m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT03022
 [1]
Histone modification H3K4me3 MLL3 ALKBH5 Direct Inhibition m6A modification AXL AXL ALKBH5 Demethylation : m6A sites
m6A Modification:
m6A Regulator RNA demethylase ALKBH5 (ALKBH5) ERASER
 Regulator Info 
m6A Target Tyrosine-protein kinase receptor UFO (AXL)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type Histone modification (HistMod)
Epigenetic Regulator Histone-lysine N-methyltransferase 2C (KMT2C) WRITER View Details
Regulated Target Histone H3 lysine 4 trimethylation (H3K4me3) View Details
Downstream Gene ALKBH5 View Details
Crosstalk Relationship Histone modification  →  m6A Inhibition
Crosstalk Mechanism histone modification directly impacts m6A modification through modulating the level of m6A regulator
Crosstalk Summary KMT2C regulates ALKBH5 expression via decreasing chromatin accessibility of ALKBH5 locus, by increasing Histone H3 lysine 4 trimethylation (H3K4me3) levels and inhibiting recruitment of MYB and Pol II. Moreover, ALKBH5 affects mRNA stability of receptor tyrosine kinase Tyrosine-protein kinase receptor UFO (AXL) in an m6A-dependent way.
Responsed Disease Acute myeloid leukaemia ICD-11: 2A60
 Disease Info 
Pathway Response PI3K-Akt signaling pathway hsa04151
Cell Process mRNA stability
In-vitro Model
 MOLM-13 Adult acute myeloid leukemia Homo sapiens CVCL_2119
THP-1 Childhood acute monocytic leukemia Homo sapiens CVCL_0006
MV4-11 Childhood acute monocytic leukemia Homo sapiens CVCL_0064
In-vivo Model C57BL/6J (CD45.2) background Alkbh5fl/fl and Mx1-cre mice were obtained from Biocytogen and the Jackson Laboratory, respectively. B6.SJL (CD45.1) and NOD.Cg-PrkdcscidIL2rgnull (B-NSG) mice were purchased from the Jackson Laboratory and Biocytogen, respectively. All transgenic and knockout mice were CD45.2+. Both male and female mice at 8-10 weeks old were used for experiments, with age- and gender-matched littermates as control. Congenic recipient mice (CD45.2) at 8-10 weeks old were used for AML transplantation, and CD45.1 recipients at 8-10 weeks old were used for normal hematopoietic transplantation assays.
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Tyrosine-protein kinase receptor UFO (AXL) 22 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Gilteritinib Approved [2]
Synonyms
UNII-66D92MGC8M; 66D92MGC8M; Gilteritinib [USAN:INN]; Gilteritinib(ASP2215); Gilteritinib (USAN/INN); Gilteritinib (ASP2215); Gilteritinib (ASP-2215); SCHEMBL282229; GTPL8708; MolPort-038-934-933; BDBM144315; C29H44N8O3; 3694AH; s7754; AKOS030234455; ZINC113476229; DB12141; CS-3885; KS-0000064E; AS-35199
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MOA Inhibitor
Activity IC50 < 1 nM
External Link
CID: 49803313
TTD: D04KZY
DrugBank: DB12141
 Compound Name Bemcentinib Phase 2 [3]
Synonyms
R428; 1037624-75-1; BGB324; R-428; BGB-324; UNII-0ICW2LX8AS; (S)-1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl)-1H-1,2,4-triazole-3,5-diamine; CHEMBL3809489; SYN1131; CS-1046; HY-15150; QC-11751; R 428; W-5845; Bemcentinib [USAN]; R428 (BGB324); Bemcentinib (USAN/INN); BemcentinibR428BGB324); SCHEMBL1639904; GTPL10478; BGB 324; DTXSID70673109; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine; AMY16774; BCP21180; C30H34N8; EX-A1720; SYN-1131; BDBM50172079; NSC824183; s2841; WHO 10631; ZINC51951669; AKOS032947237; ACN-037541; DB12411; NSC-824183; SB16614; NCGC00386665-07; 1-(6,7-Dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N~3~-[(7S)-7-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-yl]-1H-1,2,4-triazole-3,5-diamine; 1H-1,2,4-Triazole-3,5-diamine, 1-(6,7-dihydro-5H-benzo(6,7)cyclohepta(1,2-C)pyridazin-3-yl)-N3-((7S)-6,7,8,9-tetrahydro-7-(1-pyrrolidinyl)-5H-benzocyclohepten-2-yl)-; AC-28444; AS-16270; KB-80319; D11438; Q27236818; 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(S)-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 46215462
TTD: D0U8XE
DrugBank: DB12411
 Compound Name BGB-324 Phase 1/2 [4]
Synonyms
BGB-001; SiRNA therapeutic (metastasis cancer), BiobergenBio
    Click to Show/Hide
External Link
TTD: D0X9VR
 Compound Name Mecbotamab vedotin Phase 2 [5]
Synonyms
HTBA3011; HTBA3012
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: DYI4L2
 Compound Name MGCD265 Phase 2 [6]
Synonyms
MGCD-265; 875337-44-3; MGCD-265 analog; MGCD 265; N-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide; UNII-93M6577H9D; CHEMBL254760; 93M6577H9D; n-(3-fluoro-4-(2-(1-methyl-1h-imidazol-4-yl)thieno(3,2-b)pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide; N-[(3-Fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yl]oxy}phenyl)carbamothioyl]-2-phenylacetamide
    Click to Show/Hide
MOA Modulator
External Link
CID: 24901704
TTD: D08FDX
 Compound Name BI-505 Phase 2 [7]
MOA Inhibitor
External Link
TTD: D0Q7OE
 Compound Name TP-0903 Phase 1/2 [2]
Synonyms
YUAALFPUEOYPNX-UHFFFAOYSA-N; 1341200-45-0; TP0903; UNII-14D65TV20J; CHEMBL2022968; compound 13; 14D65TV20J; TP 0903; 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide; GTPL8863; SCHEMBL12813478; EX-A609; MolPort-039-193-844; ZINC84617535; BDBM50382425; AKOS026750306; CS-4281; DA-45909; HY-12963; S7846; FT-0700169; B5940; J-690134; 2-{[5-chloro-2-({4-[(4-methylpiperazin-1-yl)methyl]phenyl}amino)pyrimidin-4-yl]amino}-N,N-dimethylbenzene-1-sulfonamide
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MOA Inhibitor
Activity EC50 = 222 nM
External Link
CID: 56839178
TTD: D00LGR
DrugBank: DB15187
 Compound Name Enapotamab vedotin Phase 1/2 [8]
MOA Inhibitor
External Link
TTD: DI0ZA3
 Compound Name ONO-7475 Phase 1/2 [9]
Synonyms
1646839-59-9; UNII-0VCB95RHRV; N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide; N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide; SCHEMBL16426362; ONO7475; BCP33232; MFCD32689448; s8933; ONO 7475; HY-114358; CS-0083699; 3-Quinolinecarboxamide, N-(5-((6,7-dimethoxy-4-quinolinyl)oxy)-2-pyridinyl)-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-; N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
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MOA Inhibitor
External Link
CID: 90645873
TTD: DA1MG8
 Compound Name DS-1205 Phase 1 [2]
MOA Inhibitor
External Link
TTD: D06THG
 Compound Name AVB-S6-500 Phase 1 [2]
MOA Inhibitor
External Link
TTD: D0Y5QA
 Compound Name A416 Phase 1 [10]
MOA Inhibitor
External Link
TTD: DMLY68
 Compound Name ONO-7475 Phase 1 [2]
MOA Inhibitor
External Link
TTD: D0VH4T
 Compound Name BPI-9016 M Phase 1 [11]
MOA Inhibitor
External Link
TTD: D95YSW
 Compound Name PF-07265807 Phase 1 [12]
Synonyms
PF-5807; ARRY-067
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: DP4KH3
 Compound Name INCB81776 Phase 1 [13]
Synonyms
INCB081776
    Click to Show/Hide
MOA Inhibitor
External Link
TTD: DQX83Z
 Compound Name RXDX-106 Phase 1 [14]
Synonyms
CEP-40783; 1437321-24-8; CEP40783; UNII-1969ZJE05Q; 1969ZJE05Q; N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide; N-[4-(6,7-dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide; RXDX-106 (CEP-40783); SCHEMBL16089863; BCP25839; EX-A2540; MFCD28502441; NSC797770; s8570; AKOS032960472; ZINC205893112; CCG-270157; CS-6371; NSC-797770; SB18930; AC-31425; AS-35141; HY-100946; N-(4-((6,7-Dimethoxy-4-quinolinyl)oxy)-3-fluorophenyl)-3-(4-fluorophenyl)-1,2,3,4-tetrahydro-1-(1-methylethyl)-2,4-dioxo-5-pyrimidinecarboxamide
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MOA Inhibitor
External Link
CID: 71576419
TTD: D7HZ3T
 Compound Name Cu-anti-hAXL Preclinical [15]
External Link
TTD: D4JS3A
 Compound Name DP-3975 Preclinical [16]
MOA Inhibitor
External Link
TTD: D4K2CQ
 Compound Name YW327.6S2 Preclinical [16]
External Link
TTD: D50NHR
 Compound Name GL21.T Preclinical [16]
External Link
TTD: DU9RB1
 Compound Name LDC1267 Investigative [17]
Synonyms
1361030-48-9; LDC-1267; CHEMBL3808844; SCHEMBL167963; GTPL8247; MolPort-035-944-330; EX-A2265; AOB87188; BCP14023; BDBM50172075; s7638; ZINC113241878; AKOS026750422; CS-3603; SB19391; NCGC00386431-02; HY-12494; N-(4-((6,7-dimethoxyquinolin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
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MOA Inhibitor
Activity IC50 = 19 nM
External Link
CID: 56847486
TTD: D09TFN
2A60: Acute myeloid leukaemia 283 Compound(s) Regulating the Disease Click to Show/Hide the Full List
 Compound Name Atezolizumab Approved [2]
External Link
TTD: D0YM2K
 Compound Name ENASIDENIB MESYLATE Approved [18]
Synonyms
UNII-UF6PC17XAV; AG-221 mesylate; Enasidenib (mesylate); UF6PC17XAV; Enasidenib mesylate [USAN]; Enasidenib mesylate (USAN); Enasidenib mesilate; Enasidenib methanesulfonate; Idhifa (TN); SCHEMBL16448052; HY-18690A; CS-7541
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External Link
CID: 90480031
