m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00635				[1], [2], [3]
RNA modification H19 H19 NSUN2 Methylation : modification sites Indirect Enhancement m⁶A modification MIR22 MIR22 FTO Demethylation : m⁶A sites
m6A Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	Regulator Info
m6A Target	hsa-mir-22				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	RNA cytosine C(5)-methyltransferase NSUN2 (NSUN2)			WRITER	View Details
Regulated Target	H19 imprinted maternally expressed transcript (H19)				View Details
Crosstalk Relationship	m5C → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	NSUN2 interacts with H19 imprinted maternally expressed transcript (H19), increasing its m5C level and promoting its physical interaction with hsa-mir-22, which was regulated by FTO-mediated m6A modification.
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
In-vitro Model	HEK293	Normal	Homo sapiens		CVCL_0045

References

Ref 1	Aberrant NSUN2-mediated m(5)C modification of H19 lncRNA is associated with poor differentiation of hepatocellular carcinoma. Oncogene. 2020 Nov;39(45):6906-6919. doi: 10.1038/s41388-020-01475-w. Epub 2020 Sep 25.
Ref 2	N6-adenosine methylation in MiRNAs. PLoS One. 2015 Feb 27;10(2):e0118438. doi: 10.1371/journal.pone.0118438. eCollection 2015.
Ref 3	Long non?coding RNA H19 regulates cell growth and metastasis via the miR?22?3p/Snail1 axis in gastric cancer. Int J Oncol. 2019 Jun;54(6):2157-2168. doi: 10.3892/ijo.2019.4773. Epub 2019 Apr 4.