m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00441				[1], [2], [3], [4], [5]
RNA modification MIR214 MIR214 ADARB1 Methylation : modification sites Indirect Inhibition m⁶A modification EGFR EGFR METTL3 Methylation : m⁶A sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Epidermal growth factor receptor (EGFR)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)			WRITER	View Details
Regulated Target	MicroRNA 214 (MIR214)				View Details
Crosstalk Relationship	A-to-I → m6A			Inhibition
Crosstalk Mechanism	RNA modification indirectly impacts m6A modification through downstream signaling pathways
Crosstalk Summary	ADARB1 interacts with MicroRNA 214 (MIR214), increasing it's A-to-I level and inhibiting its physical interaction with Epidermal growth factor receptor (EGFR), which was regulated by METTL3-mediated m6A modification.
In-vitro Model	A-549	Lung adenocarcinoma	Homo sapiens		CVCL_0023
	NCI-H1299	Lung large cell carcinoma	Homo sapiens		CVCL_0060
	NCI-H460	Lung large cell carcinoma	Homo sapiens		CVCL_0459
	A-375	Amelanotic melanoma	Homo sapiens		CVCL_0132
	Huh-7	Adult hepatocellular carcinoma	Homo sapiens		CVCL_0336

Full List of Potential Compound(s) Related to This m6A-centered Crosstalk

Epidermal growth factor receptor (EGFR)		222 Compound(s) Regulating the Target	Click to Show/Hide the Full List
Compound Name	Necitumumab		Approved	[6]
Synonyms	LY3012211 Click to Show/Hide
MOA	Modulator
External Link	TTD: D03WPP
Compound Name	HEGF		Approved	[7]
MOA	Activator
External Link	TTD: D05GGP
Compound Name	Erlotinib		Approved	[8]
Synonyms	Erlotinin; Tarceva; Erlotinib Base; OSI 744; R 1415; CP 358,774; CP-358774; Erlotinib(Tarceva); Tarceva (TN); CP-358,774; Erlotinib, OS-774; N-(3-ethynylphenyl)[6,7-bis(2-methoxyethoxy)quinazolin-4-yl]amine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine; N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine; [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE; [6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine; 4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 0.1 nM
External Link	CID: 176870 TTD: D07POC DrugBank: DB00530
Compound Name	Gefitinib		Approved	[9]
Synonyms	Gefitini; IRE; Iressa; Irressat; Gefitinib [USAN]; ZD 1839; ZD1839; Iressa (TN); Iressa(TM); ZD-1839; CU-00000000396-1; Gefitinib,Iressa, ZD1839; Gefitinib (JAN/USAN/INN); ZD-1839, Iressa, Gefitinib; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamide; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine; N-(3-Chloro-4-fluoro-phenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine; 4-(3'-Chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline; 6-(3-morpholinopropoxy)-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazolin-4-amine Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.1 nM
External Link	CID: 123631 TTD: D09XZB DrugBank: DB00317
Compound Name	Panitumumab		Approved	[10]
Synonyms	Vectibix; Panitumumab (genetical recombination); Vectibix (TN); Panitumumab (USAN/INN); Panitumumab (genetical recombination) (JAN); Panitumumab (EGFR mAb inhibitor) Click to Show/Hide
MOA	Suppressor
External Link	TTD: D0HU9H
Compound Name	Cetuximab		Approved	[11]
Synonyms	Erbitux; Cetuximab (genetical recombination); Erbitux (TN); Cetuximab (USAN/INN); Cetuximab (genetical recombination) (JAN); novel EGFR mAb inhibitors Click to Show/Hide
External Link	TTD: D0N5OV
Compound Name	BIBW 2992		Approved	[12]
Synonyms	Afatinib; Tomtovok; Tovok; BIBW-2992; Tovok (TN); Tovok, BIBW2992; (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydrofuran-3-yloxy]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide; EGFR inhibitor 2nd gens Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.19 nM
External Link	CID: 10184653 TTD: D05UFG DrugBank: DB08916
Compound Name	Nitroglycerin		Approved	[7]
Synonyms	Glyceryl trinitrate; Trinitroglycerin; Nitroglycerol; Nitrostat; Nitroglycerine; Nitro-dur; Minitran; Trinitroglycerol; 55-63-0; Nitroderm; Nitroglyn; Nitrospan; Nitronet; Tridil; Glycerol trinitrate; Transderm-nitro; Transderm Nitro; Epinitril; Susadrin; Perlinganit; Nitrolingual; Nitrolan; Sustonit; Nitrocine; Trinitrin; Natispray; Lenitral; Nitrong; Niong; Nitro-Bid; Nitroderm TTS; Trinitrosan; Rectogesic; Nitroglicerina; Cordipatch; Perglottal; Nitrorectal; Gilustenon; Nitroretard; Nitroplast; Corditrine; Trinitrolong; Adesitrin; Aldonitrin; Angibid; Angiolingual; Angiplex; Anglix; Angonist; Angorin; Anogesic; Buccal; Buccard; Cardabid; Cardamist; Cardinit; Cardiodisco; Cellegesic; Chitamite; Colenitral; Dauxona; Deponit; Diafusor; Discotrine; Dynamite; GTN; Glonoin; Glycerintrinitrate; Glyceroltrinitraat; Glyceryl; Glycerylnitrat; Glytrin; Herwicard; Herzer; Klavikordal; Lentonitrina; Millisrol; Minitram; Minitro; Mionitrat; Myocon; Myoglycerin; Myovin; NTG; Niglin; Niglycon; Nirmin; Nitora; Nitradisc; Nitrangin; Nitrek; Nitriderm; NitroBid; NitroCor; NitroDur; NitroMist; NitroQuick; NitroQuik; Nitroard; Nitrobaat; Nitrobukal; Nitrocap; Nitrocard; Nitrocerin; Nitroclyn; Nitrocontin; Nitrocot; Nitrodisc; Nitrodyl; Nitrogard; Nitrogliceryna; Nitroglin; Nitroject; Nitroletten; Nitrolin; Nitrolowe; Nitromel; Nitromex; Nitromint; Nitropatch; Nitropen; Nitropercuten; Nitroperlinit; Nitroprol; Nitropront; Nitroprontan; Nitrorex; Nitrostabilin; Nitrovis; Nysconitrine; Percutol; Perganit; Plastranit; Polnitrin; Ratiopharm; Soup; Suscard; Sustac; Sustak; TNG; Temponitrin; Trinalgon; Trinipatch; Triniplas; Trinitrol; Trinitron; Turicard; Vascana; Vasoglyn; Vasolator; Vernies; Willong; Blasting gelatin; Blasting oil; Gepan Nitroglicerin; Gilucor nitro; Glycerin trinitrate; Glycerine trinitrate; Glyceryl nitrate; NITRO IV; Neos nitro OPT; Niong Retard; Nitradisc Pad; Nitradisc TTS; Nitriderm TTS; Nitro Bid; Nitro Dur; Nitro Dur TTS; Nitro Mack Retard; Nitro Retard; Nitro Rorer; Nitrobid Oint; Nitrocontin Continus; Nitroderm TTS Ext; Nitrodyl TTS; Nitrol Ointment; Nitrolingual Spray; Nitromack Retard; Nitromint Aerosol; Nitromint Retard; Nitronal Aqueous; Nitrong Retard; Nitrong parenteral; Nitrozell retard; Percutol Oint; Spirit of glonoin; Tridil sublin; Trinitrin Tablets; Trinitrina Erba; Deponit 5; Deponit TTS 10; Deponit TTS 5; Nitrocine 5; Aquo-Trimitrosan; Coro-Nitro; Deponit-5; GTN-Pohl; IMX-150; MED-2002; MQX-503; Mi-Trates; Minitran (TN); NK-843; Natispray (TN); Nit-Ret; Nitrine-TDC; Nitro-Dur 10; Nitro-Dur 5; Nitro-Gesanit Retard; Nitro-Mack Retard; Nitro-Par; Nitro-Pflaster; Nitro-Span; Nitro-Time; Nitro-lent; NitrocapTD; Nitroderm TTS-5; Nitrogard-SR; Nitroglycerin (NG); Nitroglycerin-ACC; Nitrolingual Pump Spray (TN); Nitromist (TN); Nitrong-SR; Nitrospan (TN); Nitrostat (TN); SDM No 17; SK-106N; SK-866; SK-878; Top-Nitro; Transderm Nitro (TN); Transderm-N TTS; Transderm-Nitro TTS; Transiderm-nitro; Tridil (TN); Trinipatch (TN); Trinitrate, Glyceryl; Nitro-Dur (TN); Nitro-M-Bid; Nitro-bid (TN); Transderm-nitro (TN); DWP-401 Click to Show/Hide
MOA	Activator
External Link	CID: 4510 TTD: D07YDE DrugBank: DB00727
Compound Name	Epidermal growth factor		Approved	[13]
Synonyms	62229-50-9; Urogastrone; Uroenterone; Uroanthelone; Urogastron; Kutrol; beta-Urogastrone; Anthelone U; Urogastrone [JAN]; Gastrone, gamma-uro-; Gastrone, beta-uro- (human); Epidermal growth factor (egf); CCRIS 7234; EINECS 263-468-7; EPIDERMAL GROWTH FACTOR-UROGASTRONE; Gastrone, uro- (9CI); 9010-53-1; Gentel (TN); EGF Click to Show/Hide
MOA	Modulator
External Link	CID: 56841751 TTD: D08TPS
Compound Name	Osimertinib		Approved	[14]
Synonyms	Tagrisso Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.421 nM
External Link	CID: 71496458 TTD: D0O8GK DrugBank: DB09330
Compound Name	NERATINIB MALEATE		Approved	[15]
Synonyms	UNII-9RM7XY23ZS; 9RM7XY23ZS; Neratinib maleate [MI]; hki-272 maleate; Nerlynx (TN); SCHEMBL2180998; MolPort-044-561-003; AKOS030524209; DS-19892 Click to Show/Hide
MOA	Antagonist
External Link	CID: 67307512 TTD: D0U1ZV
Compound Name	Amivantamab		Approved	[16]
MOA	Inhibitor
External Link	TTD: DQ5X1Z
Compound Name	SKI-758		Approved	[17]
Synonyms	SCHEMBL3992463; CHEMBL219557; BDBM13047; 3-quinolinecarbonitrile analog 10; ANUHLKPVOXDYSK-UHFFFAOYSA-N; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]furan-3-yl}quinoline-3-carbonitrile; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6 methoxy-7-{5-[(4-methylpiperazin-1-yl)methyl]-3-furyl}-3-quinolinecarbonitrile Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 230 nM
