m6A-centered Crosstalk Information
Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation
| Crosstalk ID |
M6ACROT00144
|
[1], [2] | |||
.png)
.png)
 : m6A sites
Direct
Enhancement
RNA modification
HNRNPLL
HNRNPLL
ADARB1
Methylation
 : modification sites
|
|||||
| m6A Modification: | |||||
|---|---|---|---|---|---|
| m6A Regulator | Methyltransferase-like 3 (METTL3) | WRITER | |||
| m6A Target | Double-stranded RNA-specific editase 1 (ADARB1) | ||||
| Epigenetic Regulation that have Cross-talk with This m6A Modification: | |||||
| Epigenetic Regulation Type | RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I) | ||||
| Epigenetic Regulator | Double-stranded RNA-specific editase 1 (ADARB1) | WRITER | View Details | ||
| Regulated Target | Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL) | View Details | |||
| Crosstalk Relationship | m6A → A-to-I | Enhancement | |||
| Crosstalk Mechanism | m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator | ||||
| Crosstalk Summary | METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Heterogeneous nuclear ribonucleoprotein L like (HNRNPLL) transcript. | ||||
| Cell Process | RNA editing | ||||
In-vitro Model |
MGG8 | Glioblastoma | Homo sapiens | CVCL_D1H4 | |
| HeLa | Endocervical adenocarcinoma | Homo sapiens | CVCL_0030 | ||
References