m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00674				[1], [2], [3]
RNA modification H19 H19 NSUN2 Methylation : modification sites Indirect Enhancement m⁶A modification hsa-mir-19a hsa-mir-19a METTL3 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	hsa-mir-19a				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2)			WRITER	View Details
Regulated Target	H19 imprinted maternally expressed transcript (H19)				View Details
Crosstalk Relationship	m5C → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-19a, which was regulated by METTL3-mediated m6A modification.
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
In-vitro Model	MKN45	Gastric adenocarcinoma	Homo sapiens		CVCL_0434

References

Ref 1	Aberrant NSUN2-mediated m(5)C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma. Oncogene. 2020 Nov;39(45):6906-6919. doi: 10.1038/s41388-020-01475-w. Epub 2020 Sep 25.
Ref 2	N(6)-methyladenosine-dependent pri-miR-17-92 maturation suppresses PTEN/TMEM127 and promotes sensitivity to everolimus in gastric cancer. Cell Death Dis. 2020 Oct 9;11(10):836. doi: 10.1038/s41419-020-03049-w.
Ref 3	Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury. Aging (Albany NY). 2019 Jun 5;11(11):3585-3600. doi: 10.18632/aging.101999.