External Link	CID: 11341869 TTD: D03MNN
Compound Name	Dacomitinib		Approved	[13]
Synonyms	PF-00299804 Click to Show/Hide
MOA	Antagonist
Activity	IC50 = 1.8 nM
External Link	CID: 11511120 TTD: D06XXH DrugBank: DB11963
Compound Name	Lapatinib		Approved	[18]
Synonyms	FMM; Tycerb; Lapatinib Ditosylate; Lapatinib [INN]; Lapatinib tosilate hydrate; GSK 572016; GSK572016; GW 572016; GW 572016X; GW572016; Lapatinib (INN); Tykerb (TN); Lapatinib, Tykerb, GW572016; N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine; N-{3-CHLORO-4-[(3-FLUOROBENZYL)OXY]PHENYL}-6-[5-({[2-(METHYLSULFONYL)ETHYL]AMINO}METHYL)-2-FURYL]-4-QUINAZOLINAMINE; N-(3-Chloro-4-((3-fluorophenyl)methoxy)phenyl)-6-(5-((2-methylsulfonylethylamino)methyl)-2-furyl)quinazolin-4-amine; N-(3-Chloro-4-{[(3-fluorophenyl)methyl]oxy}phenyl)-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furanyl]-4-quinazolinamine; 4-[[3-Chloro-4-(3-fluorobenzyloxy)phenyl]amino]-6-[5-[[(2-methanesulfonylethyl)amino]methyl]furan-2-yl]quinazoline; Lapatinib (ERBB2 inhibitor) Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 3 nM
External Link	CID: 208908 TTD: D08CDI DrugBank: DB01259
Compound Name	Merimepodib		Approved	[19]
Synonyms	Merimebodib; Merimepodib [USAN:INN]; Tyverb/Tykerb; MMPD; 198821-22-6; 2ZL2BA06FU; C23H24N4O6; CHEMBL304087; MERIMEPODIB, VI-21497, VX-497; UNII-2ZL2BA06FU; VI-21497; VX-497; VX497; Vx 497; carbamic acid Click to Show/Hide
MOA	Inhibitor
External Link	CID: 153241 TTD: D0F0ZE DrugBank: DB04862
Compound Name	Vandetanib		Approved	[20]
Synonyms	Zactima; Vandetanib [INN]; CH 331; ZD 6474; ZD6474; AZD-6474; CH-331; F9995-0087; ZD-6474; Zactima, ZD6474; Vandetanib (JAN/INN); Vandetanib, Zactima, ZD6474; N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methyl-4-piperidinyl)methoxy)-4-quinazolinamine; N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine; 4-(4-Bromo-2-fluoroanilino)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazoline; Vandetanib (Pan-TK inhibitor) Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 200 nM
External Link	CID: 3081361 TTD: D0G6QF DrugBank: DB05294
Compound Name	Sorafenib		Approved	[21]
Synonyms	Nexavar; Sorafenibum; Sorafenib [INN]; Nexavar (TN); Sorafenib (INN); N-[4-Chloro-3-(trifluoromethyl)phenyl]-N'-[4-[2-(N-methylcarbamoyl)-4-pyridyloxy]phenyl]urea; N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea; N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcar bamoyl)-4-pyridyloxy)phenyl)urea; 4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide; 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate; 4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide; 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide; 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide; 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide; 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE; Sorafenib (Pan-TK inhibitor) Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 43.5 nM
External Link	CID: 216239 TTD: D0W5HK DrugBank: DB00398
Compound Name	Icotinib hydrochloride		Registered	[22]
Synonyms	Conmana; Conmanna; Icotinib; BPI-2009-H Click to Show/Hide
MOA	Antagonist
External Link	CID: 44609731 TTD: D06WRJ
Compound Name	Rindopepimut		Phase 3	[6]
MOA	Modulator
External Link	TTD: D05FRP
Compound Name	SYM-004		Phase 3	[23]
Synonyms	Chimeric IgG1 antibody 1024 (cancer), Symphogen; Chimeric IgG1 antibody 992 (cancer), Symphogen; Chimeric IgG1 antibodies992 + 1024 (cancer), Symphogen Click to Show/Hide
External Link	TTD: D0CR8H
Compound Name	DE-766		Phase 3	[13]
MOA	Modulator
External Link	TTD: D0FJ1W
Compound Name	EGF816		Phase 3	[24]
MOA	Inhibitor
Activity	IC50 = 160.6 nM
External Link	CID: 72703790 TTD: D0K7FY
Compound Name	CO-1686		Phase 3	[25]
Synonyms	1374640-70-6; AVL-301; CO1686; UNII-72AH61702G; CNX-419; CO-1686 (AVL-301); Rociletinib(AVL-301,CNX-419,CO-1686); 72AH61702G; N-(3-((2-((4-(4-acetylpiperazin-1-yl)-2-methoxyphenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)phenyl)acrylamide; CO 1686; Rociletinib (CO-1686, AVL-301); Rociletinib [USAN:INN]; Tube721; Rociletinib (USAN/INN); Rociletinib (CO-1686); SCHEMBL4177736; GTPL7966; CHEMBL3545308; EX-A228; MolPort-035-395-816; C27H28F3N7O3; HMS3653G08; BDBM149404; BCP07085; AOB87314; ZINC98043800; s7284 Click to Show/Hide
MOA	Modulator
Activity	IC50 = 1.6 nM
External Link	CID: 57335384 TTD: D0M4AV DrugBank: DB11907
Compound Name	Zalutumumab		Phase 3	[13]
External Link	TTD: D0R4PW
Compound Name	Almonertinib		Phase 3	[26]
Synonyms	HS-10296; Ameile; 1899921-05-1; Egfr T790M inhibitor HS-10296; N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide; UNII-T4RS462G19; SCHEMBL17683063; GTPL11136; T4RS462G19; EX-A3721; HS 10296 [WHO-DD]; s8817; HS10296; example 26 [WO2016054987A1]; HY-112823; CS-0066162; 2-Propenamide, N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-((2-(dimethylamino)ethyl)methylamino)-4-methoxyphenyl)-; C1(CC1)N1C=C(C2=CC=CC=C12)C1=NC(=NC=C1)NC=1C(=CC(=C(C=1)NC(C=C)=O)N(C)CCN(C)C)OC; N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide Click to Show/Hide
MOA	Inhibitor
External Link	CID: 121280087 TTD: DDH8L6
Compound Name	ASP1929		Phase 3	[27]
Synonyms	Cetuximab sarotalocan Click to Show/Hide
MOA	Inhibitor
External Link	TTD: DWK96T
Compound Name	A140		Phase 3	[28]
External Link	TTD: DXZ31K
Compound Name	Bevacizumab + Erlotinib		Phase 3	[29]
MOA	Inhibitor
External Link	TTD: D09BKY
Compound Name	HKI-272		Phase 3	[30]
Synonyms	Neratinib (ERBB2 inhibitor) Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.08 nM
External Link	CID: 9915743 TTD: D0Q9CY DrugBank: DB11828
Compound Name	Indium-111		Phase 2/3	[31]
Synonyms	ABT-806 Click to Show/Hide
External Link	TTD: D0F3KC
Compound Name	Varlitinib		Phase 2/3	[32]
Synonyms	845272-21-1; ARRY-334543; ARRY334543; ARRY 334543; ARRY-543; UNII-846Y8197W1; ASLAN-001; 846Y8197W1; (R)-N4-(3-chloro-4-(thiazol-2-ylmethoxy)phenyl)-N6-(4-methyl-4,5-dihydrooxazol-2-yl)quinazoline-4,6-diamine; Varlitinib [USAN:INN]; Varlitinib (ARRY334543); Varlitinib free base; Varlitinib (USAN/INN); MLS006011274; GTPL7645; SCHEMBL1384578; CHEMBL2103842; SYN1192; MolPort-028-720-424; EX-A1005; 4-N-[3-chloro-4-(1,3-thiazol-2-ylmethoxy)phenyl]-6-N-[(4R)-4-methyl-4,5-dihydro-1,3-oxazol-2-yl]quinazoline-4,6-diamine Click to Show/Hide
MOA	Modulator
Activity	IC50 = 7 nM
External Link	CID: 42642648 TTD: D00NYJ DrugBank: DB05944
Compound Name	ASP8273		Phase 2	[33]
MOA	Inhibitor
Activity	IC50 = 8 nM
External Link	CID: 71667668 TTD: D02BYZ DrugBank: DB12036
Compound Name	ABT-414		Phase 2	[34]
External Link	TTD: D06XIT
Compound Name	Depatuxizumab		Phase 2	[35]
MOA	Antagonist
External Link	TTD: D0A6CC
Compound Name	Matuzumab		Phase 2	[36]
Synonyms	EMD-62000; EMD-72000; Anti-EGF receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-EGFR humanized mAb (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals; Anti-epidermal growth factor receptor humanized antibody (iv, cancer), Merck KGaA/ Takeda Pharmaceuticals Click to Show/Hide
External Link	TTD: D0BZ7V
Compound Name	HER1-VSSP vaccine		Phase 2	[37]
Synonyms	HER1-VSSP vaccine (cancer) Click to Show/Hide
External Link	TTD: D0C3LL
Compound Name	RM-1929		Phase 2	[38]
MOA	Antagonist
External Link	TTD: D0FN4T
Compound Name	CetuGEX		Phase 2	[39]
External Link	TTD: D0K9MC
Compound Name	ABX-EGF		Phase 2	[40]
External Link	TTD: D0P9RG
Compound Name	Pelitinib		Phase 2	[41]
Synonyms	EKB-569; EKI-569; WAY-EKB-569 Click to Show/Hide
MOA	Modulator
Activity	IC50 = 8.02 nM
External Link	CID: 6445562 TTD: D0S3PO DrugBank: DB05524
Compound Name	HM-78136B		Phase 2	[38]
Synonyms	Pan-Her/EGFR inhibitors (cancer), Hanmi Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.218 nM
External Link	CID: 25127713 TTD: D00YER DrugBank: DB12114
Compound Name	Pazopanib + Tyverb/Tykerb		Phase 2	[19]
MOA	Inhibitor
External Link	CID: 10113978 TTD: D03UKJ DrugBank: DB06589
Compound Name	MEHD-7945A		Phase 2	[32]
Synonyms	RG-7597; EGFR/HER3 dual monoclonal antibody, Genentech Click to Show/Hide
MOA	Modulator
External Link	TTD: D09BZJ
Compound Name	TT-100		Phase 2	[42]
