m6A-centered Crosstalk Information

Mechanism of Crosstalk between m6A Modification and Epigenetic Regulation

m6A Modification:
Crosstalk ID	M6ACROT00102				[1], [2]
m⁶A modification ADARB1 ADARB1 METTL3 Methylation : m⁶A sites Direct Enhancement RNA modification OPHN1 OPHN1 ADARB1 Methylation : modification sites
m6A Regulator	Methyltransferase-like 3 (METTL3)			WRITER	Regulator Info
m6A Target	Double-stranded RNA-specific editase 1 (ADARB1)				Targert Gene
Epigenetic Regulation that have Cross-talk with This m6A Modification:
Epigenetic Regulation Type	RNA modification (RNAMod) >> Adenosine-to-Inosine editing (A-to-I)
Epigenetic Regulator	Double-stranded RNA-specific editase 1 (ADARB1)			WRITER	View Details
Regulated Target	Oligophrenin 1 (OPHN1)				View Details
Crosstalk Relationship	m6A → A-to-I			Enhancement
Crosstalk Mechanism	m6A modification directly impacts RNA modification through modulating the expression level of RNA modification regulator
Crosstalk Summary	METTL3 methylates Double-stranded RNA-specific editase 1 (ADARB1) mRNA, thereby enhancing its protein expression, which subsequently promotes ADARB1 mediated A-to-I RNA editing of the Oligophrenin 1 (OPHN1) transcript.
Cell Process	RNA editing
In-vitro Model	MGG8	Glioblastoma	Homo sapiens		CVCL_D1H4
	U-118MG	Astrocytoma	Homo sapiens		CVCL_0633
	U-87MG ATCC	Glioblastoma	Homo sapiens		CVCL_0022

References

Ref 1	N?-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. Genes (Basel). 2019 Feb 13;10(2):141. doi: 10.3390/genes10020141.
Ref 2	Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development. PLoS One. 2014 Mar 17;9(3):e91351. doi: 10.1371/journal.pone.0091351. eCollection 2014.