m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00627
 [1], [2], [3]
m6A modification MIR126 MIR126 METTL14 Methylation : m6A sites Indirect Enhancement RNA modification CXCR4 CXCR4 FTO Demethylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 14 (METTL14) WRITER
 Regulator Info 
m6A Target microRNA 126 (MIR126)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator Fat mass and obesity-associated protein (FTO) ERASER View Details
Regulated Target C-X-C chemokine receptor type 4 (CXCR4) View Details
Crosstalk Relationship m6A  →  m6Am Enhancement
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary METTL14 interacts with microRNA 126 (MIR126), decreasing its m6A level and promoting its physical interaction with C-X-C chemokine receptor type 4 (CXCR4), which was regulated by FTO-mediated m6Am modification.
In-vitro Model
 624-mel Melanoma Homo sapiens CVCL_8054
Hep 3B2.1-7 Childhood hepatocellular carcinoma Homo sapiens CVCL_0326
SMMC-7721 Endocervical adenocarcinoma Homo sapiens CVCL_0534
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
C-X-C chemokine receptor type 4 (CXCR4) 61 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name Plerixafor Approved [4]
Synonyms
Mozobil; AMD3100; Amd 3100; JM 2987; JM 3100; JM3100; SDZ SID 791; SID791; AMD-3100; Bicyclam JM-2987; JM-3100; Mozobil (TN); GNA & AMD-3100; HHA & AMD-3100; Plerixafor (INN/USAN); 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane]; 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] & Galanthus nivalis agglutinin (GNA); 1,1'-[1,4-Phenylenebis(methylene)]bis[1,4,8,11-tetraazacyclotetradecane] & Hippeastrum hybrid agglutinin(HHA); 1,1'-{1,4-phenylenebis(methylene)}-bis{1,4,8,11-tetraaza-cyclotetradecane}; 1-[[4-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane
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MOA Antagonist
Activity IC50 = 0.057 ug.mL-1
External Link
CID: 65015
TTD: D0L5RW
DrugBank: DB06809
 Compound Name Motixafortide Approved [5]
MOA Antagonist
External Link
CID: 91865076
TTD: D0T6CN
DrugBank: DB14939
 Compound Name Ulocuplumab Phase 3 [6]
MOA Antagonist
External Link
TTD: D0C3LQ
 Compound Name Balixafortide Phase 3 [7]
Synonyms
1051366-32-5; Balixafortide [INN]; UNII-PRC974M49B; PRC974M49B; Ala-cys-ser-ala-pro-arg-tyr-cys-tyr-gln-lys-pro-pro-tyr-his cyclic (2->9)-disulfide; Cyclo(L-alanyl-L-cysteinyl-L-seryl-L-alanyl-D-prolyl-(2S)-2,4-diaminobutanoyl-L-arginyl-L-tyrosyl-L-cysteinyl-L-tyrosyl-L-glutaminyl-L-lysyl-D-prolyl-L-prolyl-L-tyrosyl-L-histidyl), cyclic (2->9)-disulfide
    Click to Show/Hide
MOA Antagonist
External Link
CID: 91864511
TTD: D0GG9P
 Compound Name AMD-070 Phase 3 [8]
Synonyms
AMD 070; AMD070; AMD11070; S14-0353; N-(1H-benzoimidazol-2-ylmethyl)-N-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine; N'-(1H-Benzo[d]imidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine Trihydrobromide Dihydrate
    Click to Show/Hide
MOA Antagonist
Activity IC50 = 13 nM
External Link
CID: 11256587
TTD: D0O2XQ
DrugBank: DB05501
 Compound Name TG-0054 Phase 2 [9]
Synonyms
CXCR4 binding inhibitor/cell mobilizer (iv, stem cell transplant), TaiGen Biotechnology
    Click to Show/Hide
MOA Inhibitor
External Link
CID: 44479007
TTD: D06KGI
DrugBank: DB11970
 Compound Name POL-6326 Phase 2 [10]
Synonyms
CXCR4 antagonists, Polyphor; POL-2438; POL-3026; Epitope mimetics (HIV fusion), Polyphor; CXCR4 antagonists (cancer/HIV), Polyphor
    Click to Show/Hide
MOA Antagonist
External Link
TTD: D0FV8P
 Compound Name CTCE-9908 Phase 1/2 [11]
Synonyms
Anticancer therapy, Chemokine Therapeutics; CTCE-9908/0019
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MOA Modulator
External Link
CID: 16186350
TTD: D01TJM
 Compound Name USL311 Phase 1/2 [12]
Synonyms
Usl-311; UNII-2BTG5MX2Q2; 2BTG5MX2Q2; SCHEMBL15347153; 2-Pyridinecarboxamide, 6-(hexahydro-4-(1-(1-methylethyl)-4-piperidinyl)-1H-1,4-diazepin-1-yl)-N-4-pyridinyl-; 1373268-67-7
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MOA Antagonist