Synonyms	TT-100, TriAct; Dual IGF-1/EGFR inhibitor (non-small-cell lung cancer), TriAct Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0T5JS
Compound Name	BMS-599626		Phase 2	[43]
Synonyms	714971-09-2; AC480; AC-480; BMS 599626; (S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbamate; UNII-2252724U5N; CHEMBL1645462; BMS599626; AC480 (BMS-599626); 2252724U5N; J-502499; C27H27FN8O3; AC 480; AC1480 (free base); PubChem22432; GTPL7647; SCHEMBL12065349; CTK8B6780; DTXSID60221714; SYN1142; AOB5594; MolPort-023-279-418; EX-A2296; ZINC6717782; KS-000008GE; BDBM50333373; s1056; C27H44O11; ANW-54337; AKOS015999853; CS-0407; RL05125; BCP9000428; SB21703 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 32 nM
External Link	CID: 10437018 TTD: D0U4FF DrugBank: DB12318
Compound Name	Tarloxotinib		Phase 2	[44]
Synonyms	Tarloxotinib cation; UNII-H8768UL06V; H8768UL06V; [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium; Tarloxotinib ion; GTPL9409; CHEMBL4297661; SCHEMBL19733352; PR610; DB14944; TH-4000; Q27279755; 1636938-13-0 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 51038316 TTD: DUW81M DrugBank: DB14944
Compound Name	VATALANIB		Phase 2	[30]
Synonyms	212141-54-3; Vatalanib base; N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine; PTK787; Pynasunate; CGP 79787; Vatalanib free base; PTK-787; Vatalanib (free base); Vatalinib; ZK-232934; CGP-79787; ZK222584; PTK/ZK; CHEMBL101253; N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine; UNII-5DX9U76296; CHEBI:90620; YCOYDOIWSSHVCK-UHFFFAOYSA-N; 1-(4-chloroanilino)-4-(4-pyridylmethyl)phthalazine; 5DX9U76296; NCGC00181350-01; 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-; DSSTox_CID_26919 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 457.7 nM
External Link	CID: 151194 TTD: D0P6DJ DrugBank: DB04879
Compound Name	BMS-690514		Phase 2	[45]
Synonyms	BMS 690514; BMS690514 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11349170 TTD: D0R6UV DrugBank: DB11665
Compound Name	CI-1033		Phase 2	[20]
Synonyms	Canertinib; Canertinib HCl; Canertinib dihydrochloride; Canertinib dihydrochloride [USAN]; CI1033; PD 183805; Canertinib dihydrochloride (USAN); PD-0183805; PD-183805; Canertinib, PD-183805, CI1033, PD183805; N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride; N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide; N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide dihydrochloride; N-(4-(3-chloro-4-fluorophenyl)amino)-7-(3-morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide dihydrochloride; N-{4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl) amino)-7-(3-(4-morpholinyl) propoxy)-6-quinazolinyl)-, dihydrochloride; 2-Propenamide, N-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-(4-morpholinyl)propoxy)-6-quinazolinyl)-, dihydrochloride Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 0.11 nM
External Link	CID: 156414 TTD: D0YB3W DrugBank: DB05424
Compound Name	CART-EGFR		Phase 1/2	[46]
MOA	CAR-T-Cell-Therapy
External Link	TTD: D04DHZ
Compound Name	SN-32793		Phase 1/2	[13]
Synonyms	PR-509; PR-610; SN-32807; Hypoxia-activated irreversible pan-erbb inhibitors, Proacta; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer); Hypoxia-selective multi-kinase inhibitors (lung cancer), Proacta; Hypoxia-selective multi-kinase inhibitors(lung cancer), Proacta/ Yakult Honsha; Hypoxia-selective multi-kinase inhibitors (NSCLC resistant to reversible tyrosine kinase inhibitor/cancer), Proacta/ Yakult Honsha Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D05ETC
Compound Name	EGFR CART		Phase 1/2	[47]
MOA	CAR-T-Cell-Therapy
External Link	TTD: D0G1ZU
Compound Name	EMD 55900		Phase 1/2	[40]
Synonyms	27686-84-6; 4,4'-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol); UNII-7BO8G1BYQU; 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R,S)-; EINECS 248-606-6; 7BO8G1BYQU; CHEMBL313972; erythro-nordihydroguaiaretic acid; CHEBI:73468 Click to Show/Hide
External Link	TTD: D0S8BG
Compound Name	TAK-186		Phase 1/2	[48]
MOA	Inhibitor
External Link	TTD: DC1GH7
Compound Name	ZN-e4		Phase 1/2	[49]
MOA	Inhibitor
External Link	TTD: DF0PR6
Compound Name	EMB-01		Phase 1/2	[50]
MOA	Inhibitor
External Link	TTD: DWQ6J1
Compound Name	Sym015		Phase 1/2	[35]
MOA	Antagonist
External Link	TTD: D0B4OK
Compound Name	BDTX-189		Phase 1/2	[51]
Synonyms	2414572-47-5; EX-A4379 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 154824631 TTD: D9FJ5V
Compound Name	AFM24		Phase 1/2	[52]
External Link	TTD: DK8QG3
Compound Name	Sym013		Phase 1/2	[35]
MOA	Antagonist
External Link	TTD: D0FF2G
Compound Name	S-222611		Phase 1b	[53]
MOA	Inhibitor
External Link	TTD: D0V4XY
Compound Name	SYN004		Phase 1	[35]
MOA	Inhibitor
External Link	TTD: D00KML
Compound Name	BIBX-1382		Phase 1	[54]
Synonyms	Falnidamol; BIBX 1382; 196612-93-8; BIBX1382; UNII-0MU316797D; CHEMBL258940; FTFRZXFNZVCRSK-UHFFFAOYSA-N; 0MU316797D; N8-(3-Chloro-4-fluorophenyl)-N2-(1-methylpiperidin-4-yl)pyrimido[5,4-d]pyrimidine-2,8-diamine; Bibx 1382bs; Falnidamol [INN]; NCGC00161422-01; AC1OCFIP; BIBX-1382BX; BIBX-1382BS; SCHEMBL158563; GTPL7646; DTXSID0048399; CHEBI:93243; EX-A570; AOB5489; MolPort-039-136-623; ZINC1494443; KS-00001CR9; BCP09515; BDBM50375639; AKOS025396660; API0007916; DB12966; CS-0691; NCGC00161422-03; AS-16894; HY-10322; AK174047 Click to Show/Hide
MOA	Antagonist
Activity	IC50 = 3 nM
External Link	CID: 6918508 TTD: D00RMC DrugBank: DB12966
Compound Name	IMGN289		Phase 1	[55]
MOA	Inhibitor
External Link	TTD: D04HSH
Compound Name	AST-1306		Phase 1	[56]
Synonyms	Allitinib; Allitinib tosylate Click to Show/Hide
MOA	Modulator
External Link	CID: 24739943 TTD: D04OLK
Compound Name	AMG 595		Phase 1	[57]
MOA	Modulator
External Link	TTD: D05LMC
Compound Name	HER-2/HER-1 vaccine		Phase 1	[13]
Synonyms	HER-2/HER-1 vaccine (solid tumors) Click to Show/Hide
External Link	TTD: D0E7RC
Compound Name	EGFR806-specific CAR T cell		Phase 1	[58]
MOA	CAR-T-Cell-Therapy
External Link	TTD: D0I7ZH
Compound Name	PF-05230907		Phase 1	[59]
MOA	Inhibitor
External Link	TTD: D0JS0W
Compound Name	MR1-1		Phase 1	[60]
Synonyms	MR1-1KDEL; EGFR-specific immunotoxin, IVAX; Anticancer immunotoxin (EGFR-specific), IVAX Click to Show/Hide
MOA	Modulator
External Link	TTD: D0N3PC
Compound Name	Anti-EGFR CAR T		Phase 1	[61]
MOA	CAR-T-Cell-Therapy
External Link	TTD: D0T0SE
Compound Name	AP32788		Phase 1	[38]
MOA	Inhibitor
External Link	TTD: D0X7BN
Compound Name	CLN-081		Phase 1	[62]
MOA	Inhibitor
External Link	TTD: D68RMI
Compound Name	LY3164530		Phase 1	[63]
MOA	Modulator
External Link	TTD: D01IJM
Compound Name	MM-151		Phase 1	[35]
MOA	Antagonist
External Link	TTD: D01NAP
Compound Name	Cipatinib		Phase 1	[32]
Synonyms	HER-1/HER-2 inhibitor (oral, cancer), Jiangsu Hengrui Click to Show/Hide
MOA	Modulator
External Link	TTD: D08JAN
Compound Name	Anti-HER3/EGFR DAF		Phase 1	[64]
MOA	Modulator
External Link	TTD: D0JW2O
Compound Name	BCA101		Phase 1	[65]
MOA	Inhibitor
External Link	TTD: D0U7XJ
Compound Name	CUDC-101		Phase 1	[66]
Synonyms	1012054-59-9; CUDC 101; CUDC101; 7-(4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide; UNII-1A7Y9MP123; CHEMBL598797; 1A7Y9MP123; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide; AK174946; 7-((4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; 7-({4-[(3-ethynylphenyl)amino]-7-methoxyquinazolin-6-yl}oxy)-N-hydroxyheptanamide; 7-((4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide; PubChem19149 Click to Show/Hide
MOA	Modulator
Activity	IC50 = 2.4 nM
External Link	CID: 24756910 TTD: D0Z4RC DrugBank: DB12174
Compound Name	SI-B001		Phase 1	[67]
External Link	TTD: D6JM8Z
Compound Name	CX-904		Phase 1	[68]
Synonyms	AMG 651 Click to Show/Hide
External Link	TTD: D73FNL
Compound Name	AZD9592		Phase 1	[69]
External Link	TTD: DN47VK
Compound Name	D2C7		Phase 1	[70]
External Link	TTD: DR4ND6
Compound Name	MCLA-158		Phase 1	[71]
MOA	Inhibitor
External Link	TTD: DV8I4Q
Compound Name	JNJ-26483327		Phase 1	[72]
Synonyms	MTKI (cancer), J&J; MTKI (cancer), Johnson & Johnson; Multi-targeted kinase inhibitor (cancer), J&J; Multi-targeted kinase inhibitor (cancer), Johnson & Johnson Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0U3XL
Compound Name	Pyrrolo[2,3-d]pyrimidine derivative 24		Patented	[73]
Synonyms	PMID28705083-Compound-22 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 90468938 TTD: D0Z2PC