TTD: D0WH4P
 Compound Name Lestaurtinib Approved (orphan drug) [19]
Synonyms
A 1544750; CEP 701; KT 5555; KT5555; SP 924; CEP-701; KT-5555; SPM-924; Lestaurtinib (USAN/INN)
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External Link
CID: 126565
TTD: D0V9WF
DrugBank: DB06469
 Compound Name Motixafortide Approved [20]
External Link
CID: 91865076
TTD: D0T6CN
DrugBank: DB14939
 Compound Name ARN-509 Approved [21]
Synonyms
Arn-509 (AR inhibitor)
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External Link
CID: 24872560
TTD: D0S7LG
DrugBank: DB11901
 Compound Name DEOXYCYTIDINE Approved [22]
Synonyms
Cytosine deoxyribonucleoside; 2'-dC; bmse000323; ACMC-209rv6; CYTIDINE, 2'-DEOXY-; Cytosine deoxy nucleoside hydrochloride; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one; Desoxycytidine; 4-amino-1-(2-deoxypentofuranosyl)pyrimidin-2(1H)-one; 4-amino-1-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one; 3h-deoxycytidine; 4-amino-1-(4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one; 40093-94-5; AC1L19OG; TimTec1_003892; NCIOpen2_004589; Oprea1_817993
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External Link
CID: 13711
TTD: D0RX7Z
DrugBank: DB02594
 Compound Name Bestatin Approved [23]
Synonyms
Bestatin (TN); CHEBI:3070; UPCMLD-DP116; CHEMBL476869; SureCN25971; Ubenimex (JP16/INN); Ubenimex (JP17/INN); SCHEMBL25971; GTPL5151; AC1L972Z; UPCMLD-DP116:001; DTXSID4048430; CHEBI:140702; ZINC1532730; ZINC01532730; BDBM50010142; AKOS026750073; NCGC00161660-01; C00732; D00087; ((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-D-leucine; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid; (2R)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenyl-butanoyl]amino]-4-methyl-pentanoic acid
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External Link
CID: 72172
TTD: D0RA5Q
DrugBank: DB03424
 Compound Name Tagraxofusp Approved [21]
Synonyms
Tagraxofusp [INN]; Molecule 129; Tagraxofusp [USAN]; UNII-8ZHS5657EH; 8ZHS5657EH; Diphtheria toxin-il-3 fusion protein targeting IL-3 receptor
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External Link
TTD: D0R7NI
 Compound Name Uracil mustard Approved [24]
Synonyms
Chlorethaminacil; Demethyldopan; Desmethyldopan; Nordopan; Uracillost; Uracilmostaza; Uramustin; Uramustina; Uramustine; Uramustinum; Aminouracil mustard; Uracil lost; Uracil lost [German]; Uracil mustard [USAN]; Uracil nitrogen mustard; ENT 50439; U 8344; CB-4835; SK-19849; U-8344; Uracil mustard (TN); Uracil mustard (USAN); Uramustina [INN-Spanish]; Uramustine (INN); Uramustinum [INN-Latin]; URACIL MUSTARD (500 MG) (FOR U.S. SALE ONLY); 2,6-Dihydroxy-5-bis(2-chloroethyl)aminopyrimidine; 2,6-Dihydroxy-5-bis[2-chloroethyl]aminopyrimidine; 5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)-2,4-(1H,3H)pyrimidinedione; 5-(Bis(2-chloroethyl)amino)uracil; 5-(Di-(beta-chloroethyl)amino)uracil; 5-(Di-2-chloroethyl)aminouracil; 5-Aminouracil mustard; 5-N,N-Bis(2-chloroethyl)aminouracil; 5-[Bis(2-chlorethyl)amino]-2,4(1H,3H)pyrimidinedione; 5-[Bis(2-chloroethyl)amino]uracil; 5-[Di(2-chloroethyl)amino]uracil; 5-[Di(beta-chloroethyl)amino]uracil; 5-[Di(beta.-chloroethyl)amino]uracil; 5-[bis(2-chloroethyl)amino]-1H-pyrimidine-2,4-dione; 5-[bis(2-chloroethyl)amino]-2,4(1H,3H)-pyrimidinedione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4(1H,3H)-dione; 5-[bis(2-chloroethyl)amino]pyrimidine-2,4-diol
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External Link
CID: 6194
TTD: D0J9UN
DrugBank: DB00791
 Compound Name Tisagenlecleucel Application submitted [25]
Synonyms
Tisagenlecleucel-T
    Click to Show/Hide
External Link
TTD: D0IM6T
 Compound Name Olutasidenib Approved [2]
Synonyms
NEQYWYXGTJDAKR-JTQLQIEISA-N; Olutasidenib; UNII-0T4IMT8S5Z; 0T4IMT8S5Z; (S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; Olutasidenib [USAN]; SCHEMBL17603134; HY-114226; CS-0080183; 5-(((1S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile; 2-Pyridinecarbonitrile, 5-(((1S)-1-(6-chloro-1,2-dihydro-2-oxo-3-quinolinyl)ethyl)amino)-1,6-dihydro-1-methyl-6-oxo-; 1887014-12-1
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External Link
CID: 118955396
TTD: D07VYP
 Compound Name Midostaurin Approved [26]
Synonyms
PKC412; 120685-11-2; Cgp 41251; 4'-N-Benzoylstaurosporine; CGP-41251; Benzoylstaurosporine; PKC-412; RYDAPT; PKC 412; UNII-ID912S5VON; N-Benzoylstaurosporine; ID912S5VON; CHEMBL608533; CHEBI:63452; Cgp 41 251; N-[(5S,6R,7R,9R)-6-methoxy-5-methyl-14-oxo-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzo[b,h]cyclonona[1,2,3,4-jkl]cyclopenta[e]-as-indacen-7-yl]-N-methylbenzamide; PKC-412(Midostaurin); Midostaurin (PKC412); Midostaurin (USAN/INN); Midostaurin [USAN:INN]; CGP 41231; Rydapt (TN); CPG 41251
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External Link
CID: 9829523
TTD: D07NVU
DrugBank: DB06595
 Compound Name Quizartinib Approved [7]
Synonyms
Quizartinib
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External Link
CID: 24889392
TTD: D07KYT
DrugBank: DB12874
 Compound Name Ivosidenib Approved [7]
Synonyms
UNII-Q2PCN8MAM6; Q2PCN8MAM6; Ivosidenib [INN]; Ivosidenib [USAN]; Ivosidenib [WHO-DD]; GTPL9217; SCHEMBL15122512; EX-A992; MolPort-044-560-317; RG120; s8206; 1448347-49-6 (Ivosidenib); AKOS028113340; ZINC205136523; CS-5122; AS-35058; HY-18767
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External Link
CID: 71657455
TTD: D07DCG
DrugBank: DB14568
 Compound Name Gemtuzumab ozogamicin Approved [27]
Synonyms
Mylotarg (TN)
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External Link
TTD: D06EWO
 Compound Name Gilteritinib Approved [21]
Synonyms
UNII-66D92MGC8M; 66D92MGC8M; Gilteritinib [USAN:INN]; Gilteritinib(ASP2215); Gilteritinib (USAN/INN); Gilteritinib (ASP2215); Gilteritinib (ASP-2215); SCHEMBL282229; GTPL8708; MolPort-038-934-933; BDBM144315; C29H44N8O3; 3694AH; s7754; AKOS030234455; ZINC113476229; DB12141; CS-3885; KS-0000064E; AS-35199
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External Link
CID: 49803313
TTD: D04KZY
DrugBank: DB12141
 Compound Name Thioguanine Approved [28]
Synonyms
6-thioguanine; Lanvis; THG; Tabloid; ThioguaninGSK; Tioguanin; Tioguanina; Tioguanine; Tioguaninum; Glaxo Wellcome Brand of Thioguanine; Glaxo Wellcome Brand of Tioguanine; GlaxoSmithKline Brand of Thioguanine; GlaxoSmithKline Brand of Tioguanine; Thioguanin GSK; Thioguanine Hemihydrate; Thioguanine Monosodium Salt; Thioguanine Tabloid; Tioguanina Wellcome; Tioguanine GlaxoSmithKline Brand; Wellcome Brand of Thioguanine; BW 5071; DX4; LT00455187; Wellcome U3B; Lanvis (TN); Thioguanin-GSK; Thioguanine [USAN:BAN]; Tioguanina[INN-Spanish]; Tioguanine (INN); Tioguaninum [INN-Latin]; Purine antimetabolite: antimetabolite: inhibits nucleic acid replication; Guanine, thio-(VAN); 2 Amino 6 Purinethiol; 2-Amino 6MP; 2-Amino-1,7-dihydro-6H-purin-6-thion; 2-Amino-1,7-dihydro-6H-purin-6-thion [Czech]; 2-Amino-1,7-dihydro-6H-purine-6-thione; 2-Amino-6-MP; 2-Amino-6-mercaptopurine; 2-Amino-6-merkaptopurin; 2-Amino-6-merkaptopurin [Czech]; 2-Amino-6-purinethiol; 2-Amino-9H-purine-6-thiol; 2-Aminopurin-6-thiol; 2-Aminopurin-6-thiol [Czech]; 2-Aminopurine-6(1H)-thione; 2-Aminopurine-6-thiol; 2-Thioguanine; 2-amino-3,7-dihydropurine-6-thione; 6 Thioguanine; 6-Mercapto-2-aminopurine; 6-Mercaptoguanine; 6-TG; 6-Thioguanine (6-TG); 6-Thioguanine, Thioguanine; Thioguanine (Guanine analog)
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CID: 2723601
TTD: D02ZXM
DrugBank: DB00352
 Compound Name Daunorubicin Approved [29]
Synonyms
Daunomycin; 20830-81-3; Rubidomycin; Cerubidine; Daunorubicine; Acetyladriamycin; Leukaemomycin C; Daunorubicinum; Daunarubicinum; Daunorrubicina; Daunamycin; Cerubidin; DaunoXome; Rubomycin C; (+)-Daunomycin; Daunoblastin; Anthracyline; Rubomycin; Daunorubicinum [INN-Latin]; RP 13057; Daunorubicin [INN:BAN]; RCRA waste no U059; FI6339; NSC-82151; DAUNORUBICIN HCL; DaunoXome (TN); UNII-ZS7284E0ZP; CCRIS 914; ZS7284E0ZP; CHEBI:41977; HSDB 5095; C27H29NO10; NCI-C04693; EINECS 244-069-7; Ondena; NSC 83142; Daunoblastine; Antibiotics from Streptomyces coeruleorubidus; DM1; FI 6339; Dauno-Rubidomycine; Daunorubicin (INN); Daunorubicin (liposomal); Daunorubicin, Hydrochloride; VS-103; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside; (7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione; (8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione; (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; Anthracycline
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CID: 30323
TTD: D01XWG
DrugBank: DB00694
 Compound Name Idarubicin Approved [30]
Synonyms
