m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00534				[1], [2], [3]
m⁶A modification MALAT1 MALAT1 METTL16 Methylation : m⁶A sites Indirect Inhibition RNA modification MIR26A1 MIR26A1 ADAR Methylation : modification sites
m6A Regulator	Methyltransferase-like 16 (METTL16)			WRITER	Regulator Info
m6A Target	Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	MicroRNA 26a-1 (MIR26A1)				View Details
Crosstalk Relationship	m6A → A-to-I			Inhibition
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL16 interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and inhibiting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification.
In-vitro Model	HEK293T	Normal	Homo sapiens		CVCL_0063
In-vitro Model	K-562	Chronic myelogenous leukemia	Homo sapiens		CVCL_0004

References

Ref 1	Characterization of METTL16 as a cytoplasmic RNA binding protein. PLoS One. 2020 Jan 15;15(1):e0227647. doi: 10.1371/journal.pone.0227647. eCollection 2020.
Ref 2	Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 Jan 14;35(1):81-94.e7. doi: 10.1016/j.ccell.2018.11.017. Epub 2019 Jan 3.
Ref 3	lncRNA MALAT1/miR?26a/26b/ST8SIA4 axis mediates cell invasion and migration in breast cancer cell lines. Oncol Rep. 2021 Aug;46(2):181. doi: 10.3892/or.2021.8132. Epub 2021 Jul 19.