Compound Name	PKI166		Discontinued in Phase 2	[74]
Synonyms	PKI-166; CGP-75166; 187724-61-4; NVP-PKI166; CHEMBL1914653; AC1OCFE0; UNII-9RIE5HW38P; 9RIE5HW38P; SCHEMBL177814; GTPL7642; CHEMBL1963502; ZINC23255; AOB1619; PKI-75166; BDBM50358046; NCGC00387215-02; AS-16676; KB-275097; PKI-166, > 4-[4-[[(1R)-1-phenylethyl]amino]-7H-pyrrolo[4,5-e]pyrimidin-6-yl]phenol Click to Show/Hide
MOA	Modulator
Activity	IC50 = 3.7 nM
External Link	CID: 6918403 TTD: D07GFF
Compound Name	RG7160		Discontinued in Phase 2	[75]
MOA	Modulator
External Link	TTD: D0E2CQ
Compound Name	PD-153035		Discontinued in Phase 1	[76]
Synonyms	183322-45-4; PD153035 hydrochloride; N-(3-Bromophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride; PD153035 HCl; PD 153035 HYDROCHLORIDE; PD-153035 hydrochloride; PD153035 (Hydrochloride); Tyrphostin AG 1517; AG 1517 hydrochloride; SU-5271 hydrochloride; UNII-AHJ252P69N; ZM 252868; SU 5271; AG 1517; 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE; AHJ252P69N; pd 153035; PD153035.HCl; CHEMBL1204168; 6,7-Dimethoxy-4-[N-(3-bromophenyl)amino]quinazoline hydrochloride; C16H15BrClN3O2; 4-Quinazolinamine, N-(3-bromo Click to Show/Hide
MOA	Modulator
Activity	Ki = 0.006 nM
External Link	CID: 4705 TTD: D0Q7HO
Compound Name	AZD4769		Discontinued in Phase 1	[77]
Synonyms	Acetic acid, ((4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)-; 127481-29-2; L-674573; ((4-Phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl)thio)acetic acid; {[4-phenyl-1-(4-(2-quinolinylmethoxy)phenyl)butyl]thio}acetic acid; L 674573; L-674,573; AC1L3YFJ; SCHEMBL9460146; CHEMBL422872; JOIXGLLMSDPZDN-UHFFFAOYSA-N; AZD-4769; 2-[[4-phenyl-1-[4-(2-quinolinylmethoxy)phenyl]butyl]thio]Acetic acid; DA-13018; FT-0734991; AZ-12096971; 2-[4-phenyl-1-[4-(quinolin-2-ylmethoxy)phenyl]butyl]sulfanylacetic Click to Show/Hide
MOA	Inhibitor
External Link	CID: 124437 TTD: D02RZL
Compound Name	TAK165		Discontinued in Phase 1	[20]
Synonyms	Mubritinib; TAK 165; Mubritinib (USAN/INN); 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole Click to Show/Hide
MOA	Inhibitor
External Link	CID: 6444692 TTD: D0A9OV DrugBank: DB12682
Compound Name	111In-hEGF		Preclinical	[78]
Synonyms	Indium-111-hEGF; Indium-111-labeled human epithelial growth factor (breast cancer), University of Toronto; 111In-labeledhuman epithelial growth factor (breast cancer), University of Toronto Click to Show/Hide
MOA	Modulator
External Link	TTD: D0V2FZ
Compound Name	EGFR/IGFR tandem adnectin		Preclinical	[79]
Synonyms	BMS-964210 Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0TI4U
Compound Name	Heparin-EGF-like factor		Terminated	[80]
Synonyms	HB-EGF, Scios Nova; Heparin-EGF-like factor, Scios Nova Click to Show/Hide
MOA	Modulator
External Link	TTD: D02GFZ
Compound Name	CGP-52411		Terminated	[81]
Synonyms	DAPH Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 160 nM
External Link	CID: 1697 TTD: D03QTP
Compound Name	CGP-53353		Terminated	[82]
Synonyms	145915-60-2; CGP 53353; DAPH 2; DAPH-7; CGP53353; PKCbetaII/EGFR Inhibitor; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; CHEMBL7939; CGP 53 353; 4,5-bis(4-Fluoroanilino)-phthalimide; CG53353; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; MolMap_000016; DAPH-2; CGP-53353, solid; SCHEMBL230492 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 700 nM
External Link	CID: 6711154 TTD: D0HO1S
Compound Name	AZD-9935		Terminated	[83]
MOA	Antagonist
External Link	TTD: D0Y1YX
Compound Name	N4-(3-chlorophenyl)quinazoline-4,6-diamine		Investigative	[84]
Synonyms	CHEMBL343352; Anilinoquinazoline, 4c; SCHEMBL1262804; AWAYNEMCHILZCF-UHFFFAOYSA-N; ZINC13527446; BDBM50133382; AKOS013915036; 6-amino-4-(3'-chloroanilino)quinazoline; N4-(3-chlorophenyl)-4,6-quinazolinediamine; 6-amino-4[(3-chlorophenyl)amino]quinazoline Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 3.38 nM
External Link	CID: 11807783 TTD: D00TJF
Compound Name	2-benzoyl-3-(3,4-dihydroxyphenyl)acrylonitrile		Investigative	[85]
Synonyms	Tyrphostin deriv. 29; AC1NS5AC; CHEMBL56132; BDBM4296; ZINC12352646; 2-(Benzoyl)-3-(3,4-dihydroxyphenyl)acrylonitrile; (E)-2-benzoyl-3-(3,4-dihydroxyphenyl)prop-2-enenitrile Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1000 nM
External Link	CID: 5328763 TTD: D00VZA
Compound Name	6,7-dimethoxy-4-(3-phenoxyprop-1-ynyl)quinazoline		Investigative	[86]
Synonyms	CHEMBL250523; BDBM50222432 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 15 nM
External Link	CID: 44442168 TTD: D00WZG
Compound Name	2-cyano-3-(3,4-dihydroxyphenyl)acrylamide		Investigative	[85]
Synonyms	Tyrphostin 46; Tyrphostin A46; AG 99; Tyrphostin B40; 122520-85-8; alpha-Cyano-(3,4-dihydroxy)cinnamide; AG-99; 3,4-Dihydroxy-alpha-cyanocinnamamide; UNII-ARL2OF9022; CHEMBL296407; ARL2OF9022; 118409-59-9; Tyrphostin AG 99; (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide; NSC666250; NSC-666250; 2-Propenamide, 2-cyano-3-(3,4-dihydroxyphenyl)-; (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide; Tyrphostin AG99; 3,4-Dihydroxy-alpha-cyanocinnamide; NSC 666250; Tocris-0497; Tyrphostin deriv. 40; BiomolKI_000013; AC1NS5AR Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 3500 nM
External Link	CID: 5328768 TTD: D01NTW
Compound Name	HM-61713B		Investigative	[13]
Synonyms	EGFR mutant selective inhibitor (cancer), Hanmi; EMSI (cancer), Hanmi Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D01SQP
Compound Name	Benzyl-quinazolin-4-yl-amine		Investigative	[87]
Synonyms	N-Benzylquinazolin-4-amine; N-benzyl-N-(4-quinazolinyl)amine; 4-(Benzylamino)quinazoline; 100818-54-0; 4-Benzylaminoquinazoline; AC1LDDI3; benzylquinazolin-4-ylamine; ChemDiv2_003678; N-benzyl-4-quinazolineamine; Oprea1_089836; MLS000701321; N-Benzyl-4-quinazolinamine #; cid_616573; CHEMBL102726; BDBM3256; SCHEMBL7612718; CHEBI:92768; MolPort-001-960-903; FVWANTDQRFSCAL-UHFFFAOYSA-N; HMS2233F15; HMS3373H15; HMS1379H04; ZINC109589; 4-[(phenylmethyl)amino]quinazoline; N-(phenylmethyl)-4-quinazolinamine Click to Show/Hide
MOA	Inhibitor
External Link	CID: 6603129 TTD: D01WDI
Compound Name	6,7-diethoxy-4-styrylquinazoline		Investigative	[86]
Synonyms	CHEMBL250925 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 15 nM
External Link	CID: 44442181 TTD: D01WXV
Compound Name	AFM-21		Investigative	[13]
Synonyms	Anti-EGFR antibody (RECRUIT-TandAb, colon/solid tumors), Affimed Click to Show/Hide
External Link	TTD: D02FGG
Compound Name	PD182905		Investigative	[88]
MOA	Inhibitor
External Link	TTD: D02GCE
Compound Name	AG 112		Investigative	[89]
Synonyms	tyrphostin A48; tyrphostin AG 112; AG-112; AG112 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 125 nM
External Link	CID: 5328804 TTD: D02KVB
Compound Name	2-(4,5-Dihydroxy-indan-1-ylidene)-malononitrile		Investigative	[90]
Synonyms	(4,5-Dihydroxyindanylidene)malononitrile; Tyrphostin deriv. 17; AC1NS59O; CHEMBL57300; BDBM4286; 133550-13-7; 2-(4,5-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; 2-(4,5-dihydroxy-2,3-dihydro-1H-inden-1-ylidene)propanedinitrile Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 7000 nM
External Link	CID: 5328755 TTD: D02RIG
Compound Name	(3-Bromo-phenyl)-quinazolin-4-yl-amine		Investigative	[91]
Synonyms	N-(3-bromophenyl)quinazolin-4-amine; CHEMBL290096; AC1LEF72; SCHEMBL2992623; BDBM3264; 4-Anilino quinazoline deriv. 15; ZINC151213; (3-bromophenyl)quinazolin-4-ylamine; N-(3-Bromophenyl)-4-quinazolinamine; AKOS002264782; MCULE-4660970870; 4-Quinazolinamine, N-(3-bromophenyl)- Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 27 nM
External Link	CID: 735125 TTD: D02ZRO
Compound Name	PD-158780		Investigative	[92]
Synonyms	171179-06-9; PD158780; pd 158780; N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AC1L1IRV; CHEMBL53753; 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine; AK160389; 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine; 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine; 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine; Pyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-bromophenyl)-N6-methyl- Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.008 nM
External Link	CID: 4707 TTD: D03ATU
Compound Name	EGFR inhibitor		Investigative	[93]