External Link
CID: 56961879
TTD: D08XQV
DrugBank: DB15265
 Compound Name ALX-0651 Phase 1 [13]
Synonyms
Anti-CXCR4 nanobodies (cancer), Ablynx
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MOA Inhibitor
External Link
TTD: D09MPD
 Compound Name CTCE-0214 Phase 1 [14]
Synonyms
CTCE-0013; CTCE-0021; CXCR4 agonists, Chemokine Therapeutics; Stem cell transplant therapy, Chemokine Therapeutics
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MOA Agonist
External Link
TTD: D0AZ3Y
 Compound Name MSX-122 Phase 1 [15]
MOA Antagonist
External Link
CID: 11687907
TTD: D0E5JC
DrugBank: DB12715
 Compound Name PF-06747143 Phase 1 [6]
MOA Antagonist
External Link
TTD: D0LC5L
 Compound Name BMS-936564 Phase 1 [16]
MOA Modulator
External Link
TTD: D0Z8JR
 Compound Name LY2624587 Phase 1 [17]
MOA Antagonist
External Link
TTD: D3KZ6M
 Compound Name GMI-1359 Phase 1 [18]
MOA Antagonist
External Link
TTD: DBDW09
 Compound Name Garnocestim Discontinued in Phase 1 [19]
Synonyms
SB-251353
    Click to Show/Hide
MOA Modulator
External Link
TTD: D0H5KK
 Compound Name SURADISTA Discontinued in Phase 1 [20]
Synonyms
PNU-145156E; FCE-26644 (formerly); PNU-151484 (Na salt); 7,7'-[Carbonylbis[imino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino(1-methyl-1H-pyrrole-4,2-diyl)carbonylimino]]bis-1,3-naphthalenedisulfonic acid tetrapotassium salt; 7,7-Ureylene-bis(1-methyl-4,2-pyrrolecarboxamido)bis(1-methyl-4,2-pyrrolecarboxamido)bis(1,3-naphthalenedisulfonic acid) tetrapotassium salt
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MOA Modulator
External Link
TTD: D0I4OX
 Compound Name MAb173 Preclinical [21]
MOA Antagonist
External Link
TTD: D2NU0H
 Compound Name KRH-2731 Terminated [22]
MOA Binder
External Link
TTD: D00FJS
 Compound Name Cyclo(-D-Tyr-L-Arg-L-MeArg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL436536
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MOA Inhibitor
Activity IC50 = 99 nM
External Link
CID: 44418888
TTD: D00GII
 Compound Name Cyclo(-D-MeTyr-D-Arg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL375993
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MOA Inhibitor
Activity IC50 = 157 nM
External Link
CID: 44418891
TTD: D00XBM
 Compound Name Cyclo(-D-Tyr-D-MeArg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL218806
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MOA Inhibitor
Activity IC50 = 3 nM
External Link
CID: 44418892
TTD: D02UES
 Compound Name GSK-812397 Investigative [24]
Synonyms
CXCR4 receptor antagonists (HIV-1 infection); CXCR4 receptor antagonists (HIV-1 infection), GlaxoSmithKline
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MOA Antagonist
Activity IC50 = 0.87 nM
External Link
CID: 11718722
TTD: D03QJA
 Compound Name AT-009 Investigative [24]
MOA Antagonist
External Link
TTD: D04ATE
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-MeNal-Gly-) Investigative [23]
Synonyms
CHEMBL426169
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 563 nM
External Link
CID: 44418894
TTD: D04BVW
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-) Investigative [23]
Synonyms
CHEMBL387120
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 170 nM
External Link
CID: 44418872
TTD: D04PDF
 Compound Name Cyclo(-D-Tyr-L-MeArg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL374421
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 23 nM
External Link
CID: 44418887
TTD: D04TED
 Compound Name Cyclo(-D-Tyr-Arg-Arg-Nal-Gly-) Investigative [25]
Synonyms
Fc-131; FC131; CHEMBL436283; FC 131; 606968-52-9; CHEMBL2180076; AC1NQNK6; SCHEMBL15987252; ZINC3925712; Cyclo(-Nal-Gly-D-Tyr-Arg-Arg-); BDBM50399002; BDBM50166106; KB-272560; B7647; N-{3-[(2S,5S,8S,14R)-5-(3-Guanidino-propyl)-14-(4-hydroxy-benzyl)-8-naphthalen-2-ylmethyl-3,6,9,12,15-pentaoxo-1,4,7,10,13pentaaza-cyclopentadec-2-yl]-propyl}-guanidine
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MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 5275843
