m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03071
 [1]
Histone modification H3K4me3 MLL1 METTL3 Direct Enhancement m6A modification MIR503 MIR503 METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target miR-503
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone-lysine N-methyltransferase 2A (KMT2A) WRITER View Details
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3) View Details
Downstream Gene METTL3 View Details
Crosstalk Relationship Histone modification  →  m6A Enhancement
Crosstalk Mechanism histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary KMT2A induced rapid Histone H3 lysine 4 trimethylation (H3K4me3) of the promoter of the methyltransferase-like 3 gene (METTL3) and resulted in its overexpression. METTL3 overexpression evokes N6-methyladenosine (m6A)-dependent miR-503 biogenesis in endothelial cells.
Responsed Disease Myocardial injury ICD-11: NB31.Z
 Disease Info 
Responsed Drug C646
 Drug Info 
Cell Process Mitochondrial metabolic dysfunction
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
NB31: Injury of heart 6 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name MyoCell Phase 2/3 [2]
Synonyms
MyoCell (TN)
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External Link
TTD: D0O7CO
 Compound Name Diannexin Phase 2 [3]
External Link
TTD: D07FQL
 Compound Name CMX-2043 Phase 2 [4]
External Link
CID: 49802864
TTD: D01TBJ
DrugBank: DB12795
 Compound Name ED1 Investigative [5]
Synonyms
ethylenediamine scaffold, 10; BDBM31426; 3-{2'-[{[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl}(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)sulfamoyl]biphenyl-3-yl}propanoic acid
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External Link
CID: 25181318
TTD: D0G1SN
 Compound Name ED45 Investigative [5]
External Link
TTD: D01NJE
 Compound Name DD7 Investigative [5]
External Link
TTD: D00QBV
References
Ref 1 Extracellular vesicle-packaged mitochondrial disturbing miRNA exacerbates cardiac injury during acute myocardial infarction. Clin Transl Med. 2022 Apr;12(4):e779. doi: 10.1002/ctm2.779.
Ref 2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 3 ClinicalTrials.gov (NCT00615966) Phase 2 Study of the Safety of Diannexin in Kidney Transplant Recipients. U.S. National Institutes of Health.
Ref 4 ClinicalTrials.gov (NCT02103959) Safety and Efficacy of CMX-2043 for Protection of the Heart and Kidneys in Subjects Undergoing Coronary Angiography. U.S. National Institutes of Health.
Ref 5 Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60.