m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00675
 [1], [2], [3], [4], [5], [6]
RNA modification H19 H19 NSUN2 Methylation : modification sites Indirect Enhancement m6A modification hsa-mir-19b-1 hsa-mir-19b-1 METTL3 Methylation : m6A sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa-mir-19b-1
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> 5-methylcytidine (m5C)
Epigenetic Regulator RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2) WRITER View Details
Regulated Target H19 imprinted maternally expressed transcript (H19) View Details
Crosstalk Relationship m5C  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-19b-1, which was regulated by METTL3-mediated m6A modification.
In-vitro Model
 Hep-G2 Hepatoblastoma Homo sapiens CVCL_0027
MKN45 Gastric adenocarcinoma Homo sapiens CVCL_0434
References
Ref 1 Aberrant NSUN2-mediated m(5)C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma. Oncogene. 2020 Nov;39(45):6906-6919. doi: 10.1038/s41388-020-01475-w. Epub 2020 Sep 25.
Ref 2 N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w.
Ref 3 LncRNA H19 inhibits high glucose-induced inflammatory responses of human retinal epithelial cells by targeting miR-19b to increase SIRT1 expression. Kaohsiung J Med Sci. 2021 Feb;37(2):101-110. doi: 10.1002/kjm2.12302. Epub 2020 Oct 6.
Ref 4 PFOS-induced placental cell growth inhibition is partially mediated by lncRNA H19 through interacting with miR-19a and miR-19b. Chemosphere. 2020 Dec;261:127640. doi: 10.1016/j.chemosphere.2020.127640. Epub 2020 Jul 13.
Ref 5 Adipose mesenchymal stem cell-derived exosomes accelerate skin wound healing via the lncRNA H19/miR-19b/SOX9 axis. Lab Invest. 2021 Sep;101(9):1254-1266. doi: 10.1038/s41374-021-00611-8. Epub 2021 May 27.
Ref 6 lncRNA H19 acts as a ceRNA to regulate the expression of CTGF by targeting miR-19b in polycystic ovary syndrome. Braz J Med Biol Res. 2020 Oct 7;53(11):e9266. doi: 10.1590/1414-431X20209266. eCollection 2020.