TTD: D04TIO
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-beta-Ala-) Investigative [23]
Synonyms
CHEMBL219135
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MOA Inhibitor
Activity IC50 = 350 nM
External Link
CID: 44418885
TTD: D04XHX
 Compound Name KUR-CXCR4 Investigative [24]
MOA Modulator
External Link
TTD: D05IXH
 Compound Name isothiourea-1t Investigative [26]
Synonyms
IT1t
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MOA Antagonist
Activity IC50 = 8 nM
External Link
CID: 25147749
TTD: D05VQJ
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Sar-) Investigative [23]
Synonyms
CHEMBL374862
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MOA Inhibitor
Activity IC50 = 256 nM
External Link
CID: 44418895
TTD: D05YHT
 Compound Name CX-02 Investigative [24]
Synonyms
CX-05; CXCR4 monoclonal antibodies (cancer); CXCR4 monoclonal antibodies (cancer), Northwest Biotherapeutics; CXCR4 therapeutics (cancer), Northwest Biotherapeutics
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External Link
TTD: D06EBJ
 Compound Name isothiourea-1a Investigative [26]
Synonyms
IT1a
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MOA Antagonist
Activity IC50 = 11 nM
External Link
CID: 11176403
TTD: D06MBD
 Compound Name ND-401 Investigative [24]
Synonyms
ND-4019; CCR5 and CXCR4 inhibitors (HIV infection), NeED Pharmaceuticals
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MOA Inhibitor
External Link
TTD: D07IZP
 Compound Name CXCR4 gene disrupted T cells Investigative [24]
Synonyms
CXCR4 gene disrupted T cells (HIV infection)
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MOA Modulator
External Link
TTD: D07VDF
 Compound Name T134 Investigative [27]
Synonyms
GTPL852
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MOA Antagonist
External Link
CID: 16197445
TTD: D08NJD
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-Ala-Sar-) Investigative [23]
Synonyms
CHEMBL219075
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MOA Inhibitor
Activity IC50 = 167 nM
External Link
CID: 44418890
TTD: D08XRM
 Compound Name Cyclo(-D-Tyr-D-Arg-L-MeArg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL376219
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MOA Inhibitor
Activity IC50 = 21 nM
External Link
CID: 44418893
TTD: D08YYV
 Compound Name ATI-2341 Investigative [24]
Synonyms
ATI-2346; ATI-2756; ATI-2766; CXCR4 agonists (cancer/bone marrow transplantation), Ascent; Pepducins (cancer/bone marrow transplantation), Ascent
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MOA Agonist
External Link
CID: 121513892
TTD: D0A7GH
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-MeNal-Gly-) Investigative [23]
Synonyms
CHEMBL375850
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 250 nM
External Link
CID: 44418889
TTD: D0B8VW
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Ala-) Investigative [23]
Synonyms
CHEMBL376811
    Click to Show/Hide
MOA Inhibitor
Activity IC50 = 92 nM
External Link
CID: 44418879
TTD: D0BH8K
 Compound Name Cyclo(-D-Tyr-D-Ala-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL384429
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MOA Inhibitor
Activity IC50 = 230 nM
External Link
CID: 44418869
TTD: D0FQ3G
 Compound Name T140 Investigative [27]
Synonyms
[L-3-(2-naphthyl)-alanine3]-T134
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MOA Antagonist
External Link
CID: 16130395
TTD: D0I6AN
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-D-Ala-) Investigative [23]
Synonyms
CHEMBL373636
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MOA Inhibitor
Activity IC50 = 11 nM
External Link
CID: 44418880
TTD: D0K0SO
 Compound Name Cyclo(-D-Ala-D-Arg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL373440
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MOA Inhibitor
Activity IC50 = 130 nM
External Link
CID: 44418868
TTD: D0K9KQ
 Compound Name CTCE-0324 Investigative [24]
Synonyms
