Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00162)
Target Name C-X-C chemokine receptor type 4 (CXCR4)
Gene Name CXCR4
Sequence
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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Family G-protein coupled receptor 1 family
Function
Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation . Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival (By similarity). (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) for human immunodeficiency virus-1/HIV-1 X4 isolates and as a primary receptor for some HIV-2 isolates. Promotes Env-mediated fusion of the virus.
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Gene ID 7852
HGNC ID HGNC:2561
Ensembl Gene ID ENSG00000121966
KEGG ID hsa:7852
Chromosomal Location 2q22.1
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00162)
C-X-C chemokine receptor type 4 (CXCR4)
N6-methyladenosine (m6A)
In total 30 m6A sequence/site(s) in this target gene
mod ID: M6ASITE047624 Click to Show/Hide the Full List
mod site chr2:136114352-136114353:- [1]
Sequence TTAATAAAAGTACATGTTAAACTTACTTAGTGTTATGTTCT
Motif Score 2.627720238
Cell/Tissue List HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494530
mod ID: M6ASITE047625 Click to Show/Hide the Full List
mod site chr2:136114473-136114474:- [2]
Sequence ATTTTGCTGTAGAAGATGGCACTTATAACCAAAGCCCAAAG
Motif Score 3.252583333
Cell/Tissue List HEK293T
Seq Type List DART-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494531
mod ID: M6ASITE047626 Click to Show/Hide the Full List
mod site chr2:136114603-136114604:- [3]
Sequence ACTGTAGAAAAGGGAACTGAACATTCCAGAGCGTGTAGTGA
Motif Score 2.951386905
Cell/Tissue List CD34; kidney; hESC-HEK293T; HeLa
Seq Type List m6A-seq; m6A-REF-seq; MAZTER-seq
Transcript ID List ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494532
mod ID: M6ASITE047627 Click to Show/Hide the Full List
mod site chr2:136114608-136114609:- [3]
Sequence GTAGGACTGTAGAAAAGGGAACTGAACATTCCAGAGCGTGT
Motif Score 3.373380952
Cell/Tissue List CD34; HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494533
mod ID: M6ASITE047628 Click to Show/Hide the Full List
mod site chr2:136114623-136114624:- [3]
Sequence GCTGTATGTCTCGTGGTAGGACTGTAGAAAAGGGAACTGAA
Motif Score 4.065041667
Cell/Tissue List CD34; HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494534
mod ID: M6ASITE047629 Click to Show/Hide the Full List
mod site chr2:136114665-136114666:- [3]
Sequence TTGATGTGTGTCTAGGCAGGACCTGTGGCCAAGTTCTTAGT
Motif Score 3.622404762
Cell/Tissue List CD34; HeLa
Seq Type List m6A-seq
Transcript ID List ENST00000466288.1; ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494535
mod ID: M6ASITE047630 Click to Show/Hide the Full List
mod site chr2:136114794-136114795:- [3]
Sequence ACATTTTTCAGATATAAAAGACTGACCAATATTGTACAGTT
Motif Score 3.319380952
Cell/Tissue List CD34; HEK293T; HeLa; GM12878; CD8T
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000466288.1; ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494536
mod ID: M6ASITE047631 Click to Show/Hide the Full List
mod site chr2:136114831-136114832:- [4]
Sequence TTTTTTTTATACGATAAATAACTTTTTTTTAAGTTACACAT
Motif Score 2.590089286
Cell/Tissue List CD8T
Seq Type List m6A-CLIP/IP
Transcript ID List ENST00000241393.3; ENST00000466288.1; ENST00000409817.1
External Link RMBase: m6A_site_494537
mod ID: M6ASITE047632 Click to Show/Hide the Full List
mod site chr2:136114853-136114854:- [1]
Sequence AGCTAACACAGATGTAAAAGACTTTTTTTTATACGATAAAT
Motif Score 3.319380952
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; GM12878; LCLs; CD8T; Huh7; Jurkat; TIME
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP
Transcript ID List ENST00000241393.3; ENST00000466288.1; ENST00000409817.1
External Link RMBase: m6A_site_494538
mod ID: M6ASITE047633 Click to Show/Hide the Full List
mod site chr2:136114868-136114869:- [5]
