m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00551				[1], [2], [3]
m⁶A modification ZEB1-AS1 ZEB1-AS1 ELAVL1 : m⁶A sites Indirect Enhancement RNA modification MIR205 MIR205 YBX1 : modification sites
m6A Regulator	ELAV-like protein 1 (ELAVL1)			READER	Regulator Info
m6A Target	ZEB1 antisense RNA 1 (ZEB1-AS1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> 5-methylcytidine (m5C)
Epigenetic Regulator	Y-box-binding protein 1 (YBX1)			READER	View Details
Regulated Target	MicroRNA 205 (MIR205)				View Details
Crosstalk Relationship	m6A → m5C			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	ELAVL1 interacts with ZEB1 antisense RNA 1 (ZEB1-AS1), reading its m6A level and promoting its physical interaction with MicroRNA 205 (MIR205), which was regulated by YBX1-mediated m5C modification.
In-vitro Model	MDA-MB-453	Breast adenocarcinoma	Homo sapiens		CVCL_0418
	MDA-MB-436	Invasive breast carcinoma of no special type	Homo sapiens		CVCL_0623
	MHCC97-H	Adult hepatocellular carcinoma	Homo sapiens		CVCL_4972
	SMMC-7721	Endocervical adenocarcinoma	Homo sapiens		CVCL_0534

References

Ref 1	ZEB1 induced-upregulation of long noncoding RNA ZEB1-AS1 facilitates the progression of triple negative breast cancer by binding with ELAVL1 to maintain the stability of ZEB1 mRNA. J Cell Biochem. 2020 Oct;121(10):4176-4187. doi: 10.1002/jcb.29572. Epub 2020 Jan 10.
Ref 2	YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma. Cancer Commun (Lond). 2021 Jul;41(7):576-595. doi: 10.1002/cac2.12164. Epub 2021 Jun 10.
Ref 3	LncRNA ZEB1-AS1 Regulates Colorectal Cancer Cells by MiR-205/YAP1 Axis. Open Med (Wars). 2020 Mar 8;15:175-184. doi: 10.1515/med-2020-0026. eCollection 2020.