m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00609
 [1], [2], [3]
m6A modification MIR320A MIR320A METTL3 Methylation : m6A sites Indirect Inhibition RNA modification E2F1 E2F1 FTO Demethylation : modification sites
m6A Modification:
m6A Regulator Methyltransferase-like 3 (METTL3) WRITER
 Regulator Info 
m6A Target hsa-mir-320a
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator Fat mass and obesity-associated protein (FTO) ERASER View Details
Regulated Target Transcription factor E2F1 (E2F1) View Details
Crosstalk Relationship m6A  →  m6Am Inhibition
Crosstalk Mechanism m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary METTL3 interacts with hsa-mir-320a, decreasing its m6A level and inhibiting its physical interaction with Transcription factor E2F1 (E2F1), which was regulated by FTO-mediated m6Am modification.
In-vitro Model
 HeLa Endocervical adenocarcinoma Homo sapiens CVCL_0030
SiHa Cervical squamous cell carcinoma Homo sapiens CVCL_0032
Full List of Potential Compound(s) Related to This m6A-centered Crosstalk
Transcription factor E2F1 (E2F1) 6 Compound(s) Regulating the Target Click to Show/Hide the Full List
 Compound Name ARQ-171 Phase 1 [4]
Synonyms
ARQ-550RP; ARQ-580; E2F modulators (anticancer); E2F modulators (anticancer), ArQule; 550 series (E2F modulators), Arqule; 550 series (anticancer), Arqule; 550 series, Arqule
    Click to Show/Hide
MOA Modulator
External Link
TTD: D00SIA
 Compound Name ISIS 113048 Investigative [5]
External Link
TTD: D01KTF
 Compound Name ISIS 113020 Investigative [5]
External Link
TTD: D08YXP
 Compound Name ISIS 113022 Investigative [5]
External Link
TTD: D09RTT
 Compound Name ISIS 113019 Investigative [5]
External Link
TTD: D0E4IZ
 Compound Name ISIS 113021 Investigative [5]
External Link
TTD: D0WM1A
References
Ref 1 The m(6)A eraser FTO facilitates proliferation and migration of human cervical cancer cells. Cancer Cell Int. 2019 Dec 2;19:321. doi: 10.1186/s12935-019-1045-1. eCollection 2019.
Ref 2 m(6)A Methylation of Precursor-miR-320/RUNX2 Controls Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells. Mol Ther Nucleic Acids. 2020 Mar 6;19:421-436. doi: 10.1016/j.omtn.2019.12.001. Epub 2019 Dec 12.
Ref 3 FGF14-AS2 accelerates tumorigenesis in glioma by forming a feedback loop with miR-320a/E2F1 axis. J Cancer. 2021 Sep 3;12(21):6429-6438. doi: 10.7150/jca.62120. eCollection 2021.
Ref 4 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800025396)
Ref 5 TTD: Therapeutic Target Database describing target druggability information. Nucleic Acids Res. 2024 Jan 5;52(D1):D1465-D1477. doi: 10.1093/nar/gkad751.