Synonyms	879127-07-8; CHEMBL387187; N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide; Cyclopropanecarboxylic acid-(3-(6-(3-trifluoromethyl-phenylamino)-pyrimidin-4-ylamino)-phenyl)-amide; K00598a; N-{3-[(6-{[3-(trifluoromethyl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}cyclopropanecarboxamide; EGFR Inhibitor 324674; SCHEMBL242230; GTPL5963; CTK8E9808; DTXSID40429554; MolPort-042-665-758; HMS3229E03; BDBM50200394; ZINC13831337; API0010446; CCG-206749; NCGC00167954-01 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 21 nM
External Link	CID: 9549299 TTD: D03BJB
Compound Name	6,7-diethoxy-4-(4-phenylbut-1-enyl)quinazoline		Investigative	[86]
Synonyms	CHEMBL399371 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 5 nM
External Link	CID: 44442182 TTD: D03CVQ
Compound Name	LA22-radioimmunoconjugates		Investigative	[13]
Synonyms	LA22-radioimmunoconjugates (cancer); Lutetium177-DOTA-LA22; LA22-radioimmunoconjugates (cancer), Welson/PekingUniversity; MAb-conjugated radioimmunotherapeutics (cancer), Welson/Peking University; 177Lu-DOTA-LA22; 177Lu-DTPA-LA22 Click to Show/Hide
MOA	Modulator
External Link	TTD: D03MTY
Compound Name	5-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide		Investigative	[94]
Synonyms	CHEMBL382537 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11717472 TTD: D03WEN
Compound Name	ICR 62		Investigative	[40]
External Link	TTD: D03ZIW
Compound Name	Bmab-200		Investigative	[13]
Synonyms	Anti-EGFR mAb (cancer), Biocon; Anti-epidermal growth factor receptor monoclonal antibody (cancer), Biocon Click to Show/Hide
External Link	TTD: D04GCH
Compound Name	HTS-00213		Investigative	[95]
Synonyms	CHEMBL461781; AC1MDDFE; MolPort-002-900-007; ZINC1028479; BDBM50292742; MCULE-3257779074; 3-((2,6-dichlorophenoxy)methyl)-5-((4-(4-(trifluoromethyl)phenyl)-4H-1,2,4-triazol-3-ylthio)methyl)-1,2,4-oxadiazole Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 6300 nM
External Link	CID: 2809539 TTD: D04HGN
Compound Name	6,7-diethoxy-4-(5-phenylpent-1-enyl)quinazoline		Investigative	[86]
Synonyms	CHEMBL251123 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 140 nM
External Link	CID: 44442183 TTD: D04LXG
Compound Name	N4-Benzyl-pyrido[4,3-d]pyrimidine-4,7-diamine		Investigative	[92]
Synonyms	CHEMBL300083; 4-N-benzylpyrido[4,3-d]pyrimidine-4,7-diamine; 7-Aminopyrido[4,3-d]pyrimidine 8a; AC1NS3PZ; SCHEMBL6839398; BDBM3331; pyrido[4,3-d]pyrimidine-4,7-diamine,n4-(phenylmethyl)-; ZINC3815364; 171178-89-5; PD-69896; KB-302882 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 578 nM
External Link	CID: 5328077 TTD: D05ARF
Compound Name	Epitinib		Investigative	[13]
Synonyms	HMPL-813; EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma Click to Show/Hide
MOA	Inhibitor
External Link	CID: 59142777 TTD: D05MEY
Compound Name	OSI-75		Investigative	[96]
MOA	Inhibitor
External Link	TTD: D06QEQ
Compound Name	(E)-5-(4-Hydroxybenzylidene)-1-phenethylhydantoin		Investigative	[97]
Synonyms	CHEMBL213560; SCHEMBL16693054; BDBM50187134 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 710 nM
External Link	CID: 15984068 TTD: D06UEK
Compound Name	HTS-02876		Investigative	[95]
Synonyms	AC1MDGL2; CHEMBL460914; MolPort-002-900-576; ZINC1030761; MCULE-7093116609 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 2810910 TTD: D07CZM
Compound Name	2-(5,6-Dihydroxy-indan-1-ylidene)-malononitrile		Investigative	[90]
Synonyms	133550-11-5; Propanedinitrile, (2,3-dihydro-5,6-dihydroxy-1H-inden-1-ylidene)-; Tyrphostin deriv. 15; ACMC-20muzh; AC1NS59I; SCHEMBL6285970; CHEMBL293584; BDBM4284; CTK0C0328; DTXSID30416170; 2-(5,6-dihydroxy-2,3-dihydroinden-1-ylidene)propanedinitrile; (5,6-Dihydroxyindanylidene)malononitrile; [(2,3-Dihydro-5,6-dihydroxy-1H-inden)-1-ylidene]malononitrile Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 500 nM
External Link	CID: 5328753 TTD: D07IHD
Compound Name	PMID8568816C56		Investigative	[98]
Synonyms	PD153035 Analog 56; 171745-13-4; AC1L1EMN; K00042; BDBM3556; GTPL5956; CTK6G1384; DTXSID40274389; MolPort-019-910-218; HMS3229C09; BCP08039; ZINC2572485; IN1496; CCG-206742; QC-8197; ACM171745134; RT-012080; SR-02000000170; SR-02000000170-1; J-010 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.006 nM
External Link	CID: 2857 TTD: D07UYV
Compound Name	MT-062		Investigative	[13]
Synonyms	EGFR inhibitor (melanoma), Medisyn Technologies Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D08RXW
Compound Name	Anti-EGFR mab		Investigative	[13]
External Link	TTD: D09RXX
Compound Name	RG-50810		Investigative	[85]
Synonyms	Tyrphostin 23; 118409-57-7; Tyrphostin A23; AG 18; (3,4-Dihydroxybenzylidene)malononitrile; AG-18; Tyrphostin AG18; Tyrphostin RG50810; 2-(3,4-dihydroxybenzylidene)malononitrile; UNII-RV0GCD31OJ; alpha-Cyano-(3,4-dihydroxy)cinnamonitrile; 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; RG 50810; Propanedinitrile,2-[(3,4-dihydroxyphenyl)methylene]-; ag18; (3,4-Dihydroxyphenyl)methylene propanedinitrile; RV0GCD31OJ; C10H6N2O2; NCGC00016043-03; (3,4-dihydroxybenzylidene)propanedinitrile; DSSTox_CID_25215 Click to Show/Hide
MOA	Inhibitor
Activity	Ki = 11000 nM
External Link	CID: 2052 TTD: D0A0JL
Compound Name	IPS-01003		Investigative	[13]
Synonyms	EGFR kinase antagonist (cancer), InnoPharmaScreen Click to Show/Hide
MOA	Antagonist
External Link	TTD: D0AC7C
Compound Name	RM-6427		Investigative	[13]
Synonyms	RM-6428; EGFR tyrosine kinase inhibitors (parasitic infection), Romark Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9931101 TTD: D0AH2V
Compound Name	N4-(3-Bromo-phenyl)-quinazoline-4,6,7-triamine		Investigative	[91]
Synonyms	bpdq; CHEMBL328216; 4-N-(3-bromophenyl)quinazoline-4,6,7-triamine; 4-[(3-Bromophenyl)amino]-6,7-diaminoquinazoline; 169205-87-2; AC1L1DNE; N4-(3-bromophenyl)-4,6,7-Quinazolinetriamine; K00041; SCHEMBL7221302; BDBM3303; 4-Anilinoquinazoline deriv. 54; CTK8F8323; ADXSZLCTQCWMTE-UHFFFAOYSA-N; IN1401; HSCI1_000040; AKOS025149794; 4-(3-bromoanilino)-6,7-diaminoquinazoline; N-(3-Bromophenyl)quinazoline-4,6,7-triamine; 4[ (3-Bromophenyl)aminol-6,7-diaminoquinazoline; J-010514 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.12 nM
External Link	CID: 2426 TTD: D0B4PH
Compound Name	3-Pyridin-4-yl-quinoline-6,7-diol		Investigative	[99]
MOA	Inhibitor
Activity	IC50 = 5000 nM
External Link	CID: 135469328 TTD: D0B8DE
Compound Name	AGT-2000		Investigative	[13]
Synonyms	Gene therapy (intravenous, brain cancer), ArmaGen Click to Show/Hide
MOA	Modulator
External Link	TTD: D0C5WE
Compound Name	3-(3-Chloro-phenyl)-5,7-dihydroxy-chromen-4-one		Investigative	[100]
Synonyms	CHEMBL7827; SCHEMBL3355884; 62845-10-7; CTK2B1467; ZINC23489; DTXSID10445847; BDBM50074745; AKOS030553076; 5,7-Dihydroxy-3-(3-chlorophenyl)-4H-1-benzopyran-4-one; 4H-1-Benzopyran-4-one, 3-(3-chlorophenyl)-5,7-dihydroxy- Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 95 nM
External Link	CID: 10850934 TTD: D0C9KC
Compound Name	ON-128		Investigative	[13]
Synonyms	ON-128060; ON-128 series (cancer); HER1/EGFR inhibitors (cancer), Onconova; Human epidermal growth factor receptor 1/epidermal growth factor receptor inhibitors (cancer), Onconova; ON-128 series (cancer), Onconova Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0CY9O
Compound Name	FHT-2107		Investigative	[13]
Synonyms	EGFR-targeting siRNA agent, ForHumanTech Click to Show/Hide
External Link	TTD: D0D0GS
Compound Name	GI-3000		Investigative	[13]
Synonyms	GI-3001; GI-6200; GlioVax-1; EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen); EGFR-expressing Saccharomyces cerevisiae-based cancer vaccine (Tarmogen), GlobeImmune Click to Show/Hide
External Link	TTD: D0D0YK
Compound Name	6,7-dimethoxy-N-m-tolylquinazolin-4-amine		Investigative	[95]
Synonyms	CHEMBL56802; AC1MDC5E; Oprea1_570563; SCHEMBL5482883; ZINC5857; 4-Quinazolinamine,6,7-dimethoxy-N-(3-methylphenyl)-; MolPort-001-734-434; BDBM50102093; MCULE-3929709513; 666839-07-2; (6,7-Dimethoxy-quinazolin-4-yl)-m-tolyl-amine; SR-02000000178; SR-02000000178-1; 6,7-dimethoxy-N-(3-methylphenyl)quinazolin-4-amine Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 4.6 nM
External Link	CID: 2808977 TTD: D0DF3Z
Compound Name	5,6-Bis-p-tolylamino-isoindole-1,3-dione		Investigative	[82]
Synonyms	CHEMBL7914; SCHEMBL8834183; BDBM50040920 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 4500 nM
