m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00486				[1], [2], [3], [4], [5], [6]
m⁶A modification SNAI1 SNAI1 METTL3 Methylation : m⁶A sites Indirect Enhancement RNA modification MIR22 MIR22 FTO Demethylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Zinc finger protein SNAI1 (SNAI1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> N6,2'-O-dimethyladenosine (m6Am)
Epigenetic Regulator	Fat mass and obesity-associated protein (FTO)			ERASER	View Details
Regulated Target	hsa-mir-22				View Details
Crosstalk Relationship	m6Am → m6A			Enhancement
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	FTO interacts with hsa-mir-22, decreasing it's m6Am level and promoting its physical interaction with Zinc finger protein SNAI1 (SNAI1), which was regulated by METTL3-mediated m6A modification.
In-vitro Model	Hep-G2	Hepatoblastoma	Homo sapiens		CVCL_0027
	MHCC97-H	Adult hepatocellular carcinoma	Homo sapiens		CVCL_4972
	SUNE1	Nasopharyngeal carcinoma	Homo sapiens		CVCL_6946
	AGS	Gastric adenocarcinoma	Homo sapiens		CVCL_0139
	HCT 116	Colon carcinoma	Homo sapiens		CVCL_0291
	SW480	Colon adenocarcinoma	Homo sapiens		CVCL_0546
	HEK293	Normal	Homo sapiens		CVCL_0045

References

Ref 1	SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma. Theranostics. 2020 Apr 27;10(13):5671-5686. doi: 10.7150/thno.42539. eCollection 2020.
Ref 2	The m6A methyltransferase METTL3 aggravates the progression of nasopharyngeal carcinoma through inducing EMT by m6A-modified Snail mRNA. Minerva Med. 2022 Apr;113(2):309-314. doi: 10.23736/S0026-4806.20.06653-7. Epub 2020 Jun 5.
Ref 3	HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis. J Exp Clin Cancer Res. 2021 Feb 9;40(1):62. doi: 10.1186/s13046-021-01859-0.
Ref 4	RNA m(6)A methyltransferase METTL3 promotes colorectal cancer cell proliferation and invasion by regulating Snail expression. Oncol Lett. 2021 Oct;22(4):711. doi: 10.3892/ol.2021.12972. Epub 2021 Aug 5.
Ref 5	N6-adenosine methylation in MiRNAs. PLoS One. 2015 Feb 27;10(2):e0118438. doi: 10.1371/journal.pone.0118438. eCollection 2015.
Ref 6	Long non?coding RNA H19 regulates cell growth and metastasis via the miR?22?3p/Snail1 axis in gastric cancer. Int J Oncol. 2019 Jun;54(6):2157-2168. doi: 10.3892/ijo.2019.4773. Epub 2019 Apr 4.