DMDR; Idamycin; Idarubicina; Idarubicine; Idarubicinum; Zavedos; Idarubicin Hcl; Idarubicin Hcl Pfs; Idarubicin hydrochloride; DM5; I 1656; IMI 30; IMI-30; Idamycin (TN); Idarubicin (INN); Idarubicin [INN:BAN]; Idarubicina [INN-Spanish]; Idarubicine [INN-French]; Idarubicinum [INN-Latin]; Zavedos (TN); (1S,3S)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside; (1s,3s)-3-acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-A-l-lyxo-hexopyranoside; (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-8,10-dihydro-7H-tetracene-5,12-dione; (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione; 4-DMD; 4-Demethoxydaunomycin; 4-Demethoxydaunorubicin; 4-Desmethoxydaunorubicin
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CID: 42890
TTD: D01XDL
DrugBank: DB01177
 Compound Name Aclarubicin Approved [31]
Synonyms
Aclacin; Aclacur; Aclarubicine; Aclarubicino; Aclarubicinum; Jaclacin; Aclacinomycin A; Aclucinomycin A; Antibiotic MA 144A; Antibiotic MA 144A1; Antibiotic MA 144G1; MA 144G1; Aclarubicine [INN-French]; Aclarubicino [INN-Spanish]; Aclarubicinum [INN-Latin]; Antibiotic MA144-A1; MA 144-A1; MA-144A1; Acene-1-carboxylate; Aclarubicin (USAN/INN); Aclarubicin [USAN:BAN:INN]; Alpha-L-lyxo-hexopyranosyl]-oxy]-1-naphthacenecarboxalic acid methyl ester; 10-epi-Aclacinomycin A
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CID: 451415
TTD: D01UBX
DrugBank: DB11617
 Compound Name Magrolimab Phase 3 [32]
Synonyms
GS-4721
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External Link
TTD: DN5CM6
 Compound Name DSP-7888 Phase 2 [2]
External Link
TTD: DE5L6B
 Compound Name 131I-labelled aCD45 Phase 3 [33]
External Link
TTD: DC8EN0
 Compound Name ATIR101 Phase 3 [34]
External Link
TTD: D6O2PN
 Compound Name Dociparstat sodium Phase 3 [35]
Synonyms
DSTAT
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TTD: D5VRX2
 Compound Name Iomab-B CD45 Phase 3 [2]
External Link
TTD: D0Z0MI
 Compound Name Tasisulam Phase 3 [36]
Synonyms
Tasisulam sodium; LY-573636; LY-573636 sodium; LY-573636Na; Apoptosis stimulator (cancer), Lilly
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CID: 10160238
TTD: D0X0KM
DrugBank: DB11941
 Compound Name Vadastuximab talirine Phase 3 [25]
Synonyms
Vadastuximab talirine [INN]; Vadastuximab talirine [USAN]; Vadastuximab talirine [WHO-DD]; UNII-T13V17U431; T13V17U431; UNII-X1TW58ZV0U component BNJNAEJASPUJTO-DUOHOMBCSA-N; 1436390-64-5
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CID: 122706909
TTD: D0W2BF
 Compound Name Abexinostat Phase 3 [2]
Synonyms
PCI-24781; 783355-60-2; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide
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External Link
CID: 11749858
TTD: D0V0SL
DrugBank: DB12565
 Compound Name Peginterferon lambda-1a Phase 3 [37]
Synonyms
BMS-914143; IFN lambda, ZymoGenetics/Novo Nordisk; Interferon lambda 1, ZymoGenetics/Novo Nordisk; PEG-IL-29; PEG-rIL-29; Interleukin-29, ZymoGenetics/Novo Nordisk; PEG-IFN lambda, ZymoGenetics/Novo Nordisk; PEG-interferon lambda, ZymoGenetics/Novo Nordisk; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk; Peginterferon lambda-1a, ZymoGenetics/Bristol-Myers Squibb; PEG-IFN lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; PEG-interferon lambda, ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb; Recombinant PEG-interferon lambda-1, ZymoGenetics/Bristol-Myers Squibb; PEGylated IL-29 (HCV infection), ZymoGenetics/Novo Nordisk/Bristol-Myers Squibb
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TTD: D0T6IN
 Compound Name CPX-351 Phase 3 [7]
Synonyms
Vyxeos; Cytarabine / daunonubicin; Daunonubicin / cytarabine; CPX 351; Cytarabine mixture with daunonubicin; Daunonubicin mixture with cytarabine; Daunonubicin and cytarabine liposomal injection; SCHEMBL3959238; 1256639-86-7; 5,12-Naphthacenedione, 8-acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)-, mixt. with 4-amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
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CID: 11422859
TTD: D0SB1B
 Compound Name BYM338 Phase 2/3 [38]
External Link
TTD: D0S5FF
 Compound Name SGI110 Phase 3 [39]
External Link
CID: 137295284
TTD: D0Q5KZ
 Compound Name Elacytarabine Phase 3 [40]
Synonyms
Elacyt (TN)
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CID: 6438895
TTD: D0PY5D
DrugBank: DB05494
 Compound Name RG7388 Phase 3 [41]
Synonyms
Idasanutlin; 1229705-06-9; Idasanutlin (RG-7388); RG-7388; UNII-QSQ883V35U; QSQ883V35U; CHEMBL2402737; Benzoic acid, 4-((((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl)carbonyl)amino)-3-methoxy-; RO5503781; Idasanutlin [USAN:INN]; Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-; RG-7388;Idasanutlin; RO-5503781; SCHEMBL442856
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CID: 53358942
TTD: D0OC4O
DrugBank: DB12325
 Compound Name Galinpepimut-S Phase 3 [42]
External Link
TTD: D0M9OO
 Compound Name Pracinostat Phase 3 [7]
Synonyms
929016-96-6; SB939; SB 939; Pracinostat (SB939); SB-939; UNII-GPO2JN4UON; GPO2JN4UON; CHEMBL1851943; (E)-3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzo[d]imidazol-5-yl)-N-hydroxyacrylamide; 2-Propenamide, 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-, (2E)-; Pracinostat [INN]; (2E)-3-(2-Butyl-1-[2-(diethylamino)ethyl]-1h-1,3-benzodiazol-5-yl)-n-hydroxyprop-2-enamide; 2-Propenamide, 3-(2-butyl-1-(2-(diethylamino)ethyl)-1H-benzimidazol-5-yl)-N-hydroxy-, (2E)-
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CID: 49855250
TTD: D0L2UQ
DrugBank: DB05223
 Compound Name DFP-10917 Phase 3 [2]
External Link
CID: 119184
TTD: D0KE1F
DrugBank: DB11667
 Compound Name AG-881 Phase 1 [2]
Synonyms
Vorasidenib; 1644545-52-7; UNII-789Q85GA8P; 789Q85GA8P; AG881; 9UO; 6-(6-chloropyridin-2-yl)-N2,N4-bis[(2R)-1,1,1-trifluoropropan-2-yl]-1,3,5-triazine-2,4-diamine; Vorasidenib [INN]; Vorasidenib (AG-881); SCHEMBL16393139; AG 881 [WHO-DD]; QCZAWDGAVJMPTA-RNFRBKRXSA-N; BDBM279948; EX-A2574; US10028961, Compound 101; AG 881; s8611; CS-8033; HY-104042; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoro propan-2-yl)-1,3,5-triazine-2,4-diamine; 6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoroprop
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CID: 117817422
TTD: D0K9PC
 Compound Name AG-221 Phase 1/2 [43]
Synonyms
AG-221 (IDH2 inhibitor)
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CID: 89683805
TTD: D0K7FT
DrugBank: DB13874
 Compound Name CP-868596 Phase 3 [2]
Synonyms
Crenolanib; 670220-88-9; Crenolanib (CP-868596); ARO-002; UNII-LQF7I567TQ; LQF7I567TQ; CP-868596 (Crenolanib); CP-868,596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine; 1-(2-(5-((3-Methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine; CP868569; 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine; J-502712; 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
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CID: 10366136
TTD: D0J1GR
DrugBank: DB11832
 Compound Name Rydaptmidostaurin Phase 3 [2]
External Link
TTD: D0H6BS
 Compound Name Sapacitabine Phase 3 [44]
Synonyms
CYC682
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CID: 153970
TTD: D0D4RF
DrugBank: DB06365
 Compound Name S-110 Phase 3 [39]
Synonyms
DNA demethylating agent (myelodysplastic syndrome), Supergen
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TTD: D0A2BO
 Compound Name VAL-083 Phase 1/2 [45]
Synonyms
Dianhydrogalactitol; 23261-20-3; UNII-4S465RYF7M; 1,2:5,6-DIANHYDROGALACTITOL; Dulcitoldiepoxide; 4S465RYF7M; Dianhydrogalactitol [USAN:INN]; SCHEMBL4306431; Dianhydrogalactitol (USAN/INN); CHEMBL3137322; AAFJXZWCNVJTMK-GUCUJZIJSA-N; ZINC4963497; CS-1358; DB12873; NSC-1323313; HY-16513; BC657197; D10623; W-5268; J-015059; 457899-38-6
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CID: 15942827
TTD: D0A1IL
DrugBank: DB12873
 Compound Name CC-486 Phase 3 [2]
Synonyms
AG-14361; AG14361; 328543-09-5; UNII-48N0U0K50I; AG 14361; CHEMBL65892; 48N0U0K50I; Imidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, 2-[4-[(dimethylamino)methyl]phenyl]-5,6-dihydro-; AG-014361; 1-(4-((dimethylamino)methyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; Imidazo(4,5,1-jk)(1,4)benzodiazepin-7(4H)-one, 2-(4-((dimethylamino)methyl)phenyl)-5,6-dihydro-; 2-[4-[(Dimethylamino)methyl]phenyl]-5,6-dihydroimidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one; SMR000486393; MLS006011157; MLS001065917; Nucleoside analogue
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CID: 9840076
TTD: D09NTC
 Compound Name Hu5F9-G4 Phase 3 [25]
External Link
TTD: D09JYL
 Compound Name Iomab-B Phase 3 [46]
Synonyms
Iomab-B (TN)
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TTD: D08BBL
 Compound Name PEG arginine deiminase Phase 1 [2]
Synonyms
ADI-PEG 20
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TTD: D07UAS
 Compound Name CPI-613 Phase 3 [7]
Synonyms
