m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00126				[1], [2], [3]
m⁶A modification ADAR1 ADAR1 METTL3 Methylation : m⁶A sites Direct Enhancement RNA modification VCAM1 VCAM1 ADAR Methylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Interferon-inducible protein 4 (ADAR1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Interferon-inducible protein 4 (ADAR1)			WRITER	View Details
Regulated Target	Vascular cell adhesion protein 1 (VCAM1)				View Details
Crosstalk Relationship	m6A → A-to-I			Enhancement
Crosstalk Mechanism	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary	METTL3 methylates Interferon-inducible protein 4 (ADAR1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADAR mediated A-to-I RNA editing of the Vascular cell adhesion protein 1 (VCAM1) transcript.
Responsed Drug	ISIS 3792				Drug Info
Pathway Response	mRNA surveillance pathway				hsa03015
Pathway Response	RNA degradation				hsa03018
Cell Process	RNA stability
In-vitro Model	MGG8	Glioblastoma	Homo sapiens		CVCL_D1H4
	U-87MG ATCC	Glioblastoma	Homo sapiens		CVCL_0022
	U-118MG	Astrocytoma	Homo sapiens		CVCL_0633
	HUVEC-C	Normal	Homo sapiens		CVCL_2959

Full List of Potential Compound(s) Related to This m6A-centered Crosstalk

Vascular cell adhesion protein 1 (VCAM1)		9 Compound(s) Regulating the Target	Click to Show/Hide the Full List
Compound Name	ISIS 3792		Investigative	[4]
External Link	TTD: D02TPS
Compound Name	ISIS 3801		Investigative	[4]
External Link	TTD: D02WXX
Compound Name	SYMBIOPOLYOL		Investigative	[5]
MOA	Inhibitor
External Link	CID: 46872950 TTD: D04RGN
Compound Name	ISIS 5876		Investigative	[4]
External Link	TTD: D08YCI
Compound Name	ISIS 5875		Investigative	[4]
External Link	TTD: D0A7AV
Compound Name	ISIS 3804		Investigative	[4]
External Link	TTD: D0A7SE
Compound Name	ISIS 5884		Investigative	[4]
External Link	TTD: D0J7IV
Compound Name	ISIS 3805		Investigative	[4]
External Link	TTD: D0P3FU
Compound Name	ISIS 5874		Investigative	[4]
External Link	TTD: D0R5NX

References

Ref 1	N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2	ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism. Genome Biol. 2021 Jan 28;22(1):51. doi: 10.1186/s13059-021-02271-9.
Ref 3	ADAR1 is targeted by miR-143 to regulate IL-1beta-induced endothelial activation through the NFkappaB pathway. Int J Biochem Cell Biol. 2017 Aug;89:25-33. doi: 10.1016/j.biocel.2017.05.021. Epub 2017 May 17.
Ref 4	US patent application no. 5,843,738, Oligonucleotide modulation of cell adhesion.
Ref 5	Symbiopolyol, a VCAM-1 inhibitor from a symbiotic dinoflagellate of the jellyfish Mastigias papua. J Nat Prod. 2010 Jul 23;73(7):1318-22. doi: 10.1021/np100221k.