m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00634
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Enhancement
RNA modification
SNAI1
SNAI1
YBX1
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | hsa-mir-22 | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> 5-methylcytidine (m5C) | ||||
| Epigenetic Regulator | Y-box-binding protein 1 (YBX1) | READER | View Details | ||
| Regulated Target | Zinc finger protein SNAI1 (SNAI1) | View Details | |||
| Crosstalk Relationship | m6A → m5C | Enhancement | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | FTO interacts with hsa-mir-22, reading its m6A level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YBX1-mediated m5C modification. | ||||
In-vitro Model |
MDA-MB-435S | Amelanotic melanoma | Homo sapiens | CVCL_0622 | |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens | CVCL_0062 | ||
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | ||
| HEK293 | Normal | Homo sapiens | CVCL_0045 | ||
References