Vascular disease therapeutic, Chemokine Therapeutics
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MOA Modulator
External Link
TTD: D0L3GH
 Compound Name Cyclo(-D-Tyr-L-Ala-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL374108
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MOA Inhibitor
Activity IC50 = 63 nM
External Link
CID: 44418865
TTD: D0M6RQ
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-beta-Ala-) Investigative [23]
Synonyms
CHEMBL375991
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MOA Inhibitor
Activity IC50 = 47 nM
External Link
CID: 44418878
TTD: D0P7UV
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL219474
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MOA Inhibitor
Activity IC50 = 4 nM
External Link
CID: 11158428
TTD: D0Q3MM
 Compound Name LP-0067 Investigative [24]
Synonyms
CXCR4 antagonists (autoimmune disease); CXCR4 antagonists (autoimmune disease), Leo Pharma
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MOA Antagonist
External Link
TTD: D0Q7XS
 Compound Name NB-325 Investigative [24]
Synonyms
PEHMB; Polyethylene hexamethylene biguanide
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MOA Modulator
External Link
CID: 15954275
TTD: D0R4WT
 Compound Name Cyclo(-D-MeTyr-L-Arg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL219096
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MOA Inhibitor
Activity IC50 = 128 nM
External Link
CID: 44418886
TTD: D0S0GV
 Compound Name Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-D-Ala-) Investigative [23]
Synonyms
CHEMBL375990
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MOA Inhibitor
Activity IC50 = 11 nM
External Link
CID: 44418873
TTD: D0S0PU
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-L-Pic-) Investigative [23]
Synonyms
CHEMBL373637
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MOA Inhibitor
Activity IC50 = 640 nM
External Link
CID: 44418883
TTD: D0ST1U
 Compound Name T22 Investigative [27]
Synonyms
[Tyr5,12,Lys7]-polyphemusin II
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MOA Antagonist
External Link
CID: 16197316
TTD: D0TL6C
 Compound Name TN-14003 Investigative [28]
Synonyms
UNII-1TW3FT746I; 1TW3FT746I; TN14003; BDBM194584; US9205085, MSX-207; H-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-DLys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2; L-Argininamide, L-arginyl-L-arginyl-3-(2-naphthalenyl)-L-alanyl-L-cysteinyl-L-tyrosyl-N5-(aminocarbonyl)-L-ornithyl-L-lysyl-D-lysyl-L-prolyl-L-tyrosyl-L-arginyl-N5-(aminocarbonyl)-L-ornithyl-L-cysteinyl-, cyclic (4->13)-disulfide
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MOA Inhibitor
External Link
CID: 16130647
TTD: D0Y3OX
 Compound Name Cyclo(-D-Tyr-D-Arg-L-Arg-L-Nal-Gly-) Investigative [23]
Synonyms
CHEMBL219339
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MOA Inhibitor
Activity IC50 = 8 nM
External Link
CID: 11331592
TTD: D0ZO3C
 Compound Name CXCL8 Investigative [29]
Synonyms
Interleukin-8; CHEMBL411250; IL-8
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MOA Agonist
External Link
CID: 74974005
TTD: D07PHS
 Compound Name viral macrophage inflammatory protein-II Investigative [30]
Synonyms
CFLTKRGRQVC; vMIP-II; AC1LAF0N; GTPL768; vMIP-II (RESIDUE 41-51, CYCLIC); (4R,7S,10S,13S,19S,22S,25S,28S,31S,34R)-34-amino-22-(4-aminobutyl)-10-(3-amino-3-oxopropyl)-31-benzyl-13,19-bis[3-(diaminomethylideneamino)propyl]-25-[(1R)-1-hydroxyethyl]-28-(2-methylpropyl)-6,9,12,15,18,21,24,27,30,33-decaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29,32-decazacyclopentatriacontane-4-carboxylic acid
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MOA Antagonist
External Link
CID: 486830
TTD: D09PZD
References
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Ref 3 lncRNA HOTAIR promotes gastric cancer proliferation and metastasis via targeting miR-126 to active CXCR4 and RhoA signaling pathway. Cancer Med. 2019 Nov;8(15):6768-6779. doi: 10.1002/cam4.1302. Epub 2019 Sep 13.
