Phase 3 [298]
Synonyms
Zosuquidar HCl; Zosuquidar Trihydrochloride; LY 335979; LY-335979; Zosuquidar (TN); Zosuquidar trihydrochloride (USAN); RS-33295-198; Zosuquidar trihydrochloride, RS-33295-198, LY335979; (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, trihydrochloride
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 Compound Name Lintuzumab Bi-213 Discontinued in Phase 1/2 [299]
Synonyms
Bismab-A (TN)
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External Link
 Compound Name HuM-195-Bi-213 Discontinued in Phase 1/2 [299]
Synonyms
SMART 213Bi-M195; SMART Y90-M195; Y90-HuM195; Bismuth-213-HuM195; SMART bismuth-213-M195; Yttrium-90-HuM195; Alpha-particle-emitting radioisotope-linked lintuzumab; 213Bi-HuM195
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External Link
 Compound Name CER-227185 Discontinued in Phase 1/2 [300]
Synonyms
TCTP inhibitor (cancer), Cerenis; Translationally controlled tumor protein inhibitor (acute myeloid leukemia), Cerenis
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 Compound Name Autologous Anti-CD 123 CAR TCR/4-1BB-expressing T-lymphocytes Phase 0 [301]
External Link
 Compound Name ATA2321 Preclinical [302]
External Link
 Compound Name 2-D08 Preclinical [303]
Synonyms
144707-18-6; 2',3',4'-trihydroxyflavone; 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one; SCHEMBL1772778; CHEMBL3115475; AOB4275; SYN5001; AMY31051; BCP18314; EX-A3562; MFCD27995567; s8696; ZINC97439024; CCG-267148; AC-31428; AK312791; AS-16368; HY-114166; 2D08;2 D08; CS-0077855; A16852; 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE
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External Link
 Compound Name CAR-T cells targeting CD117 Preclinical [296]
External Link
 Compound Name CAR-T cells targeting CD123 Preclinical [296]
External Link
 Compound Name CAR-T cells targeting Mucl Preclinical [296]
External Link
 Compound Name CAR-T cells targeting CD33 Preclinical [296]
External Link
 Compound Name CAR-T cells targeting CD34 Preclinical [296]
External Link
 Compound Name CAR-T cells targeting CD133 Preclinical [296]
External Link
 Compound Name CEP-4186 Terminated [304]
Synonyms
CB-1093; CEP-3265; GS-1590; Neurotrophic compounds, Cephalon/LEO Pharma; Neurotrophic factors, Cephalon/LEO Pharma
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External Link
 Compound Name BI 7273 Investigative [305]
Synonyms
BI-7273; 1883429-21-7; CHEMBL3823478; 4-(4-((Dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; 4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one; 4-{4-[(dimethylamino)methyl]-2,6-dimethoxyphenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one; 5SW; BI7273; GTPL9146; SCHEMBL19869878; EX-A990; BCP17545; BDBM50183448; MFCD30489736; s8179; ZINC575448880; CCG-268068; CS-5887; HY-100351; J3.533.936A; A16068; Q27075221
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 Compound Name G3139 + cytarabine (ARA-C) Investigative [306]
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 Compound Name G3139 + Fludarabine Investigative [306]
External Link
 Compound Name CG-1255 Investigative [307]
Synonyms
CG-1552; Histone deacetylase inhibitors, CircaGen
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 Compound Name AC-501 Investigative [307]
External Link
 Compound Name AKN-028 Investigative [308]
Synonyms
Flt3 tyrosine kinase inhibitor (AML), Akinion/Swedish Orphan Biovitrum/Karolinska
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 Compound Name VLIM-88 Investigative [307]
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 Compound Name G3139 + G-CSF Investigative [306]
External Link
 Compound Name Anti-CD44 mab Investigative [307]
Synonyms
Hyaloxan; MAT-102; AML therapy (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia therapy (chimerized monoclonal antibody), MAT Biopharma; Anti-CD44 mAb (AML); Anti-CD44 mAb (AML), MAT Biopharma; Anti-CD44 monoclonal antibody (acute myeloid leukemia), MAT Biopharma
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External Link
 Compound Name SB-559457 Investigative [309]
External Link
 Compound Name COTI-001 Investigative [307]
Synonyms
COTI-002; COTI-003E; Protein tyrosine kinase inhibitors (AML); Protein tyrosine kinase inhibitors (AML), Critical Outcome Technologies
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External Link
 Compound Name Rebelex Investigative [307]
Synonyms
Spleen tyrosine kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals; Syk kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals
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External Link
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Ref 202 ClinicalTrials.gov (NCT00087165) GTI-2040, Docetaxel, and Prednisone in Treating Patients With Prostate Cancer. U.S. National Institutes of Health.