External Link	CID: 10360970 TTD: D0EH6L
Compound Name	HTS-05058		Investigative	[93]
Synonyms	MLS000327715; SMR000180717; 3-(1H-imidazol-5-ylmethylene)-1,3-dihydro-2H-indol-2-one; (3Z)-3-(1H-imidazol-5-ylmethylidene)-1H-indol-2-one; Angiogenesis Inhibitor; 372164-79-9; AC1NWWY9; CHEMBL261692; SCHEMBL2998484; REGID_for_CID_667701; BDBM41079; cid_5714572; REGID_for_CID_5714572; MolPort-002-870-304; MolPort-002-901-109; HMS2463B12; ZINC4693510; AKOS015992864; (3Z)-3-(1H-imidazol-5-ylmethylene)oxindole; 4X-0884; J-011988 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 5714572 TTD: D0EP1G
Compound Name	N-(4-m-Tolylamino-quinazolin-7-yl)-acrylamide		Investigative	[101]
Synonyms	CHEMBL297968; SCHEMBL2994207; FAGJCAQBJKSOOS-UHFFFAOYSA-N; BDBM50077245; N-[4-(3-Methylanilino)quinazoline-7-yl]acrylamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 90 nM
External Link	CID: 10494722 TTD: D0F6FZ
Compound Name	4-(4-(2-nitrovinyl)phenoxysulfonyl)benzoic acid		Investigative	[85]
Synonyms	CHEMBL76958; BDBM50007075; 4-[4-(2-Nitro-vinyl)-phenoxysulfonyl]-benzoic acid; 4-[4-[(E)-2-Nitroethenyl]phenoxysulfonyl]benzoic acid Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1000 nM
External Link	CID: 14862522 TTD: D0G4HR
Compound Name	Benzo[g]quinazolin-4-yl-(3-bromo-phenyl)-amine		Investigative	[91]
Synonyms	CHEMBL63786; N-(3-bromophenyl)benzo[g]quinazolin-4-amine; Benzoquinazoline deriv. 23; AC1NS43R; SCHEMBL4348523; BDBM3585; BUVKJPOCMOXSSQ-UHFFFAOYSA-; ZINC3815025; 4-[(3-Bromophenyl)amino]benzo[g]quinazoline; N-(3-Bromophenyl)benzo[g]quinazoline-4-amine Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.003 nM
External Link	CID: 5328245 TTD: D0G9KD
Compound Name	ARX-AHD		Investigative	[13]
Synonyms	Dolastatin-conjugated HER2 antibody (breast cancer), Ambrx Click to Show/Hide
External Link	TTD: D0GB7F
Compound Name	TGF alpha		Investigative	[13]
Synonyms	TGF alpha (neurological damage) Click to Show/Hide
MOA	Modulator
External Link	TTD: D0H3FX
Compound Name	AG 9		Investigative	[89]
Synonyms	tyrphostin 1; tyrphostin A1; AG9; AG-9 Click to Show/Hide
MOA	Inhibitor
Activity	Ki > 400000 nM
External Link	CID: 2063 TTD: D0H3UI
Compound Name	N4-(3-Bromo-phenyl)-quinazoline-4,6-diamine		Investigative	[102]
Synonyms	N4-(3-Bromophenyl)quinazoline-4,6-diamine; 169205-78-1; 4-N-(3-bromophenyl)quinazoline-4,6-diamine; CHEMBL52765; AK-25174; N4-(3-bromophenyl)-4,6-quinazolinediamine; 4,6-Quinazolinediamine, N4-(3-bromophenyl)-; C14H11BrN4; nchembio866-comp32; Anilinoquinazoline, 4b; AC1NS3N2; BDBM3294; SCHEMBL1417740; 4-Anilinoquinazoline deriv. 45; KS-00000HMR; CTK4D3225; DTXSID40416141; IZQHULBHKPGOAP-UHFFFAOYSA-N; MolPort-009-198-483; ZINC3815034; BCP18882; ANW-50332; AKOS013915836; 6-amino 4-(3-bromoanilino)quinazoline; GS-4221 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.78 nM
External Link	CID: 5328042 TTD: D0HM5W
Compound Name	4-(5-Bromoindole-3-yl)-6,7-dimethoxyquinazoline		Investigative	[103]
Synonyms	CHEMBL473320; SCHEMBL5616932 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 131 nM
External Link	CID: 11696664 TTD: D0I7RA
Compound Name	Theliatinib		Investigative	[13]
Synonyms	HMPL-309; Second EGFR tyrosine kinase inhibitor (cancer), Hutchison Medipharma Click to Show/Hide
MOA	Inhibitor
External Link	CID: 54759275 TTD: D0J3EA
Compound Name	4-(3-Bromo-phenylamino)-quinazoline-6,7-diol		Investigative	[91]
MOA	Inhibitor
External Link	CID: 5328050 TTD: D0J9WO
Compound Name	6,7-dimethoxy-4-(4-phenylbut-1-ynyl)quinazoline		Investigative	[86]
Synonyms	CHEMBL250318; BDBM50222435 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 14 nM
External Link	CID: 44442165 TTD: D0K2VO
Compound Name	4-(2-nitroprop-1-enyl)benzene-1,2-diol		Investigative	[85]
Synonyms	13662-96-9; 1,2-Benzenediol, 4-(2-nitro-1-propenyl)-; AC1MMGH2; Oprea1_551147; CTK0F3796; DTXSID20390758; AKOS017269192 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 3260632 TTD: D0K2YY
Compound Name	EDP-13		Investigative	[13]
Synonyms	Epidermal growth factor receptor antagonist (cancer), BiolineRx/Matrix Pharma Click to Show/Hide
MOA	Antagonist
External Link	TTD: D0K3FG
Compound Name	N4-(3-Bromo-phenyl)-quinazoline-4,7-diamine		Investigative	[87]
Synonyms	CHEMBL420624; 7-amino-4-[(3-bromophenyl)amino]quinazoline; 4-N-(3-bromophenyl)quinazoline-4,7-diamine; 4-Anilinoquinazoline deriv. 48; AC1NS3NB; BDBM3297; SCHEMBL2986298; GHVBIROTJQDRQB-UHFFFAOYSA-N; ZINC3815072; AKOS014671983; 7-Amino-4-(3-bromoanilino)quinazoline; 7-amino-4(3-bromoanilino)-quinazoline; 7-amino-4-(3-bromoanilino)-quinazoline; 169205-81-6; N-(3-Bromophenyl)quinazoline-4,7-diamine; 7-Amino-4-[(3-bromophenyl)aminolquinazoline; FT-0768311; 7-amino-4-[(3-bromophenyl)-amino]quinazoline Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.1 nM
External Link	CID: 5328045 TTD: D0K7GD
Compound Name	(S)-benzyl 4-chloro-3-oxobutan-2-ylcarbamate		Investigative	[85]
Synonyms	Z-L-Ala-chloromethylketone; 41036-43-5; Benzyloxycarbonylalanine chloromethyl ketone; Z-Ala-chloromethyl ketone; AC1NUSRJ; PubChem11548; Benzyloxycarbonyl-ala-chloromethyl ketone; CHEMBL483443; SCHEMBL6437509; DTXSID50194009; ZINC34206665; AKOS027382196; FT-0603930; benzyl N-[(2S)-4-chloro-3-oxobutan-2-yl]carbamate; [(S)-1-Methyl-2-oxo-3-chloropropyl]carbamic acid benzyl ester; Carbamic acid, (3-chloro-1-methyl-2-oxopropyl)-, phenylmethyl ester, (S)- Click to Show/Hide
MOA	Inhibitor
External Link	CID: 5491980 TTD: D0KN1L
Compound Name	4-(2-nitrovinyl)benzene-1,2-diol		Investigative	[85]
Synonyms	SL-1; CHEMBL78224; 108074-44-8; SL-1 Pigment; 1,2-Dihydroxy-4-(nitroethenyl)benzene; 4-[(E)-2-nitroethenyl]benzene-1,2-diol; AC1O5R3K; SCHEMBL2052283; SCHEMBL2052285; beta-Nitro-3,4-dihydroxystyrene; LLJASJHXECDHOM-ONEGZZNKSA-N; BDBM50007069; AKOS010878666; 4-(2-Nitro-vinyl)-benzene-1,2-diol; 1,2-Benzenediol, 4-(2-nitroethenyl)-, (E)- Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 8800 nM
External Link	CID: 6439158 TTD: D0L3SN
Compound Name	AG-538		Investigative	[85]
Synonyms	Tyrphostin AG 538; AG 538; NSC676485; (E)-2-(3,4-dihydroxybenzoyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile; alpha-Cyano-(3,4-dihydroxy)cinnamoyl-(3& -dihydroxyphenyl)ketone; Tyrphostin deriv. 24; Lopac-T-7822; AC1NS5A3; Lopac0_001261; MLS002153408; CHEMBL56393; SCHEMBL2678764; SCHEMBL2678765; BDBM4293; REGID_for_CID_660907; CHEBI:92138; cid_5328760; REGID_for_CID_5328760; HMS3263N04; HMS2233K10; ZINC3871438; 133550-18-2; Tox21_501261; HSCI1_000189; CCG-205335; NSC-676485; LP01261; NCGC00094499-02 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 370 nM
External Link	CID: 5328760 TTD: D0NH7M
Compound Name	WZ-3146		Investigative	[13]
Synonyms	WZ-4002; WZ-8040; EGFR-T790M kinase inhibitors (lung cancer); EGFR-T790M kinase inhibitors (lung cancer), Gatekeeper Pharmaceuticals Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44607360 TTD: D0NJ3Q
Compound Name	2-methoxy-4-(2-nitrovinyl)phenol		Investigative	[85]
Synonyms	6178-42-3; 2-Methoxy-4-[(E)-2-nitroethenyl]phenol; 1-(4-HYDROXY-3-METHOXYPHENYL)-2-NITROETHENE; (E)-2-methoxy-4-(2-nitrovinyl)phenol; trans-4-Hydroxy-3-methoxy-beta-nitrostyrene; 2-methoxy-4-[(E)-2-nitrovinyl]phenol; CHEMBL309016; 22568-51-0; AF-467/00017042; 2-methoxy-4-(2-nitroethenyl)phenol; 2-Methoxy-4-(2-nitro-vinyl)-phenol; 4-((1E)-2-nitrovinyl)-2-methoxyphenol; 4-{2-nitrovinyl}-2-methoxyphenol; 4-Hydroxy-3-methoxy-beta-nitrostyrene; AC1LCWDN; PubChem19447; AC1Q1WR9; MLS000574924 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 7900 nM
External Link	CID: 638439 TTD: D0O9UR
Compound Name	MG-111		Investigative	[104]
Synonyms	134865-04-6; EGF, Hitachi Click to Show/Hide
MOA	Modulator
External Link	CID: 16143379 TTD: D0P0JW
Compound Name	6,7-dimethoxy-4-(2-phenylethynyl)quinazoline		Investigative	[86]
Synonyms	CHEMBL250315; SCHEMBL6180450; BDBM50222433 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 5600 nM
External Link	CID: 18770812 TTD: D0P2GE
Compound Name	Anti-EGFR humanized mabs		Investigative	[13]
Synonyms	Anti-EGFR humanized mAbs (cancer); Anti-EGFR humanized mAbs (cancer), Xencor; Anti-EGFR humanized monoclonal antibodies (cancer), Xencor Click to Show/Hide
External Link	TTD: D0R2RV
Compound Name	4-biphenyl-2-ylethynyl-6,7-dimethoxy-quinazoline		Investigative	[86]
