m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00511				[1], [2], [3], [4], [5]
RNA modification MIR18A MIR18A ADAR Methylation : modification sites Indirect Enhancement m⁶A modification PTEN PTEN METTL3 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Mutated in multiple advanced cancers 1 (PTEN)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	hsa-mir-18a				View Details
Crosstalk Relationship	A-to-I → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by METTL3-mediated m6A modification.
In-vitro Model	MOLM-13	Adult acute myeloid leukemia	Homo sapiens		CVCL_2119
	ARPE-19	Normal	Homo sapiens		CVCL_0145
	K-562	Chronic myelogenous leukemia	Homo sapiens		CVCL_0004
	CAL-27	Tongue squamous cell carcinoma	Homo sapiens		CVCL_1107
	HN4	Clear cell renal cell carcinoma	Homo sapiens		CVCL_IS30

References

Ref 1	The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat Med. 2017 Nov;23(11):1369-1376. doi: 10.1038/nm.4416. Epub 2017 Sep 18.
Ref 2	Overexpression of METTL3 attenuates high-glucose induced RPE cell pyroptosis by regulating miR-25-3p/PTEN/Akt signaling cascade through DGCR8. Aging (Albany NY). 2020 May 4;12(9):8137-8150. doi: 10.18632/aging.103130. Epub 2020 May 4.
Ref 3	Dysregulation of LINC00470 and METTL3 promotes chemoresistance and suppresses autophagy of chronic myelocytic leukaemia cells. J Cell Mol Med. 2021 May;25(9):4248-4259. doi: 10.1111/jcmm.16478. Epub 2021 Mar 21.
Ref 4	ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 5	Long Noncoding RNA WDFY3-AS2 Represses the Progression of Esophageal Cancer through miR-18a/PTEN Axis. J Oncol. 2021 Jun 5;2021:9951010. doi: 10.1155/2021/9951010. eCollection 2021.