m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00533				[1], [2], [3], [4], [5], [6]
m⁶A modification MALAT1 MALAT1 METTL3 Methylation : m⁶A sites Indirect Enhancement RNA modification MIR26A1 MIR26A1 ADAR Methylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Metastasis associated lung adenocarcinoma transcript 1 (MALAT1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	MicroRNA 26a-1 (MIR26A1)				View Details
Crosstalk Relationship	m6A → A-to-I			Enhancement
Crosstalk Mechanism	m6A modification indirectly impacts RNA modification through downstream signaling pathways
Crosstalk Summary	METTL3 interacts with Metastasis associated lung adenocarcinoma transcript 1 (MALAT1), increasing its m6A level and promoting its physical interaction with MicroRNA 26a-1 (MIR26A1), which was regulated by ADAR1-mediated A-to-I modification.
In-vitro Model	MGG8	Glioblastoma	Homo sapiens		CVCL_D1H4
	HK2	Normal	Acipenser baerii		CVCL_YE28
	U-87MG ATCC	Glioblastoma	Homo sapiens		CVCL_0022
	MCF-7	Invasive breast carcinoma	Homo sapiens		CVCL_0031
	K-562	Chronic myelogenous leukemia	Homo sapiens		CVCL_0004

References

Ref 1	N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2	m(6)A-induced lncRNA MALAT1 aggravates renal fibrogenesis in obstructive nephropathy through the miR-145/FAK pathway. Aging (Albany NY). 2020 Mar 23;12(6):5280-5299. doi: 10.18632/aging.102950. Epub 2020 Mar 23.
Ref 3	METTL3 enhances the stability of MALAT1 with the assistance of HuR via m6A modification and activates NF-KappaB to promote the malignant progression of IDH-wildtype glioma. Cancer Lett. 2021 Jul 28;511:36-46. doi: 10.1016/j.canlet.2021.04.020. Epub 2021 Apr 29.
Ref 4	The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis. Cancer Cell Int. 2021 Aug 21;21(1):441. doi: 10.1186/s12935-021-02113-5.
Ref 5	Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation. Cancer Cell. 2019 Jan 14;35(1):81-94.e7. doi: 10.1016/j.ccell.2018.11.017. Epub 2019 Jan 3.
Ref 6	lncRNA MALAT1/miR?26a/26b/ST8SIA4 axis mediates cell invasion and migration in breast cancer cell lines. Oncol Rep. 2021 Aug;46(2):181. doi: 10.3892/or.2021.8132. Epub 2021 Jul 19.