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Ref 8 Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65. doi: 10.1097/QAI.0b013e3181627566.
Ref 9 CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28. doi: 10.3727/096368914X681739. Epub 2014 May 12.
Ref 10 CXCR4 inhibitors: tumor vasculature and therapeutic challenges. Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):251-64. doi: 10.2174/157489212801820039.
Ref 11 A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6. doi: 10.1016/j.jss.2008.06.044. Epub 2008 Aug 9.
Ref 12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
Ref 13 Therapeutic antibodies directed at G protein-coupled receptors. MAbs. 2010 Nov-Dec; 2(6): 594-606.
Ref 14 Beneficial effect of a CXCR4 agonist in murine models of systemic inflammation. Inflammation. 2012 Feb;35(1):130-7. doi: 10.1007/s10753-011-9297-5.
Ref 15 Comparative evaluation of CC chemokine-induced migration of murine CD8alpha+ and CD8alpha- dendritic cells and their in vivo trafficking. J Leukoc Biol. 2004 Feb;75(2):275-85. doi: 10.1189/jlb.1202613. Epub 2003 Nov 3.
Ref 16 BMS-936564/MDX-1338: a fully human anti-CXCR4 antibody induces apoptosis in vitro and shows antitumor activity in vivo in hematologic malignancies. Clin Cancer Res. 2013 Jan 15;19(2):357-66. doi: 10.1158/1078-0432.CCR-12-2333. Epub 2012 Dec 4.
Ref 17 Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies. PLoS One. 2016 Mar 8;11(3):e0150585. doi: 10.1371/journal.pone.0150585. eCollection 2016.
Ref 18 Clinical pipeline report, company report or official report of GlycoMimetics.
Ref 19 CN patent application no. 101094684, With the combination of chemokine activation progenitor cells/stem cells.
Ref 20 Suradista NSC 651016 inhibits the angiogenic activity of CXCL12-stromal cell-derived factor 1alpha. Clin Cancer Res. 2002 Dec;8(12):3955-60.
Ref 21 Caspase-dependent apoptosis of cells expressing the chemokine receptor CXCR4 is induced by cell membrane-associated human immunodeficiency virus type 1 envelope glycoprotein (gp120). Virology. 2000 Mar 15;268(2):329-44. doi: 10.1006/viro.1999.0151.
Ref 22 Progress in targeting HIV-1 entry. Drug Discov Today. 2005 Aug 15;10(16):1085-94. doi: 10.1016/S1359-6446(05)03550-6.
Ref 23 Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities. J Med Chem. 2007 Jan 25;50(2):192-8. doi: 10.1021/jm0607350.
Ref 24 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 71).
Ref 25 Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4124-9. doi: 10.1016/j.bmcl.2008.05.092. Epub 2008 May 29.
Ref 26 Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivo. J Med Chem. 2008 Dec 25;51(24):7915-20. doi: 10.1021/jm801065q.
Ref 27 A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140. Biochem Biophys Res Commun. 1998 Dec 30;253(3):877-82. doi: 10.1006/bbrc.1998.9871.
Ref 28 Discovery of small molecule CXCR4 antagonists. J Med Chem. 2007 Nov 15;50(23):5655-64. doi: 10.1021/jm070679i. Epub 2007 Oct 24.
Ref 29 Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11791-6. doi: 10.1073/pnas.0402090101. Epub 2004 Jul 28.
Ref 30 A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science. 1997 Sep 12;277(5332):1656-9. doi: 10.1126/science.277.5332.1656.