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Ref 205 ClinicalTrials.gov (NCT03050216) QUILT-3.033: Haplo NK With SQ ALT-803 for Adults With Relapsed or Refractory AML. U.S. National Institutes of Health.
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Ref 207 Clinical pipeline report, company report or official report of Asterias.
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Ref 209 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 210 Iomab-B for Hematopoetic Stem Cells Transplantation. Pipeline report of Actinium Pharmaecuticals. 2012.
Ref 211 ClinicalTrials.gov (NCT00559871) Safety and Efficacy Study of Fipamezole in Treatment of Motor Dysfunctions in Parkinson's Disease. U.S. National Institutes of Health.
Ref 212 ClinicalTrials.gov (NCT00544674) PR104 in Treating Patients With Previously Untreated or Relapsed Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 213 ClinicalTrials.gov (NCT00363649) Interferon and GM-CSF Compared With Imatinib Mesylate and Vaccine Therapy in Patients With Chronic Phase CML on a TKI. U.S. National Institutes of Health.
Ref 214 ClinicalTrials.gov (NCT01686334) Efficacy Study of Dendritic Cell Vaccination in Patients With Acute Myeloid Leukemia in Remission. U.S. National Institutes of Health.
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Ref 216 ClinicalTrials.gov (NCT01687387) Efficacy Study of Anti-KIR Monoclonal Antibody as Maintenance Treatment in Acute Myeloid Leukemia (EFFIKIR). U.S. National Institutes of Health.
Ref 217 ClinicalTrials.gov (NCT04079296) A Study Investigating the Safety, Tolerability and Efficacy of ASP7517 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML) and Relapsed/Refractory Higher Risk Myelodysplastic Syndrome (MDS). U.S. National Institutes of Health.
Ref 218 ClinicalTrials.gov (NCT04477291) A Study of CG-806 in Patients With Relapsed or Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 219 ClinicalTrials.gov (NCT04067336) First in Human Study of KO-539 in Relapsed or Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 220 ClinicalTrials.gov (NCT03594955) First in Human Testing of Dose-escalation of SAR440234 in Patients With Acute Myeloid Leukemia, Acute Lymphoid Leukemia and Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 221 ClinicalTrials.gov (NCT03850574) Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM43239 in Patients With Relapsed or Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 222 ClinicalTrials.gov (NCT03176277) A Study of ONO-7475 in Patients With Acute Leukemias. U.S. National Institutes of Health.
Ref 223 ClinicalTrials.gov (NCT03194685) Study of FF-10101-01 in Patients With Relapsed or Refractory Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 224 ClinicalTrials.gov (NCT02113982) SL-401 in Patients With Blastic Plasmacytoid Dendritic Cell Neoplasm or Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 225 ClinicalTrials.gov (NCT03008187) SEL24/MEN1703 in Patients With Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 226 ClinicalTrials.gov (NCT03222674) Multi-CAR T Cell Therapy for Acute Myeloid Leukemia
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Ref 229 ClinicalTrials.gov (NCT02862704) A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART)
Ref 230 ClinicalTrials.gov (NCT01606579) Safety and Efficacy Study of PRI-724 in Subjects With Advanced Myeloid Malignancies. U.S. National Institutes of Health.