95809-78-2; 6,8-bis(benzylthio)octanoic acid; CPI 613; MLS006010202; SCHEMBL1062218; 6,8-Bis(benzylsulfanyl)octanoic acid; Octanoic acid, 6,8-bis((phenylmethyl)thio)-; Octanoic acid, 6,8-bis[(phenylMethyl)thio]-; 6,8-Bis[(phenylmethyl)thio]octanoic acid; CPI613; CHEMBL3186849; QCR-193; AOB1058; MolPort-023-219-128; HMS3656L06; C22H28O2S2; BCP04663; EX-A2043; s2776; AKOS025142095; BCP9000552; DB12109; RL06062; CS-0961; NCGC00344764-01; SMR004701300; AS-16613; BC261916; AK174899; HY-15453; BCP0726000030; KB-293127; AB0035874
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CID: 24770514
TTD: D07NVI
DrugBank: DB12109
 Compound Name Zarnestra Phase 3 [47]
Synonyms
JAN; Tipifarnib; Tipifarnib [USAN]; R 115777; R115777; R-11577; R-115777; Tipifarnib (USAN/INN); Zarnestra, IND 58359, R115777, Tipifarnib; (R)-6-(Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; (R)-R115777; 2 (1H))-Quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-, 2(1H)-quinolinone; 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one; 6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one; 6-[(S)-AMINO(4-CHLOROPHENYL)(1-METHYL-1H-IMIDAZOL-5-YL)METHYL]-4-(3-CHLOROPHENYL)-1-METHYLQUINOLIN-2(1H)-ONE
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CID: 159324
TTD: D07NPS
DrugBank: DB04960
 Compound Name LMT-X Phase 3 [48]
Synonyms
Second-generation tau aggregation inhibitor (Alzheimer's disease); Second-generation tau aggregation inhibitor (Alzheimer's disease), TauRx
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TTD: D05XDZ
 Compound Name Elesclomol Phase 3 [49]
Synonyms
488832-69-5; Elesclomol (STA-4783); STA-4783; UNII-6UK191M53P; CHEBI:79369; 6UK191M53P; Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]; 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid; N'1,N'3-dimethyl-N'1,N'3-di(phenylcarbonothioyl)malonohydrazide; J-503879; C19H20N4O2S2; 1-N'-Benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl-oxopropanehydrazidide; Elesclomol [USAN:INN]; elesclomolum
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CID: 300471
TTD: D05IRV
DrugBank: DB05719
 Compound Name GMI-1271 Phase 3 [50]
Synonyms
Uproleselan
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External Link
CID: 71600085
TTD: D03PWD
DrugBank: DB14829
 Compound Name AT-406 Phase 3 [51]
Synonyms
1071992-99-8; SM 406; (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; CHEMBL2158051; QCR-136; UNII-N65WC8PXDD; N65WC8PXDD; AT406 (SM-406, ARRY-334543); J-501625; (5S,8S,10aR)-N-(Diphenylmethyl)-5-[(N-methyl-L-alanyl)amino]-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide; AT-406/Debio-1143
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CID: 25022340
TTD: D03MXK
 Compound Name PR1 peptide antigen vaccine Phase 3 [52]
Synonyms
PR1 peptide antigen vaccine (leukemia); PR1 peptide antigen vaccine (leukemia), MD Anderson; PR1 peptide antigen vaccine (leukemia), Vaccine Company
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TTD: D03GHV
 Compound Name CPI-0610 Phase 3 [2]
External Link
CID: 57389999
TTD: D01LVE
 Compound Name SNS-595 Phase 3 [53]
Synonyms
Voreloxin; Vosaroxin; AG 7352; SNS 595; SPC 595; AG 7352 (TN); AG-7352; SNS 595 (TN); SPC 595 (TN); SPC-595; Voreloxin (TN); Voreloxin (USAN); SNS-595 (TN); 1,4-Dihydro-7-(3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
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CID: 9952884
TTD: D00NVM
DrugBank: DB11999
 Compound Name Selinexor Phase 3 [7]
Synonyms
Xpovio; KPT 330; KPT-330; KPT-330(Selinexor); KPT330;Selinexor; 1393477-72-9; 31TZ62FO8F; CHEMBL3545185; SCHEMBL14678327; Selinexor (KPT-330); Selinexor [USAN:INN]; Tube706; UNII-31TZ62FO8F
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CID: 71481097
TTD: D00LNW
DrugBank: DB11942
 Compound Name Volasertib Phase 3 [7]
Synonyms
755038-65-4; BI 6727; BI-6727; BI6727 (Volasertib); Volasertib (BI 6727); UNII-6EM57086EA; 6EM57086EA; BI6727; N-{trans-4-[4-(Cyclopropylmethyl)piperazin-1-Yl]cyclohexyl}-4-{[(7r)-7-Ethyl-5-Methyl-8-(1-Methylethyl)-6-Oxo-5,6,7,8-Tetrahydropteridin-2-Yl]amino}-3-Methoxybenzamide; Volasertib [USAN:INN]; IBI; Volasertib (USAN); BI6727,Volasertib; Volasertib(BI6727); BI6727 - Volasertib; Volasertib (BI6727); BI6727 (Volasertib)/; BI 6727 (Volasertib); MLS006011195; SCHEMBL738946; SCHEMBL9888052; SCHEMBL2169101; GTPL7947
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CID: 10461508
TTD: D00BYM
DrugBank: DB12062
 Compound Name Rivo-cel Phase 2/3 [54]
Synonyms
BPX-501
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TTD: D4OU6H
 Compound Name CLL1 CAR-T Cell Phase 2/3 [55]
External Link
TTD: D0RF4J
 Compound Name NLG8189 Phase 2/3 [2]
Synonyms
1-Methyl-D-tryptophan; Indoximod; 110117-83-4; D-Tryptophan, 1-methyl-; D-1MT; Indoximod (NLG-8189); D-1-methyltryptophan; UNII-TX5CYN1KMZ; D-(+)-1-Methyltryptophan; TX5CYN1KMZ; (R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methylindol-3-yl)propanoic acid; NSC-721782; (2R)-2-amino-3-(1-methyl-3-indolyl)propanoic acid; 1-MT; (2R)-2-azanyl-3-(1-methylindol-3-yl)propanoic acid; (2R)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic acid; D-l-Methyltryptophan; Indoximod [USAN:INN]; NLG-8189; NLG 8189
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CID: 405012
TTD: D0B5HS
DrugBank: DB12827
 Compound Name CD123/CLL1 CAR-T Cells Phase 2/3 [55]
External Link
TTD: D04GGG
 Compound Name K-NK002 Phase 2 [56]
Synonyms
CSTD-002-NK
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TTD: DTU7W2
 Compound Name Dilanubicel Phase 2 [57]
Synonyms
NLA101
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TTD: DS01GZ
 Compound Name DS-3201b Phase 2 [58]
Synonyms
Valemetostat; 1809336-39-7; UNII-60RD0234VE; 60RD0234VE; 1809336-39-7 (free base); DS-3201; (2R)-7-chloro-2-[trans-4-(dimethylamino)cyclohexyl]-N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-2,4-dimethyl-1,3-benzodioxole-5-carboxamide; Valemetostat 2HCl; Valemetostat [INN]; Valemetostat (DS-3201); CHEMBL4597193; EZH1/2 inhibitor DS-3201; SCHEMBL18393626; SCHEMBL18393627; SCHEMBL18639210; EX-A3423; DS3201; NSC813381; s8926; NSC-813381; HY-109108; CS-0039740; D11551
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External Link
CID: 126481870
TTD: DNM79H
 Compound Name BST-236 Phase 2 [59]
Synonyms
Aspacytarabine; UNII-JL7V54Z2BR; JL7V54Z2BR; 2098942-53-9; N4-(1-beta-D-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)-; Astarabine; Aspacytarabine [INN]; CHEMBL4297599; L-Asparagine, N-(1-beta-D-arabinofuranosyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-; N4-(1-N2-D-Arabinofuranosyl-2-oxo-1,2-dihydropyrimidin-4-yl)- L-asparagine
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External Link
CID: 135390942
TTD: DGN26L
 Compound Name Zelenoleucel Phase 2 [60]
External Link
TTD: D4T8JV
 Compound Name CX-01 Phase 2 [2]
External Link
TTD: D0ZI4L
 Compound Name LY2090314 Phase 2 [61]
Synonyms
603288-22-8; LY-2090314; UNII-822M3GYM67; Kinome_3681; LY 2090314; CHEMBL362558; 822M3GYM67; 3-(9-Fluoro-2-(piperidine-1-carbonyl)-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indol-7-yl)-4-(imidazo[1,2-a]pyridin-3-yl)-1H-pyrrole-2,5-dione; SCHEMBL633455; GTPL7958; DTXSID90209085; MolPort-035-944-332; EX-A2214; ZINC3817327; BCP07855; s7063; BDBM50150699; AKOS032950045; AKOS026750195; CS-1633; DB11913; SB16558; NCGC00378942-05; NCGC00378942-02; BC600682; QC-11735; HY-16294; KB-78238; FT-0698670; LY2090314, &gt
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External Link
CID: 10029385
TTD: D0Z1DH
DrugBank: DB11913
 Compound Name Flotetuzumab Phase 2 [62]
External Link
TTD: D0YA1B
 Compound Name BGB-324 Phase 1/2 [7]
Synonyms
BGB-001; SiRNA therapeutic (metastasis cancer), BiobergenBio
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External Link
TTD: D0X9VR
 Compound Name PTX-200 Phase 2 [2]
Synonyms
Plant-derived antiparkinsonian, Phytrix
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External Link
TTD: D0X7CV
 Compound Name LY2523355 Phase 2 [63]
Synonyms
Litronesib
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External Link
CID: 25167017
TTD: D0W9SL
DrugBank: DB11861
 Compound Name Prexigebersen Phase 2 [2]
Synonyms
Prexigebersen [INN]; Prexigebersen [USAN:INN]; UNII-8W1O4Y961B; 8W1O4Y961B; BP-100-1.01/L-Grb2; DNA, d(A-T-A-T-T-T-G-G-C-G-A-T-G-G-C-T-T-C); 202484-91-1; 1352967-54-4
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External Link
CID: 123132008
TTD: D0W3GR
 Compound Name ALT-801 Phase 2 [64]
Synonyms
ALT-801 (donor lymphocyte infusion, cancer); ALT-801 (donor lymphocyte infusion, cancer), Altor; STAR IL-2 conjugate (donor lymphocyte infusion, cancer), Altor; STAR-Ck (donor lymphocyte infusion, cancer), Altor; Soluble T-cell Antigen Receptor IL-2 conjugate (donor lymphocyte infusion, cancer), Altor
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External Link
