m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00536
|
[1], [2], [3], [4] | |||
.png)
.png)
 : m6A sites
Indirect
Inhibition
RNA modification
MIR26A1
MIR26A1
ADAR
Methylation
 : modification sites
|
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| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Fat mass and obesity-associated protein (FTO) | ERASER | |||
| m6A Target | Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Interferon-inducible protein 4 (ADAR1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 26a-1 (MIR26A1) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Inhibition | |||
| Crosstalk Mechanism | m6A modification indirectly impacts RNA modification through downstream signaling pathways | ||||
| Crosstalk Summary | FTO interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification. | ||||
In-vitro Model |
253J | Bladder carcinoma | Homo sapiens | CVCL_7935 | |
| HT-1197 | Recurrent bladder carcinoma | Homo sapiens | CVCL_1291 | ||
| HT-1376 | Bladder carcinoma | Homo sapiens | CVCL_1292 | ||
| K-562 | Chronic myelogenous leukemia | Homo sapiens | CVCL_0004 | ||
References