Epigenetic Target Information

General Information of the Epigenetic Target (ID: EPITAR00069)
Target Name Vascular cell adhesion protein 1 (VCAM1)
Gene Name VCAM1
Sequence
MPGKMVVILGASNILWIMFAASQAFKIETTPESRYLAQIGDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGPLEAGKPITVKCSVADVYPFDRLEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSVPTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNLQHLSGNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLTLSPVSFENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQLPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQLRSLTLDVQGRENNKDYFSPELLVLYFASSLIIPAIGMIIYFARKANMKGSYSLVEAQKSKV
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Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
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Gene ID 7412
HGNC ID HGNC:12663
Ensembl Gene ID ENSG00000162692
KEGG ID hsa:7412
Chromosomal Location 1p21.2
RNA Modification Sequencing Data Associated with the Target (ID: EPITAR00069)
Vascular cell adhesion protein 1 (VCAM1)
N6-methyladenosine (m6A)
In total 11 m6A sequence/site(s) in this target gene
mod ID: M6ASITE040149 Click to Show/Hide the Full List
mod site chr1:100723303-100723304:+ [1]
Sequence ATGAAATGGATTCTGTGCCCACAGTAAGGCAGGCTGTAAAA
Motif Score 2.053113095
Cell/Tissue List kidney
Seq Type List m6A-REF-seq
Transcript ID List ENST00000650339.1; ENST00000347652.6; ENST00000370119.8; ENST00000370115.1; ENST00000294728.7
External Link RMBase: m6A_site_42465
mod ID: M6ASITE040159 Click to Show/Hide the Full List
mod site chr1:100738090-100738091:+ [2]
Sequence ATGCTATCTTTTTGTACTAGACATTAATTGCATCCATTTTG
Motif Score 2.897386905
Cell/Tissue List iSLK
Seq Type List MeRIP-seq
Transcript ID List ENST00000294728.7; ENST00000347652.6; ENST00000370115.1; ENST00000370119.8; ENST00000603679.1; ENST00000650339.1
External Link RMBase: m6A_site_42466
mod ID: M6ASITE040162 Click to Show/Hide the Full List
mod site chr1:100738131-100738132:+ [3]
Sequence TTATTTTCCAGGAAGAGAAAACAACAAAGACTATTTTTCTC
Motif Score 2.20572619
Cell/Tissue List GM12878; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000370115.1; ENST00000370119.8; ENST00000650339.1; ENST00000347652.6; ENST00000603679.1; ENST00000294728.7
External Link RMBase: m6A_site_42467
mod ID: M6ASITE040169 Click to Show/Hide the Full List
mod site chr1:100738140-100738141:+ [3]
Sequence AGGAAGAGAAAACAACAAAGACTATTTTTCTCCTGAGCTTC
Motif Score 3.319380952
Cell/Tissue List GM12878; iSLK
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000650339.1; ENST00000294728.7; ENST00000370115.1; ENST00000370119.8; ENST00000347652.6; ENST00000603679.1
External Link RMBase: m6A_site_42468
mod ID: M6ASITE040177 Click to Show/Hide the Full List
mod site chr1:100738309-100738310:+ [1]
Sequence CTTGATATGTTCAACTGGAGACACTATTTATCTGTGCAAAT
Motif Score 2.897386905
Cell/Tissue List kidney; fibroblasts; GM12878; iSLK
Seq Type List m6A-REF-seq; m6A-seq; MeRIP-seq
Transcript ID List ENST00000603679.1; ENST00000347652.6; ENST00000294728.7; ENST00000650339.1; ENST00000370115.1; ENST00000370119.8
External Link RMBase: m6A_site_42469
mod ID: M6ASITE040179 Click to Show/Hide the Full List
mod site chr1:100738361-100738362:+ [4]
Sequence CTCATCATTCCTTGAGAAAAACAATGAGCTGAGAGGCAGAC
Motif Score 2.20572619
Cell/Tissue List fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000370115.1; ENST00000347652.6; ENST00000650339.1; ENST00000603679.1; ENST00000370119.8; ENST00000294728.7
External Link RMBase: m6A_site_42470
mod ID: M6ASITE040180 Click to Show/Hide the Full List
mod site chr1:100738380-100738381:+ [4]
Sequence AACAATGAGCTGAGAGGCAGACTTCCCTGAATGTATTGAAC
Motif Score 3.319380952
Cell/Tissue List fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000603679.1; ENST00000294728.7; ENST00000370119.8; ENST00000347652.6; ENST00000650339.1; ENST00000370115.1
External Link RMBase: m6A_site_42471
mod ID: M6ASITE040181 Click to Show/Hide the Full List
mod site chr1:100738399-100738400:+ [4]
Sequence GACTTCCCTGAATGTATTGAACTTGGAAAGAAATGCCCATC
Motif Score 3.373380952
Cell/Tissue List fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000294728.7; ENST00000370115.1; ENST00000370119.8; ENST00000603679.1; ENST00000650339.1; ENST00000347652.6
External Link RMBase: m6A_site_42472
mod ID: M6ASITE040182 Click to Show/Hide the Full List
mod site chr1:100738455-100738456:+ [4]
Sequence GAGCAAGAAGTCAAAGTAAAACTTGCTGCCTGAAGAACAGT
Motif Score 2.627720238
Cell/Tissue List fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000347652.6; ENST00000603679.1; ENST00000370115.1; ENST00000294728.7; ENST00000650339.1; ENST00000370119.8
External Link RMBase: m6A_site_42473
mod ID: M6ASITE040183 Click to Show/Hide the Full List
mod site chr1:100738471-100738472:+ [1]
Sequence TAAAACTTGCTGCCTGAAGAACAGTAACTGCCATCAAGATG
Motif Score 2.951386905
Cell/Tissue List kidney; fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-REF-seq; m6A-seq; MeRIP-seq
Transcript ID List ENST00000603679.1; ENST00000294728.7; ENST00000370119.8; ENST00000370115.1; ENST00000347652.6; ENST00000650339.1
External Link RMBase: m6A_site_42474
mod ID: M6ASITE040184 Click to Show/Hide the Full List
mod site chr1:100738497-100738498:+ [4]
Sequence ACTGCCATCAAGATGAGAGAACTGGAGGAGTTCCTTGATCT
Motif Score 3.373380952
Cell/Tissue List fibroblasts; GM12878; iSLK; MSC
Seq Type List m6A-seq; MeRIP-seq
Transcript ID List ENST00000294728.7; ENST00000347652.6; ENST00000370119.8; ENST00000370115.1; ENST00000603679.1; ENST00000650339.1
External Link RMBase: m6A_site_42475