TTD: D0V5JH
 Compound Name ENMD-2076 Phase 2 [65]
Synonyms
934353-76-1; ENMD 2076; (E)-N-(5-Methyl-1H-pyrazol-3-yl)-6-(4-methylpiperazin-1-yl)-2-styrylpyrimidin-4-amine; UNII-J6U9WP10T7; ENMD2076; J6U9WP10T7; CHEMBL482968; 6-(4-methylpiperazin-1-yl)-N-(5-methyl-1H-pyrazol-3-yl)-2-[(E)-2-phenylethenyl]pyrimidin-4-amine; 6-(4-METHYL-1-PIPERAZINYL)-N-(5-METHYL-1H-PYRAZOL-3-YL)-2-[(1E)-2-PHENYLETHENYL]-4-PYRIMIDINAMINE; ENMD-981693; MLS006011042; SCHEMBL596481; GTPL7885; SCHEMBL15668060; SCHEMBL10122872; ENND-2076; EX-A235; DTXSID60239430; MolPort-009-679-391; AOB87159
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External Link
CID: 16041424
TTD: D0S7HM
 Compound Name FPI-01 Phase 2 [66]
Synonyms
WT-1 therapeutic vaccine (cancer), Formula Pharmaceuticals
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External Link
TTD: D0RG8Z
 Compound Name Inecalcitol oral Phase 2 [2]
Synonyms
Inecalcitol; TX-522; UNII-05FZV98342; TX 522; 163217-09-2; AC1OCD0K; 19-Nor-14-epi-23-yne-1,25 dihydroxyvitamin D3; 05FZV98342; (1R,3R)-5-[(2E)-2-[(1R,3aR,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol; (7E)-(1R,3R,14R)-19-nor-23-yne-9,10-seco-5,7-cholestadiene-1,3,25-triol; Inecalcitol [INN]; SCHEMBL754593; GTPL7747; CHEMBL2105107; LMST03020649; 8151AH; ZINC12504514; AKOS025312295; AN-7569; DB04796; TX-527; Vitamin D analogs, Catholic University of Leuven; Vitamin D analogs, KULeuven; Inecalcitol (oral, hyperthyroidism), Hybrigenics; Inecalcitol (sc, psoriasis), Hybrigenics; Vitamin D analog (sc, psoriasis), Hybrigenics; Inecalcitol (oral, prostate cancer/psoriasis), Hybrigenics
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External Link
CID: 6915835
TTD: D0R8IE
DrugBank: DB04796
 Compound Name Eryaspase Phase 2 [2]
External Link
TTD: D0P0SD
 Compound Name ALXN6000 Phase 2 [25]
Synonyms
Samalizumab
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External Link
TTD: D0OY9L
 Compound Name BI 2536 Phase 2 [67]
Synonyms
BI2536, BI 2536
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External Link
CID: 11364421
TTD: D0O0LQ
 Compound Name MK8242 Phase 2 [68]
External Link
TTD: D0NT6P
 Compound Name Leukemia DNA vaccine Phase 2 [69]
External Link
TTD: D0N6UA
 Compound Name Anti-CD45 mAb 131I-BC8 Phase 2 [7]
External Link
TTD: D0N4NH
 Compound Name BREQUINAR Phase 1/2 [70]
Synonyms
96187-53-0; 6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid; brequinarum [Latin]; Brequinar [INN]; Biphenquinate; 6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid; Brequinarum [INN-Latin]; UNII-5XL19F49H6; C23H15F2NO2; NSC-368390; NSC 368390; 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid; PHEZJEYUWHETKO-UHFFFAOYSA-N; Dup 785; 5XL19F49H6; 6-FLUORO-2-(2'-FLUORO-1,1'-BIPHENYL-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLIC ACID; brequinarum
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External Link
CID: 57030
TTD: D0N3XT
DrugBank: DB03523
 Compound Name Leukemia cancer vaccine Phase 2 [71]
External Link
TTD: D0M0OT
 Compound Name ADCT-301 Phase 1 [2]
Synonyms
camidanlumab tesirine
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External Link
TTD: D0LL1N
 Compound Name Flavopiridol Phase 2 [7]
Synonyms
FLAVO; Alvocidib [INN]; Flavopiridol hydrochloride; L 868275; HMR-1275; L-868275; L86-8275; HMR-1275, Alvocidib, L868275, Flavopiridol; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one; 2-(2-CHLORO-PHENYL)-5,7-DIHYDROXY-8-(3-HYDROXY-1-METHYL-PIPERIDIN-4-YL)-4H-BENZOPYRAN-4-ONE; 2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]chromen-4-one
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External Link
CID: 5287969
TTD: D0LF1U
DrugBank: DB03496
 Compound Name BP-100-1-01 Phase 2 [72]
External Link
TTD: D0L3KA
 Compound Name IRX-2 Phase 2 [73]
External Link
TTD: D0KS6F
 Compound Name Cenersen Phase 2 [74]
External Link
CID: 56841947
TTD: D0K4VW
 Compound Name Lirilumab Phase 2 [75]
External Link
TTD: D0I7PU
 Compound Name LOR-2040 Phase 2 [76]
External Link
TTD: D0I7NG
 Compound Name Sodium butyrate Phase 2 [77]
Synonyms
Butyrate sodium; Sodium butanoate; Sodium propanecarboxylate; OR8783; Butanoic acid, sodium salt; Butyric Acid, Na; Sodium butyrate (USP); Sodium n-butyrate; TPA/BA; Tetradecanoyl phorbol acetate/ sodium butyrate; Butanoic acid, sodium salt (1:1); Tetradecanoyl phorbol acetate (TPA)/ sodium butyrate (BA)
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External Link
CID: 5222465
TTD: D0I7IB
 Compound Name GRNVAC1 Phase 2 [78]
External Link
TTD: D0I6RI
 Compound Name H3B-8800 Phase 1 [2]
External Link
TTD: D0H7BF
 Compound Name GS-9973 Phase 2 [2]
Synonyms
Entospletinib; 1229208-44-9; Entospletinib (GS-9973); gs9973; UNII-6I3O3W6O3B; 6-(1H-Indazol-6-yl)-N-(4-morpholinophenyl)imidazo[1,2-a]pyrazin-8-amine; GS 9973; 6I3O3W6O3B; CHEMBL3265032; C23H21N7O; 6-(1H-Indazol-6-yl)-N-(4-(morpholin-4-yl)phenyl)imidazo(1,2-a)pyrazin-8-amine; Entospletinib [INN]; Entospletinib [USAN:INN]; 4puz; 6-(1h-Indazol-6-Yl)-N-[4-(Morpholin-4-Yl)phenyl]imidazo[1,2-A]pyrazin-8-Amine; SCHEMBL2483776; GTPL7889; MolPort-035-395-879; HMS3653D13; EX-A1120; BCP09582; AOB87385
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External Link
CID: 59473233
TTD: D0G9AW
DrugBank: DB12121
 Compound Name ALT-803 Phase 2 [79]
Synonyms
IL-15 agonist/ IL-15R alpha-Fc fusion complex (cancer), Altor BioScience
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External Link
TTD: D0FD7H
 Compound Name CHR-2797 Phase 2 [80]
Synonyms
Tosedostat; Tosedostat, CHR2797, CHR-2797
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External Link
CID: 15547703
TTD: D0F2JS
DrugBank: DB11781
 Compound Name HTERT RNA vaccine Phase 2 [81]
External Link
TTD: D0CQ1X
 Compound Name MB-102 Phase 2 [25]
Synonyms
Relmapirazin; UNII-Q3UQB8PQ6H; Q3UQB8PQ6H; Relmapirazin [INN]; CHEMBL1949708; SCHEMBL16738795; N,N'-((3,6-Diamino-2,5-pyrazinediyl)dicarbonyl)bis(D-serine); D-Serine, N,N'-((3,6-diamino-2,5-pyrazinediyl)dicarbonyl)bis-; 1313706-17-0
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External Link
CID: 53389120
TTD: D0C3JB
 Compound Name phorbol 12-myristate 13-acetate Phase 2 [2]
Synonyms
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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External Link
CID: 27924
TTD: D09DHT
 Compound Name AEB1102 Phase 1 [2]
External Link
TTD: D08WQU
 Compound Name Ifabotuzumab Phase 2 [25]
External Link
TTD: D08NZG
 Compound Name BP1001 Phase 2 [7]
External Link
TTD: D08IVF
 Compound Name AS-101 Phase 2 [82]
Synonyms
Ossirene; Tellaxium trichloride glycol; IVX-Q-101
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External Link
CID: 11260998
TTD: D08EAI
 Compound Name ALRN-6924 Phase 2 [2]
External Link
TTD: D07UKT
 Compound Name GO-203-2c Phase 2 [2]
External Link
TTD: D07OAD
 Compound Name Talacotuzumab Phase 2 [25]
Synonyms
JNJ 473; JNJ 56022473; TAL
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External Link
TTD: D07MGC
 Compound Name AST-VAC1 Phase 2 [83]
External Link
TTD: D07KAB
 Compound Name Lomab B Phase 2 [84]
Synonyms
BCS-I-131 construct
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External Link
TTD: D07CQW
 Compound Name Fipamezole Phase 2 [85]
Synonyms
150586-58-6; JP-1730; 1H-Imidazole,5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-; Fipamezole [INN]; ACMC-1BZQD; AC1Q4NYS; SCHEMBL935549; AC1L4U51; SCHEMBL18826053; CHEMBL1255582; CTK4C6705; 5-(2-ethyl-5-fluoro-1,3-dihydroinden-2-yl)-1H-imidazole; KXSUAWAUCNFBQJ-UHFFFAOYSA-N; 5-(2-ethyl-5-fluoro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole; BDBM50417007; SB17014; 4-(2-ethyl-5-fluoro-indan-2-yl)-1H-imidazole; L001472; 4-((2RS)-2-Ethyl-5-fluoroindan-2-yl)-1H-imidazole
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External Link
CID: 213041
TTD: D05LGX
DrugBank: DB06585
 Compound Name PR104 Phase 2 [86]
Synonyms
851627-62-8; PR-104; UNII-V16D2ZT7DT; V16D2ZT7DT; 2-((2-Bromoethyl)(2,4-dinitro-6-((2-(phosphonooxy)ethyl)carbamoyl)phenyl)amino)ethyl methanesulfonate; 2-[(2-bromoethyl)(2,4-dinitro-6-{[2-(phosphonooxy)ethyl]carbamoyl}phenyl)amino]ethyl methanesulfonate; PR 104; SCHEMBL367963; ZINC43131754; AKOS022174966; RL05275; KB-80083; 4CA-1041; AX8282408; J-507569; Benzamide, 2-((2-bromoethyl)(2-((methylsulfonyl)oxy)ethyl)amino)-3,5- dinitro-N-(2-(phosphonooxy)ethyl)-
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External Link
CID: 11455973
TTD: D05CFG
DrugBank: DB05968
 Compound Name BI-836858 Phase 1/2 [2]
External Link
TTD: D04MGW
 Compound Name Ficlatuzumab Phase 2 [2]
Synonyms
AV-299
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External Link
TTD: D03UBW
 Compound Name K562/GM-CSF Phase 2 [87]
Synonyms
GM-CSF-secreting cells+tumor cell vaccine, Cell Genesys/Johns Hopkins
