m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00446
|
[1], [2], [3], [4], [5] | |||
.png)
.png)
 : modification sites
Indirect
Inhibition
m6A modification
PTEN
PTEN
IGF2BP1
 : m6A sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) | READER | |||
| m6A Target | Mutated in multiple advanced cancers 1 (PTEN) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Double-stranded RNA-specific editase 1 (ADARB1) | WRITER | View Details | ||
| Regulated Target | MicroRNA 214 (MIR214) | View Details | |||
| Crosstalk Relationship | A-to-I → m6A | Inhibition | |||
| Crosstalk Mechanism | RNA modification indirectly impacts m6A modification through downstream signaling pathways | ||||
| Crosstalk Summary | ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Mutated in multiple advanced cancers 1 (PTEN), which was regulated by IGF2BP1-mediated m6A modification. | ||||
In-vitro Model |
U2OS | Osteosarcoma | Homo sapiens | CVCL_0042 | |
| U-87MG ATCC | Glioblastoma | Homo sapiens | CVCL_0022 | ||
| U-373MG ATCC | Astrocytoma | Homo sapiens | CVCL_2219 | ||
| Huh-7 | Adult hepatocellular carcinoma | Homo sapiens | CVCL_0336 | ||
References