m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00650
 [1], [2], [3], [4]
m6A modification MIR221 MIR221 METTL3 Methylation : m6A sites Indirect Enhancement RNA modification FOS FOS FTO Demethylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target microRNA 221 (MIR221)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator Fat mass and obesity-associated protein (FTO) ERASER View Details
Regulated Target Protein c-Fos (FOS) View Details
Crosstalk Relationship m6A  →  m6Am Enhancement
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary METTL3 interacts with microRNA 221 (MIR221), decreasing its m6A level and promoting its physical interaction with Protein c-Fos (FOS), which was regulated by FTO-mediated m6Am modification.
In-vitro Model
 COV434 Ovarian small cell carcinoma, hypercalcemic type Homo sapiens CVCL_2010
KGN Ovarian granulosa cell tumor Homo sapiens CVCL_0375
T24 Bladder carcinoma Homo sapiens CVCL_0554
Ej138 Bladder carcinoma Homo sapiens CVCL_2443
MCF-7 Invasive breast carcinoma Homo sapiens CVCL_0031
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Protein c-Fos (FOS) 1 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ISIS 10639 Investigative [5]
External Link
TTD: D0Z2OW
References
Ref 1 The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging. Cell Death Dis. 2021 Jul 27;12(8):744. doi: 10.1038/s41419-021-04016-9.
Ref 2 METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. Mol Cancer. 2019 Jun 22;18(1):110. doi: 10.1186/s12943-019-1036-9.
Ref 3 METTL3 promotes adriamycin resistance in MCF-7 breast cancer cells by accelerating pri-microRNA-221-3p maturation in a m6A-dependent manner. Exp Mol Med. 2021 Jan;53(1):91-102. doi: 10.1038/s12276-020-00510-w. Epub 2021 Jan 8.
Ref 4 Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS. J Cell Physiol. 2019 Nov;234(11):21113-21125. doi: 10.1002/jcp.28714. Epub 2019 May 12.
Ref 5 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.