m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00621				[1], [2], [3]
m⁶A modification hsa-miR-34a hsa-miR-34a METTL14 Methylation : m⁶A sites Indirect Enhancement RNA modification CYCS CYCS FTO Demethylation : modification sites
m6A Regulator	Methyltransferase-like 14 (METTL14)			WRITER	Regulator Info
m6A Target	hsa-miR-34a				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	View Details
Regulated Target	Cytochrome c, somatic (CYCS)				View Details
Crosstalk Relationship	m6A → m6Am			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL14 interacts with hsa-miR-34a, decreasing its m6A level and promoting its physical interaction with Cytochrome c, somatic (CYCS), which was regulated by FTO-mediated m6Am modification.
In-vitro Model	769-P	Renal cell carcinoma	Homo sapiens		CVCL_1050
In-vitro Model	786-O	Renal cell carcinoma	Homo sapiens		CVCL_1051

References

Ref 1	N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1Alpha signalling axis. J Cell Mol Med. 2019 Mar;23(3):2163-2173. doi: 10.1111/jcmm.14128. Epub 2019 Jan 16.
Ref 2	N6-Methyladenosine Induced miR-34a-5p Promotes TNF-alpha-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1. Front Cell Dev Biol. 2021 Mar 5;9:642437. doi: 10.3389/fcell.2021.642437. eCollection 2021.
Ref 3	MiR-34a Interacts with Cytochrome c and Shapes Stroke Outcomes. Sci Rep. 2020 Feb 24;10(1):3233. doi: 10.1038/s41598-020-59997-y.