m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
Crosstalk ID
M6ACROT00510
 [1], [2], [3], [4]
RNA modification MIR18A MIR18A ADAR Methylation : modification sites Indirect Enhancement m6A modification PTEN PTEN IGF2BP1 : m6A sites
m6A Modification:
m6A Regulator Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) READER
 Regulator Info 
m6A Target Mutated in multiple advanced cancers 1 (PTEN)
 Targert Gene 
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type RNA modification (RNAMod)  >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator Interferon-inducible protein 4 (ADAR1) WRITER View Details
Regulated Target hsa-mir-18a View Details
Crosstalk Relationship A-to-I  →  m6A Enhancement
Crosstalk Mechanism RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary ADAR1 interacts with hsa-mir-18a, increasing it's A-to-I level and promoting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification.
In-vitro Model
 U2OS Osteosarcoma Homo sapiens CVCL_0042
U-87MG ATCC Glioblastoma Homo sapiens CVCL_0022
U-373MG ATCC Astrocytoma Homo sapiens CVCL_2219
CAL-27 Tongue squamous cell carcinoma Homo sapiens CVCL_1107
HN4 Clear cell renal cell carcinoma Homo sapiens CVCL_IS30
References
Ref 1 IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling. Genes Dev. 2012 Jan 15;26(2):176-89. doi: 10.1101/gad.177642.111.
Ref 2 MicroRNA-873 (miRNA-873) inhibits glioblastoma tumorigenesis and metastasis by suppressing the expression of IGF2BP1. J Biol Chem. 2015 Apr 3;290(14):8938-48. doi: 10.1074/jbc.M114.624700. Epub 2015 Feb 10.
Ref 3 ADAR1 promotes the epithelial-to-mesenchymal transition and stem-like cell phenotype of oral cancer by facilitating oncogenic microRNA maturation. J Exp Clin Cancer Res. 2019 Jul 17;38(1):315. doi: 10.1186/s13046-019-1300-2.
Ref 4 Long Noncoding RNA WDFY3-AS2 Represses the Progression of Esophageal Cancer through miR-18a/PTEN Axis. J Oncol. 2021 Jun 5;2021:9951010. doi: 10.1155/2021/9951010. eCollection 2021.