Ref 231 ClinicalTrials.gov (NCT03556982) CART-123 FOR Relapsed/Refractory Acute Myelocytic LeukemiaAML
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Ref 233 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017917)
Ref 234 ClinicalTrials.gov (NCT02028455) A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia
Ref 235 ClinicalTrials.gov (NCT03701295) Pinometostat and Azacitidine in Treating Patients With Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia With 11q23 Rearrangement. U.S. National Institutes of Health.
Ref 236 ClinicalTrials.gov (NCT00397579) DT388IL3 Fusion Protein in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndromes. U.S. National Institutes of Health.
Ref 237 ClinicalTrials.gov (NCT04493619) PLX2853 as a Single Agent in Advanced Gynecological Malignancies and in Combination With Carboplatin in Platinum-Resistant Epithelial Ovarian Cancer. U.S. National Institutes of Health.
Ref 238 ClinicalTrials.gov (NCT03055286) Clinical Study of CWP232291 in Acute Myeloid Leukemia Patients. U.S. National Institutes of Health.
Ref 239 ClinicalTrials.gov (NCT04372706) RTX-240 Monotherapy. U.S. National Institutes of Health.
Ref 240 Clinical pipeline report, company report or official report of Genus 0ncology.
Ref 241 ClinicalTrials.gov (NCT02303782) A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in Patients With Newly-diagnosed Acute Myeloid Leukemia (AML) Not Candidate for Standard Intensive Induction Therapy (SIIT). U.S. National Institutes of Health.
Ref 242 CLT030, a leukemic stem cell-targeting CLL1 antibody-drug conjugate for treatment of acute myeloid leukemia. Blood Adv. 2018 Jul 24;2(14):1738-1749.
Ref 243 ClinicalTrials.gov (NCT03841110) FT500 as Monotherapy and in Combination With Immune Checkpoint Inhibitors in Subjects With Advanced Solid Tumors. U.S. National Institutes of Health.
Ref 244 ClinicalTrials.gov (NCT03705858) Actinium-225-Lintuzumab in Patients With Acute Myeloid Leukemia. U.S. National Institutes of Health.
Ref 245 ClinicalTrials.gov (NCT03927261) A Phase 1/1b Safety Study of PRGN-3006 Adoptive Cellular Therapy in Patients With CD33-Positive Relapsed or Refractory Acute Myeloid Leukemia, Minimal Residual Disease Positive Acute Myeloid Leukemia, and Higher Risk Myelodysplastic Syndrome. U.S.National Institutes of Health.
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Ref 247 ClinicalTrials.gov (NCT04702425) VOB560-MIK665 Combination First in Human Trial in Patients With Hematological Malignancies (Relapsed/Refractory Non-Hodgkin Lymphoma, Relapsed/Refractory Acute Myeloid Leukemia, or Relapsed/Refractory Multiple Myeloma). U.S. National Institutes of Health.
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Ref 249 ClinicalTrials.gov (NCT04623944) NKX101, Intravenous Allogeneic Engineered Natural Killer Cells, in Adults With AML or MDS. U.S. National Institutes of Health.
Ref 250 ClinicalTrials.gov (NCT05086315) An Open-label, First-in-human, Dose-escalation/Expansion Study of SAR443579 Administered as Single Agent by Intravenous Infusion in Adult and Pediatric Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML), B-cell Acute Lymphoblastic Leukemia (B-ALL), High Risk-myelodysplasia (HR-MDS), or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN). U.S.National Institutes of Health.
Ref 251 ClinicalTrials.gov (NCT04372433) IO-202 as Monotherapy in Patients in AML and CMML. U.S. National Institutes of Health.
Ref 252 ClinicalTrials.gov (NCT03884829) A Phase I Study of CYC140, a PLK-1 Inhibitor, in Advanced Leukemias or MDS. U.S. National Institutes of Health.
Ref 253 ClinicalTrials.gov (NCT03564288) Study to Find a Safe and Effective Dose of SKI-G-801 in the Treatment of Patients With Acute Myeloid Leukemia (AML). U.S. National Institutes of Health.