Synonyms	CHEMBL250924; BDBM50222419 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 26 nM
External Link	CID: 44442180 TTD: D0S9QP
Compound Name	AL-6802		Investigative	[13]
Synonyms	EGFR modulators (cancer), Advenchen/Simcere Click to Show/Hide
MOA	Modulator
External Link	TTD: D0T7OS
Compound Name	BPIQ-I		Investigative	[91]
Synonyms	174709-30-9; N-(3-bromophenyl)-3-methyl-3H-imidazo[4,5-g]quinazolin-8-amine; 8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline; Imidazoquinazoline deriv. 12; AC1L1DNH; GTPL5939; CHEMBL174426; BDBM3574; SCHEMBL17931472; CTK8E6742; DTXSID60274366; MolPort-044-561-412; HMS3229C05; ZINC2391775; IN1402; HSCI1_000090; AKOS025394452; CCG-206740; ACM174709309; RT-011807; J-011030; BRD-K72211743-001-01-1 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.025 nM
External Link	CID: 2427 TTD: D0U6WB
Compound Name	mabionHER2		Investigative	[13]
Synonyms	Humanized monoclonal antibody (breast cancer), Mabion Click to Show/Hide
External Link	TTD: D0V0JV
Compound Name	4-(2-nitrovinyl)phenol		Investigative	[85]
Synonyms	4-Hydroxy-b-nitrostyrene; (E)-4-(2-nitrovinyl)phenol; 4-hydroxy-beta-nitrostyrene; trans-4-Hydroxy-beta-nitrostyrene; 22568-49-6; Phenol, p-(2-nitrovinyl)-; 4-[(E)-2-Nitroethenyl]phenol; 4-[(E)-2-nitrovinyl]phenol; CHEMBL307481; CTJKRKMPTRJAIT-AATRIKPKSA-N; NSC81594; 1-(4-hydroxyphenyl)-2-nitroethene; 4-(2-(Hydroxy(oxido)amino)vinyl)phenol; 4-(2-Nitro-vinyl)-phenol; NSC30299; AC1LCWDH; 4-Hydroxy--nitrostyrene; 4'-hydroxy-beta-nitrostyrene; Phenol,4-(2-nitroethenyl)- Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 10000 nM
External Link	CID: 638437 TTD: D0W1BE
Compound Name	4-acrylamido-N-(3-bromophenyl)-2-hydroxybenzamide		Investigative	[94]
Synonyms	CHEMBL200958 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 44406548 TTD: D0W2PQ
Compound Name	MDP-01		Investigative	[13]
Synonyms	Peptabody-EGF (anticancer), Med Discovery Click to Show/Hide
MOA	Inhibitor
External Link	TTD: D0WD8R
Compound Name	N4-(3-methylphenyl)-4,6-quinazolinediamine		Investigative	[105]
Synonyms	CHEMBL336113; Anilinoquinazoline, 4a; 6-amino-4-[(3-methylphenyl)amino]quinazoline; SMA52; SCHEMBL159209; ZINC6328; SMA-52; NFBCSWGEYDCCDW-UHFFFAOYSA-N; BDBM50133384; AKOS013914431; N4-m-Tolyl-quinazoline-4,6-diamine; 153436-70-5; 6-amino-4-(3'-methylanilino)quinazoline; 6-amino-4-(3-methylphenylamino)-quinazoline; FT-0765557; 6-amino-4[(3-methylphenyl)amino]quinazoline Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1000 nM
External Link	CID: 10220590 TTD: D0X4UE
Compound Name	RX-1792		Investigative	[13]
Synonyms	EGF antagonist, Rexahn; RX-0183 Click to Show/Hide
MOA	Antagonist
External Link	TTD: D0Y1LD
Compound Name	(3-Bromo-phenyl)-(5-nitro-quinazolin-4-yl)-amine		Investigative	[87]
Synonyms	N-(3-bromophenyl)-5-nitroquinazolin-4-amine; AC1NS3MQ; BDBM3290; CHEMBL116308; 4-Anilinoquinazoline deriv. 41 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 355 nM
External Link	CID: 5328038 TTD: D0Y2AM
Compound Name	NRC-2694		Investigative	[13]
MOA	Inhibitor
External Link	CID: 16129168 TTD: D0Y6MD
Compound Name	Cochliobolic acid		Investigative	[106]
Synonyms	CHEMBL464721; 185846-15-5; AC1O516J; BDBM50292386; 2-Furancarboxylic acid, tetrahydro-3-hydroxy-5-(17-methyl-13,14-dioxo-1,3,5,7,9,11,15-nonadecaheptaenyl)-, (2alpha,3beta,5alpha(1E,3E,5E,7E,9E,11E,15E))-(partial)-; (2R,3R,5S)-3-hydroxy-5-[(1E,3E,5E,7E,9E,11E,15E)-17-methyl-13,14-dioxononadeca-1,3,5,7,9,11,15-heptaenyl]oxolane-2-carboxylic acid Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 1600 nM
External Link	CID: 6450172 TTD: D0ZT9D
Compound Name	PD-168393		Investigative	[107]
Synonyms	PD168393; 194423-15-9; pd 168393; UNII-3R996Y9T0I; 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; n-{4-[(3-bromophenyl)amino]quinazolin-6-yl}prop-2-enamide; N-[4-(3-bromoanilino)quinazolin-6-yl]prop-2-enamide; CHEMBL285063; 3R996Y9T0I; C17H13BrN4O; N-[4-(3-Bromo-phenylamino)-quinazolin-6-yl]-acrylamide; 2-Propenamide, N-(4-((3-bromophenyl)amino)-6-quinazolinyl)-; 2-Propenamide, N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-; nchembio866-comp2; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)acrylamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.08 nM
External Link	CID: 4708 TTD: D01VFR DrugBank: DB07662
Compound Name	N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide		Investigative	[101]
Synonyms	CHEMBL31815; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl]acrylamide; N-[4-[(3-methyl-phenyl)amino]quinazolin-6-yl)acrylamide; SCHEMBL2991796; AWQLTDUXGVCRBV-UHFFFAOYSA-N; BDBM50077244 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.42 nM
External Link	CID: 9995195 TTD: D01WYI
Compound Name	4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline		Investigative	[108]
Synonyms	CHEMBL98798 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 70 nM
External Link	CID: 44331231 TTD: D03HLH
Compound Name	4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinoline		Investigative	[108]
Synonyms	CHEMBL101581 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2500 nM
External Link	CID: 44331083 TTD: D05QMN
Compound Name	YH013		Investigative	[109]
External Link	TTD: D0AM9O
Compound Name	LAVENDUSTIN A		Investigative	[110]
Synonyms	125697-92-9; RG14355; UNII-3Y0G32G2RV; CHEMBL103552; 3Y0G32G2RV; C21H19NO6; Lavendustin A, from Streptomyces griseolavendus; Benzoic acid,5-[[(2,5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy-; RG 14355; 5-(((2,5-Dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxybenzoic acid; Benzoic acid, 5-(((2,5-dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxy-; 5-Amino-((N-2,5-dihydroxybenzyl)-N -2-hydroxybenzyl)salicylic acid Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.004 ug.mL-1
External Link	CID: 3894 TTD: D0D9TU
Compound Name	PF 5208766		Investigative	[111]
Synonyms	WAY-178357 Click to Show/Hide
MOA	Modulator
External Link	TTD: D0J2CP
Compound Name	6-chloro-N-(3-chlorophenyl)quinazolin-4-amine		Investigative	[112]
Synonyms	4-Anilidoquinazoline deriv. 12a; AC1NS5EY; SCHEMBL4355658; BDBM4397 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 2700 nM
External Link	CID: 5328819 TTD: D0J5SK
Compound Name	N-(4-(phenylamino)quinazolin-6-yl)acrylamide		Investigative	[107]
Synonyms	CHEMBL1221699; N-[4-(phenylamino)quinazolin-6-yl]prop-2-enamide; nchembio866-comp4; SCHEMBL614989; BDBM50324687; DB08462; N-(4-Anilinoquinazoline-6-yl)acrylamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 < 1 nM
External Link	CID: 10401956 TTD: D0N8TQ DrugBank: DB08462
Compound Name	AG-213		Investigative	[103]
MOA	Inhibitor
Activity	Ki = 850 nM
External Link	CID: 667601 TTD: D0Q3GG
Compound Name	SYM-011		Investigative	[13]
Synonyms	Dimercept; Hermodulins; Herstatin; RB-200; RBLX-200; RBLX-242; RBLX-242h; RBLX-642h Click to Show/Hide
MOA	Modulator
External Link	TTD: D0Q8GX
Compound Name	10-hydroxy-18-methoxybetaenone		Investigative	[113]
Synonyms	CHEMBL498247; BDBM50269144 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 10500 nM
External Link	CID: 10644450 TTD: D0W6CE
Compound Name	4557W		Investigative	[114]
Synonyms	EGFR/ErbB-2 Inhibitor; 179248-61-4; 4-(4-Benzyloxyanilino)-6,7-dimethoxyquinazoline; SCHEMBL242224; GTPL5964; CHEMBL563845; CTK8E8822; DTXSID40431718; MolPort-018-661-221; HMS3229C21; ZINC1485577; IN1350; HSCI1_000238; AKOS002350936; CCG-206748; RT-012453; J-011438; BRD-K76819286-001-01-0; N-[4-(Benzyloxy)phenyl]-6,7-dimethoxyquinazoline-4-amine; N-[4-(benzyloxy)phenyl]-6,7-dimethoxyquinazolin-4-amine Click to Show/Hide
MOA	Inhibitor
External Link	CID: 9843206 TTD: D0X4OU
Compound Name	Tyrphostin ag-1478		Investigative	[100]
Synonyms	AG-1478; 153436-53-4; Tyrphostin AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; 175178-82-2; 4-(3-Chloroanilino)-6,7-dimethoxyquinazoline; AG 1478; AG1478; TYRPHOSTIN; 4-Quinazolinamine, N-(3-chlorophenyl)-6,7-dimethoxy-; UNII-SUH0SEZ9HY; SUH0SEZ9HY; AG-1478 hydrochloride; AG-1478 (Tyrphostin AG-1478); CHEMBL7917; CHEBI:75404; N-(3-Chlorophenyl)-6,7-dimethoxy-4-quinazolinamine; NSC-693255; AK-63142; N-(3-chlorophenyl)-6,7-dimethoxy-quinazolin-4-amine; BRD6408; BRD-6408; SR-01000076156; NSC693255 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 120 nM
External Link	CID: 2051 TTD: D0ZH1U
Compound Name	CL-387785		Investigative	[95]
