m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00615				[1], [2], [3], [4]
m⁶A modification hsa-miR-34a hsa-miR-34a METTL14 Methylation : m⁶A sites Indirect Enhancement RNA modification SNAI1 SNAI1 YBX1 : modification sites
m6A Regulator	Methyltransferase-like 14 (METTL14)			WRITER	Regulator Info
m6A Target	hsa-miR-34a				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)			READER	View Details
Regulated Target	Zinc finger protein SNAI1 (SNAI1)				View Details
Crosstalk Relationship	m6A → m5C			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL14 interacts with hsa-miR-34a, reading its m6A level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by YBX1-mediated m5C modification.
In-vitro Model	MDA-MB-435S	Amelanotic melanoma	Homo sapiens		CVCL_0622
	MDA-MB-231	Breast adenocarcinoma	Homo sapiens		CVCL_0062
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens		CVCL_0336

References

Ref 1	Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell. 2009 May 5;15(5):402-15. doi: 10.1016/j.ccr.2009.03.017.
Ref 2	Prostaglandin E2 promotes hepatocellular carcinoma cell invasion through upregulation of YB-1 protein expression. Int J Oncol. 2014 Mar;44(3):769-80. doi: 10.3892/ijo.2013.2234. Epub 2013 Dec 30.
Ref 3	N6-Methyladenosine Induced miR-34a-5p Promotes TNF-alpha-Induced Nucleus Pulposus Cell Senescence by Targeting SIRT1. Front Cell Dev Biol. 2021 Mar 5;9:642437. doi: 10.3389/fcell.2021.642437. eCollection 2021.
Ref 4	Competing Endogenous RNA of Snail and Zeb1 UTR in Therapeutic Resistance of Colorectal Cancer. Int J Mol Sci. 2021 Sep 3;22(17):9589. doi: 10.3390/ijms22179589.