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External Link
TTD: D03PRC
 Compound Name PCM-075 Phase 2 [2]
Synonyms
Onvansertib
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External Link
CID: 49792852
TTD: D03HUX
DrugBank: DB15110
 Compound Name Actimab-A Phase 2 [25]
External Link
TTD: D03HSA
 Compound Name IMG-7289 Phase 2 [2]
Synonyms
KQKBMHGOHXOHTD-KKUQBAQOSA-N; UNII-Y2T4ALDEAT; Y2T4ALDEAT; SCHEMBL17984236; Benzamide, N-((1S)-4-(((1R,2S)-2-(4-fluorophenyl)cyclopropyl)amino)-1-((4-methyl-1-piperazinyl)carbonyl)butyl)-4-(1H-1,2,3-triazol-1-yl)-; 1990504-34-1; N-[(2S)-1-(4-(methyl)piperazin-1-yl)-5-[[(1R,2S)-2-(4-fluorophenyl)-cyclopropyl]amino]-1-oxopentan-2-yl]-4-(1H-1,2,3-triazol-1-yl)benzamide
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External Link
CID: 122460381
TTD: D03EOZ
DrugBank: DB15126
 Compound Name WT1-targeted autologous dendritic cell vaccine Phase 2 [88]
Synonyms
WT1-targeted autologous dendritic cell vaccine (cancer)
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External Link
TTD: D02MLO
 Compound Name AZD-4877 Phase 2 [89]
Synonyms
Anticancer therapeutic (solid tumors), AstraZeneca
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External Link
CID: 10368812
TTD: D02AAO
DrugBank: DB11671
 Compound Name IPH-2102 Phase 2 [90]
External Link
TTD: D00RYU
 Compound Name ASP7517 Phase 1/2 [91]
External Link
TTD: DYM1J4
 Compound Name CG-806 Phase 1/2 [92]
Synonyms
1370466-81-1; UNII-7W3FGR71NN; 7W3FGR71NN; 1-(3-fluoro-4-(7-(4-methyl-1H-imidazol-2-yl)-1-oxoisoindolin-4-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea; SCHEMBL1292507; EX-A2932; NSC810717; CG'806; NSC-810717; CG-026806; HY-112646; CS-0058852; 1-(3-Fluoro-4-(7-(5-methyl-1H-imidazol-2-yl)-1-oxo-2,3-dihydro-1H-isoindo-1-4-yl)-phenyl)-3-(3-trifluoromethyl-phenyl)urea; Urea, N-(4-(2,3-dihydro-7-(5-methyl-1H-imidazol-2-yl)-1-oxo-1H-isoindol-4-yl)-3-fluorophenyl)-N'-(3-(trifluoromethyl)phenyl)-
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External Link
CID: 66981446
TTD: DT3BA1
 Compound Name KO-539 Phase 1/2 [93]
Synonyms
UNII-4MOD1F4ENC; 4MOD1F4ENC; SCHEMBL20846943; KO539; Menin-mll interaction inhibitor KO 539; (S)-4-Methyl-5-((4-((2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno(2,3-d)pyrimidin-4-yl)amino)piperidin-1-yl)methyl)-1-(2-(4-(methylsulfonyl)piperazin-1-yl)propyl)-1H-indole-2-carbonitrile; 2134675-36-6
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External Link
CID: 138497449
TTD: DS4JE8
 Compound Name SAR440234 Phase 1/2 [94]
External Link
TTD: DL1FG3
 Compound Name HM43239 Phase 1/2 [95]
External Link
TTD: DI1VM3
 Compound Name Annamycin Phase 1/2 [2]
Synonyms
92689-49-1; UNII-SNU299M83Q; 2'-Iodo-3'-hydroxy-4'-epi-4-demethoxydoxorubicin; SNU299M83Q; (7S,9S)-7-(((2R,3R,4R,5R,6S)-4,5-Dihydroxy-3-iodo-6-methyltetrahydro-2H-pyran-2-yl)oxy)-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-7,8,9,10-tetrahydrotetracene-5,12-dione; AR-522; SCHEMBL19368; (7S,9S)-7-[(2R,3R,4R,5R,6S)-4,5-dihydroxy-3-iodo-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-8,10-dihydro-7H-tetracene-5,12-dione; ZINC3918134; DB06420; 5,12-Naphthacenedione, 7-((2,6-dideoxy-2-iodo-alpha-L-mannopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(hydroxyacetyl)-, (7S-cis)-; 689A491; Q4767903
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External Link
CID: 115212
TTD: DCT2Q3
DrugBank: DB06420
 Compound Name ONO-7475 Phase 1/2 [96]
Synonyms
1646839-59-9; UNII-0VCB95RHRV; N-(5-((6,7-Dimethoxyquinolin-4-yl)oxy)pyridin-2-yl)-2,5-dioxo-1-phenyl-1,2,5,6,7,8-hexahydroquinoline-3-carboxamide; N-[5-[(6,7-Dimethoxy-4-quinolinyl)oxy]-2-pyridinyl]-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-3-quinolinecarboxamide; SCHEMBL16426362; ONO7475; BCP33232; MFCD32689448; s8933; ONO 7475; HY-114358; CS-0083699; 3-Quinolinecarboxamide, N-(5-((6,7-dimethoxy-4-quinolinyl)oxy)-2-pyridinyl)-1,2,5,6,7,8-hexahydro-2,5-dioxo-1-phenyl-; N-[5-(6,7-dimethoxyquinolin-4-yl)oxypyridin-2-yl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
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External Link
CID: 90645873
TTD: DA1MG8
 Compound Name FF-10101 Phase 1/2 [97]
Synonyms
1472797-69-5; UNII-7V7IHI0SYG; 7V7IHI0SYG; (S,E)-N-(1-((5-(2-((4-Cyanophenyl)amino)-4-(propylamino)pyrimidin-5-yl)pent-4-yn-1-yl)amino)-1-oxopropan-2-yl)-4-(dimethylamino)-N-methylbut-2-enamide; SCHEMBL15584726; SCHEMBL16443760; BDBM397428; BCP23613; s8899; US9987278, Compound Reference 38; HY-109584; CS-0032038; FF 10101; FF10101; (E)-N-[(2S)-1-[5-[2-(4-cyanoanilino)-4-(propylamino)pyrimidin-5-yl]pent-4-ynylamino]-1-oxopropan-2-yl]-4-(dimethylamino)-N-methylbut-2-enamide; 2-Butenamide, N-((1S)-2-((5-(2-((4-cyanophenyl)amino)-4-(propylamino)-5-pyrimidinyl)-4-pentyn-1-yl)amino)-1-methyl-2-oxoethyl)-4-(dimethylamino)-N-methyl-, (2E)-
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External Link
CID: 90052320
TTD: D28HJI
 Compound Name SL-401 Phase 1/2 [98]
External Link
TTD: D0Z2ZY
 Compound Name SEL-24 Phase 1/2 [2]
Synonyms
Multikinase inhibitor (cancer), Selvita; SEL-24-1; SEL-24-11; SEL-24-20; Pim-1 kinase inhibitors (cancer), Selvita
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External Link
TTD: D0X8ID
 Compound Name SEL24 Phase 1/2 [99]
Synonyms
MEN1703
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External Link
TTD: D0V2ZC
 Compound Name CD38-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D0UJ3C
 Compound Name HuM-195-Ac-225 Phase 1/2 [101]
Synonyms
HuM-195 [225Ac]; SMART 225Ac-M195; Actinium-225-M195; SMART actinium-225-M195; Actinium-225-HuM-195; 225Ac-HuM-195; 225Ac-lintuzumab
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TTD: D0TV6H
 Compound Name NEXI-001 Phase 1/2 [102]
External Link
TTD: D0SZT3
 Compound Name INCB59872 Phase 1/2 [2]
External Link
TTD: D0R7CD
 Compound Name MG7-CART Phase 1/2 [103]
External Link
TTD: D0Q5GK
 Compound Name PRI-724 Phase 1/2 [104]
External Link
CID: 71509318
TTD: D0Q0ZY
DrugBank: DB15034
 Compound Name CART-123 cells Phase 1/2 [105]
External Link
TTD: D0N6PE
 Compound Name OXi4503 Phase 1/2 [2]
Synonyms
Combretastatin A-1 phosphate; 288847-34-7; Combretastatin A1 disodium phosphate; 1,2-Benzenediol, 3-methoxy-6-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-, bis(dihydrogen phosphate), tetrasodium salt
    Click to Show/Hide
External Link
CID: 6918545
TTD: D0N4HQ
 Compound Name CIK-CAR.CD19 Phase 1/2 [2]
External Link
TTD: D0M2XK
 Compound Name RhH1.3 Phase 1/2 [106]
Synonyms
Oncohist; Histone H1, SymbioTec; Recombinant human histone H1.3, SymbioTec; RhH1.3, SymbioTec
    Click to Show/Hide
External Link
TTD: D0K6UG
 Compound Name JTCR016 Phase 1/2 [25]
External Link
TTD: D0J6AJ
 Compound Name Muc1-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D0IQ3E
 Compound Name Lintuzumab Ac-225 Phase 1/2 [107]
Synonyms
Actimab-A (TN)
    Click to Show/Hide
External Link
TTD: D0HV7A
 Compound Name CD33-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D0G9MY
 Compound Name CD19 specific CAR T cells Phase 1/2 [108]
External Link
TTD: D0FR3J
 Compound Name EPZ-5676 Phase 1/2 [109]
Synonyms
pinometostat; 1380288-87-8; EPZ5676; UNII-8V9YR09EF3; UNII-F66X4M38G5; 8V9YR09EF3; CHEMBL3087499; CHEMBL3414626; F66X4M38G5; 1380288-88-9; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol; Pinometostat, trans-; 5'-[{cis-3-[2-(5-Tert-Butyl-1h-Benzimidazol-2-Yl)ethyl]cyclobutyl}(Propan-2-Yl)amino]-5'-Deoxyadenosine
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External Link
CID: 57345410
TTD: D0C6GK
DrugBank: DB12920
 Compound Name BSK01 Phase 1/2 [25]
External Link
TTD: D0AZ1N
 Compound Name CNDO-109 Phase 1/2 [7]
External Link
TTD: D0A0CY
 Compound Name DT388IL-3 Phase 1/2 [110]
External Link
TTD: D08MKR
 Compound Name PLX2853 Phase 1/2 [111]
External Link
TTD: D07GHA
 Compound Name CWP232291 Phase 1/2 [112]
External Link
TTD: D07AYI
 Compound Name BPX-501 Phase 1/2 [2]
External Link
TTD: D06LYI
 Compound Name RTX-240 Phase 1/2 [113]
External Link
TTD: D05ZBV
 Compound Name G0-203-2c Phase 1/2 [114]
External Link
TTD: D04WHM
 Compound Name CD123-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D04MLR
 Compound Name CD56-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D03HML
 Compound Name OTX-015 Phase 1/2 [115]
Synonyms
MK 8628
    Click to Show/Hide
External Link
CID: 9936746
TTD: D02YNI
DrugBank: DB15189
 Compound Name FF-10501-01 Phase 1/2 [2]
External Link
TTD: D02BVW
 Compound Name SGN-CD33A Phase 1/2 [7]
External Link
TTD: D01KKI
 Compound Name CLL1-specific gene-engineered T cells Phase 1/2 [100]
External Link
TTD: D00QWK
 Compound Name CLT030 Phase 1 [116]
External Link
TTD: DW01LJ
 Compound Name FT500 Phase 1 [117]
External Link
TTD: DSYM73
 Compound Name 225Ac-labelled aCD33 Phase 1 [118]
External Link
TTD: DSI4G9