Sequence TCAAGTTTTCACTCCAGCTAACACAGATGTAAAAGACTTTT
Motif Score 2.168095238
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1; ENST00000466288.1
External Link RMBase: m6A_site_494539
mod ID: M6ASITE047634 Click to Show/Hide the Full List
mod site chr2:136114919-136114920:- [1]
Sequence TCCAAAGGAAAGCGAGGTGGACATTCATCTGTTTCCACTGA
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; HEK293T; A549; hESC-HEK293T; HepG2; hNPCs; GM12878; LCLs; Huh7; Jurkat; TIME; AML
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List ENST00000409817.1; ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494540
mod ID: M6ASITE047635 Click to Show/Hide the Full List
mod site chr2:136114996-136114997:- [1]
Sequence TCCTTGGAGCCAAATTTAAAACCTCTGCCCAGCACGCACTC
Motif Score 2.185083333
Cell/Tissue List HeLa; CD34; HEK293T; HepG2; hNPCs; GM12878; LCLs; Huh7; Jurkat; HEK293A-TOA; TIME; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000466288.1; ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494541
mod ID: M6ASITE047636 Click to Show/Hide the Full List
mod site chr2:136115034-136115035:- [1]
Sequence TTTCTTCCACTGTTGTCTGAACCCCATCCTCTATGCTTTCC
Motif Score 2.930744048
Cell/Tissue List HeLa; CD34; HEK293T; HepG2; hNPCs; GM12878; LCLs; Huh7; HEK293A-TOA; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000466288.1; ENST00000409817.1; ENST00000241393.3
External Link RMBase: m6A_site_494542
mod ID: M6ASITE047637 Click to Show/Hide the Full List
mod site chr2:136115094-136115095:- [1]
Sequence GCAAGGGTGTGAGTTTGAGAACACTGTGCACAAGTGGATTT
Motif Score 2.951386905
Cell/Tissue List HeLa; CD34; HEK293T; hESC-HEK293T; HepG2; GM12878; LCLs; CD8T; Huh7; TIME
Seq Type List m6A-seq; MeRIP-seq; m6A-REF-seq; MAZTER-seq; m6A-CLIP/IP
Transcript ID List ENST00000241393.3; ENST00000409817.1; ENST00000466288.1
External Link RMBase: m6A_site_494543
mod ID: M6ASITE047638 Click to Show/Hide the Full List
mod site chr2:136115160-136115161:- [5]
Sequence CGCCTGTTGGCTGCCTTACTACATTGGGATCAGCATCGACT
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000466288.1; ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494544
mod ID: M6ASITE047639 Click to Show/Hide the Full List
mod site chr2:136115209-136115210:- [1]
Sequence AGAAGCGCAAGGCCCTCAAGACCACAGTCATCCTCATCCTG
Motif Score 2.876744048
Cell/Tissue List HeLa; CD34; HEK293T; HepG2; GM12878; LCLs; Huh7; TIME
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1; ENST00000466288.1
External Link RMBase: m6A_site_494545
mod ID: M6ASITE047640 Click to Show/Hide the Full List
mod site chr2:136115246-136115247:- [5]
Sequence ATTATCATCTCCAAGCTGTCACACTCCAAGGGCCACCAGAA
Motif Score 2.047297619
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000241393.3; ENST00000466288.1; ENST00000409817.1
External Link RMBase: m6A_site_494546
mod ID: M6ASITE047641 Click to Show/Hide the Full List
mod site chr2:136115349-136115350:- [4]
Sequence TGACCGCTTCTACCCCAATGACTTGTGGGTGGTTGTGTTCC
Motif Score 3.28175
Cell/Tissue List CD8T; AML
Seq Type List m6A-CLIP/IP; miCLIP
Transcript ID List ENST00000409817.1; ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494547
mod ID: M6ASITE047642 Click to Show/Hide the Full List
mod site chr2:136115529-136115530:- [1]
Sequence CCTGGCCTTCATCAGTCTGGACCGCTACCTGGCCATCGTCC
Motif Score 3.622404762
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; H1A; H1B; hESCs; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000466288.1; ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494548
mod ID: M6ASITE047643 Click to Show/Hide the Full List
mod site chr2:136115610-136115611:- [1]
Sequence GGCAAACTGGTACTTTGGGAACTTCCTATGCAAGGCAGTCC
Motif Score 3.373380952
Cell/Tissue List HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; GM12878; LCLs; CD8T; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List ENST00000241393.3; ENST00000466288.1; ENST00000409817.1
External Link RMBase: m6A_site_494549