Synonyms	194423-06-8; EKI-785; CL-387785 (EKI-785); CL-387,785; UNII-B4W27J1Z8B; CL-387785(EKI785; WAY-EKI 785); EKB-785; CHEMBL91867; B4W27J1Z8B; N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-butynamide; N-(4-((3-bromophenyl)amino)quinazolin-6-yl)but-2-ynamide; CHEBI:90180; C18H13BrN4O; N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide; N-[4-[(3-Bromophenyl)amino]quinazolin-6-yl]but-2-ynamide; N-[4-[(3-bromophenyl)amino]-6-quinazolinyl)-2-butynamide; N-{4-[(3-bromophenyl)amino]-6-quinazolinyl}-2-butynamide Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.37 nM
External Link	CID: 2776 TTD: D00TZD
Compound Name	HDS-029		Investigative	[115]
Synonyms	HDS 029 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.3 nM
External Link	CID: 11566580 TTD: D05FFT
Compound Name	WHI-P154		Investigative	[116]
MOA	Inhibitor
External Link	CID: 3795 TTD: D0E5IP
Compound Name	PMID24915291C38		Investigative	[117]
Synonyms	GTPL8145; PLS-123; BDBM50020476; 1431727-04-6 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 7 nM
External Link	CID: 71556703 TTD: D06BJG
Compound Name	HKI-9924129		Investigative	[118]
MOA	Inhibitor
Activity	IC50 = 390 nM
External Link	CID: 5311104 TTD: D0D5EW
Compound Name	PD-0173956		Investigative	[118]
Synonyms	UNII-YR2DP5GJ1Y; YR2DP5GJ1Y; PD173956; PD-173956; AC1NS9BQ; 305820-76-2; SCHEMBL1334768; BDBM6569; CHEMBL574059; Pyrido(2,3-d)pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-((4-fluorophenyl)amino)-8-methyl-; 6-(2,6-dichlorophenyl)-2-(4-fluoroanilino)-8-methylpyrido[2,3-d]pyrimidin-7-one; 6-(2,6-dichlorophenyl)-2-[(4-fluorophenyl)amino]-8-methyl-7H,8H-pyrido[2,3-d]pyrimidin-7-one Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 380 nM
External Link	CID: 5330524 TTD: D0GW4Q
Compound Name	PD-0166326		Investigative	[118]
Synonyms	PD-166326 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 90 nM
External Link	CID: 447700 TTD: D0P3JW DrugBank: DB08339
Compound Name	PP121		Investigative	[119]
Synonyms	PP-121; PP 121 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 260 nM
External Link	CID: 24905142 TTD: D03EHM DrugBank: DB08052
Compound Name	3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione		Investigative	[120]
Synonyms	CHEMBL380598; SCHEMBL3148490; HVQJGNALTWNDMX-UHFFFAOYSA-N; BDBM50375058; 2-(1H-Indole-3-yl)-3-phenylmaleimide Click to Show/Hide
MOA	Inhibitor
External Link	CID: 15422868 TTD: D06AOY
Compound Name	Ro-4396686		Investigative	[121]
Synonyms	SCHEMBL5809947; CHEMBL606964 Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 545 nM
External Link	CID: 11396738 TTD: D09XIL
Compound Name	3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione		Investigative	[120]
Synonyms	1H-Pyrrole-2,5-dione, 3,4-bis(4-methoxyphenyl)-; 108774-82-9; ACMC-20mbs9; CHEMBL381099; CTK0G2626; DTXSID90449388 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 10946795 TTD: D00NYT
Compound Name	3,4-diphenyl-1H-pyrrole-2,5-dione		Investigative	[120]
Synonyms	2,3-diphenylmaleimide; 1H-Pyrrole-2,5-dione, 3,4-diphenyl-; 31295-36-0; AC1MBL6S; SCHEMBL114611; CHEMBL201949; CTK1B9880; 3,4-diphenylpyrrole-2,5-dione; DTXSID70372903; ZINC3847556 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 2752461 TTD: D0C3WY
Compound Name	3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione		Investigative	[120]
Synonyms	CHEMBL372076; SCHEMBL3822337 Click to Show/Hide
MOA	Inhibitor
External Link	CID: 11572699 TTD: D0EK0G
Compound Name	Osimertinib		Approved	[14]
Synonyms	Tagrisso Click to Show/Hide
MOA	Inhibitor
Activity	IC50 = 0.421 nM
External Link	CID: 71496458 TTD: D0O8GK DrugBank: DB09330
Compound Name	PMID27774824-Compound-Figure9Example2down		Patented	[122]
External Link	TTD: D01DBB
Compound Name	Mobocertinib		Approved	[122]
Synonyms	1847461-43-1; TAK-788; TAK788; AP32788; UNII-39HBQ4A67L; 39HBQ4A67L; propan-2-yl 2-[4-{[2-(dimethylamino)ethyl](methyl)amino}-2-methoxy-5-(prop-2-enamido)anilino]-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Mobocertinib [INN]; Mobocertinib [USAN]; AP-32788; Mobocertinib (TAK788); Mobocertinib(TAK-788); SCHEMBL17373133; GTPL10468; BDBM368374; BCP31045; EX-A3392; US10227342, Example 10; MFCD32669806; NSC825519; s6813; TAK-788;AP32788; WHO 11183; NSC-825519; example 94 [WO2015195228A1]; HY-135815; CS-0114256; TAK-788;TAK 788; AP 32788; 5-Pyrimidinecarboxylic acid, 2-((4-((2-(dimethylamino)ethyl)methylamino)-2-methoxy-5-((1-oxo-2-propen-1-yl)amino)phenyl)amino)-4-(1-methyl-1H-indol-3-yl)-, 1-methylethyl ester; C(C=C)(=O)NC=1C(=CC(=C(C=1)NC1=NC=C(C(=N1)C1=CN(C2=CC=CC=C12)C)C(=O)OC(C)C)OC)N(C)CCN(C)C; Isopropyl 2-((5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenyl)amino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Isopropyl 2-(5-acrylamido-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyphenylamino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; Propan-2-yl 2-(5-(acryloylamino)-4-((2-(dimethylamino)ethyl)(methyl)amino)-2-methoxyanilino)-4-(1-methyl-1H-indol-3-yl)pyrimidine-5-carboxylate; propan-2-yl 2-[4-[2-(dimethylamino)ethyl-methylamino]-2-methoxy-5-(prop-2-enoylamino)anilino]-4-(1-methylindol-3-yl)pyrimidine-5-carboxylate Click to Show/Hide
External Link	CID: 118607832 TTD: DI4HA7
Compound Name	DZD9008		Phase 1/2	[122]
External Link	TTD: DM8Y2N
Compound Name	AC0010		Phase 3	[122]
Synonyms	Avitinib; 1557267-42-1; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; Avitinib free base; SCHEMBL15453394; KS-00000TON; EX-A783; MolPort-042-663-560; Avitinib(AC0010/AC0010MA); ZINC142081723; AKOS030632728; CS-W008904; N-(3-{2-[3-Fluoro-4-(4-methyl-piperazin-1-yl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy}-phenyl)-acrylamide; DS-19269; AK543905; 2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4- Click to Show/Hide
External Link	CID: 72734520 TTD: D0FV3K DrugBank: DB15327
Compound Name	EGFR antisense DNA		Phase 1/2	[122]
Synonyms	Antisense therapy, UPCI; EGFR antisense DNA, University of Pittsburgh Click to Show/Hide
External Link	TTD: D06VFF
Compound Name	CK-101		Phase 1/2	[122]
Synonyms	IDRGFNPZDVBSSE-UHFFFAOYSA-N; 1660963-42-7; RX-518; N-(3-(2-((2,3-Difluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)amino)quinazolin-8-yl)phenyl)acrylamide; EGFR-IN-3; UNII-708TLB8J3Y; 708TLB8J3Y; AK543910; N-[3-[2-[[2,3-difluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]phenyl]amino]quinazolin-8-yl]phenyl]acrylamide; GTPL9863; SCHEMBL16514522; KS-00000TOQ; MolPort-042-663-562; RX518; CK101; EX-A1142; BCP19075; RX 518; ZINC514250913; AKOS030632731; DS-19272; HY-19815; CS-0016788; Example 153 [US20170050936A1]; J-690231; 2-Propena Click to Show/Hide
External Link	CID: 117909640 TTD: D09BZS
Compound Name	Pyrotinib		Phase 1	[122]
Synonyms	UNII-CJN36EQM0H; SHR-1258; CJN36EQM0H; SHR1258; 1269662-73-8; SCHEMBL9948753; GTPL9662; SADXACCFNXBCFY-IYNHSRRRSA-N; BDBM139991; AKOS032946680; CS-7940; compound 12 [PMID: 28115222]; 2-Propenamide, N-(4-((3-chloro-4-(2-pyridinylmethoxy)phenyl)amino)-3-cyano-7-ethoxy-6-quinolinyl)-3-((2R)-1-methyl-2-pyrrolidinyl)-, (2E)-; HY-104065; US8901140, 5; (E)-N-[4-[[3-chloro-4-(2-pyridylmethoxy)phenyl]amino]-3-cyano-7-ethoxy-6-quinolyl]-3-[(2R)-1-methylpyrrolidin-2-yl]prop-2-enamide; (E)-N-[4-[3-chloro-4-(pyridin-2-ylmetho Click to Show/Hide
External Link	CID: 51039030 TTD: D0M8YM DrugBank: DB14993
Compound Name	Anti-EGFRvIII CAR transduced PBL		Phase 1/2	[122]
External Link	TTD: D08RJY
Compound Name	EGFRvIII CAR		Phase 1/2	[122]
External Link	TTD: D0LU4N
Compound Name	Anti-EGFR V III CAR-T cells		Phase 1/2	[122]
External Link	TTD: D0Q4EJ
Compound Name	EGFRvIII CAR T cells		Phase 1	[122]
External Link	TTD: D01LWE
Compound Name	CAR-T cells targeting EGFRviii		Phase 1	[122]
External Link	TTD: D03CMZ
Compound Name	Anti-EGFRvIII CAR T cells		Phase 1	[122]
External Link	TTD: D09OSC
Compound Name	CART-EGFRvIII T cells		Phase 1	[122]
External Link	TTD: D0B5PV
Compound Name	EGFRvIII-CARs		Phase 1	[122]
External Link	TTD: D0PT2M
Compound Name	CAR-T Cells targeting EGFRvIII		Phase 1	[122]
External Link	TTD: D0ZQ6N
Compound Name	RG6156		Phase 1	[122]
External Link	TTD: DF8X5N
Compound Name	AMG 596		Phase 1	[122]
External Link	TTD: DOJ6E8
Compound Name	D2C7		Phase 1	[70]
External Link	TTD: DR4ND6

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