 Compound Name PRGN-3006 Phase 1 [119]
External Link
TTD: DR0L8A
 Compound Name GEM333 Phase 1 [120]
External Link
TTD: DQD1T2
 Compound Name VOB560 Phase 1 [121]
Synonyms
S 65487
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External Link
TTD: DP63FS
 Compound Name SEL120 Phase 1 [122]
Synonyms
SEL120-34A HCl; UNII-SDM3M518PJ; SDM3M518PJ; 1609452-30-3; SEL-120; SEL120-34A (monohydrochloride); SE-120-34A; 1609452-30-3 (HCl); 7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline Hydrochloride; CHEMBL4578881; SCHEMBL17106021; s8840; EX-A2929-1; HY-111388A; BS-16042; CS-0041061; A17086; SEL120(SEL120-34,SEL120-34A); 4H-Imidazo(4,5,1-ij)quinoline, 7,8-dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-, hydrochloride (1:1); 7,8-Dibromo-5,6-dihydro-9-methyl-2-(1-piperazinyl)-4himidazo(4,5,1-ij)quinoline hydrochloride
    Click to Show/Hide
External Link
CID: 73776232
TTD: DOJG79
 Compound Name NKX101 Phase 1 [123]
External Link
TTD: DOBZ63
 Compound Name AMG 673 Phase 1 [2]
External Link
TTD: DNS2P1
 Compound Name SAR443579 Phase 1 [124]
External Link
TTD: DMKG40
 Compound Name IO-202 Phase 1 [125]
External Link
TTD: DM9GO4
 Compound Name CYC140 Phase 1 [126]
Synonyms
Telparevir; Telaprevir - VX-950; SCHEMBL6468440; CS-M3592; ZINC164377440; (1S,3aR,6aS)-2-((R)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide; (3S,3aS,6aR)-2-[(2R)-2-[[(2S)-2-cyclohexyl-2-(pyrazine-2-carbonylamino)acetyl]amino]-3,3-dimethylbutanoyl]-N-[(3S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide; Cyclopenta[c]pyrrole-1-carboxamide, (2S)-2-cyclohexyl-N-(2-pyrazinylcarbonyl)glycyl-3-methyl-L-valyl-N-[(1S)-1-[2-(cyclopropylamino)-2-oxoacetyl]butyl]octahydro-, (1S,3aR,6aS)-
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External Link
CID: 57336523
TTD: DK26FL
 Compound Name SKI-G-801 Phase 1 [127]
External Link
TTD: DIA08F
 Compound Name CC-90002 Phase 1 [25]
External Link
TTD: DI8WC4
 Compound Name TAS-1440 Phase 1 [128]
External Link
TTD: DI17KH
 Compound Name RG6007 Phase 1 [129]
External Link
TTD: DHWF68
 Compound Name CB-5339 Phase 1 [130]
External Link
TTD: DFC0V4
 Compound Name SAR445419 Phase 1 [131]
External Link
TTD: DCQ6L4
 Compound Name AB-110 Phase 1 [132]
External Link
TTD: DC6LS1
 Compound Name LP-108 Phase 1 [133]
External Link
TTD: DBY42T
 Compound Name H3B-8800 Phase 1 [134]
Synonyms
(2S,3S,6S,7R,10R,E)-7,10-Dihydroxy-3,7-dimethyl-12-oxo-2-((R,2E,4E)-6-(pyridin-2-yl)hepta-2,4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate; 1825302-42-8; SCHEMBL17255784; DB14017
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External Link
CID: 92135969
TTD: DB5O1U
DrugBank: DB14017
 Compound Name CD123-CD33 Ccar Phase 1 [135]
External Link
TTD: DB4C5H
 Compound Name JNJ-63709178 Phase 1 [2]
External Link
TTD: D9TG4H
 Compound Name JNJ-67571244 Phase 1 [136]
External Link
TTD: D9OZ3B
 Compound Name AMG 427 Phase 1 [137]
External Link
TTD: D91CMX
 Compound Name AMG 330 Phase 1 [2]
External Link
TTD: D8AOC1
 Compound Name ABBV-184 Phase 1 [138]
External Link
TTD: D7QHV6
 Compound Name MIK665 Phase 1 [139]
Synonyms
1799631-75-6; (2~{R})-2-[5-[3-chloranyl-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy-3-[2-[[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy]phenyl]propanoic acid; (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; MIK-665; S-64315; SCHEMBL16815710; EX-A2912; NSC809971; NSC-809971; HY-112218; CS-0044179; (5R)-(R)-2-((5-(3-Chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid; 1799831-02-9; OK5
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External Link
CID: 118157243
TTD: D7LC8N
 Compound Name FT538 Phase 1 [140]
External Link
TTD: D79JZU
 Compound Name BGB-11417 Phase 1 [141]
External Link
TTD: D74BRK
 Compound Name SEA-CD70 Phase 1 [142]
External Link
TTD: D6H9TE
 Compound Name CLL1-CD33 cCART cell therapy Phase 1 [143]
External Link
TTD: D5T9GZ
 Compound Name KITE-222 Phase 1 [144]
External Link
TTD: D4UQ2B
 Compound Name CYAD-02 Phase 1 [145]
External Link
TTD: D2Z7EL
 Compound Name GDX012 Phase 1 [146]
External Link
TTD: D2V9RQ
 Compound Name APVO436 Phase 1 [147]
External Link
TTD: D2GY5C
 Compound Name LAM-003 Phase 1 [2]
External Link
TTD: D20IMG
 Compound Name IMGN779 Phase 1 [2]
External Link
TTD: D0ZR1Z
 Compound Name BPX-701 Phase 1 [25]
External Link
TTD: D0ZA1K
 Compound Name BMS-936564 Phase 1 [148]
External Link
TTD: D0Z8JR
 Compound Name UCART123 Phase 1 [2]
External Link
TTD: D0Z7QK
 Compound Name FF-10101-01 Phase 1 [2]
External Link
TTD: D0YQ9I
 Compound Name CART-56 cells Phase 1 [149]
External Link
TTD: D0YH5L
 Compound Name AVB-S6-500 Phase 1 [2]
External Link
TTD: D0Y5QA
 Compound Name BB-MPI-03 Phase 1 [83]
External Link
TTD: D0W1TL
 Compound Name ONO-7475 Phase 1 [2]
External Link
TTD: D0VH4T
 Compound Name LC-1 Phase 1 [150]
Synonyms
Dimethylamino-parthenolide; Parthenolide analog (leukemia), Leuchemix
    Click to Show/Hide
External Link
TTD: D0V5AL
 Compound Name CART123 cells Phase 1 [151]
External Link
TTD: D0R5NU
 Compound Name NKR-2 cells Phase 1 [152]
External Link
TTD: D0QR2K
 Compound Name CART-33 cells Phase 1 [149]
External Link
TTD: D0P6YN
 Compound Name BI-811283 Phase 1 [153]
External Link
TTD: D0P5IZ
 Compound Name INNO-305 Phase 1 [154]
External Link
TTD: D0P2ZY
 Compound Name IGN523 Phase 1 [155]
External Link
TTD: D0OQ5R
 Compound Name CART-34 cells Phase 1 [149]
External Link
TTD: D0NY1Y
 Compound Name CM-CS1 T-cell Phase 1 [156]
External Link
TTD: D0NC9M
 Compound Name Mivebresib Phase 1 [2]
Synonyms
ABBV-075; 1445993-26-9; UNII-VR86R11J7J; VR86R11J7J; N-[4-(2,4-Difluorophenoxy)-3-(6-Methyl-7-Oxo-6,7-Dihydro-1h-Pyrrolo[2,3-C]pyridin-4-Yl)phenyl]ethanesulfonamide; N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide; 8NG; Mivebresib [INN]; ABBV-075 (Mivebresib); ABBV075; GTPL9117; SCHEMBL15068241; CHEMBL3987016; Mivebresib(ABBV-075 pound(c); MolPort-044-561-801; RDONXGFGWSSFMY-UHFFFAOYSA-N; BDBM220447; EX-A1082; s8400; ZINC146486516; AKOS030628486; CS-5815
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External Link
CID: 71600087
TTD: D0M2TS
 Compound Name AMV564 Phase 1 [2]
External Link
TTD: D0LP7U
 Compound Name SAR-103168 Phase 1 [157]
External Link
TTD: D0LO5N
 Compound Name DS-3201 Phase 1 [2]
Synonyms
QTGYNKYZRZATJB-UHFFFAOYSA-N; 701899-63-0; 2-(2-(2-Methyl-1H-imidazol-5-yl)ethyl)isoindoline-1,3-dione; 2-(2-(2-Methyl-1H-imidazol-5-yl)-ethyl)isoindoline-1,3-dione; SCHEMBL7743461; MolPort-035-945-474; MolPort-035-690-353; ZINC98086069; AKOS024459002; AKOS024262663; MCULE-2708350770; FCH4077443; AK158834; AX8292467; ST2403812; 2-[2-(2-methyl-1H-imidazol-5-yl)ethyl]-2,3-dihydro-1H-isoindole-1,3-dione
    Click to Show/Hide
External Link
CID: 22627096
TTD: D0LG8T
 Compound Name PF-06747143 Phase 1 [25]
External Link
TTD: D0LC5L
 Compound Name DCLL9718S Phase 1 [2]
External Link
TTD: D0K6JZ
 Compound Name CD123CAR-41BB-CD3zeta-EGFRt-expressing T cells Phase 1 [158]
External Link
TTD: D0JX7M
 Compound Name CSL-362 Phase 1 [159]
Synonyms
CSL-360; Monoclonal antibody (acute myelogenous leukemia), CSL; Therapeutic leukaemia antibody (AML), CSL; 7G3
    Click to Show/Hide
External Link
TTD: D0JF9Z
 Compound Name AMG 176 Phase 1 [160]
Synonyms
JQNINBDKGLWYMU-GEAQBIRJSA-N; AMG-176; 1883727-34-1; AMG176; SCHEMBL17550216; EX-A2666; HY-101565; CS-0021721; Spiro[5,7-etheno-1H,11H-cyclobut[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-2(3H),1'(2'H)-naphthalen]-8(9H)-one, 6'-chloro-3',4',12,13,16,16a,17,18,18a,19-decahydro-16-methoxy-11,12-dimethyl-,10,10-dioxide, (1'S,11R,12S,14E,16S,16aR,18aR)-
    Click to Show/Hide
External Link
CID: 118910268
TTD: D0I5DP
 Compound Name XmAb14045 Phase 1 [2]
External Link
TTD: D0I4BK
 Compound Name SY-1425 Phase 1 [2]
External Link
TTD: D0HY3D
 Compound Name AGS62P1 Phase 1 [2]
Synonyms
AGS-62P1
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External Link
TTD: D0H3ND
 Compound Name CART-117 cells Phase 1 [149]
External Link
TTD: D0E0SH
 Compound Name CART-Muc1 cells Phase 1 [149]
External Link
TTD: D0DJ8S
 Compound Name BAY1436032 Phase 1 [2]
Synonyms
RNMAUIMMNAHKQR-QFBILLFUSA-N; BAY-1436032; 1803274-65-8; BAY 1436032; SCHEMBL17009632; EX-A1606; AKOS032946249; SB19763; HY-100020; CS-0017982; 3-(2-((4-(trifluoromethoxy)phenyl)amino)-1-((1R,5R)-3,3,5-trimethylcyclohexyl)-1H-benzo[d]imidazol-5-yl)propanoic acid
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External Link
CID: 118310260
TTD: D0C6RM
 Compound Name CD33-CAR-T Cell Phase 1 [161]
External Link
TTD: D0C4GN
 Compound Name CART-123 cells Phase 1 [149]
External Link
TTD: D0AW4T
 Compound Name FATE-NK100 Phase 1 [2]
External Link
TTD: D0A9GE
 Compound Name CC-90009 Phase 1 [2]
External Link
TTD: D09WIR
 Compound Name NKR-2 CAR-T Cells Phase 1 [162]
External Link
TTD: D08YHE