mod ID: M6ASITE047644 Click to Show/Hide the Full List
mod site chr2:136115625-136115626:- [1]
Sequence GGCAGTTGATGCCGTGGCAAACTGGTACTTTGGGAACTTCC
Motif Score 2.627720238
Cell/Tissue List HeLa; CD34; HepG2; HEK293T; A549; H1A; H1B; hNPCs; hESCs; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1; ENST00000466288.1
External Link RMBase: m6A_site_494550
mod ID: M6ASITE047645 Click to Show/Hide the Full List
mod site chr2:136115706-136115707:- [1]
Sequence GAAACTGAGAAGCATGACGGACAAGTACAGGCTGCACCTGT
Motif Score 3.643047619
Cell/Tissue List HeLa; CD34; HEK293T; A549; hESC-HEK293T; HepG2; H1B; H1A; hNPCs; hESCs; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; HEC-1-A; GSCs; NB4; AML
Seq Type List m6A-seq; MeRIP-seq; MAZTER-seq; miCLIP
Transcript ID List ENST00000409817.1; ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494551
mod ID: M6ASITE047646 Click to Show/Hide the Full List
mod site chr2:136115723-136115724:- [1]
Sequence GTCATGGGTTACCAGAAGAAACTGAGAAGCATGACGGACAA
Motif Score 2.627720238
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; H1A; H1B; hNPCs; GM12878; LCLs; MM6; Huh7; Jurkat; CD4T; peripheral-blood; GSC-11; HEK293A-TOA; TIME; TREX; endometrial; NB4; AML
Seq Type List m6A-seq; MeRIP-seq; miCLIP
Transcript ID List ENST00000409817.1; ENST00000241393.3; ENST00000466288.1
External Link RMBase: m6A_site_494552
mod ID: M6ASITE047647 Click to Show/Hide the Full List
mod site chr2:136115849-136115850:- [1]
Sequence GACTATGACTCCATGAAGGAACCCTGTTTCCGTGAAGAAAA
Motif Score 2.930744048
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; hNPCs; GM12878; LCLs; MT4; MM6; Huh7; Jurkat; CD4T; HEK293A-TOA; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000241393.3; ENST00000409817.1; ENST00000466288.1
External Link RMBase: m6A_site_494553
mod ID: M6ASITE047648 Click to Show/Hide the Full List
mod site chr2:136115868-136115869:- [1]
Sequence CGAGGAAATGGGCTCAGGGGACTATGACTCCATGAAGGAAC
Motif Score 4.065041667
Cell/Tissue List HeLa; CD34; HEK293T; A549; HepG2; hNPCs; GM12878; LCLs; CD8T; MT4; MM6; Jurkat; CD4T; HEK293A-TOA; TIME; TREX; AML
Seq Type List m6A-seq; MeRIP-seq; m6A-CLIP/IP; miCLIP
Transcript ID List ENST00000409817.1; ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494554
mod ID: M6ASITE047649 Click to Show/Hide the Full List
mod site chr2:136115892-136115893:- [5]
Sequence GATATACACTTCAGATAACTACACCGAGGAAATGGGCTCAG
Motif Score 2.078666667
Cell/Tissue List hESC-HEK293T
Seq Type List MAZTER-seq
Transcript ID List ENST00000466288.1; ENST00000241393.3; ENST00000409817.1
External Link RMBase: m6A_site_494555
mod ID: M6ASITE047650 Click to Show/Hide the Full List
mod site chr2:136117687-136117688:- [1]
Sequence CGCGCTGCCTCGGGACTCAGACCACCGGTCTCTTCCTTGGG
Motif Score 2.876744048
Cell/Tissue List HeLa; GM12878; MT4; MM6; Jurkat; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494556
mod ID: M6ASITE047651 Click to Show/Hide the Full List
mod site chr2:136117693-136117694:- [1]
Sequence GGCGTGCGCGCTGCCTCGGGACTCAGACCACCGGTCTCTTC
Motif Score 4.065041667
Cell/Tissue List HeLa; GM12878; MT4; MM6; Jurkat; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000466288.1; ENST00000241393.3
External Link RMBase: m6A_site_494557
mod ID: M6ASITE047652 Click to Show/Hide the Full List
mod site chr2:136118072-136118073:- [1]
Sequence GTAGCCACCGCATCTGGAGAACCAGCGGTTACCATGGAGGG
Motif Score 2.930744048
Cell/Tissue List HeLa; CD34; HepG2; GM12878; MT4; MM6; Jurkat; CD4T; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000241393.3
External Link RMBase: m6A_site_494558
mod ID: M6ASITE047653 Click to Show/Hide the Full List
mod site chr2:136118153-136118154:- [1]
Sequence AAGTCCGGCCGCGGCCAGAAACTTCAGTTTGTTGGCTGCGG
Motif Score 2.627720238
Cell/Tissue List HeLa; CD34; HepG2; GM12878; MT4; MM6; Jurkat; CD4T; peripheral-blood; TIME; TREX
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000241393.3
External Link RMBase: m6A_site_494559