Ref 254 ClinicalTrials.gov (NCT04282668) A Study of TAS1440 With ATRA in Subjects With r/r AML. U.S. National Institutes of Health.
Ref 255 Clinical pipeline report, company report or official report of Roche
Ref 256 ClinicalTrials.gov (NCT04402541) Study of CB-5339 in Acute Myeloid Leukemia or Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 257 ClinicalTrials.gov (NCT05712278) A Phase I, Single-arm, Open Label, Dose Escalation, Multicenter Study of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML). U.S.National Institutes of Health.
Ref 258 ClinicalTrials.gov (NCT03483324) Trial of AB-110 in Adults With Hematologic Malignancies Undergoing Cord Blood Transplantation. U.S. National Institutes of Health.
Ref 259 ClinicalTrials.gov (NCT04139434) Dose-escalation Study of Oral Administration of LP-108 in Patients With Relapsed or Refractory Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML). U.S. National Institutes of Health.
Ref 260 ClinicalTrials.gov (NCT02841540) A Study of H3B-8800 in Participants With Myelodysplastic Syndromes, Acute Myeloid Leukemia, and Chronic Myelomonocytic Leukemia. U.S. National Institutes of Health.
Ref 261 ClinicalTrials.gov (NCT04156256) CD123-CD33 cCAR in Patients With Relapsed and/or Refractory, High Risk Hematologic Malignancies. U.S. National Institutes of Health.
Ref 262 ClinicalTrials.gov (NCT03915379) A Study of JNJ-67571244 in Participants With Relapsed or Refractory Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS). U.S. National Institutes of Health.
Ref 263 ClinicalTrials.gov (NCT03541369) Safety, Tolerability, PK, PD, and Efficacy of AMG 427 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (20170528). U.S. National Institutes of Health.
Ref 264 ClinicalTrials.gov (NCT04272203) A Study to Determine Safety, Tolerability, Pharmacokinetics, and Recommended Phase 2 Dose (RP2D) of Intravenous ABBV-184 in Adult Participants With Previously Treated Cancers. U.S. National Institutes of Health.
Ref 265 ClinicalTrials.gov (NCT02979366) Phase I Study of S64315 Administred Intravenously in Patients With Acute Myeloid Leukaemia or Myelodysplastic Syndrome. U.S. National Institutes of Health.
Ref 266 ClinicalTrials.gov (NCT04614636) FT538 in Subjects With Advanced Hematologic Malignancies. U.S. National Institutes of Health.
Ref 267 ClinicalTrials.gov (NCT04771130) A Study of BGB-11417 in Participants With Myeloid Malignancies. U.S. National Institutes of Health.
Ref 268 ClinicalTrials.gov (NCT04227847) A Safety Study of SEA-CD70 in Patients With Myeloid Malignancies. U.S. National Institutes of Health.
Ref 269 Clinical pipeline report, company report or official report of iCell Gene Therapeutics.
Ref 270 ClinicalTrials.gov (NCT04789408) A Phase 1 Open-label, Multicenter Study Evaluating the Safety of KITE-222, an Autologous Anti-CLL-1 CAR T-cell Therapy, in Subjects With Relapsed/Refractory Acute Myeloid Leukemia. U.S.National Institutes of Health.
Ref 271 ClinicalTrials.gov (NCT04167696) Study in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Patients to Determine the Recommended Dose of CYAD-02 (CYCLE-1). U.S. National Institutes of Health.
Ref 272 ClinicalTrials.gov (NCT05001451) A Phase 1, Open Label, Dose Escalation, and Dose Expansion Study to Assess the Safety, Tolerability, and Preliminary Antileukemic Activity of GDX012 in Patients With Minimal Residual Disease (MRD) Positive Acute Myeloid Leukemia. U.S.National Institutes of Health.
Ref 273 ClinicalTrials.gov (NCT03647800) Study of APVO436 in Patients With AML or MDS. U.S. National Institutes of Health.