 Compound Name Anti-CEA CAR-T cells Phase 1 [163]
External Link
TTD: D08UVN
 Compound Name RG7775 Phase 1 [164]
External Link
TTD: D08TNG
 Compound Name OTSSP167 Phase 1 [2]
Synonyms
OTSSP 167; OTSSP-167; AMX10201
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External Link
CID: 135398499
TTD: D08FIX
 Compound Name IMC-EB10 Phase 1 [165]
Synonyms
Anti-Flt-3 Mab
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External Link
TTD: D07ZNF
 Compound Name TCN-P Phase 1 [166]
Synonyms
TRICIRIBINE PHOSPHATE; 61966-08-3; UNII-5L5GE3DV88; Triciribine phosphate [USAN]; Tricirbine Phosphate; NSC-280594; C13H17N6O7P; NSC 280594; Pentaazaacenaphthylene-5' phosphate ester; 5L5GE3DV88; PHOSPHATE SALT OF TRICYCLIC NUCLEOSIDE; 3-Amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(dihydrogen phosphate); Triciribine phosphate (USAN); VQD-002; TCN-monophosphate; 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-; NSC280594
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External Link
CID: 43860
TTD: D07TWK
DrugBank: DB14636
 Compound Name CART-38 cells Phase 1 [149]
External Link
TTD: D06OES
 Compound Name ABBV-744 Phase 1 [2]
Synonyms
OEDSFMUSNZDJFD-UHFFFAOYSA-N; 2138861-99-9; N-ethyl-4-(2-(4-fluoro-2,6-dimethylphenoxy)-5-(2-hydroxypropan-2-yl)phenyl)-6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide; ABBV 744; SCHEMBL19463409; EX-A2713; ACN-054460; HY-112090; CS-0043318
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External Link
CID: 132010322
TTD: D05ICT
 Compound Name AGS-67E Phase 1 [25]
External Link
TTD: D04MBK
 Compound Name PNK-007 Phase 1 [25]
External Link
TTD: D03IRG
 Compound Name GSK-2130579A Phase 1 [167]
Synonyms
Leukemia vaccine, GlaxoSmithKline; WT1 ASCI, GlaxoSmithKline; WT1 antigen specific cancer immunotherapeutic, GlaxoSmithKline; WT1 vaccine, GlaxoSmithKline
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External Link
TTD: D02JEW
 Compound Name SGN-CD123A Phase 1 [2]
External Link
TTD: D01BRD
 Compound Name IM23 Phase 1 [168]
External Link
TTD: D00HAN
 Compound Name Anti-CD33 Phase 1 [2]
External Link
TTD: D00DIB
 Compound Name KW-2449 Phase 1 [169]
Synonyms
Tumor antigen-specific mAb (cancer), Kyowa; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kirin; Tumor antigen-specific monoclonal antibody (cancer), Kyowa Hakko Kogyo
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External Link
CID: 11427553
TTD: D00ABO
 Compound Name CAR-T cells targeting CD56 Clinical trial [170]
External Link
TTD: D0V6WW
 Compound Name CAR-T cells targeting CD38 Clinical trial [170]
External Link
TTD: D0V6WU
 Compound Name Valspodar Discontinued in Phase 3 [171]
External Link
CID: 5281884
TTD: D09TGX
DrugBank: DB11869
 Compound Name LY335979 Discontinued in Phase 3 [172]
Synonyms
Zosuquidar HCl; Zosuquidar Trihydrochloride; LY 335979; LY-335979; Zosuquidar (TN); Zosuquidar trihydrochloride (USAN); RS-33295-198; Zosuquidar trihydrochloride, RS-33295-198, LY335979; (R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, trihydrochloride
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External Link
CID: 153997
TTD: D06DCL
 Compound Name Lintuzumab Bi-213 Discontinued in Phase 1/2 [173]
Synonyms
Bismab-A (TN)
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External Link
TTD: D0S1LE
 Compound Name HuM-195-Bi-213 Discontinued in Phase 1/2 [173]
Synonyms
SMART 213Bi-M195; SMART Y90-M195; Y90-HuM195; Bismuth-213-HuM195; SMART bismuth-213-M195; Yttrium-90-HuM195; Alpha-particle-emitting radioisotope-linked lintuzumab; 213Bi-HuM195
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External Link
TTD: D0IJ1D
 Compound Name CER-227185 Discontinued in Phase 1/2 [174]
Synonyms
TCTP inhibitor (cancer), Cerenis; Translationally controlled tumor protein inhibitor (acute myeloid leukemia), Cerenis
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External Link
TTD: D01CEQ
 Compound Name Autologous Anti-CD 123 CAR TCR/4-1BB-expressing T-lymphocytes Phase 0 [175]
External Link
TTD: D0H8UT
 Compound Name ATA2321 Preclinical [176]
External Link
TTD: DI2X8V
 Compound Name 2-D08 Preclinical [177]
Synonyms
144707-18-6; 2',3',4'-trihydroxyflavone; 2-(2,3,4-trihydroxyphenyl)-4H-1-benzopyran-4-one; 2-(2,3,4-Trihydroxyphenyl)-4H-chromen-4-one; SCHEMBL1772778; CHEMBL3115475; AOB4275; SYN5001; AMY31051; BCP18314; EX-A3562; MFCD27995567; s8696; ZINC97439024; CCG-267148; AC-31428; AK312791; AS-16368; HY-114166; 2D08;2 D08; CS-0077855; A16852; 2-(2,3,4-TRIHYDROXYPHENYL)CHROMEN-4-ONE
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External Link
CID: 22507438
TTD: D4UFT5
 Compound Name CAR-T cells targeting CD117 Preclinical [170]
External Link
TTD: D0TS2B
 Compound Name CAR-T cells targeting CD123 Preclinical [170]
External Link
TTD: D0N4VG
 Compound Name CAR-T cells targeting Mucl Preclinical [170]
External Link
TTD: D0JW9E
 Compound Name CAR-T cells targeting CD33 Preclinical [170]
External Link
TTD: D0JT0U
 Compound Name CAR-T cells targeting CD34 Preclinical [170]
External Link
TTD: D08ABX
 Compound Name CAR-T cells targeting CD133 Preclinical [170]
External Link
TTD: D04JSI
 Compound Name CEP-4186 Terminated [178]
Synonyms
CB-1093; CEP-3265; GS-1590; Neurotrophic compounds, Cephalon/LEO Pharma; Neurotrophic factors, Cephalon/LEO Pharma
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External Link
TTD: D0T9SJ
 Compound Name BI 7273 Investigative [179]
Synonyms
BI-7273; 1883429-21-7; CHEMBL3823478; 4-(4-((Dimethylamino)methyl)-3,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one; 4-[4-[(Dimethylamino)methyl]-3,5-Dimethoxy-Phenyl]-2-Methyl-2,7-Naphthyridin-1-One; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1-one; 4-{4-[(dimethylamino)methyl]-2,6-dimethoxyphenyl}-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one; 4-[4-[(dimethylamino)methyl]-3,5-dimethoxyphenyl]-2-methyl-2,7-naphthyridin-1(2H)-one; 5SW; BI7273; GTPL9146; SCHEMBL19869878; EX-A990; BCP17545; BDBM50183448; MFCD30489736; s8179; ZINC575448880; CCG-268068; CS-5887; HY-100351; J3.533.936A; A16068; Q27075221
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External Link
CID: 118796358
TTD: DVZ6M1
 Compound Name G3139 + cytarabine (ARA-C) Investigative [180]
External Link
CID: 91865905
TTD: D0XU9F
 Compound Name G3139 + Fludarabine Investigative [180]
External Link
CID: 91865905
TTD: D0LM3T
 Compound Name CG-1255 Investigative [181]
Synonyms
CG-1552; Histone deacetylase inhibitors, CircaGen
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External Link
TTD: D0J3QN
 Compound Name AC-501 Investigative [181]
External Link
TTD: D0E1UY
 Compound Name AKN-028 Investigative [182]
Synonyms
Flt3 tyrosine kinase inhibitor (AML), Akinion/Swedish Orphan Biovitrum/Karolinska
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External Link
CID: 44177328
TTD: D0D0TQ
DrugBank: DB12746
 Compound Name VLIM-88 Investigative [181]
External Link
TTD: D0B1TN
 Compound Name G3139 + G-CSF Investigative [180]
External Link
CID: 91865905
TTD: D0B0HK
 Compound Name Anti-CD44 mab Investigative [181]
Synonyms
Hyaloxan; MAT-102; AML therapy (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia (chimerized monoclonal antibody), MAT Biopharma; Acute myeloid leukemia therapy (chimerized monoclonal antibody), MAT Biopharma; Anti-CD44 mAb (AML); Anti-CD44 mAb (AML), MAT Biopharma; Anti-CD44 monoclonal antibody (acute myeloid leukemia), MAT Biopharma
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External Link
TTD: D0A9JA
 Compound Name SB-559457 Investigative [183]
External Link
TTD: D09WOY
 Compound Name COTI-001 Investigative [181]
Synonyms
COTI-002; COTI-003E; Protein tyrosine kinase inhibitors (AML); Protein tyrosine kinase inhibitors (AML), Critical Outcome Technologies
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External Link
TTD: D04BXH
 Compound Name Rebelex Investigative [181]
Synonyms
Spleen tyrosine kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals; Syk kinase inhibitor (siRNA/oligonucleotide, acute myelogenous leukemia), Biothorpe Pharmaceuticals
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External Link
TTD: D01UJS
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Ref 128 ClinicalTrials.gov (NCT04282668) A Study of TAS1440 With ATRA in Subjects With r/r AML. U.S. National Institutes of Health.
Ref 129 Clinical pipeline report, company report or official report of Roche
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Ref 131 ClinicalTrials.gov (NCT05712278) A Phase I, Single-arm, Open Label, Dose Escalation, Multicenter Study of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in Participants With Relapsed or Refractory Acute Myeloid Leukemia (R/R AML). U.S.National Institutes of Health.
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