Ref 274 ClinicalTrials.gov (NCT02305563) Phase 1 Study of BMS-936564. U.S. National Institutes of Health.
Ref 275 ClinicalTrials.gov (NCT03291444) CAR-T Cells Combined With Peptide Specific Dendritic Cell in Relapsed/Refractory Leukemia/MDS
Ref 276 A water soluble parthenolide analogue suppresses in vivo tumor growth of two tobacco associated cancers, lung and bladder cancer, by targeting NF- B and generating reactive oxygen species. Int J Cancer. 2011 May 15; 128(10): 2481-2494.
Ref 277 ClinicalTrials.gov (NCT03766126) Lentivirally Redirected CD123 Autologous T Cells in AML
Ref 278 ClinicalTrials.gov (NCT03310008) Dose Escalation and Dose Expansion Phase I Study to Assess the Safety and Clinical Activity of Multiple Doses of NKR-2 Administered Concurrently With FOLFOX in Colorectal Cancer With Potentially Resectable Liver Metastases
Ref 279 ClinicalTrials.gov (NCT00701324) BI 811283 in Various Solid Tumours. U.S. National Institutes of Health.
Ref 280 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023753)
Ref 281 ClinicalTrials.gov (NCT02040506) A Phase I Study of IGN523 in Subjects With Relapsed or Refractory AML. U.S. National Institutes of Health.
Ref 282 ClinicalTrials.gov (NCT02203825) Safety Study of Chimeric Antigen Receptor Modified T-cells Targeting NKG2D-Ligands
Ref 283 ClinicalTrials.gov (NCT00981240) Dose Escalation, Safety and Pharmacokinetic Study of SAR103168 in Patients Refractory/ Relapsed Acute Leukemias or High-risk Myelodysplastic Syndromes. U.S. National Institutes of Health.
Ref 284 ClinicalTrials.gov (NCT03114670) Donor-derived Anti-CD123-CART Cells for Recurred AML After Allo-HSCT
Ref 285 ClinicalTrials.gov (NCT01632852) A Study of CSL362 in Patients With CD123+ Acute Myeloid Leukemia Currently in Remission. U.S. National Institutes of Health.
Ref 286 ClinicalTrials.gov (NCT03797261) A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic Malignancies. U.S. National Institutes of Health.
Ref 287 ClinicalTrials.gov (NCT03126864) Study of Adoptive Cellular Therapy Using Autologous T Cells Transduced With Lentivirus to Express a CD33 Specific Chimeric Antigen Receptor in Patients With Relapsed or Refractory CD33-Positive Acute Myeloid Leukemia
Ref 288 ClinicalTrials.gov (NCT03612739) EPITHINK: Epigenetic Drug Treatment and Therapeutic Immunotherapy With NKR-2
Ref 289 ClinicalTrials.gov (NCT02416466) CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases
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Ref 291 ClinicalTrials.gov (NCT00887926) Study of EB10 in Patients With Leukemia. U.S. National Institutes of Health.
Ref 292 ClinicalTrials.gov (NCT00363454) Phase I Study of Triciribine Phosphate Monohydrate (TCN-PM, VD-0002) in Adult Subjects With Metastatic Cancer. U.S. National Institutes of Health.
Ref 293 ClinicalTrials.gov (NCT01051063) Evaluation of a New Anti-cancer Immunotherapy in Adult Acute Myeloid Leukemia Patients With a Suboptimal Clinical Response to Induction Chemotherapy. U.S. National Institutes of Health.
Ref 294 ClinicalTrials.gov (NCT03585517) Safety and Efficacy Evaluation of IM23 CAR-T Cells (IM23CAR-T)
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Ref 296 ClinicalTrials.gov (NCT03473457) CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia
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Ref 300 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026293)
Ref 301 ClinicalTrials.gov (NCT02623582) CD123 Redirected Autologous T Cells for AML
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Ref 303 2-D08 as a SUMOylation inhibitor induced ROS accumulation mediates apoptosis of acute myeloid leukemia cells possibly through the deSUMOylation of NOX2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):1063-1069.
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